HMG20B (high mobility group 20B) - Rat Genome Database

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Gene: HMG20B (high mobility group 20B) Homo sapiens
Analyze
Symbol: HMG20B
Name: high mobility group 20B
RGD ID: 1347672
HGNC Page HGNC:5002
Description: Predicted to enable DNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of protein sumoylation; positive regulation of neuron differentiation; and skeletal muscle cell differentiation. Located in nuclear body.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BRAF25; BRAF35; BRCA2-associated factor 35; FLJ26127; high-mobility group 20B; HMG box domain containing 2; HMG box-containing protein 20B; HMG domain-containing protein 2; HMG domain-containing protein HMGX2; HMGX2; HMGXB2; PP7706; pp8857; SMARCE1-related protein; SMARCE1r; Sox-like transcriptional factor; SOXL; structural DNA-binding protein BRAF35; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1-related
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,572,944 - 3,579,083 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,572,777 - 3,579,088 (+)EnsemblGRCh38hg38GRCh38
GRCh37193,572,942 - 3,579,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,523,943 - 3,530,081 (+)NCBINCBI36Build 36hg18NCBI36
Build 34193,525,521 - 3,530,079NCBI
Celera193,509,760 - 3,515,897 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,338,210 - 3,344,475 (+)NCBIHuRef
CHM1_1193,572,606 - 3,578,717 (+)NCBICHM1_1
T2T-CHM13v2.0193,551,100 - 3,557,239 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
nuclear body  (IDA)
nucleoplasm  (IDA,TAS)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10486208   PMID:10773667   PMID:11207365   PMID:11997092   PMID:12032298   PMID:12083779   PMID:12083780   PMID:12234937   PMID:12477932   PMID:12493763   PMID:12809554   PMID:14702039  
PMID:15057824   PMID:15325272   PMID:15489334   PMID:16079794   PMID:16140033   PMID:16169070   PMID:16189514   PMID:17961134   PMID:18816836   PMID:20530487   PMID:21258344   PMID:21399666  
PMID:21516116   PMID:21832049   PMID:21873635   PMID:22570500   PMID:22939629   PMID:23082233   PMID:23752268   PMID:25416956   PMID:25486196   PMID:25609649   PMID:26186194   PMID:26496610  
PMID:26673895   PMID:27503909   PMID:28514442   PMID:28760657   PMID:29892012   PMID:30804502   PMID:31527615   PMID:31540324   PMID:31753913   PMID:32296183   PMID:32814053   PMID:33640491  
PMID:33961781   PMID:34189442   PMID:34315543   PMID:34383978   PMID:34709266   PMID:35140242   PMID:35271311   PMID:35819319   PMID:35831314   PMID:35833506   PMID:36129980   PMID:36171271  
PMID:38297188  


Genomics

Comparative Map Data
HMG20B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,572,944 - 3,579,083 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,572,777 - 3,579,088 (+)EnsemblGRCh38hg38GRCh38
GRCh37193,572,942 - 3,579,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,523,943 - 3,530,081 (+)NCBINCBI36Build 36hg18NCBI36
Build 34193,525,521 - 3,530,079NCBI
Celera193,509,760 - 3,515,897 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,338,210 - 3,344,475 (+)NCBIHuRef
CHM1_1193,572,606 - 3,578,717 (+)NCBICHM1_1
T2T-CHM13v2.0193,551,100 - 3,557,239 (+)NCBIT2T-CHM13v2.0
Hmg20b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,181,880 - 81,186,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,181,882 - 81,186,314 (-)EnsemblGRCm39 Ensembl
GRCm381081,346,046 - 81,350,943 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,346,048 - 81,350,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,808,791 - 80,813,202 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,749,181 - 80,753,539 (-)NCBIMGSCv36mm8
Celera1082,366,836 - 82,371,247 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Hmg20b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,019,670 - 9,024,382 (+)NCBIGRCr8
mRatBN7.278,368,934 - 8,373,650 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,368,990 - 8,373,640 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,254,569 - 11,259,228 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,130,054 - 13,134,714 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,997,679 - 11,002,358 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,238,594 - 11,243,312 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,238,630 - 11,243,310 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,405,476 - 11,410,192 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,853,290 - 9,857,970 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,837,939 - 9,857,556 (+)NCBI
Celera76,558,025 - 6,562,701 (+)NCBICelera
Cytogenetic Map7q11NCBI
Hmg20b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,524,874 - 5,529,926 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,515,996 - 5,530,424 (+)NCBIChiLan1.0ChiLan1.0
HMG20B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,970,098 - 7,976,304 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,202,040 - 7,208,250 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,598,588 - 2,604,799 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,548,451 - 3,554,725 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,548,451 - 3,554,725 (+)Ensemblpanpan1.1panPan2
HMG20B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,840,192 - 55,844,949 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,841,959 - 55,844,862 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,565,327 - 55,570,345 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,500,142 - 56,505,157 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12055,555,796 - 55,560,811 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,039,212 - 56,044,218 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,237,958 - 56,242,974 (-)NCBIUU_Cfam_GSD_1.0
Hmg20b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,802,182 - 215,807,432 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,027,317 - 2,032,834 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,027,360 - 2,032,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMG20B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,093,075 - 75,098,536 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,093,071 - 75,098,566 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HMG20B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,333,731 - 3,340,033 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,333,885 - 3,340,138 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660815,148,505 - 5,155,151 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmg20b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,278,111 - 6,283,244 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,277,743 - 6,283,154 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HMG20B
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.3(chr19:1565575-4108128)x3 copy number gain See cases [RCV000052878] Chr19:1565575..4108128 [GRCh38]
Chr19:1565574..4108126 [GRCh37]
Chr19:1516574..4059126 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:1972245-9648879)x3 copy number gain See cases [RCV000052879] Chr19:1972245..9648879 [GRCh38]
Chr19:1972244..9759555 [GRCh37]
Chr19:1923244..9620555 [NCBI36]
Chr19:19p13.3-13.2		 pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:265917-8564134)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|See cases [RCV000052876] Chr19:265917..8564134 [GRCh38]
Chr19:265917..8629018 [GRCh37]
Chr19:216917..8535018 [NCBI36]
Chr19:19p13.3-13.2		 pathogenic
GRCh38/hg38 19p13.3(chr19:233565-4699472)x3 copy number gain See cases [RCV000052575] Chr19:233565..4699472 [GRCh38]
Chr19:233565..4699484 [GRCh37]
Chr19:184565..4650484 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:2926238-4051635)x1 copy number loss See cases [RCV000053942] Chr19:2926238..4051635 [GRCh38]
Chr19:2926236..4051633 [GRCh37]
Chr19:2877236..4002633 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:3554635-4690965)x1 copy number loss See cases [RCV000053943] Chr19:3554635..4690965 [GRCh38]
Chr19:3554633..4690977 [GRCh37]
Chr19:3505633..4641977 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:3338024-4833139)x1 copy number loss See cases [RCV000134482] Chr19:3338024..4833139 [GRCh38]
Chr19:3338022..4833151 [GRCh37]
Chr19:3289022..4784151 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:1549144-4288720)x1 copy number loss See cases [RCV000134795] Chr19:1549144..4288720 [GRCh38]
Chr19:1549143..4288717 [GRCh37]
Chr19:1500143..4239717 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:3437996-4039217)x1 copy number loss See cases [RCV000135779] Chr19:3437996..4039217 [GRCh38]
Chr19:3437994..4039215 [GRCh37]
Chr19:3388994..3990215 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:3080621-4912622)x3 copy number gain See cases [RCV000137713] Chr19:3080621..4912622 [GRCh38]
Chr19:3080619..4912634 [GRCh37]
Chr19:3031619..4863634 [NCBI36]
Chr19:19p13.3		 likely pathogenic
GRCh38/hg38 19p13.3(chr19:3080621-3730716)x3 copy number gain See cases [RCV000054107] Chr19:3080621..3730716 [GRCh38]
Chr19:3080619..3730714 [GRCh37]
Chr19:3031619..3681714 [NCBI36]
Chr19:19p13.3		 uncertain significance
GRCh38/hg38 19p13.3(chr19:259395-6795611)x3 copy number gain See cases [RCV000142627] Chr19:259395..6795611 [GRCh38]
Chr19:259395..6795622 [GRCh37]
Chr19:210395..6746622 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:2652901-4342179)x3 copy number gain See cases [RCV000448078] Chr19:2652901..4342179 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.874G>A (p.Glu292Lys) single nucleotide variant not specified [RCV004307566] Chr19:3578046 [GRCh38]
Chr19:3578044 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-13.2(chr19:3120160-9732820)x3 copy number gain not provided [RCV000684096] Chr19:3120160..9732820 [GRCh37]
Chr19:19p13.3-13.2		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3(chr19:3471275-3647901)x3 copy number gain not provided [RCV000740003] Chr19:3471275..3647901 [GRCh37]
Chr19:19p13.3		 benign
GRCh37/hg19 19p13.3(chr19:3076808-4796782) copy number loss not provided [RCV000767742] Chr19:3076808..4796782 [GRCh37]
Chr19:19p13.3		 pathogenic
NC_000019.9:g.1406030_3597207dup duplication Neurodevelopmental disorder [RCV000787423] Chr19:1406030..3597207 [GRCh37]
Chr19:19p13.3		 uncertain significance
Single allele deletion Internal malformations [RCV000787421] Chr19:2229488..4004142 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:3132909-3907470)x3 copy number gain not provided [RCV000847631] Chr19:3132909..3907470 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:260911-4788357)x3 copy number gain not provided [RCV000846988] Chr19:260911..4788357 [GRCh37]
Chr19:19p13.3		 pathogenic
NC_000019.9:g.(?_589946)_(4818389_?)dup duplication not provided [RCV003105391] Chr19:589946..4818389 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:260912-4384674)x3 copy number gain See cases [RCV001007443] Chr19:260912..4384674 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:3501624-5357124)x1 copy number loss not provided [RCV001834187] Chr19:3501624..5357124 [GRCh37]
Chr19:19p13.3		 pathogenic
NC_000019.9:g.(?_589946)_(5696788_?)dup duplication not provided [RCV003113597] Chr19:589946..5696788 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.772G>A (p.Ala258Thr) single nucleotide variant not specified [RCV004126092] Chr19:3577071 [GRCh38]
Chr19:3577069 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.488G>C (p.Gly163Ala) single nucleotide variant not specified [RCV004231223] Chr19:3576276 [GRCh38]
Chr19:3576274 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.740C>G (p.Ala247Gly) single nucleotide variant not specified [RCV004125211] Chr19:3577039 [GRCh38]
Chr19:3577037 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.728G>T (p.Arg243Leu) single nucleotide variant not specified [RCV004129075] Chr19:3577027 [GRCh38]
Chr19:3577025 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.573G>C (p.Glu191Asp) single nucleotide variant not specified [RCV004100810] Chr19:3576606 [GRCh38]
Chr19:3576604 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.746A>T (p.Gln249Leu) single nucleotide variant not specified [RCV004172367] Chr19:3577045 [GRCh38]
Chr19:3577043 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.685A>T (p.Ser229Cys) single nucleotide variant not specified [RCV004204732] Chr19:3576984 [GRCh38]
Chr19:3576982 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.833G>A (p.Gly278Asp) single nucleotide variant not specified [RCV004097392] Chr19:3578005 [GRCh38]
Chr19:3578003 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.55G>A (p.Ala19Thr) single nucleotide variant not specified [RCV004149972] Chr19:3573708 [GRCh38]
Chr19:3573706 [GRCh37]
Chr19:19p13.3		 uncertain significance
NC_000019.9:g.(?_1206913)_(3771740_?)dup duplication not provided [RCV003154903] Chr19:1206913..3771740 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3-13.2(chr19:260912-7246777)x3 copy number gain not provided [RCV003485190] Chr19:260912..7246777 [GRCh37]
Chr19:19p13.3-13.2		 pathogenic
NM_006339.3(HMG20B):c.149C>G (p.Pro50Arg) single nucleotide variant not specified [RCV004399647] Chr19:3574384 [GRCh38]
Chr19:3574382 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_006339.3(HMG20B):c.733A>G (p.Thr245Ala) single nucleotide variant not specified [RCV004399649] Chr19:3577032 [GRCh38]
Chr19:3577030 [GRCh37]
Chr19:19p13.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5360
Count of miRNA genes:1046
Interacting mature miRNAs:1307
Transcripts:ENST00000262949, ENST00000333651, ENST00000416526, ENST00000417382, ENST00000435022, ENST00000453933, ENST00000461099, ENST00000464304, ENST00000470356, ENST00000483417, ENST00000486028, ENST00000487894, ENST00000488973, ENST00000493191, ENST00000585741, ENST00000585900
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH41867  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,578,975 - 3,579,040UniSTSGRCh37
Build 36193,529,975 - 3,530,040RGDNCBI36
Celera193,515,791 - 3,515,856RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,344,369 - 3,344,434UniSTS
GeneMap99-GB4 RH Map1932.22UniSTS
STS-H97929  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,578,787 - 3,578,929UniSTSGRCh37
Build 36193,529,787 - 3,529,929RGDNCBI36
Celera193,515,603 - 3,515,745RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,344,181 - 3,344,323UniSTS
GeneMap99-GB4 RH Map1932.33UniSTS
RH44855  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,578,924 - 3,579,032UniSTSGRCh37
Build 36193,529,924 - 3,530,032RGDNCBI36
Celera193,515,740 - 3,515,848RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,344,318 - 3,344,426UniSTS
GeneMap99-GB4 RH Map1932.22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 2432 2846 1715 614 1890 456 4219 1967 3063 417 1447 1608 171 1204 2652 4
Low 1 138 8 8 58 8 137 228 646 1 4 136
Below cutoff 3 3 3 2 1 16 1 7 4 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_006339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017026144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024451326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054319533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF146223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF288679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF318366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF331191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC134413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI561304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000262949   ⟹   ENSP00000262949
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,572,986 - 3,577,107 (+)Ensembl
RefSeq Acc Id: ENST00000333651   ⟹   ENSP00000328269
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,572,944 - 3,579,083 (+)Ensembl
RefSeq Acc Id: ENST00000416526   ⟹   ENSP00000410924
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,572,777 - 3,576,944 (+)Ensembl
RefSeq Acc Id: ENST00000417382   ⟹   ENSP00000393904
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,572,948 - 3,575,642 (+)Ensembl
RefSeq Acc Id: ENST00000435022   ⟹   ENSP00000393481
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,572,979 - 3,576,602 (+)Ensembl
RefSeq Acc Id: ENST00000453933   ⟹   ENSP00000402877
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,572,977 - 3,575,614 (+)Ensembl
RefSeq Acc Id: ENST00000461099
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,576,885 - 3,578,444 (+)Ensembl
RefSeq Acc Id: ENST00000464304
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,575,876 - 3,577,022 (+)Ensembl
RefSeq Acc Id: ENST00000470356
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,572,823 - 3,574,269 (+)Ensembl
RefSeq Acc Id: ENST00000483417
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,575,542 - 3,576,987 (+)Ensembl
RefSeq Acc Id: ENST00000486028
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,574,293 - 3,575,964 (+)Ensembl
RefSeq Acc Id: ENST00000487894
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,575,651 - 3,578,671 (+)Ensembl
RefSeq Acc Id: ENST00000488973
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,572,979 - 3,579,088 (+)Ensembl
RefSeq Acc Id: ENST00000493191
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,576,352 - 3,578,342 (+)Ensembl
RefSeq Acc Id: ENST00000585741
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,573,697 - 3,574,161 (+)Ensembl
RefSeq Acc Id: ENST00000585900   ⟹   ENSP00000465293
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl193,576,616 - 3,579,083 (+)Ensembl
RefSeq Acc Id: NM_006339   ⟹   NP_006330
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,572,944 - 3,579,083 (+)NCBI
GRCh37193,572,936 - 3,579,081 (+)NCBI
Build 36193,523,943 - 3,530,081 (+)NCBI Archive
HuRef193,338,210 - 3,344,475 (+)ENTREZGENE
CHM1_1193,572,606 - 3,578,717 (+)NCBI
T2T-CHM13v2.0193,551,100 - 3,557,239 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017026144   ⟹   XP_016881633
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,572,944 - 3,579,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054319533   ⟹   XP_054175508
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0193,551,100 - 3,557,239 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_006330   ⟸   NM_006339
- UniProtKB: Q9Y491 (UniProtKB/Swiss-Prot),   Q9HD21 (UniProtKB/Swiss-Prot),   Q8NBD5 (UniProtKB/Swiss-Prot),   Q6IBP8 (UniProtKB/Swiss-Prot),   D6W616 (UniProtKB/Swiss-Prot),   A6NMS5 (UniProtKB/Swiss-Prot),   Q9Y4A2 (UniProtKB/Swiss-Prot),   Q9P0W2 (UniProtKB/Swiss-Prot),   A8K0D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016881633   ⟸   XM_017026144
- Peptide Label: isoform X1
- UniProtKB: A8K0D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000328269   ⟸   ENST00000333651
RefSeq Acc Id: ENSP00000402877   ⟸   ENST00000453933
RefSeq Acc Id: ENSP00000465293   ⟸   ENST00000585900
RefSeq Acc Id: ENSP00000410924   ⟸   ENST00000416526
RefSeq Acc Id: ENSP00000393904   ⟸   ENST00000417382
RefSeq Acc Id: ENSP00000262949   ⟸   ENST00000262949
RefSeq Acc Id: ENSP00000393481   ⟸   ENST00000435022
RefSeq Acc Id: XP_054175508   ⟸   XM_054319533
- Peptide Label: isoform X1
Protein Domains
HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9P0W2-F1-model_v2 AlphaFold Q9P0W2 1-317 view protein structure

Promoters
RGD ID:6795389
Promoter ID:HG_KWN:28524
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000262949,   ENST00000333651,   ENST00000402569,   OTTHUMT00000318089,   OTTHUMT00000318092,   OTTHUMT00000318094,   OTTHUMT00000318098,   OTTHUMT00000318099,   OTTHUMT00000318100,   UC010DTM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36193,523,501 - 3,524,342 (+)MPROMDB
RGD ID:6795634
Promoter ID:HG_KWN:28525
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000318091
Position:
Human AssemblyChrPosition (strand)Source
Build 36193,524,616 - 3,525,116 (+)MPROMDB
RGD ID:6852926
Promoter ID:EP74282
Type:multiple initiation site
Name:HS_HMG20B
Description:High-mobility group 20B.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36193,525,379 - 3,525,439EPD
RGD ID:6795390
Promoter ID:HG_KWN:28526
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562
Transcripts:ENST00000405446,   OTTHUMT00000318090,   OTTHUMT00000318095,   OTTHUMT00000318096,   OTTHUMT00000318097,   OTTHUMT00000318101
Position:
Human AssemblyChrPosition (strand)Source
Build 36193,526,441 - 3,528,072 (+)MPROMDB
RGD ID:7238023
Promoter ID:EPDNEW_H24757
Type:initiation region
Name:HMG20B_1
Description:high mobility group 20B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24758  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,572,944 - 3,573,004EPDNEW
RGD ID:7238025
Promoter ID:EPDNEW_H24758
Type:initiation region
Name:HMG20B_2
Description:high mobility group 20B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24757  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,574,381 - 3,574,441EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5002 AgrOrtholog
COSMIC HMG20B COSMIC
Ensembl Genes ENSG00000064961 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000262949.7 UniProtKB/TrEMBL
  ENST00000333651 ENTREZGENE
  ENST00000333651.11 UniProtKB/Swiss-Prot
  ENST00000416526.5 UniProtKB/TrEMBL
  ENST00000417382.5 UniProtKB/TrEMBL
  ENST00000435022.5 UniProtKB/TrEMBL
  ENST00000453933.5 UniProtKB/TrEMBL
  ENST00000585900.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000064961 GTEx
HGNC ID HGNC:5002 ENTREZGENE
Human Proteome Map HMG20B Human Proteome Map
InterPro HMG_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10362 UniProtKB/Swiss-Prot
NCBI Gene 10362 ENTREZGENE
OMIM 605535 OMIM
PANTHER HIGH MOBILITY GROUP PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29332 PharmGKB
PRINTS HIGHMOBLTY12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HMG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4IF61_HUMAN UniProtKB/TrEMBL
  A6NMS5 ENTREZGENE
  A8K0D5 ENTREZGENE, UniProtKB/TrEMBL
  B5MDG7_HUMAN UniProtKB/TrEMBL
  C9J8X5_HUMAN UniProtKB/TrEMBL
  C9JQA7_HUMAN UniProtKB/TrEMBL
  C9K049_HUMAN UniProtKB/TrEMBL
  D6W616 ENTREZGENE
  F8WES5_HUMAN UniProtKB/TrEMBL
  HM20B_HUMAN UniProtKB/Swiss-Prot
  K7EJR8_HUMAN UniProtKB/TrEMBL
  Q6IBP8 ENTREZGENE
  Q8NBD5 ENTREZGENE
  Q9HD21 ENTREZGENE
  Q9P0W2 ENTREZGENE
  Q9Y491 ENTREZGENE
  Q9Y4A2 ENTREZGENE
UniProt Secondary A6NMS5 UniProtKB/Swiss-Prot
  D6W616 UniProtKB/Swiss-Prot
  Q6IBP8 UniProtKB/Swiss-Prot
  Q8NBD5 UniProtKB/Swiss-Prot
  Q9HD21 UniProtKB/Swiss-Prot
  Q9Y491 UniProtKB/Swiss-Prot
  Q9Y4A2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 HMG20B  high mobility group 20B  HMG20B  high-mobility group 20B  Symbol and/or name change 5135510 APPROVED