DEPDC4 (DEP domain containing 4) - Rat Genome Database

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Gene: DEPDC4 (DEP domain containing 4) Homo sapiens
Analyze
Symbol: DEPDC4
Name: DEP domain containing 4
RGD ID: 1349120
HGNC Page HGNC:22952
Description: Predicted to be involved in intracellular signal transduction.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DEP domain-containing protein 4; DEP.4; FLJ33505
RGD Orthologs
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812100,231,635 - 100,281,972 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12100,203,669 - 100,267,079 (-)EnsemblGRCh38hg38GRCh38
GRCh3712100,625,413 - 100,660,857 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361299,170,172 - 99,184,988 (-)NCBINCBI36Build 36hg18NCBI36
Build 341299,099,914 - 99,163,325NCBI
Celera12100,311,307 - 100,326,123 (-)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1297,707,267 - 97,722,185 (-)NCBIHuRef
CHM1_112100,611,692 - 100,626,500 (-)NCBICHM1_1
T2T-CHM13v2.012100,192,869 - 100,243,198 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10737800   PMID:12477932   PMID:14702039   PMID:23422819   PMID:24739740  


Genomics

Comparative Map Data
DEPDC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812100,231,635 - 100,281,972 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12100,203,669 - 100,267,079 (-)EnsemblGRCh38hg38GRCh38
GRCh3712100,625,413 - 100,660,857 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361299,170,172 - 99,184,988 (-)NCBINCBI36Build 36hg18NCBI36
Build 341299,099,914 - 99,163,325NCBI
Celera12100,311,307 - 100,326,123 (-)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1297,707,267 - 97,722,185 (-)NCBIHuRef
CHM1_112100,611,692 - 100,626,500 (-)NCBICHM1_1
T2T-CHM13v2.012100,192,869 - 100,243,198 (-)NCBIT2T-CHM13v2.0
DEPDC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210108,307,829 - 108,333,184 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112108,304,223 - 108,329,581 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01297,823,521 - 97,848,900 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112101,230,356 - 101,255,105 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12101,240,778 - 101,255,105 (-)Ensemblpanpan1.1panPan2
DEPDC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11539,354,753 - 39,365,130 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1539,726,630 - 39,744,105 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01540,010,738 - 40,028,201 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11539,268,335 - 39,285,799 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01539,374,698 - 39,392,175 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01539,648,856 - 39,666,338 (-)NCBIUU_Cfam_GSD_1.0
Depdc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494520,554,833 - 20,579,092 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493649213,564,905 - 13,583,943 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DEPDC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl583,878,603 - 83,894,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1583,878,718 - 83,899,408 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2588,065,383 - 88,070,382 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DEPDC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11195,562,468 - 95,582,728 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037149,462,392 - 149,482,738 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in DEPDC4
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q23.1(chr12:100078579-100273980)x3 copy number gain See cases [RCV000053685] Chr12:100078579..100273980 [GRCh38]
Chr12:100472357..100667758 [GRCh37]
Chr12:98996488..99191889 [NCBI36]
Chr12:12q23.1		 pathogenic
GRCh38/hg38 12q23.1-23.2(chr12:97394550-101410225)x3 copy number gain See cases [RCV000137891] Chr12:97394550..101410225 [GRCh38]
Chr12:97788328..101804003 [GRCh37]
Chr12:96312459..100328134 [NCBI36]
Chr12:12q23.1-23.2		 likely pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
NM_001364818.2(DEPDC4):c.355A>G (p.Lys119Glu) single nucleotide variant not specified [RCV004319820] Chr12:100263696 [GRCh38]
Chr12:100657474 [GRCh37]
Chr12:12q23.1		 uncertain significance
GRCh37/hg19 12q23.1-23.3(chr12:100580198-105804075)x3 copy number gain See cases [RCV000445929] Chr12:100580198..105804075 [GRCh37]
Chr12:12q23.1-23.3		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12q23.1(chr12:99725136-100857873)x3 copy number gain not provided [RCV000683458] Chr12:99725136..100857873 [GRCh37]
Chr12:12q23.1		 uncertain significance
GRCh37/hg19 12q23.1(chr12:100340426-100726200)x1 copy number loss not provided [RCV000683427] Chr12:100340426..100726200 [GRCh37]
Chr12:12q23.1		 uncertain significance
GRCh37/hg19 12q23.1(chr12:96719383-101537641)x3 copy number gain not provided [RCV000683473] Chr12:96719383..101537641 [GRCh37]
Chr12:12q23.1		 likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12q23.1(chr12:100413785-100732927)x3 copy number gain not provided [RCV000738016] Chr12:100413785..100732927 [GRCh37]
Chr12:12q23.1		 benign
GRCh37/hg19 12q22-23.2(chr12:94881995-103635998)x3 copy number gain not provided [RCV000750524] Chr12:94881995..103635998 [GRCh37]
Chr12:12q22-23.2		 pathogenic
GRCh37/hg19 12q23.1(chr12:100455466-100697174)x3 copy number gain not provided [RCV000847924] Chr12:100455466..100697174 [GRCh37]
Chr12:12q23.1		 uncertain significance
GRCh37/hg19 12q23.1(chr12:100185181-100736359)x1 copy number loss not provided [RCV000847832] Chr12:100185181..100736359 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.587C>T (p.Ala196Val) single nucleotide variant not specified [RCV004291994] Chr12:100262377 [GRCh38]
Chr12:100656155 [GRCh37]
Chr12:12q23.1		 uncertain significance
GRCh37/hg19 12q23.1-23.3(chr12:100580198-105804075) copy number gain not specified [RCV002053014] Chr12:100580198..105804075 [GRCh37]
Chr12:12q23.1-23.3		 uncertain significance
GRCh37/hg19 12q23.1-23.2(chr12:100564593-103021075) copy number loss not specified [RCV002053013] Chr12:100564593..103021075 [GRCh37]
Chr12:12q23.1-23.2		 uncertain significance
NM_001364818.2(DEPDC4):c.194A>C (p.Asp65Ala) single nucleotide variant not specified [RCV004201894] Chr12:100263857 [GRCh38]
Chr12:100657635 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.414G>T (p.Met138Ile) single nucleotide variant not specified [RCV004109678] Chr12:100263637 [GRCh38]
Chr12:100657415 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.676C>A (p.Pro226Thr) single nucleotide variant not specified [RCV004226651] Chr12:100262288 [GRCh38]
Chr12:100656066 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.375A>C (p.Gln125His) single nucleotide variant not specified [RCV004159964] Chr12:100263676 [GRCh38]
Chr12:100657454 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.85C>T (p.Leu29Phe) single nucleotide variant not specified [RCV004093386] Chr12:100266992 [GRCh38]
Chr12:100660770 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.262A>G (p.Lys88Glu) single nucleotide variant not specified [RCV004165924] Chr12:100263789 [GRCh38]
Chr12:100657567 [GRCh37]
Chr12:12q23.1		 likely benign
NM_001364818.2(DEPDC4):c.154A>G (p.Thr52Ala) single nucleotide variant not specified [RCV004115657] Chr12:100266923 [GRCh38]
Chr12:100660701 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.418A>G (p.Lys140Glu) single nucleotide variant not specified [RCV004163587] Chr12:100263633 [GRCh38]
Chr12:100657411 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.599G>T (p.Gly200Val) single nucleotide variant not specified [RCV004173804] Chr12:100262365 [GRCh38]
Chr12:100656143 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.22G>C (p.Ala8Pro) single nucleotide variant not specified [RCV004371096] Chr12:100267055 [GRCh38]
Chr12:100660833 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.611T>C (p.Ile204Thr) single nucleotide variant not specified [RCV004371099] Chr12:100262353 [GRCh38]
Chr12:100656131 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.17A>G (p.Glu6Gly) single nucleotide variant not specified [RCV004371095] Chr12:100267060 [GRCh38]
Chr12:100660838 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.314T>G (p.Met105Arg) single nucleotide variant not specified [RCV004371097] Chr12:100263737 [GRCh38]
Chr12:100657515 [GRCh37]
Chr12:12q23.1		 uncertain significance
NM_001364818.2(DEPDC4):c.37G>C (p.Ala13Pro) single nucleotide variant not specified [RCV004371098] Chr12:100267040 [GRCh38]
Chr12:100660818 [GRCh37]
Chr12:12q23.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1362
Count of miRNA genes:668
Interacting mature miRNAs:761
Transcripts:ENST00000299185, ENST00000378244, ENST00000416321, ENST00000547823, ENST00000548313, ENST00000549100, ENST00000549249, ENST00000549341, ENST00000550587, ENST00000551642
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D12S2127  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712100,617,991 - 100,618,121UniSTSGRCh37
Build 361299,142,122 - 99,142,252RGDNCBI36
Celera12100,283,265 - 100,283,395RGD
Cytogenetic Map12q23.1UniSTS
HuRef1297,679,247 - 97,679,377UniSTS
Stanford-G3 RH Map124166.0UniSTS
GeneMap99-G3 RH Map124112.0UniSTS
D12S2146  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712100,602,914 - 100,603,043UniSTSGRCh37
Build 361299,127,045 - 99,127,174RGDNCBI36
Celera12100,268,188 - 100,268,317RGD
Cytogenetic Map12q23.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 3
Low 426 69 789 269 752 196 645 91 817 274 1008 729 84 44 232 4
Below cutoff 1989 2675 934 353 1013 268 3626 2008 2886 141 436 872 86 1151 2481

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001319310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001364818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001387213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_152317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_170594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_170595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_170596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_170597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001748573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_944493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC026110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC253559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI023188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000299185   ⟹   ENSP00000299185
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12100,252,480 - 100,267,079 (-)Ensembl
RefSeq Acc Id: ENST00000378244   ⟹   ENSP00000367490
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12100,203,669 - 100,267,079 (-)Ensembl
RefSeq Acc Id: ENST00000416321   ⟹   ENSP00000396234
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12100,252,263 - 100,267,079 (-)Ensembl
RefSeq Acc Id: ENST00000547823
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12100,241,735 - 100,252,305 (-)Ensembl
RefSeq Acc Id: ENST00000548313   ⟹   ENSP00000448728
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12100,252,458 - 100,262,356 (-)Ensembl
RefSeq Acc Id: ENST00000549100
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12100,237,800 - 100,252,279 (-)Ensembl
RefSeq Acc Id: ENST00000549249   ⟹   ENSP00000448338
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12100,252,480 - 100,267,079 (-)Ensembl
RefSeq Acc Id: ENST00000549341   ⟹   ENSP00000447392
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12100,252,480 - 100,267,079 (-)Ensembl
RefSeq Acc Id: ENST00000550587   ⟹   ENSP00000448385
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12100,240,062 - 100,267,079 (-)Ensembl
RefSeq Acc Id: ENST00000551642   ⟹   ENSP00000449590
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12100,255,873 - 100,267,055 (-)Ensembl
RefSeq Acc Id: NM_001319310   ⟹   NP_001306239
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,255,861 - 100,267,079 (-)NCBI
CHM1_112100,615,302 - 100,626,500 (-)NCBI
T2T-CHM13v2.012100,217,095 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001319311   ⟹   NP_001306240
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,240,062 - 100,267,079 (-)NCBI
CHM1_112100,599,634 - 100,626,500 (-)NCBI
T2T-CHM13v2.012100,201,298 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001364818   ⟹   NP_001351747
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,240,062 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,201,298 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387201   ⟹   NP_001374130
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,199,034 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387205   ⟹   NP_001374134
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,199,034 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387206   ⟹   NP_001374135
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,231,635 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,192,869 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387207   ⟹   NP_001374136
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,199,034 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387208   ⟹   NP_001374137
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,248,993 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,210,227 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387209   ⟹   NP_001374138
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,240,062 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,201,298 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387210   ⟹   NP_001374139
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,199,034 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387211   ⟹   NP_001374140
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,240,062 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,201,298 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387212   ⟹   NP_001374141
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,248,993 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,210,227 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001387213   ⟹   NP_001374142
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,199,034 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_152317   ⟹   NP_689530
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,252,263 - 100,267,079 (-)NCBI
GRCh3712100,597,447 - 100,660,857 (-)NCBI
Build 361299,170,172 - 99,184,988 (-)NCBI Archive
Celera12100,311,307 - 100,326,123 (-)RGD
HuRef1297,707,267 - 97,722,185 (-)ENTREZGENE
CHM1_112100,611,692 - 100,626,500 (-)NCBI
T2T-CHM13v2.012100,213,497 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NR_170594
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,248,993 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,210,227 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NR_170595
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,231,635 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,192,869 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NR_170596
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,199,034 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: NR_170597
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,231,635 - 100,267,079 (-)NCBI
T2T-CHM13v2.012100,192,869 - 100,228,305 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018779   ⟹   XP_016874268
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,267,079 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018782   ⟹   XP_016874271
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,267,079 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018783   ⟹   XP_016874272
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,281,972 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018785   ⟹   XP_016874274
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,252,394 - 100,267,079 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047428275   ⟹   XP_047284231
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,267,079 (-)NCBI
RefSeq Acc Id: XM_054371044   ⟹   XP_054227019
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012100,199,034 - 100,228,305 (-)NCBI
RefSeq Acc Id: XM_054371045   ⟹   XP_054227020
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012100,199,034 - 100,228,305 (-)NCBI
RefSeq Acc Id: XM_054371046   ⟹   XP_054227021
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012100,199,034 - 100,228,305 (-)NCBI
RefSeq Acc Id: XM_054371047   ⟹   XP_054227022
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012100,199,034 - 100,243,198 (-)NCBI
RefSeq Acc Id: XM_054371048   ⟹   XP_054227023
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012100,213,628 - 100,228,305 (-)NCBI
RefSeq Acc Id: XR_008488523
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012100,199,034 - 100,228,305 (-)NCBI
RefSeq Acc Id: XR_944493
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,237,798 - 100,267,079 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001306239 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306240 (Get FASTA)   NCBI Sequence Viewer  
  NP_001351747 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374130 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374134 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374135 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374136 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374137 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374138 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374139 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374140 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374141 (Get FASTA)   NCBI Sequence Viewer  
  NP_001374142 (Get FASTA)   NCBI Sequence Viewer  
  NP_689530 (Get FASTA)   NCBI Sequence Viewer  
  XP_016874268 (Get FASTA)   NCBI Sequence Viewer  
  XP_016874271 (Get FASTA)   NCBI Sequence Viewer  
  XP_016874272 (Get FASTA)   NCBI Sequence Viewer  
  XP_016874274 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284231 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227019 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227020 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227021 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227022 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227023 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH15117 (Get FASTA)   NCBI Sequence Viewer  
  AAI00929 (Get FASTA)   NCBI Sequence Viewer  
  AAI00930 (Get FASTA)   NCBI Sequence Viewer  
  AAI00931 (Get FASTA)   NCBI Sequence Viewer  
  BAC03525 (Get FASTA)   NCBI Sequence Viewer  
  EAW97628 (Get FASTA)   NCBI Sequence Viewer  
  EAW97629 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000299185.8
  ENSP00000367490.2
  ENSP00000396234
  ENSP00000396234.1
  ENSP00000447392.1
  ENSP00000448338.1
  ENSP00000448385
  ENSP00000448385.2
  ENSP00000448728.1
  ENSP00000449590
  ENSP00000449590.1
GenBank Protein Q8N2C3 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_689530   ⟸   NM_152317
- Peptide Label: isoform 1
- UniProtKB: Q496C8 (UniProtKB/Swiss-Prot),   Q96BW0 (UniProtKB/Swiss-Prot),   Q8N2C3 (UniProtKB/Swiss-Prot),   H0YIL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001306240   ⟸   NM_001319311
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: NP_001306239   ⟸   NM_001319310
- Peptide Label: isoform 2
- UniProtKB: H0YIL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016874272   ⟸   XM_017018783
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016874271   ⟸   XM_017018782
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016874268   ⟸   XM_017018779
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016874274   ⟸   XM_017018785
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: NP_001351747   ⟸   NM_001364818
- Peptide Label: isoform 4
- UniProtKB: E9PGM3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000448728   ⟸   ENST00000548313
RefSeq Acc Id: ENSP00000396234   ⟸   ENST00000416321
RefSeq Acc Id: ENSP00000299185   ⟸   ENST00000299185
RefSeq Acc Id: ENSP00000367490   ⟸   ENST00000378244
RefSeq Acc Id: ENSP00000447392   ⟸   ENST00000549341
RefSeq Acc Id: ENSP00000448338   ⟸   ENST00000549249
RefSeq Acc Id: ENSP00000448385   ⟸   ENST00000550587
RefSeq Acc Id: ENSP00000449590   ⟸   ENST00000551642
RefSeq Acc Id: NP_001374135   ⟸   NM_001387206
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001374139   ⟸   NM_001387210
- Peptide Label: isoform 9
RefSeq Acc Id: NP_001374142   ⟸   NM_001387213
- Peptide Label: isoform 12
RefSeq Acc Id: NP_001374134   ⟸   NM_001387205
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001374136   ⟸   NM_001387207
- Peptide Label: isoform 4
- UniProtKB: E9PGM3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001374130   ⟸   NM_001387201
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001374140   ⟸   NM_001387211
- Peptide Label: isoform 10
RefSeq Acc Id: NP_001374138   ⟸   NM_001387209
- Peptide Label: isoform 8
RefSeq Acc Id: NP_001374141   ⟸   NM_001387212
- Peptide Label: isoform 11
RefSeq Acc Id: NP_001374137   ⟸   NM_001387208
- Peptide Label: isoform 7
RefSeq Acc Id: XP_047284231   ⟸   XM_047428275
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054227022   ⟸   XM_054371047
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054227021   ⟸   XM_054371046
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054227020   ⟸   XM_054371045
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054227019   ⟸   XM_054371044
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054227023   ⟸   XM_054371048
- Peptide Label: isoform X5
Protein Domains
DEP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8N2C3-F1-model_v2 AlphaFold Q8N2C3 1-294 view protein structure

Promoters
RGD ID:6790471
Promoter ID:HG_KWN:16429
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000378244,   ENST00000378250,   NM_017988,   NM_152317,   UC001THH.1,   UC001THJ.1,   UC001THK.1,   UC001THL.1,   UC001THM.1,   UC009ZTV.1,   UC009ZTW.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361299,184,556 - 99,185,317 (+)MPROMDB
RGD ID:7225143
Promoter ID:EPDNEW_H18317
Type:initiation region
Name:DEPDC4_1
Description:DEP domain containing 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,267,076 - 100,267,136EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:22952 AgrOrtholog
COSMIC DEPDC4 COSMIC
Ensembl Genes ENSG00000166153 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000299185.12 UniProtKB/Swiss-Prot
  ENST00000378244.6 UniProtKB/Swiss-Prot
  ENST00000416321 ENTREZGENE
  ENST00000416321.5 UniProtKB/Swiss-Prot
  ENST00000548313.5 UniProtKB/TrEMBL
  ENST00000549249.5 UniProtKB/TrEMBL
  ENST00000549341.1 UniProtKB/Swiss-Prot
  ENST00000550587 ENTREZGENE
  ENST00000550587.6 UniProtKB/TrEMBL
  ENST00000551642 ENTREZGENE
  ENST00000551642.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000166153 GTEx
HGNC ID HGNC:22952 ENTREZGENE
Human Proteome Map DEPDC4 Human Proteome Map
InterPro DEP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:120863 UniProtKB/Swiss-Prot
NCBI Gene 120863 ENTREZGENE
PANTHER DEP DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEP DOMAIN-CONTAINING PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134981607 PharmGKB
PROSITE DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4FU15_HUMAN UniProtKB/TrEMBL
  DEPD4_HUMAN UniProtKB/Swiss-Prot
  E9PGM3 ENTREZGENE, UniProtKB/TrEMBL
  H0YI71_HUMAN UniProtKB/TrEMBL
  H0YIL0 ENTREZGENE, UniProtKB/TrEMBL
  Q3ZCN8_HUMAN UniProtKB/TrEMBL
  Q496C8 ENTREZGENE
  Q8N2C3 ENTREZGENE
  Q96BW0 ENTREZGENE
UniProt Secondary E9PE97 UniProtKB/TrEMBL
  Q496C8 UniProtKB/Swiss-Prot
  Q96BW0 UniProtKB/Swiss-Prot