Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | PPIL3 | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ppil3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PPIL3 mRNA | CTD | PMID:21570461 | PPIL3 | Human | 2,4-dinitrotoluene | affects expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of PPIL3 mRNA | CTD | PMID:21346803 | PPIL3 | Human | 2,6-dinitrotoluene | affects expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of PPIL3 mRNA | CTD | PMID:21346803 | PPIL3 | Human | 2-hydroxypropanoic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of PPIL3 mRNA | CTD | PMID:30851411 | PPIL3 | Human | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Ppil3 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of PPIL3 mRNA | CTD | PMID:18648102 | PPIL3 | Human | 4-amino-2,6-dinitrotoluene | affects expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of PPIL3 mRNA | CTD | PMID:21346803 | PPIL3 | Human | 6-propyl-2-thiouracil | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of PPIL3 mRNA | CTD | PMID:30047161 | PPIL3 | Human | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of PPIL3 gene | CTD | PMID:27153756 | PPIL3 | Human | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of PPIL3 mRNA | CTD | PMID:33167477 | PPIL3 | Human | amitrole | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of PPIL3 mRNA | CTD | PMID:30047161 | PPIL3 | Human | ammonium chloride | affects expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of PPIL3 mRNA | CTD | PMID:16483693 | PPIL3 | Human | arsenous acid | multiple interactions | EXP | | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PPIL3 protein] | CTD | PMID:26598702 | PPIL3 | Human | benzo[a]pyrene | increases expression | ISO | Ppil3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PPIL3 mRNA | CTD | PMID:19770486 and PMID:22228805 | PPIL3 | Human | bis(2-ethylhexyl) phthalate | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Diethylhexyl Phthalate results in increased expression of PPIL3 mRNA | CTD | PMID:21318169 | PPIL3 | Human | bisphenol A | decreases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of PPIL3 mRNA | CTD | PMID:25181051 | PPIL3 | Human | bisphenol A | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PPIL3 mRNA | CTD | PMID:32145629 | PPIL3 | Human | bisphenol A | affects methylation | ISO | Ppil3 (Rattus norvegicus) | 6480464 | bisphenol A affects the methylation of PPIL3 promoter | CTD | PMID:27415467 | PPIL3 | Human | butan-1-ol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of PPIL3 mRNA | CTD | PMID:29432896 | PPIL3 | Human | C60 fullerene | decreases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | fullerene C60 results in decreased expression of PPIL3 mRNA | CTD | PMID:19167457 | PPIL3 | Human | carbon nanotube | increases expression | ISO | Ppil3 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of PPIL3 mRNA | CTD | PMID:25554681 | PPIL3 | Human | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of PPIL3 mRNA | CTD | PMID:27594783 | PPIL3 | Human | clofibric acid | multiple interactions | ISO | Ppil3 (Rattus norvegicus) | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PPIL3 mRNA | CTD | PMID:17602206 | PPIL3 | Human | copper(II) sulfate | decreases expression | EXP | | 6480464 | Copper Sulfate results in decreased expression of PPIL3 mRNA | CTD | PMID:19549813 | PPIL3 | Human | diarsenic trioxide | multiple interactions | EXP | | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PPIL3 protein] | CTD | PMID:26598702 | PPIL3 | Human | dicrotophos | decreases expression | EXP | | 6480464 | dicrotophos results in decreased expression of PPIL3 mRNA | CTD | PMID:28302478 | PPIL3 | Human | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of PPIL3 mRNA | CTD | PMID:29803840 | PPIL3 | Human | epoxiconazole | increases expression | ISO | Ppil3 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of PPIL3 mRNA | CTD | PMID:35436446 | PPIL3 | Human | ethanol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of PPIL3 mRNA | CTD | PMID:29432896 | PPIL3 | Human | fenthion | decreases expression | ISO | Ppil3 (Mus musculus) | 6480464 | Fenthion results in decreased expression of PPIL3 mRNA | CTD | PMID:34813904 | PPIL3 | Human | fipronil | decreases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | fipronil results in decreased expression of PPIL3 mRNA | CTD | PMID:34044035 | PPIL3 | Human | flutamide | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of PPIL3 mRNA | CTD | PMID:24136188 | PPIL3 | Human | glafenine | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Glafenine results in increased expression of PPIL3 mRNA | CTD | PMID:24136188 | PPIL3 | Human | isobutanol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of PPIL3 mRNA | CTD | PMID:29432896 | PPIL3 | Human | methidathion | decreases expression | ISO | Ppil3 (Mus musculus) | 6480464 | methidathion results in decreased expression of PPIL3 mRNA | CTD | PMID:34813904 | PPIL3 | Human | methimazole | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of PPIL3 mRNA | CTD | PMID:30047161 | PPIL3 | Human | N-nitrosodiethylamine | multiple interactions | ISO | Ppil3 (Rattus norvegicus) | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PPIL3 mRNA | CTD | PMID:17602206 | PPIL3 | Human | nimesulide | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | nimesulide results in increased expression of PPIL3 mRNA | CTD | PMID:24136188 | PPIL3 | Human | oxaliplatin | multiple interactions | ISO | Ppil3 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PPIL3 mRNA | CTD | PMID:25729387 | PPIL3 | Human | paracetamol | affects expression | ISO | Ppil3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PPIL3 mRNA | CTD | PMID:17562736 | PPIL3 | Human | paracetamol | decreases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of PPIL3 mRNA | CTD | PMID:33387578 | PPIL3 | Human | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PPIL3 mRNA | CTD | PMID:21420995 | PPIL3 | Human | perfluorooctane-1-sulfonic acid | affects expression | ISO | Ppil3 (Mus musculus) | 6480464 | perfluorooctane sulfonic acid affects the expression of PPIL3 mRNA | CTD | PMID:19429403 | PPIL3 | Human | perfluorooctanoic acid | affects expression | ISO | Ppil3 (Mus musculus) | 6480464 | perfluorooctanoic acid affects the expression of PPIL3 mRNA | CTD | PMID:19429403 | PPIL3 | Human | perfluorooctanoic acid | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | perfluorooctanoic acid results in increased expression of PPIL3 mRNA | CTD | PMID:19162173 and PMID:21318169 | PPIL3 | Human | phenobarbital | affects expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Phenobarbital affects the expression of PPIL3 mRNA | CTD | PMID:19162173 | PPIL3 | Human | phenobarbital | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Phenobarbital results in increased expression of PPIL3 mRNA | CTD | PMID:21318169 | PPIL3 | Human | pirinixic acid | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | pirinixic acid results in increased expression of PPIL3 mRNA | CTD | PMID:19162173 and PMID:21318169 | PPIL3 | Human | pregnenolone 16alpha-carbonitrile | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Pregnenolone Carbonitrile results in increased expression of PPIL3 mRNA | CTD | PMID:19162173 and PMID:21318169 | PPIL3 | Human | rac-lactic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of PPIL3 mRNA | CTD | PMID:30851411 | PPIL3 | Human | sulfadimethoxine | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of PPIL3 mRNA | CTD | PMID:30047161 | PPIL3 | Human | tetrahydropalmatine | decreases expression | EXP | | 6480464 | tetrahydropalmatine results in decreased expression of PPIL3 protein | CTD | PMID:20109541 | PPIL3 | Human | thioacetamide | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of PPIL3 mRNA | CTD | PMID:23411599 and PMID:34492290 | PPIL3 | Human | topotecan | multiple interactions | ISO | Ppil3 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PPIL3 mRNA | CTD | PMID:25729387 | PPIL3 | Human | triptonide | decreases expression | ISO | Ppil3 (Mus musculus) | 6480464 | triptonide results in decreased expression of PPIL3 mRNA | CTD | PMID:33045310 | PPIL3 | Human | valproic acid | increases expression | ISO | Ppil3 (Rattus norvegicus) | 6480464 | Valproic Acid results in increased expression of PPIL3 mRNA | CTD | PMID:21318169 | PPIL3 | Human | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of PPIL3 mRNA | CTD | PMID:23179753 | |