BIRC8 (baculoviral IAP repeat containing 8) - Rat Genome Database

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Gene: BIRC8 (baculoviral IAP repeat containing 8) Homo sapiens
Analyze
Symbol: BIRC8
Name: baculoviral IAP repeat containing 8
RGD ID: 1349757
HGNC Page HGNC:14878
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; and positive regulation of protein ubiquitination. Predicted to be active in cytoplasm and nucleus.
Type: pseudo (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Previously known as: baculoviral IAP repeat-containing 8; baculoviral IAP repeat-containing protein 8; hILP2; IAP-like protein 2; ILP-2; ILP2; inhibitor of apoptosis-like protein 2; RNF136; testis-specific inhibitor of apoptosis
RGD Orthologs
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,289,601 - 53,291,434 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,289,664 - 53,291,131 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,289,601 - 53,291,426 (-)EnsemblGRCh38hg38GRCh38
GRCh371953,792,854 - 53,794,687 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,484,666 - 58,486,687 (-)NCBINCBI36Build 36hg18NCBI36
Build 341958,484,667 - 58,486,687NCBI
Celera1950,834,544 - 50,836,565 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,113,485 - 50,115,506 (-)NCBIHuRef
CHM1_11953,794,759 - 53,796,780 (-)NCBICHM1_1
T2T-CHM13v2.01956,369,089 - 56,370,922 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11390657   PMID:11597143   PMID:12372615   PMID:12477932   PMID:15485395   PMID:16344560   PMID:19549727   PMID:19690564   PMID:20800603   PMID:21873635   PMID:23222679   PMID:24266799  
PMID:25416956   PMID:25800559   PMID:26186194   PMID:28514442   PMID:28604741   PMID:30106449   PMID:32296183   PMID:33961781   PMID:34857952  


Genomics

Comparative Map Data
BIRC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,289,601 - 53,291,434 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,289,664 - 53,291,131 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,289,601 - 53,291,426 (-)EnsemblGRCh38hg38GRCh38
GRCh371953,792,854 - 53,794,687 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,484,666 - 58,486,687 (-)NCBINCBI36Build 36hg18NCBI36
Build 341958,484,667 - 58,486,687NCBI
Celera1950,834,544 - 50,836,565 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,113,485 - 50,115,506 (-)NCBIHuRef
CHM1_11953,794,759 - 53,796,780 (-)NCBICHM1_1
T2T-CHM13v2.01956,369,089 - 56,370,922 (-)NCBIT2T-CHM13v2.0
LOC100971253
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22059,313,641 - 59,316,477 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11961,230,108 - 61,234,905 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01950,206,563 - 50,208,496 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,088,102 - 59,089,920 (-)NCBIpanpan1.1PanPan1.1panPan2
LOC103239976
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1134,650,421 - 4,651,630 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040180,881,318 - 180,882,367 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in BIRC8
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_033341.4(BIRC8):c.375C>T (p.Phe125=) single nucleotide variant Malignant melanoma [RCV000072331] Chr19:53290000 [GRCh38]
Chr19:53793253 [GRCh37]
Chr19:58485065 [NCBI36]
Chr19:19q13.42		 not provided
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:98
Interacting mature miRNAs:101
Transcripts:ENST00000426466
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
PMC87089P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371953,793,001 - 53,793,370UniSTSGRCh37
Build 361958,484,813 - 58,485,182RGDNCBI36
Celera1950,834,691 - 50,835,060RGD
HuRef1950,113,632 - 50,114,001UniSTS
PMC87089P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371953,792,853 - 53,793,694UniSTSGRCh37
Build 361958,484,665 - 58,485,506RGDNCBI36
Celera1950,834,543 - 50,835,384RGD
HuRef1950,113,484 - 50,114,325UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 300
Low 1 2 1 2 72 3 1
Below cutoff 467 635 304 55 303 31 761 362 700 25 194 310 24 232 542

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000651384
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,289,601 - 53,291,426 (-)Ensembl
RefSeq Acc Id: ENST00000652230
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,289,664 - 53,291,131 (-)Ensembl
RefSeq Acc Id: NR_159880
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,289,601 - 53,291,434 (-)NCBI
T2T-CHM13v2.01956,369,089 - 56,370,922 (-)NCBI
Sequence:
Reference Protein Sequences
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96P09-F1-model_v2 AlphaFold Q96P09 1-236 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14878 AgrOrtholog
COSMIC BIRC8 COSMIC
Ensembl Genes ENSG00000163098 Ensembl
  ENSG00000293247 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000651384 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000163098 GTEx
  ENSG00000293247 GTEx
HGNC ID HGNC:14878 ENTREZGENE
Human Proteome Map BIRC8 Human Proteome Map
InterPro BIR_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  XIAP/BIRC8_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 112401 ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INHIBITOR OF APOPTOSIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25365 PharmGKB
PROSITE BIR_REPEAT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt BIRC8_HUMAN UniProtKB/Swiss-Prot
  Q6PIA0_HUMAN UniProtKB/TrEMBL
  Q96P09 ENTREZGENE
UniProt Secondary Q6IPY1 UniProtKB/Swiss-Prot
  Q96RW5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 BIRC8  baculoviral IAP repeat containing 8  BIRC8  baculoviral IAP repeat-containing 8  Symbol and/or name change 5135510 APPROVED