TRBV19 (T cell receptor beta variable 19) - Rat Genome Database

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Pathways
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Gene: TRBV19 (T cell receptor beta variable 19) Homo sapiens
Analyze
Symbol: TRBV19
Name: T cell receptor beta variable 19
RGD ID: 1349212
HGNC Page HGNC:12194
Description: Predicted to be involved in cell surface receptor signaling pathway. Part of alpha-beta T cell receptor complex.
Type: gene (Ensembl: TR_V_gene)
RefSeq Status: VALIDATED
Previously known as: TCRBV17S1A1T; TCRBV19S1
RGD Orthologs
Mouse
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387142,619,057 - 142,619,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7142,618,849 - 142,619,532 (+)EnsemblGRCh38hg38GRCh38
GRCh377142,326,571 - 142,327,046 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,007,563 - 142,008,038 (+)NCBINCBI36Build 36hg18NCBI36
Celera7137,134,738 - 137,135,213 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7136,655,049 - 136,655,524 (+)NCBIHuRef
CHM1_17142,253,029 - 142,253,504 (+)NCBICHM1_1
T2T-CHM13v2.07143,975,860 - 143,976,335 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8020962   PMID:8650574   PMID:8872162   PMID:12477932   PMID:21081917   PMID:21873635  


Genomics

Comparative Map Data
TRBV19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387142,619,057 - 142,619,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7142,618,849 - 142,619,532 (+)EnsemblGRCh38hg38GRCh38
GRCh377142,326,571 - 142,327,046 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,007,563 - 142,008,038 (+)NCBINCBI36Build 36hg18NCBI36
Celera7137,134,738 - 137,135,213 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7136,655,049 - 136,655,524 (+)NCBIHuRef
CHM1_17142,253,029 - 142,253,504 (+)NCBICHM1_1
T2T-CHM13v2.07143,975,860 - 143,976,335 (+)NCBIT2T-CHM13v2.0
Trbv19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39641,155,523 - 41,155,982 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl641,155,309 - 41,155,982 (+)EnsemblGRCm39 Ensembl
GRCm38641,178,589 - 41,179,048 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl641,178,375 - 41,179,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv37641,128,588 - 41,129,047 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera641,133,245 - 41,133,704 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map619.27NCBI
TRBV19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl187,538,530 - 7,552,113 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1187,537,830 - 7,539,600 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q34-35(chr7:141126407-145652221)x3 copy number gain See cases [RCV000133645] Chr7:141126407..145652221 [GRCh38]
Chr7:140826207..145349314 [GRCh37]
Chr7:140472676..144980247 [NCBI36]
Chr7:7q34-35		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q33-36.2(chr7:137751200-154815582)x3 copy number gain See cases [RCV000136592] Chr7:137751200..154815582 [GRCh38]
Chr7:137435946..154607292 [GRCh37]
Chr7:137086486..154238225 [NCBI36]
Chr7:7q33-36.2		 pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q34(chr7:142237788-142779344)x3 copy number gain See cases [RCV000137716] Chr7:142237788..142779344 [GRCh38]
Chr7:141584064..142187156 [NCBI36]
Chr7:7q34		 likely benign
GRCh38/hg38 7q34-36.3(chr7:141960861-159335866)x1 copy number loss See cases [RCV000137256] Chr7:141960861..159335866 [GRCh38]
Chr7:142528609..159128556 [GRCh37]
Chr7:141307130..158821317 [NCBI36]
Chr7:7q34-36.3		 pathogenic
GRCh38/hg38 7q33-36.3(chr7:134666829-158591882)x1 copy number loss See cases [RCV000138120] Chr7:134666829..158591882 [GRCh38]
Chr7:134351581..158384574 [GRCh37]
Chr7:134002121..158077335 [NCBI36]
Chr7:7q33-36.3		 pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3		 pathogenic
GRCh38/hg38 7q34(chr7:142578930-142753745)x1 copy number loss See cases [RCV000138582] Chr7:142578930..142753745 [GRCh38]
Chr7:141967536..142141170 [NCBI36]
Chr7:7q34		 likely benign
GRCh38/hg38 7q34(chr7:142503036-142753076)x1 copy number loss See cases [RCV000139181] Chr7:142503036..142753076 [GRCh38]
Chr7:141871507..142140501 [NCBI36]
Chr7:7q34		 likely benign
GRCh38/hg38 7q33-36.1(chr7:135017687-148807400)x1 copy number loss See cases [RCV000138903] Chr7:135017687..148807400 [GRCh38]
Chr7:134702438..148504492 [GRCh37]
Chr7:134352978..148135425 [NCBI36]
Chr7:7q33-36.1		 pathogenic
GRCh38/hg38 7q34(chr7:142578930-142752607)x3 copy number gain See cases [RCV000139475] Chr7:142578930..142752607 [GRCh38]
Chr7:141967536..142140032 [NCBI36]
Chr7:7q34		 likely benign
GRCh38/hg38 7q32.3-36.3(chr7:132444095-159335866)x3 copy number gain See cases [RCV000139654] Chr7:132444095..159335866 [GRCh38]
Chr7:132128854..159128556 [GRCh37]
Chr7:131779394..158821317 [NCBI36]
Chr7:7q32.3-36.3		 pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3		 pathogenic
GRCh38/hg38 7q34(chr7:142503036-142753745)x1 copy number loss See cases [RCV000142812] Chr7:142503036..142753745 [GRCh38]
Chr7:141871507..142141170 [NCBI36]
Chr7:7q34		 likely benign
GRCh38/hg38 7q32.3-36.3(chr7:131228764-159335866)x3 copy number gain See cases [RCV000142802] Chr7:131228764..159335866 [GRCh38]
Chr7:130913523..159128556 [GRCh37]
Chr7:130564063..158821317 [NCBI36]
Chr7:7q32.3-36.3		 pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131171478-159327017)x3 copy number gain See cases [RCV000143754] Chr7:131171478..159327017 [GRCh38]
Chr7:130856237..159119707 [GRCh37]
Chr7:130506777..158812468 [NCBI36]
Chr7:7q32.3-36.3		 pathogenic
GRCh38/hg38 7q34-35(chr7:140061285-144622893)x3 copy number gain See cases [RCV000143724] Chr7:140061285..144622893 [GRCh38]
Chr7:139761085..144319986 [GRCh37]
Chr7:139407554..143950919 [NCBI36]
Chr7:7q34-35		 uncertain significance
GRCh37/hg19 7q34(chr7:141937588-142486548)x3 copy number gain See cases [RCV000143759] Chr7:141937588..142486548 [GRCh37]
Chr7:141584062..142186550 [NCBI36]
Chr7:7q34		 uncertain significance
GRCh38/hg38 7q32.3-36.3(chr7:132438072-159327017)x3 copy number gain See cases [RCV000143707] Chr7:132438072..159327017 [GRCh38]
Chr7:132122831..159119707 [GRCh37]
Chr7:131773371..158812468 [NCBI36]
Chr7:7q32.3-36.3		 pathogenic
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3		 pathogenic
GRCh38/hg38 7q34-35(chr7:142578948-144254897)x1 copy number loss See cases [RCV000050639] Chr7:142578948..144254897 [GRCh38]
Chr7:142528609..143951990 [GRCh37]
Chr7:141967554..143582923 [NCBI36]
Chr7:7q34-35		 pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132850196-159325876)x3 copy number gain See cases [RCV000051101] Chr7:132850196..159325876 [GRCh38]
Chr7:132534956..159118566 [GRCh37]
Chr7:132185496..158811327 [NCBI36]
Chr7:7q32.3-36.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q33-36.3(chr7:136309982-159307523)x3 copy number gain See cases [RCV000053576] Chr7:136309982..159307523 [GRCh38]
Chr7:135994730..159100212 [GRCh37]
Chr7:135645270..158792973 [NCBI36]
Chr7:7q33-36.3		 pathogenic
GRCh38/hg38 7q34-36.3(chr7:142021716-159325876)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053577]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053577]|See cases [RCV000053577] Chr7:142021716..159325876 [GRCh38]
Chr7:142528609..159118566 [GRCh37]
Chr7:141367985..158811327 [NCBI36]
Chr7:7q34-36.3		 pathogenic
GRCh38/hg38 7q32.3-36.1(chr7:132023155-149309794)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|See cases [RCV000054172] Chr7:132023155..149309794 [GRCh38]
Chr7:131707914..149006885 [GRCh37]
Chr7:131358454..148637818 [NCBI36]
Chr7:7q32.3-36.1		 pathogenic
GRCh38/hg38 7q33-35(chr7:135414108-144140219)x1 copy number loss See cases [RCV000054173] Chr7:135414108..144140219 [GRCh38]
Chr7:135098857..143837312 [GRCh37]
Chr7:134749397..143468245 [NCBI36]
Chr7:7q33-35		 pathogenic
GRCh38/hg38 7q34-36.3(chr7:139365967-159282531)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|See cases [RCV000054175] Chr7:139365967..159282531 [GRCh38]
Chr7:139050713..159075220 [GRCh37]
Chr7:138701253..158767981 [NCBI36]
Chr7:7q34-36.3		 pathogenic
GRCh38/hg38 7q34-36.3(chr7:140754198-159307523)x1 copy number loss See cases [RCV000054176] Chr7:140754198..159307523 [GRCh38]
Chr7:140453998..159100212 [GRCh37]
Chr7:140100467..158792973 [NCBI36]
Chr7:7q34-36.3		 pathogenic
GRCh38/hg38 7q34-36.3(chr7:142358524-159282531)x1 copy number loss See cases [RCV000054177] Chr7:142358524..159282531 [GRCh38]
Chr7:142528609..159075220 [GRCh37]
Chr7:141726947..158767981 [NCBI36]
Chr7:7q34-36.3		 pathogenic
GRCh38/hg38 7q33-36.3(chr7:137463392-159345973)x3 copy number gain Neurodevelopmental disorder [RCV003327609] Chr7:137463392..159345973 [GRCh38]
Chr7:7q33-36.3		 pathogenic
GRCh38/hg38 7q34-36.3(chr7:138620939-159233475)x3 copy number gain Neurodevelopmental disorder [RCV003327610] Chr7:138620939..159233475 [GRCh38]
Chr7:7q34-36.3		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:289
Count of miRNA genes:268
Interacting mature miRNAs:284
Transcripts:ENST00000390393
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-171858  
Human AssemblyChrPosition (strand)SourceJBrowse
Build 367142,006,359 - 142,006,643RGDNCBI36
Celera7137,133,534 - 137,133,818RGD
Cytogenetic Map7q34UniSTS
HuRef7136,653,845 - 136,654,129UniSTS
CRA_TCAGchr7v27141,698,089 - 141,698,373UniSTS
D3S4005  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377142,327,045 - 142,327,169UniSTSGRCh37
Build 367142,008,037 - 142,008,161RGDNCBI36
Celera7137,135,212 - 137,135,336RGD
Cytogenetic Map7q34UniSTS
HuRef7136,655,523 - 136,655,647UniSTS
CRA_TCAGchr7v27141,699,767 - 141,699,891UniSTS
Stanford-G3 RH Map76030.0UniSTS
Whitehead-YAC Contig Map3 UniSTS
NCBI RH Map7995.0UniSTS
GeneMap99-G3 RH Map76030.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 31 288 18 2 416 2 4 10 6 28 2
Low 694 823 573 187 876 135 625 105 249 154 389 943 51 540 298 1
Below cutoff 924 900 654 286 62 191 1681 713 1423 126 544 332 96 472 1059 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000390393   ⟹   ENSP00000374916
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7142,618,849 - 142,619,532 (+)Ensembl
Protein Sequences
GenBank Protein A0A075B6N1 (Get FASTA)   NCBI Sequence Viewer  
  AAB49730 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000374916.3
  ENSP00000487807.1
Reference Protein Sequences
RefSeq Acc Id: ENSP00000374916   ⟸   ENST00000390393
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A075B6N1-F1-model_v2 AlphaFold A0A075B6N1 1-114 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12194 AgrOrtholog
COSMIC TRBV19 COSMIC
Ensembl Genes ENSG00000211746 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000282621 UniProtKB/TrEMBL
Ensembl Transcript ENST00000390393.3 UniProtKB/Swiss-Prot
  ENST00000632638.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000211746 GTEx
  ENSG00000282621 GTEx
HGNC ID HGNC:12194 ENTREZGENE
Human Proteome Map TRBV19 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene TRBV19 ENTREZGENE
PANTHER T CELL RECEPTOR BETA VARIABLE 19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-CELL RECEPTOR BETA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36874 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A075B6N1 ENTREZGENE
  A0A5B3_HUMAN UniProtKB/TrEMBL
  A0A8S4QGD6_HUMAN UniProtKB/TrEMBL
  TVB19_HUMAN UniProtKB/Swiss-Prot