SLC17A3 (solute carrier family 17 member 3) - Rat Genome Database

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Gene: SLC17A3 (solute carrier family 17 member 3) Homo sapiens
Analyze
Symbol: SLC17A3
Name: solute carrier family 17 member 3
RGD ID: 1344101
HGNC Page HGNC:10931
Description: Enables several functions, including toxin transmembrane transporter activity; urate transmembrane transporter activity; and voltage-gated monoatomic anion channel activity. Involved in urate metabolic process; urate transport; and xenobiotic detoxification by transmembrane export across the plasma membrane. Located in apical plasma membrane; endoplasmic reticulum membrane; and perinuclear region of cytoplasm. Implicated in gout.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GOUT4; Na(+)/PI cotransporter 4; NPT4; sodium-dependent phosphate transport protein 4; sodium/phosphate cotransporter 4; solute carrier family 17 (organic anion transporter), member 3; solute carrier family 17 (sodium phosphate), member 3; UAQTL4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38625,844,856 - 25,874,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl625,833,066 - 25,882,286 (-)EnsemblGRCh38hg38GRCh38
GRCh37625,845,084 - 25,874,471 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36625,953,307 - 25,982,450 (-)NCBINCBI36Build 36hg18NCBI36
Build 34625,953,308 - 25,990,493NCBI
Celera627,072,523 - 27,101,662 (-)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef625,788,565 - 25,817,700 (-)NCBIHuRef
CHM1_1625,847,566 - 25,876,701 (-)NCBICHM1_1
T2T-CHM13v2.0625,710,672 - 25,740,056 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
gout  (EXP,IAGP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9149941   PMID:12477932   PMID:15505377   PMID:16712791   PMID:18834626   PMID:19571809   PMID:19862010   PMID:19890391   PMID:20053405   PMID:20162743   PMID:20379614   PMID:20587610  
PMID:20810651   PMID:21282933   PMID:21778665   PMID:21873635   PMID:23222517   PMID:23263486   PMID:23824729   PMID:24816252   PMID:24954895   PMID:27772792   PMID:34384670   PMID:34663856  


Genomics

Comparative Map Data
SLC17A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38625,844,856 - 25,874,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl625,833,066 - 25,882,286 (-)EnsemblGRCh38hg38GRCh38
GRCh37625,845,084 - 25,874,471 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36625,953,307 - 25,982,450 (-)NCBINCBI36Build 36hg18NCBI36
Build 34625,953,308 - 25,990,493NCBI
Celera627,072,523 - 27,101,662 (-)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef625,788,565 - 25,817,700 (-)NCBIHuRef
CHM1_1625,847,566 - 25,876,701 (-)NCBICHM1_1
T2T-CHM13v2.0625,710,672 - 25,740,056 (-)NCBIT2T-CHM13v2.0
Slc17a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391324,020,905 - 24,044,701 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1324,023,417 - 24,044,699 (+)EnsemblGRCm39 Ensembl
GRCm381323,836,922 - 23,860,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1323,839,434 - 23,860,716 (+)EnsemblGRCm38mm10GRCm38
MGSCv371323,931,303 - 23,952,583 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361323,847,094 - 23,867,208 (+)NCBIMGSCv36mm8
Celera1324,071,131 - 24,092,378 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map139.95NCBI
Slc17a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81741,698,679 - 41,729,057 (-)NCBIGRCr8
mRatBN7.21741,270,804 - 41,300,132 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1741,270,812 - 41,295,256 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1741,343,893 - 41,369,438 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01742,947,941 - 42,973,483 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01741,226,512 - 41,251,991 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01743,518,760 - 43,545,160 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,518,655 - 43,543,185 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01745,373,769 - 45,400,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41748,599,049 - 48,620,786 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11748,601,889 - 48,623,627 (+)NCBI
Celera1740,901,815 - 40,925,982 (-)NCBICelera
Cytogenetic Map17p11NCBI
Slc17a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554831,234,975 - 1,260,158 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554831,235,122 - 1,260,161 (+)NCBIChiLan1.0ChiLan1.0
SLC17A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2540,490,853 - 40,520,394 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1636,492,314 - 36,521,841 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0625,678,412 - 25,707,948 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1626,336,696 - 26,365,958 (-)NCBIpanpan1.1PanPan1.1panPan2
SLC17A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13523,792,281 - 23,831,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3523,792,286 - 23,809,001 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3523,694,675 - 23,734,306 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03523,907,710 - 23,954,114 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3523,907,888 - 23,972,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13523,723,922 - 23,770,263 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03523,774,858 - 23,814,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03525,207,713 - 25,247,557 (-)NCBIUU_Cfam_GSD_1.0
SLC17A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl720,596,549 - 20,643,868 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1720,591,797 - 20,643,754 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2721,829,971 - 21,836,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC17A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11746,376,480 - 46,404,371 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1746,377,386 - 46,404,372 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604425,784,564 - 25,824,068 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc17a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247561,145,554 - 1,163,081 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247561,136,641 - 1,162,087 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC17A3
42 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001098486.2(SLC17A3):c.911T>C (p.Phe304Ser) single nucleotide variant Uric acid concentration, serum, quantitative trait locus 4 [RCV000030654] Chr6:25850541 [GRCh38]
Chr6:25850769 [GRCh37]
Chr6:6p22.2		 association
NM_001098486.2(SLC17A3):c.202A>C (p.Asn68His) single nucleotide variant Uric acid concentration, serum, quantitative trait locus 4 [RCV000030655] Chr6:25862334 [GRCh38]
Chr6:25862562 [GRCh37]
Chr6:6p22.2		 risk factor
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33		 pathogenic
NM_001098486.1(SLC17A3):c.1124G>A (p.Gly375Glu) single nucleotide variant Malignant melanoma [RCV000067229] Chr6:25849952 [GRCh38]
Chr6:25850180 [GRCh37]
Chr6:25958159 [NCBI36]
Chr6:6p22.2		 not provided
GRCh38/hg38 6p22.3-22.2(chr6:23252522-25967277)x1 copy number loss See cases [RCV000138710] Chr6:23252522..25967277 [GRCh38]
Chr6:23252750..25967505 [GRCh37]
Chr6:23360729..26075484 [NCBI36]
Chr6:6p22.3-22.2		 uncertain significance
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33		 pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p22.2(chr6:25839165-26536884)x4 copy number gain See cases [RCV000447433] Chr6:25839165..26536884 [GRCh37]
Chr6:6p22.2		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.2(chr6:25851789-26319486)x3 copy number gain not provided [RCV000682656] Chr6:25851789..26319486 [GRCh37]
Chr6:6p22.2		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.2(chr6:25622751-25853825)x1 copy number loss not provided [RCV001258881] Chr6:25622751..25853825 [GRCh37]
Chr6:6p22.2		 uncertain significance
GRCh37/hg19 6p22.2(chr6:25839165-26536884) copy number gain not specified [RCV002053562] Chr6:25839165..26536884 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.832G>A (p.Val278Ile) single nucleotide variant not specified [RCV004154868] Chr6:25850620 [GRCh38]
Chr6:25850848 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.175A>G (p.Met59Val) single nucleotide variant not specified [RCV004233648] Chr6:25862361 [GRCh38]
Chr6:25862589 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.1223C>T (p.Thr408Ile) single nucleotide variant not specified [RCV004141939] Chr6:25849853 [GRCh38]
Chr6:25850081 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.763G>A (p.Asp255Asn) single nucleotide variant not specified [RCV004152137] Chr6:25850827 [GRCh38]
Chr6:25851055 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.1316T>C (p.Ile439Thr) single nucleotide variant not specified [RCV004216372] Chr6:25849420 [GRCh38]
Chr6:25849648 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.130G>A (p.Val44Ile) single nucleotide variant not specified [RCV004215389] Chr6:25862406 [GRCh38]
Chr6:25862634 [GRCh37]
Chr6:6p22.2		 likely benign
NM_001098486.2(SLC17A3):c.1274A>G (p.Tyr425Cys) single nucleotide variant not specified [RCV004237372] Chr6:25849462 [GRCh38]
Chr6:25849690 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.49G>A (p.Ala17Thr) single nucleotide variant not specified [RCV004200847] Chr6:25868339 [GRCh38]
Chr6:25868567 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.626G>A (p.Gly209Glu) single nucleotide variant not specified [RCV004178528] Chr6:25855230 [GRCh38]
Chr6:25855458 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.124G>A (p.Ala42Thr) single nucleotide variant not specified [RCV004178005] Chr6:25862412 [GRCh38]
Chr6:25862640 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.1483C>T (p.Leu495Phe) single nucleotide variant not specified [RCV004211020] Chr6:25845396 [GRCh38]
Chr6:25845624 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.1229G>A (p.Cys410Tyr) single nucleotide variant not specified [RCV004203774] Chr6:25849847 [GRCh38]
Chr6:25850075 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.213C>A (p.Ser71Arg) single nucleotide variant not specified [RCV004174838] Chr6:25862323 [GRCh38]
Chr6:25862551 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.1490G>A (p.Arg497His) single nucleotide variant not specified [RCV004225139] Chr6:25845389 [GRCh38]
Chr6:25845617 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.1469C>T (p.Ala490Val) single nucleotide variant not specified [RCV004215769] Chr6:25845410 [GRCh38]
Chr6:25845638 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.155C>T (p.Thr52Met) single nucleotide variant not specified [RCV004263717] Chr6:25862381 [GRCh38]
Chr6:25862609 [GRCh37]
Chr6:6p22.2		 likely benign
NM_001098486.2(SLC17A3):c.215C>T (p.Pro72Leu) single nucleotide variant not specified [RCV004347594] Chr6:25862321 [GRCh38]
Chr6:25862549 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.137A>G (p.His46Arg) single nucleotide variant not specified [RCV004343302] Chr6:25862399 [GRCh38]
Chr6:25862627 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.41G>A (p.Ser14Asn) single nucleotide variant not specified [RCV004352727] Chr6:25868347 [GRCh38]
Chr6:25868575 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.1490G>T (p.Arg497Leu) single nucleotide variant not specified [RCV004335099] Chr6:25845389 [GRCh38]
Chr6:25845617 [GRCh37]
Chr6:6p22.2		 uncertain significance
GRCh37/hg19 6p22.3-22.2(chr6:21704602-26187420)x1 copy number loss not provided [RCV003485505] Chr6:21704602..26187420 [GRCh37]
Chr6:6p22.3-22.2		 likely pathogenic
GRCh37/hg19 6p22.2(chr6:25560739-26008260)x3 copy number gain not specified [RCV003986669] Chr6:25560739..26008260 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.1140A>G (p.Ser380=) single nucleotide variant SLC17A3-related condition [RCV003969003] Chr6:25849936 [GRCh38]
Chr6:25850164 [GRCh37]
Chr6:6p22.2		 benign
NM_001098486.2(SLC17A3):c.835G>A (p.Gly279Arg) single nucleotide variant SLC17A3-related condition [RCV003974023] Chr6:25850617 [GRCh38]
Chr6:25850845 [GRCh37]
Chr6:6p22.2		 benign
NM_001098486.2(SLC17A3):c.1210T>A (p.Cys404Ser) single nucleotide variant SLC17A3-related condition [RCV003909471] Chr6:25849866 [GRCh38]
Chr6:25850094 [GRCh37]
Chr6:6p22.2		 benign
NM_001098486.2(SLC17A3):c.59T>C (p.Met20Thr) single nucleotide variant not specified [RCV004448561] Chr6:25868329 [GRCh38]
Chr6:25868557 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.1381A>T (p.Arg461Trp) single nucleotide variant not specified [RCV004448557] Chr6:25845498 [GRCh38]
Chr6:25845726 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.1407C>T (p.Ala469=) single nucleotide variant SLC17A3-related condition [RCV003942047] Chr6:25845472 [GRCh38]
Chr6:25845700 [GRCh37]
Chr6:6p22.2		 benign
NM_001098486.2(SLC17A3):c.1319C>G (p.Ala440Gly) single nucleotide variant not specified [RCV004448556] Chr6:25849417 [GRCh38]
Chr6:25849645 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.577T>G (p.Trp193Gly) single nucleotide variant not specified [RCV004448558] Chr6:25861672 [GRCh38]
Chr6:25861900 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.41G>C (p.Ser14Thr) single nucleotide variant not specified [RCV004448559] Chr6:25868347 [GRCh38]
Chr6:25868575 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_001098486.2(SLC17A3):c.853C>A (p.Leu285Ile) single nucleotide variant not specified [RCV004448562] Chr6:25850599 [GRCh38]
Chr6:25850827 [GRCh37]
Chr6:6p22.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1532
Count of miRNA genes:795
Interacting mature miRNAs:899
Transcripts:ENST00000308453, ENST00000360657, ENST00000361703, ENST00000397060, ENST00000449356, ENST00000481949, ENST00000503922, ENST00000505420, ENST00000506105, ENST00000509714
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D6S2385  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37625,866,120 - 25,866,312UniSTSGRCh37
Build 36625,974,099 - 25,974,291RGDNCBI36
Celera627,093,309 - 27,093,501RGD
Cytogenetic Map6p21.3UniSTS
HuRef625,809,348 - 25,809,540UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High 3
Medium 192 192 192 221 2 2
Low 7 74 527 243 12 243 5 1 140 64 363 27 3 1
Below cutoff 1404 2158 718 91 998 13 1914 951 1780 47 714 1025 79 868 1206

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_032922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001098486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK296070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL138726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX107915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB163247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC340735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC361549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z83953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000308453
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl625,850,525 - 25,868,460 (-)Ensembl
RefSeq Acc Id: ENST00000360657   ⟹   ENSP00000353873
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl625,845,100 - 25,882,286 (-)Ensembl
RefSeq Acc Id: ENST00000361703   ⟹   ENSP00000355307
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl625,845,100 - 25,874,212 (-)Ensembl
RefSeq Acc Id: ENST00000397060   ⟹   ENSP00000380250
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl625,844,856 - 25,874,243 (-)Ensembl
RefSeq Acc Id: ENST00000449356   ⟹   ENSP00000415622
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl625,850,773 - 25,868,455 (-)Ensembl
RefSeq Acc Id: ENST00000481949   ⟹   ENSP00000421855
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl625,833,066 - 25,849,877 (-)Ensembl
RefSeq Acc Id: ENST00000503922
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl625,850,178 - 25,874,238 (-)Ensembl
RefSeq Acc Id: ENST00000505420   ⟹   ENSP00000424027
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl625,841,305 - 25,849,394 (-)Ensembl
RefSeq Acc Id: ENST00000506105   ⟹   ENSP00000424729
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl625,849,913 - 25,874,235 (-)Ensembl
RefSeq Acc Id: ENST00000509714
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl625,849,814 - 25,868,489 (-)Ensembl
RefSeq Acc Id: NM_001098486   ⟹   NP_001091956
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38625,844,856 - 25,874,243 (-)NCBI
GRCh37625,845,328 - 25,874,471 (-)RGD
Build 36625,953,307 - 25,982,450 (-)NCBI Archive
Celera627,072,523 - 27,101,662 (-)RGD
HuRef625,788,565 - 25,817,700 (-)RGD
CHM1_1625,847,566 - 25,876,701 (-)NCBI
T2T-CHM13v2.0625,710,672 - 25,740,056 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006632   ⟹   NP_006623
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38625,844,856 - 25,874,243 (-)NCBI
GRCh37625,845,328 - 25,874,471 (-)RGD
Build 36625,953,307 - 25,982,450 (-)NCBI Archive
Celera627,072,523 - 27,101,662 (-)RGD
HuRef625,788,565 - 25,817,700 (-)RGD
CHM1_1625,847,566 - 25,876,701 (-)NCBI
T2T-CHM13v2.0625,710,672 - 25,740,056 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_006623   ⟸   NM_006632
- Peptide Label: isoform b
- UniProtKB: Q8WWC7 (UniProtKB/Swiss-Prot),   B7Z511 (UniProtKB/Swiss-Prot),   B7WNJ5 (UniProtKB/Swiss-Prot),   Q9H533 (UniProtKB/Swiss-Prot),   O00476 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001091956   ⟸   NM_001098486
- Peptide Label: isoform a
- UniProtKB: O00476 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000424027   ⟸   ENST00000505420
RefSeq Acc Id: ENSP00000424729   ⟸   ENST00000506105
RefSeq Acc Id: ENSP00000353873   ⟸   ENST00000360657
RefSeq Acc Id: ENSP00000355307   ⟸   ENST00000361703
RefSeq Acc Id: ENSP00000421855   ⟸   ENST00000481949
RefSeq Acc Id: ENSP00000415622   ⟸   ENST00000449356
RefSeq Acc Id: ENSP00000380250   ⟸   ENST00000397060
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O00476-F1-model_v2 AlphaFold O00476 1-420 view protein structure

Promoters
RGD ID:6872232
Promoter ID:EPDNEW_H9281
Type:initiation region
Name:SLC17A3_1
Description:solute carrier family 17 member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38625,874,243 - 25,874,303EPDNEW
RGD ID:6804579
Promoter ID:HG_KWN:52569
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000360657,   OTTHUMT00000040069
Position:
Human AssemblyChrPosition (strand)Source
Build 36625,990,326 - 25,990,826 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10931 AgrOrtholog
COSMIC SLC17A3 COSMIC
Ensembl Genes ENSG00000124564 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000360657.7 UniProtKB/Swiss-Prot
  ENST00000361703 ENTREZGENE
  ENST00000361703.10 UniProtKB/Swiss-Prot
  ENST00000397060 ENTREZGENE
  ENST00000397060.8 UniProtKB/Swiss-Prot
  ENST00000449356.2 UniProtKB/TrEMBL
  ENST00000481949.6 UniProtKB/TrEMBL
  ENST00000505420.5 UniProtKB/TrEMBL
  ENST00000506105.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000124564 GTEx
HGNC ID HGNC:10931 ENTREZGENE
Human Proteome Map SLC17A3 Human Proteome Map
InterPro MFS UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na-dep_P-transpt_4_prd UniProtKB/Swiss-Prot
KEGG Report hsa:10786 UniProtKB/Swiss-Prot
NCBI Gene 10786 ENTREZGENE
OMIM 611034 OMIM
PANTHER SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot
PharmGKB PA35822 PharmGKB
PIRSF Na(+)/PI_cotransporter4_prd UniProtKB/Swiss-Prot
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B7WNJ5 ENTREZGENE
  B7Z511 ENTREZGENE
  E9PBQ8_HUMAN UniProtKB/TrEMBL
  H0Y8R7_HUMAN UniProtKB/TrEMBL
  H0Y9F7_HUMAN UniProtKB/TrEMBL
  NPT4_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q8WWC7 ENTREZGENE
  Q9H533 ENTREZGENE
UniProt Secondary B7WNJ5 UniProtKB/Swiss-Prot
  B7Z511 UniProtKB/Swiss-Prot
  Q8WWC7 UniProtKB/Swiss-Prot
  Q9H533 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 SLC17A3  solute carrier family 17 member 3  SLC17A3  solute carrier family 17 (organic anion transporter), member 3  Symbol and/or name change 5135510 APPROVED
2013-07-23 SLC17A3  solute carrier family 17 (organic anion transporter), member 3  SLC17A3  solute carrier family 17 (sodium phosphate), member 3  Symbol and/or name change 5135510 APPROVED