ZNF300 (zinc finger protein 300) - Rat Genome Database

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Gene: ZNF300 (zinc finger protein 300) Homo sapiens
Analyze
Symbol: ZNF300
Name: zinc finger protein 300
RGD ID: 1349700
HGNC Page HGNC:13091
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nuclear body and nucleolus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DKFZp686B24204; kruppel-like zinc finger protein
RGD Orthologs
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: AC025588.4   ZNF300P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,894,399 - 150,904,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,894,392 - 150,904,983 (-)EnsemblGRCh38hg38GRCh38
GRCh375150,273,961 - 150,284,542 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,254,157 - 150,264,584 (-)NCBINCBI36Build 36hg18NCBI36
Build 345150,254,156 - 150,264,584NCBI
Celera5146,355,280 - 146,365,871 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,419,818 - 145,430,409 (-)NCBIHuRef
CHM1_15149,706,761 - 149,717,352 (-)NCBICHM1_1
T2T-CHM13v2.05151,430,897 - 151,441,478 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear body  (IDA)
nucleolus  (IDA)
nucleoplasm  (IDA)
nucleus  (IBA,IDA,IEA)

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:14746915   PMID:15489334   PMID:16341674   PMID:16344560   PMID:17541838   PMID:17554300   PMID:18350257   PMID:20471086   PMID:20549515   PMID:20585888  
PMID:21777376   PMID:21873635   PMID:23128233   PMID:23284306   PMID:23665872   PMID:23686814   PMID:24378760   PMID:24393131   PMID:30568000   PMID:32296183   PMID:32393512   PMID:33078469  
PMID:33961781   PMID:35166026   PMID:35563538  


Genomics

Comparative Map Data
ZNF300
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,894,399 - 150,904,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,894,392 - 150,904,983 (-)EnsemblGRCh38hg38GRCh38
GRCh375150,273,961 - 150,284,542 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,254,157 - 150,264,584 (-)NCBINCBI36Build 36hg18NCBI36
Build 345150,254,156 - 150,264,584NCBI
Celera5146,355,280 - 146,365,871 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,419,818 - 145,430,409 (-)NCBIHuRef
CHM1_15149,706,761 - 149,717,352 (-)NCBICHM1_1
T2T-CHM13v2.05151,430,897 - 151,441,478 (-)NCBIT2T-CHM13v2.0
Zfp600
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0 Ensembl1138,727,048 - 38,773,607 (+)EnsemblRnor6.0rn6Rnor6.0
Celera158,043,821 - 58,091,761 (-)NCBICelera
Cytogenetic Map1 NCBI
Znf300
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554153,703,845 - 3,713,311 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554153,701,434 - 3,713,097 (+)NCBIChiLan1.0ChiLan1.0
ZNF300
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,124,084 - 146,136,931 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,261,386 - 144,276,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,321,953 - 146,332,550 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,324,546 - 152,335,158 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5152,324,546 - 152,335,155 (-)Ensemblpanpan1.1panPan2
ZNF300
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,259,623 - 58,306,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,295,193 - 58,305,585 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,025,286 - 58,043,498 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,739,703 - 58,758,151 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1458,529,240 - 58,547,686 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,641,896 - 58,660,342 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,173,234 - 59,191,699 (+)NCBIUU_Cfam_GSD_1.0
Znf300
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,407,027 - 142,418,434 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365043,987,812 - 3,994,656 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365043,981,019 - 3,991,480 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF300
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,842,009 - 151,856,042 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,842,002 - 151,872,343 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZNF300
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,503,737 - 53,514,191 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2353,504,759 - 53,507,914 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603424,200,846 - 24,213,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf300
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477410,142,938 - 10,162,365 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477410,142,969 - 10,164,131 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ZNF300
25 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
NM_001172831.1(ZNF300):c.95A>G (p.Asp32Gly) single nucleotide variant Malignant melanoma [RCV000061179] Chr5:150898523 [GRCh38]
Chr5:150278085 [GRCh37]
Chr5:150258278 [NCBI36]
Chr5:5q33.1		 not provided
NM_052860.4(ZNF300):c.299G>A (p.Cys100Tyr) single nucleotide variant not specified [RCV004256895] Chr5:150896940 [GRCh38]
Chr5:150276502 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1367A>T (p.Gln456Leu) single nucleotide variant not specified [RCV004276656] Chr5:150895872 [GRCh38]
Chr5:150275434 [GRCh37]
Chr5:5q33.1		 uncertain significance
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q33.1(chr5:150806692-150930666)x1 copy number loss See cases [RCV000140327] Chr5:150806692..150930666 [GRCh38]
Chr5:150186254..150310228 [GRCh37]
Chr5:150166447..150290421 [NCBI36]
Chr5:5q33.1		 likely benign
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
NM_052860.4(ZNF300):c.1160G>A (p.Gly387Glu) single nucleotide variant not specified [RCV004266031] Chr5:150896079 [GRCh38]
Chr5:150275641 [GRCh37]
Chr5:5q33.1		 uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV002231249]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NM_052860.4(ZNF300):c.925A>C (p.Lys309Gln) single nucleotide variant not specified [RCV004302959] Chr5:150896314 [GRCh38]
Chr5:150275876 [GRCh37]
Chr5:5q33.1		 uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q33.1(chr5:150186254-150356223)x1 copy number loss not provided [RCV000762709] Chr5:150186254..150356223 [GRCh37]
Chr5:5q33.1		 likely benign
NM_052860.4(ZNF300):c.690T>C (p.Asn230=) single nucleotide variant not provided [RCV000969502] Chr5:150896549 [GRCh38]
Chr5:150276111 [GRCh37]
Chr5:5q33.1		 benign
NM_052860.4(ZNF300):c.513T>G (p.Phe171Leu) single nucleotide variant not provided [RCV000950694] Chr5:150896726 [GRCh38]
Chr5:150276288 [GRCh37]
Chr5:5q33.1		 benign
NM_052860.4(ZNF300):c.649G>A (p.Gly217Arg) single nucleotide variant not provided [RCV000950693] Chr5:150896590 [GRCh38]
Chr5:150276152 [GRCh37]
Chr5:5q33.1		 benign
GRCh37/hg19 5q33.1(chr5:150155711-150316261)x1 copy number loss not provided [RCV000847388] Chr5:150155711..150316261 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.640C>G (p.Gln214Glu) single nucleotide variant not specified [RCV004317656] Chr5:150896599 [GRCh38]
Chr5:150276161 [GRCh37]
Chr5:5q33.1		 likely benign
NM_052860.4(ZNF300):c.1074C>T (p.Cys358=) single nucleotide variant not provided [RCV000956329] Chr5:150896165 [GRCh38]
Chr5:150275727 [GRCh37]
Chr5:5q33.1		 benign
GRCh37/hg19 5q32-35.3(chr5:149010383-180719789) copy number gain Hunter-McAlpine craniosynostosis [RCV002280612] Chr5:149010383..180719789 [GRCh37]
Chr5:5q32-35.3		 pathogenic
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
NM_052860.4(ZNF300):c.829G>A (p.Ala277Thr) single nucleotide variant not specified [RCV004331016] Chr5:150896410 [GRCh38]
Chr5:150275972 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1058A>G (p.Tyr353Cys) single nucleotide variant not specified [RCV004324981] Chr5:150896181 [GRCh38]
Chr5:150275743 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.602C>T (p.Pro201Leu) single nucleotide variant not specified [RCV004100878] Chr5:150896637 [GRCh38]
Chr5:150276199 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1622G>A (p.Arg541Gln) single nucleotide variant not specified [RCV004141339] Chr5:150895617 [GRCh38]
Chr5:150275179 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.712G>A (p.Val238Ile) single nucleotide variant not specified [RCV004162550] Chr5:150896527 [GRCh38]
Chr5:150276089 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1657G>A (p.Glu553Lys) single nucleotide variant not specified [RCV004118805] Chr5:150895582 [GRCh38]
Chr5:150275144 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.76G>C (p.Asp26His) single nucleotide variant not specified [RCV004118694] Chr5:150898494 [GRCh38]
Chr5:150278056 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1075G>A (p.Gly359Arg) single nucleotide variant not specified [RCV004118803] Chr5:150896164 [GRCh38]
Chr5:150275726 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.519G>C (p.Glu173Asp) single nucleotide variant not specified [RCV004107280] Chr5:150896720 [GRCh38]
Chr5:150276282 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1273A>G (p.Ile425Val) single nucleotide variant not specified [RCV004113982] Chr5:150895966 [GRCh38]
Chr5:150275528 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1547C>T (p.Thr516Ile) single nucleotide variant not specified [RCV004106941] Chr5:150895692 [GRCh38]
Chr5:150275254 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1575A>C (p.Glu525Asp) single nucleotide variant not specified [RCV004137279] Chr5:150895664 [GRCh38]
Chr5:150275226 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.947A>G (p.Gln316Arg) single nucleotide variant not specified [RCV004149284] Chr5:150896292 [GRCh38]
Chr5:150275854 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.899G>A (p.Gly300Asp) single nucleotide variant not specified [RCV004270891] Chr5:150896340 [GRCh38]
Chr5:150275902 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1486A>C (p.Ser496Arg) single nucleotide variant not specified [RCV004494368] Chr5:150895753 [GRCh38]
Chr5:150275315 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.838A>G (p.Lys280Glu) single nucleotide variant not specified [RCV004494375] Chr5:150896401 [GRCh38]
Chr5:150275963 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1427G>A (p.Arg476His) single nucleotide variant not specified [RCV004494367] Chr5:150895812 [GRCh38]
Chr5:150275374 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.349A>G (p.Arg117Gly) single nucleotide variant not specified [RCV004494371] Chr5:150896890 [GRCh38]
Chr5:150276452 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.352G>A (p.Asp118Asn) single nucleotide variant not specified [RCV004494372] Chr5:150896887 [GRCh38]
Chr5:150276449 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.769A>C (p.Ile257Leu) single nucleotide variant not specified [RCV004494374] Chr5:150896470 [GRCh38]
Chr5:150276032 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.1394A>T (p.Tyr465Phe) single nucleotide variant not specified [RCV004494366] Chr5:150895845 [GRCh38]
Chr5:150275407 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.-21G>A single nucleotide variant not specified [RCV004494370] Chr5:150903176 [GRCh38]
Chr5:150282738 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_052860.4(ZNF300):c.760C>A (p.Gln254Lys) single nucleotide variant not specified [RCV004494373] Chr5:150896479 [GRCh38]
Chr5:150276041 [GRCh37]
Chr5:5q33.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2706
Count of miRNA genes:730
Interacting mature miRNAs:811
Transcripts:ENST00000274599, ENST00000394226, ENST00000418587, ENST00000427179, ENST00000446148
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-53373  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375150,274,280 - 150,274,458UniSTSGRCh37
Build 365150,254,473 - 150,254,651RGDNCBI36
Celera5146,355,606 - 146,355,784RGD
Cytogenetic Map5q33.1UniSTS
HuRef5145,420,144 - 145,420,322UniSTS
TNG Radiation Hybrid Map569974.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 67 92 555 23 96 23 706 61 662 62 831 670 4 24 516
Low 2296 2295 1071 505 1031 345 3320 1786 3025 321 582 896 166 1 1180 1955 2 2
Below cutoff 49 596 97 95 719 96 328 345 44 29 31 29 4 317 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_016866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001172831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001172832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_052860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC010441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF395541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK026949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM824443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR933727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA497503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB094933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC376791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ908918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000274599   ⟹   ENSP00000274599
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,894,399 - 150,904,980 (-)Ensembl
RefSeq Acc Id: ENST00000394226   ⟹   ENSP00000377773
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,894,399 - 150,904,978 (-)Ensembl
RefSeq Acc Id: ENST00000418587   ⟹   ENSP00000392593
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,894,392 - 150,904,983 (-)Ensembl
RefSeq Acc Id: ENST00000427179   ⟹   ENSP00000414195
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,894,399 - 150,904,789 (-)Ensembl
RefSeq Acc Id: ENST00000446148   ⟹   ENSP00000397178
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,894,392 - 150,904,983 (-)Ensembl
RefSeq Acc Id: NM_001172831   ⟹   NP_001166302
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,894,399 - 150,904,980 (-)NCBI
GRCh375150,273,954 - 150,284,545 (-)RGD
Celera5146,355,280 - 146,365,871 (-)RGD
HuRef5145,419,818 - 145,430,409 (-)ENTREZGENE
CHM1_15149,706,761 - 149,717,352 (-)NCBI
T2T-CHM13v2.05151,430,897 - 151,441,478 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001172832   ⟹   NP_001166303
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,894,399 - 150,904,980 (-)NCBI
GRCh375150,273,954 - 150,284,545 (-)RGD
Celera5146,355,280 - 146,365,871 (-)RGD
HuRef5145,419,818 - 145,430,409 (-)ENTREZGENE
CHM1_15149,706,761 - 149,717,352 (-)NCBI
T2T-CHM13v2.05151,430,897 - 151,441,478 (-)NCBI
Sequence:
RefSeq Acc Id: NM_052860   ⟹   NP_443092
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,894,399 - 150,904,980 (-)NCBI
GRCh375150,273,954 - 150,284,545 (-)RGD
Build 365150,254,157 - 150,264,584 (-)NCBI Archive
Celera5146,355,280 - 146,365,871 (-)RGD
HuRef5145,419,818 - 145,430,409 (-)ENTREZGENE
CHM1_15149,706,761 - 149,717,352 (-)NCBI
T2T-CHM13v2.05151,430,897 - 151,441,478 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047417874   ⟹   XP_047273830
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,894,399 - 150,903,317 (-)NCBI
RefSeq Acc Id: XM_054353792   ⟹   XP_054209767
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05151,430,897 - 151,439,815 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_443092   ⟸   NM_052860
- Peptide Label: isoform 2
- UniProtKB: Q17RP3 (UniProtKB/Swiss-Prot),   Q06DQ3 (UniProtKB/Swiss-Prot),   F5GWS1 (UniProtKB/Swiss-Prot),   B4DU78 (UniProtKB/Swiss-Prot),   B3KU35 (UniProtKB/Swiss-Prot),   A8MY91 (UniProtKB/Swiss-Prot),   Q5H9N5 (UniProtKB/Swiss-Prot),   Q96RE9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001166302   ⟸   NM_001172831
- Peptide Label: isoform 1
- UniProtKB: Q96RE9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001166303   ⟸   NM_001172832
- Peptide Label: isoform 3
- UniProtKB: Q96RE9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000414195   ⟸   ENST00000427179
RefSeq Acc Id: ENSP00000392593   ⟸   ENST00000418587
RefSeq Acc Id: ENSP00000274599   ⟸   ENST00000274599
RefSeq Acc Id: ENSP00000397178   ⟸   ENST00000446148
RefSeq Acc Id: ENSP00000377773   ⟸   ENST00000394226
RefSeq Acc Id: XP_047273830   ⟸   XM_047417874
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054209767   ⟸   XM_054353792
- Peptide Label: isoform X1
Protein Domains
KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96RE9-F1-model_v2 AlphaFold Q96RE9 1-604 view protein structure

Promoters
RGD ID:6803718
Promoter ID:HG_KWN:51547
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_001172831,   NM_001172832,   NM_052860,   OTTHUMT00000252368,   OTTHUMT00000337308
Position:
Human AssemblyChrPosition (strand)Source
Build 365150,264,351 - 150,264,851 (-)MPROMDB
RGD ID:6871294
Promoter ID:EPDNEW_H8812
Type:initiation region
Name:ZNF300_2
Description:zinc finger protein 300
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8813  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,904,867 - 150,904,927EPDNEW
RGD ID:6871296
Promoter ID:EPDNEW_H8813
Type:initiation region
Name:ZNF300_1
Description:zinc finger protein 300
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8812  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,904,978 - 150,905,038EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13091 AgrOrtholog
COSMIC ZNF300 COSMIC
Ensembl Genes ENSG00000145908 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000274599 ENTREZGENE
  ENST00000274599.10 UniProtKB/Swiss-Prot
  ENST00000427179.5 UniProtKB/TrEMBL
  ENST00000446148.7 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/Swiss-Prot
GTEx ENSG00000145908 GTEx
HGNC ID HGNC:13091 ENTREZGENE
Human Proteome Map ZNF300 Human Proteome Map
InterPro KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report hsa:91975 UniProtKB/Swiss-Prot
NCBI Gene 91975 ENTREZGENE
OMIM 612429 OMIM
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/Swiss-Prot
  ZINC FINGER PROTEIN 879 UniProtKB/Swiss-Prot
  ZINC FINGER PROTEIN 939 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot
PharmGKB PA37666 PharmGKB
PROSITE KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF109640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57667 UniProtKB/Swiss-Prot
UniProt A8MY91 ENTREZGENE
  B3KU35 ENTREZGENE
  B4DU78 ENTREZGENE
  F5GWS1 ENTREZGENE
  F8WE31_HUMAN UniProtKB/TrEMBL
  Q06DQ3 ENTREZGENE
  Q17RP3 ENTREZGENE
  Q5H9N5 ENTREZGENE
  Q96RE9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8MY91 UniProtKB/Swiss-Prot
  B3KU35 UniProtKB/Swiss-Prot
  B4DU78 UniProtKB/Swiss-Prot
  F5GWS1 UniProtKB/Swiss-Prot
  Q06DQ3 UniProtKB/Swiss-Prot
  Q17RP3 UniProtKB/Swiss-Prot
  Q5H9N5 UniProtKB/Swiss-Prot