OR52B6 (olfactory receptor family 52 subfamily B member 6)

Gene: OR52B6 (olfactory receptor family 52 subfamily B member 6) Homo sapiens

Analyze

Symbol:

OR52B6

Name:

olfactory receptor family 52 subfamily B member 6

RGD ID:

1351225

HGNC Page

HGNC:15211

Description:

Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

olfactory receptor 52B6; olfactory receptor OR11-47; olfactory receptor, family 52, subfamily B, member 6; OR11-47

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	5,580,877 - 5,581,884 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	5,580,877 - 5,581,884 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	5,602,107 - 5,603,114 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	5,558,683 - 5,559,690 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	5,558,682 - 5,559,690	NCBI
Celera	11	5,720,726 - 5,721,733 (+)	NCBI		Celera
Cytogenetic Map	11	p15.4	NCBI
HuRef	11	5,259,967 - 5,260,974 (+)	NCBI		HuRef
CHM1_1	11	5,601,070 - 5,602,077 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	5,640,298 - 5,641,305 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2-hydroxypropanoic acid (EXP)

benzo[a]pyrene (EXP)

bisphenol A (ISO)

CGP 52608 (EXP)

rac-lactic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of chemical stimulus involved in sensory perception of smell (IEA)

G protein-coupled receptor signaling pathway (IEA)

sensory perception of smell (IEA)

signal transduction (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA,TAS)

Molecular Function

G protein-coupled receptor activity (IEA)

olfactory receptor activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:14983052	PMID:21873635

Genomics

Comparative Map Data

OR52B6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	5,580,877 - 5,581,884 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	5,580,877 - 5,581,884 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	5,602,107 - 5,603,114 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	5,558,683 - 5,559,690 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	5,558,682 - 5,559,690	NCBI
Celera	11	5,720,726 - 5,721,733 (+)	NCBI		Celera
Cytogenetic Map	11	p15.4	NCBI
HuRef	11	5,259,967 - 5,260,974 (+)	NCBI		HuRef
CHM1_1	11	5,601,070 - 5,602,077 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	5,640,298 - 5,641,305 (+)	NCBI		T2T-CHM13v2.0

Or52b6-ps1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	103,855,236 - 103,856,213 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	103,852,644 - 103,857,072 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	104,206,029 - 104,207,006 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	104,203,437 - 104,207,865 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	111,354,543 - 111,355,520 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	104,079,850 - 104,080,827 (+)	NCBI		MGSCv36	mm8
Celera	7	104,586,594 - 104,587,571 (+)	NCBI		Celera
Cytogenetic Map	7	E3	NCBI
cM Map	7	55.42	NCBI

Or52z13
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	167,370,752 - 167,371,699 (+)	NCBI		GRCr8
mRatBN7.2	1	157,958,861 - 157,959,808 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	157,958,861 - 157,959,808 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	165,928,821 - 165,929,768 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	173,108,837 - 173,109,784 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	165,997,046 - 165,997,993 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	168,680,596 - 168,681,543 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	174,848,753 - 174,849,700 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	161,318,671 - 161,319,618 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	161,398,416 - 161,399,364 (+)	NCBI
Celera	1	155,997,277 - 155,998,224 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

LOC102007648
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955414	21,480,839 - 21,485,708 (+)	NCBI	ChiLan1.0	ChiLan1.0

LOC100983779
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	8,017,722 - 8,021,085 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	7,975,413 - 7,978,778 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	5,715,668 - 5,717,218 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	5,398,719 - 5,399,726 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	5,398,719 - 5,399,726 (+)	Ensembl	panpan1.1		panPan2

LOC485282
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	28,583,411 - 28,584,393 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	28,356,068 - 28,364,527 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	29,399,498 - 29,407,974 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	29,406,994 - 29,407,974 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	28,715,333 - 28,716,325 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	28,913,232 - 28,921,448 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	29,048,970 - 29,057,434 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101969186
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	57,519,653 - 57,520,646 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004937097	58,102 - 59,089 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100516630
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	9	4,225,092 - 4,226,110 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	4,668,634 - 4,669,644 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC101715885
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	7,019,699 - 7,020,655 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624817	7,019,645 - 7,020,655 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in OR52B6
16 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 11p15.4(chr11:3745061-7846057)x3	copy number gain	See cases [RCV000053616]	Chr11:3745061..7846057 [GRCh38] Chr11:3766291..7867604 [GRCh37] Chr11:3722867..7824180 [NCBI36] Chr11:11p15.4	pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3	copy number gain	See cases [RCV000053613]	Chr11:202758..31726224 [GRCh38] Chr11:202758..31747772 [GRCh37] Chr11:192758..31704348 [NCBI36] Chr11:11p15.5-13	pathogenic
NM_001005162.2(OR52B6):c.911C>T (p.Pro304Leu)	single nucleotide variant	Malignant melanoma [RCV000069472]	Chr11:5581787 [GRCh38] Chr11:5603017 [GRCh37] Chr11:5559593 [NCBI36] Chr11:11p15.4	not provided
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3	copy number gain	See cases [RCV000133997]	Chr11:446754..18904742 [GRCh38] Chr11:446754..18926289 [GRCh37] Chr11:436754..18882865 [NCBI36] Chr11:11p15.5-15.1	pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:61793-10727969)x3	copy number gain	See cases [RCV000139987]	Chr11:61793..10727969 [GRCh38] Chr11:61793..10749516 [GRCh37] Chr11:51793..10706092 [NCBI36] Chr11:11p15.5-15.4	pathogenic
GRCh37/hg19 11p15.5-15.3(chr11:193146-12643136)	copy number gain	Silver-Russell syndrome 1 [RCV000767567]	Chr11:193146..12643136 [GRCh37] Chr11:11p15.5-15.3	pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-6644927)x3	copy number gain	See cases [RCV000449417]	Chr11:230615..6644927 [GRCh37] Chr11:11p15.5-15.4	pathogenic
GRCh37/hg19 11p15.4(chr11:5528520-5603113)x1	copy number loss	See cases [RCV000448095]	Chr11:5528520..5603113 [GRCh37] Chr11:11p15.4	uncertain significance
GRCh37/hg19 11p15.4(chr11:5485210-5719251)x1	copy number loss	See cases [RCV000512062]	Chr11:5485210..5719251 [GRCh37] Chr11:11p15.4	likely benign
GRCh37/hg19 11p15.4(chr11:5361271-5616544)x1	copy number loss	See cases [RCV000510264]	Chr11:5361271..5616544 [GRCh37] Chr11:11p15.4	uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)	copy number gain	See cases [RCV000511729]	Chr11:230616..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3	copy number gain	See cases [RCV000511561]	Chr11:230615..37698540 [GRCh37] Chr11:11p15.5-12	pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3	copy number gain	See cases [RCV000510881]	Chr11:230616..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3	copy number gain	See cases [RCV000512225]	Chr11:230615..25584362 [GRCh37] Chr11:11p15.5-14.3	pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3	copy number gain	See cases [RCV000512477]	Chr11:230615..31995219 [GRCh37] Chr11:11p15.5-13	pathogenic
GRCh37/hg19 11p15.5-15.1(chr11:230615-17099213)x3	copy number gain	not provided [RCV000683372]	Chr11:230615..17099213 [GRCh37] Chr11:11p15.5-15.1	pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-9704511)x3	copy number gain	not provided [RCV000683369]	Chr11:230615..9704511 [GRCh37] Chr11:11p15.5-15.4	pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3	copy number gain	not provided [RCV000737348]	Chr11:198510..134934063 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3	copy number gain	not provided [RCV000749874]	Chr11:70864..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p15.4(chr11:5094756-5785959)x3	copy number gain	See cases [RCV003317674]	Chr11:5094756..5785959 [GRCh37] Chr11:11p15.4	likely benign
GRCh37/hg19 11p15.5-15.4(chr11:230616-8250724)x3	copy number gain	not provided [RCV002472435]	Chr11:230616..8250724 [GRCh37] Chr11:11p15.5-15.4	pathogenic
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3	copy number gain	not provided [RCV001006372]	Chr11:235934..33826995 [GRCh37] Chr11:11p15.5-13	pathogenic
GRCh37/hg19 11p15.4(chr11:5505304-6199376)x3	copy number gain	not provided [RCV001006381]	Chr11:5505304..6199376 [GRCh37] Chr11:11p15.4	likely benign
GRCh37/hg19 11p15.5-15.4(chr11:210300-8664358)x3	copy number gain	Silver-Russell syndrome 1 [RCV001263222]	Chr11:210300..8664358 [GRCh37] Chr11:11p15.5-15.4	pathogenic
GRCh37/hg19 11p15.4(chr11:5485211-5693876)x1	copy number loss	not provided [RCV001259584]	Chr11:5485211..5693876 [GRCh37] Chr11:11p15.4	uncertain significance
GRCh37/hg19 11p15.4(chr11:5488908-5701819)x1	copy number loss	not provided [RCV001829211]	Chr11:5488908..5701819 [GRCh37] Chr11:11p15.4	uncertain significance
GRCh37/hg19 11p15.5-14.2(chr11:230615-26881146)x3	copy number gain	See cases [RCV002286351]	Chr11:230615..26881146 [GRCh37] Chr11:11p15.5-14.2	pathogenic
GRCh37/hg19 11p15.4(chr11:5361272-5660023)x1	copy number loss	not provided [RCV002474937]	Chr11:5361272..5660023 [GRCh37] Chr11:11p15.4	uncertain significance
GRCh37/hg19 11p15.4(chr11:5279153-5619949)x3	copy number gain	not provided [RCV002472403]	Chr11:5279153..5619949 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.734T>A (p.Phe245Tyr)	single nucleotide variant	Inborn genetic diseases [RCV002686634]	Chr11:5581610 [GRCh38] Chr11:5602840 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.323G>T (p.Gly108Val)	single nucleotide variant	Inborn genetic diseases [RCV002737928]	Chr11:5581199 [GRCh38] Chr11:5602429 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.14G>A (p.Arg5Lys)	single nucleotide variant	Inborn genetic diseases [RCV002845333]	Chr11:5580890 [GRCh38] Chr11:5602120 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.698T>C (p.Ile233Thr)	single nucleotide variant	Inborn genetic diseases [RCV002950604]	Chr11:5581574 [GRCh38] Chr11:5602804 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.811T>C (p.Tyr271His)	single nucleotide variant	Inborn genetic diseases [RCV002798914]	Chr11:5581687 [GRCh38] Chr11:5602917 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.158T>C (p.Ile53Thr)	single nucleotide variant	Inborn genetic diseases [RCV002784793]	Chr11:5581034 [GRCh38] Chr11:5602264 [GRCh37] Chr11:11p15.4	likely benign
NM_001005162.2(OR52B6):c.688A>T (p.Ile230Phe)	single nucleotide variant	Inborn genetic diseases [RCV002853567]	Chr11:5581564 [GRCh38] Chr11:5602794 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.697A>T (p.Ile233Phe)	single nucleotide variant	Inborn genetic diseases [RCV002892366]	Chr11:5581573 [GRCh38] Chr11:5602803 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.26A>C (p.Lys9Thr)	single nucleotide variant	Inborn genetic diseases [RCV002804674]	Chr11:5580902 [GRCh38] Chr11:5602132 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.766G>A (p.Ala256Thr)	single nucleotide variant	Inborn genetic diseases [RCV002941660]	Chr11:5581642 [GRCh38] Chr11:5602872 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.955A>C (p.Ile319Leu)	single nucleotide variant	Inborn genetic diseases [RCV003198680]	Chr11:5581831 [GRCh38] Chr11:5603061 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.502C>A (p.Leu168Met)	single nucleotide variant	Inborn genetic diseases [RCV003194986]	Chr11:5581378 [GRCh38] Chr11:5602608 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.584A>G (p.His195Arg)	single nucleotide variant	Inborn genetic diseases [RCV003361937]	Chr11:5581460 [GRCh38] Chr11:5602690 [GRCh37] Chr11:11p15.4	uncertain significance
NM_001005162.2(OR52B6):c.508C>T (p.His170Tyr)	single nucleotide variant	Inborn genetic diseases [RCV003385339]	Chr11:5581384 [GRCh38] Chr11:5602614 [GRCh37] Chr11:11p15.4	uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:230615-8821443)x3	copy number gain	Russell-Silver syndrome [RCV003444025]	Chr11:230615..8821443 [GRCh37] Chr11:11p15.5-15.4	pathogenic

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	137
Count of miRNA genes:	135
Interacting mature miRNAs:	135
Transcripts:	ENST00000345043
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

ECD01293

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,601,862 - 5,602,732	UniSTS	GRCh37
Build 36	11	5,558,438 - 5,559,308	RGD	NCBI36
Celera	11	5,720,481 - 5,721,351	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,259,722 - 5,260,592	UniSTS

ECD20276

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,601,226 - 5,601,516	UniSTS	GRCh37
Build 36	11	5,557,802 - 5,558,092	RGD	NCBI36
Celera	11	5,719,846 - 5,720,136	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,259,087 - 5,259,377	UniSTS

ECD23616

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,600,262 - 5,600,445	UniSTS	GRCh37
Build 36	11	5,556,838 - 5,557,021	RGD	NCBI36
Celera	11	5,718,880 - 5,719,063	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,258,121 - 5,258,304	UniSTS

REN98782

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,600,182 - 5,600,442	UniSTS	GRCh37
Build 36	11	5,556,758 - 5,557,018	RGD	NCBI36
Celera	11	5,718,801 - 5,719,060	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,258,041 - 5,258,301	UniSTS

REN98783

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,600,423 - 5,600,683	UniSTS	GRCh37
Build 36	11	5,556,999 - 5,557,259	RGD	NCBI36
Celera	11	5,719,041 - 5,719,301	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,258,282 - 5,258,542	UniSTS

REN98784

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,600,573 - 5,600,834	UniSTS	GRCh37
Build 36	11	5,557,149 - 5,557,410	RGD	NCBI36
Celera	11	5,719,191 - 5,719,452	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,258,432 - 5,258,693	UniSTS

REN98785

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,601,113 - 5,601,337	UniSTS	GRCh37
Build 36	11	5,557,689 - 5,557,913	RGD	NCBI36
Celera	11	5,719,733 - 5,719,957	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,258,974 - 5,259,198	UniSTS

REN98786

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,601,309 - 5,601,542	UniSTS	GRCh37
Build 36	11	5,557,885 - 5,558,118	RGD	NCBI36
Celera	11	5,719,929 - 5,720,162	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,259,170 - 5,259,403	UniSTS

REN98787

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,601,836 - 5,602,060	UniSTS	GRCh37
Build 36	11	5,558,412 - 5,558,636	RGD	NCBI36
Celera	11	5,720,455 - 5,720,679	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,259,696 - 5,259,920	UniSTS

REN98788

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,602,054 - 5,602,313	UniSTS	GRCh37
Build 36	11	5,558,630 - 5,558,889	RGD	NCBI36
Celera	11	5,720,673 - 5,720,932	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,259,914 - 5,260,173	UniSTS

REN98789

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,602,308 - 5,602,548	UniSTS	GRCh37
Build 36	11	5,558,884 - 5,559,124	RGD	NCBI36
Celera	11	5,720,927 - 5,721,167	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,260,168 - 5,260,408	UniSTS

REN98790

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,602,486 - 5,602,754	UniSTS	GRCh37
Build 36	11	5,559,062 - 5,559,330	RGD	NCBI36
Celera	11	5,721,105 - 5,721,373	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,260,346 - 5,260,614	UniSTS

REN98791

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,602,742 - 5,602,994	UniSTS	GRCh37
Build 36	11	5,559,318 - 5,559,570	RGD	NCBI36
Celera	11	5,721,361 - 5,721,613	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,260,602 - 5,260,854	UniSTS

REN98792

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,602,984 - 5,603,228	UniSTS	GRCh37
Build 36	11	5,559,560 - 5,559,804	RGD	NCBI36
Celera	11	5,721,603 - 5,721,847	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,260,844 - 5,261,088	UniSTS

REN98793

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,603,200 - 5,603,443	UniSTS	GRCh37
Build 36	11	5,559,776 - 5,560,019	RGD	NCBI36
Celera	11	5,721,819 - 5,722,062	RGD
Cytogenetic Map	11	p15.4	UniSTS
HuRef	11	5,261,060 - 5,261,303	UniSTS

stSG611077

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,600,389 - 5,601,509	UniSTS	GRCh37
Build 36	11	5,556,965 - 5,558,085	RGD	NCBI36
Celera	11	5,719,007 - 5,720,129	RGD
HuRef	11	5,258,248 - 5,259,370	UniSTS

stSG611078

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	5,601,490 - 5,602,931	UniSTS	GRCh37
Build 36	11	5,558,066 - 5,559,507	RGD	NCBI36
Celera	11	5,720,110 - 5,721,550	RGD
HuRef	11	5,259,351 - 5,260,791	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

entire extraembryonic component

High

Medium

Low

Below cutoff

991

1534

758

181

890

100

1632

701

1069

115

784

743

479

1096

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB065858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC015691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BK004275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KP290361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000345043 ⟹ ENSP00000341581

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	5,580,877 - 5,581,884 (+)	Ensembl

RefSeq Acc Id:

NM_001005162 ⟹ NP_001005162

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	11	5,580,877 - 5,581,884 (+)	NCBI
GRCh37	11	5,602,107 - 5,603,114 (+)	RGD
Build 36	11	5,558,683 - 5,559,690 (+)	NCBI Archive
Celera	11	5,720,726 - 5,721,733 (+)	RGD
HuRef	11	5,259,967 - 5,260,974 (+)	RGD
CHM1_1	11	5,601,070 - 5,602,077 (+)	NCBI
T2T-CHM13v2.0	11	5,640,298 - 5,641,305 (+)	NCBI

Sequence:

show sequence

ATGGCACAGGTGAGGGCGCTGCATAAAATCATGGCCCTTTTTTCTGCTAACAGCATAGGTGCTA
TGAACAACTCTGACACTCGCATAGCAGGCTGCTTCCTCACTGGCATCCCTGGGCTGGAGCAACT
ACATATCTGGCTGTCCATCCCCTTCTGCATCATGTACATCACTGCCCTGGAAGGCAATGGCATC
CTAATTTGTGTCATCCTCTCCCAGGCAATCCTGCATGAGCCCATGTACATATTCTTATCTATGC
TGGCCAGTGCTGATGTCTTGCTCTCTACCACCACCATGCCTAAGGCCCTGGCCAATTTGTGGCT
AGGTTATAGCCTCATTTCCTTTGATGGCTGCCTCACTCAGATGTTCTTCATTCACTTCCTCTTC
ATTCACTCTGCTGTCCTGCTGGCCATGGCCTTTGACCGCTATGTGGCCATCTGCTCCCCCCTGC
GATATGTCACAATCCTCACAAGCAAGGTCATTGGGAAGATCGTCACTGCCGCCCTGAGCCACAG
CTTCATCATTATGTTTCCATCCATCTTTCTCCTTGAGCACCTGCACTATTGCCAGATCAATATC
ATTGCACACACATTTTGTGAGCACATGGGCATTGCCCATCTGTCCTGTTCTGATATCTCCATCA
ATGTCTGGTATGGGTTGGCAGCTGCTCTTCTCTCCACAGGCCTAGACATCATGCTTATTACTGT
TTCCTACATCCACATCCTCCAAGCAGTCTTCCGCCTCCTTTCTCAAGATGCCCGCTCCAAGGCC
CTGAGTACCTGTGGATCCCATATCTGTGTCATCCTACTCTTCTATGTCCCTGCGCTTTTTTCTG
TCTTTGCCTACAGGTTTGGTGGGAGAAGCGTCCCATGCTATGTCCATATTCTCCTGGCCAGCCT
CTACGTTGTCATTCCTCCTATGCTCAATCCCGTTATTTATGGAGTGAGGACTAAGCCAATACTG
GAAGGGGCTAAGCAGATGTTTTCAAATCTTGCCAAAGGATCTAAATAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001005162	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ALI87537	(Get FASTA)	NCBI Sequence Viewer
	BAC06076	(Get FASTA)	NCBI Sequence Viewer
	DAA04673	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000341581
	ENSP00000341581.2
GenBank Protein	Q8NGF0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001005162 ⟸ NM_001005162

- UniProtKB:

Q6IFI7 (UniProtKB/Swiss-Prot), Q8NGF0 (UniProtKB/Swiss-Prot), A0A126GVW0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAQVRALHKIMALFSANSIGAMNNSDTRIAGCFLTGIPGLEQLHIWLSIPFCIMYITALEGNGI
LICVILSQAILHEPMYIFLSMLASADVLLSTTTMPKALANLWLGYSLISFDGCLTQMFFIHFLF
IHSAVLLAMAFDRYVAICSPLRYVTILTSKVIGKIVTAALSHSFIIMFPSIFLLEHLHYCQINI
IAHTFCEHMGIAHLSCSDISINVWYGLAAALLSTGLDIMLITVSYIHILQAVFRLLSQDARSKA
LSTCGSHICVILLFYVPALFSVFAYRFGGRSVPCYVHILLASLYVVIPPMLNPVIYGVRTKPIL
EGAKQMFSNLAKGSK

hide sequence

RefSeq Acc Id:

ENSP00000341581 ⟸ ENST00000345043

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8NGF0-F1-model_v2	AlphaFold	Q8NGF0	1-335	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:15211	AgrOrtholog
COSMIC	OR52B6	COSMIC
Ensembl Genes	ENSG00000187747	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000345043	ENTREZGENE
	ENST00000345043.2	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000187747	GTEx
HGNC ID	HGNC:15211	ENTREZGENE
Human Proteome Map	OR52B6	Human Proteome Map
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Olfact_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:340980	UniProtKB/Swiss-Prot
NCBI Gene	340980	ENTREZGENE
PANTHER	OLFACTORY RECEPTOR 52B6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OLFACTORY RECEPTOR 56B1-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA32400	PharmGKB
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OLFACTORYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A126GVW0	ENTREZGENE, UniProtKB/TrEMBL
	O52B6_HUMAN	UniProtKB/Swiss-Prot
	Q6IFI7	ENTREZGENE
	Q8NGF0	ENTREZGENE
UniProt Secondary	Q6IFI7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-15	OR52B6	olfactory receptor family 52 subfamily B member 6	OR52B6	olfactory receptor, family 52, subfamily B, member 6	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar