ARL10 (ADP ribosylation factor like GTPase 10) - Rat Genome Database

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Gene: ARL10 (ADP ribosylation factor like GTPase 10) Homo sapiens
Analyze
Symbol: ARL10
Name: ADP ribosylation factor like GTPase 10
RGD ID: 1344087
HGNC Page HGNC:22042
Description: Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADP-ribosylation factor like GTPase 10; ADP-ribosylation factor-like 10A; ADP-ribosylation factor-like membrane-associated protein; ADP-ribosylation factor-like protein 10; ARL10A; FLJ39249
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385176,365,487 - 176,415,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5176,365,487 - 176,401,865 (+)EnsemblGRCh38hg38GRCh38
GRCh375175,792,490 - 175,808,912 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365175,725,108 - 175,733,109 (+)NCBINCBI36Build 36hg18NCBI36
Build 345175,725,110 - 175,733,109NCBI
Celera5172,701,905 - 172,709,953 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5170,717,012 - 170,725,052 (+)NCBIHuRef
CHM1_15175,225,451 - 175,233,453 (+)NCBICHM1_1
T2T-CHM13v2.05176,909,834 - 176,959,829 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15033445   PMID:26186194   PMID:27432908   PMID:28380382   PMID:28514442   PMID:28675297   PMID:28712289   PMID:33961781   PMID:35007762   PMID:35844135  


Genomics

Comparative Map Data
ARL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385176,365,487 - 176,415,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5176,365,487 - 176,401,865 (+)EnsemblGRCh38hg38GRCh38
GRCh375175,792,490 - 175,808,912 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365175,725,108 - 175,733,109 (+)NCBINCBI36Build 36hg18NCBI36
Build 345175,725,110 - 175,733,109NCBI
Celera5172,701,905 - 172,709,953 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5170,717,012 - 170,725,052 (+)NCBIHuRef
CHM1_15175,225,451 - 175,233,453 (+)NCBICHM1_1
T2T-CHM13v2.05176,909,834 - 176,959,829 (+)NCBIT2T-CHM13v2.0
Arl10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,722,860 - 54,730,578 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,722,828 - 54,728,941 (+)EnsemblGRCm39 Ensembl
GRCm381354,575,047 - 54,582,765 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,575,015 - 54,581,128 (+)EnsemblGRCm38mm10GRCm38
MGSCv371354,676,374 - 54,682,489 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,584,687 - 54,590,750 (+)NCBIMGSCv36mm8
Celera1355,641,328 - 55,647,443 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.82NCBI
Arl10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,035,320 - 10,043,732 (-)NCBIGRCr8
mRatBN7.21710,030,213 - 10,038,625 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,030,213 - 10,038,703 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,044,375 - 10,052,786 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01711,577,557 - 11,586,085 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,040,812 - 10,049,223 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01710,567,064 - 10,575,518 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1710,568,959 - 10,575,203 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01712,693,062 - 12,701,533 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,094,098 - 16,100,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,094,097 - 16,100,342 (-)NCBI
Celera1710,105,092 - 10,111,341 (-)NCBICelera
Cytogenetic Map17p14NCBI
Arl10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,670,670 - 28,678,711 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,671,451 - 28,678,711 (+)NCBIChiLan1.0ChiLan1.0
ARL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24171,444,564 - 171,460,995 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15169,584,106 - 169,600,534 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05171,662,241 - 171,670,512 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15178,735,211 - 178,744,201 (+)NCBIpanpan1.1PanPan1.1panPan2
ARL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1436,946,111 - 36,954,321 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl436,949,878 - 36,954,319 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha436,907,325 - 36,922,213 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,307,451 - 37,322,292 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,313,765 - 37,322,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1437,139,047 - 37,147,579 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,320,308 - 37,335,216 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0437,829,330 - 37,844,217 (-)NCBIUU_Cfam_GSD_1.0
Arl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213121,611,057 - 121,626,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936597635,937 - 652,761 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936597635,967 - 651,604 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl281,496,825 - 81,506,329 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1281,496,823 - 81,506,344 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2283,148,227 - 83,157,753 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARL10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12378,368,593 - 78,377,869 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2378,369,699 - 78,375,855 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660759,498,138 - 9,506,540 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arl10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473313,750,631 - 13,761,755 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473313,749,437 - 13,761,766 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARL10
28 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q35.2-35.3(chr5:176132340-177586960)x1 copy number loss See cases [RCV000050645] Chr5:176132340..177586960 [GRCh38]
Chr5:175559343..177013961 [GRCh37]
Chr5:175491949..176946567 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3		 pathogenic
GRCh38/hg38 5q33.3-35.3(chr5:160029980-181269805)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|See cases [RCV000051865] Chr5:160029980..181269805 [GRCh38]
Chr5:159456987..180696806 [GRCh37]
Chr5:159389565..180629412 [NCBI36]
Chr5:5q33.3-35.3		 pathogenic
GRCh38/hg38 5q34-35.3(chr5:168689326-181269946)x3 copy number gain See cases [RCV000051866] Chr5:168689326..181269946 [GRCh38]
Chr5:168116331..180696947 [GRCh37]
Chr5:168048909..180629553 [NCBI36]
Chr5:5q34-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:175851047-178365049)x3 copy number gain See cases [RCV000051867] Chr5:175851047..178365049 [GRCh38]
Chr5:175278050..177792050 [GRCh37]
Chr5:175210656..177724656 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:175889986-180793986)x3 copy number gain See cases [RCV000051868] Chr5:175889986..180793986 [GRCh38]
Chr5:175316989..180220986 [GRCh37]
Chr5:175249595..180153592 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:175007241-179089812)x1 copy number loss See cases [RCV000052151] Chr5:175007241..179089812 [GRCh38]
Chr5:174434244..178516813 [GRCh37]
Chr5:174366850..178449419 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:176043476-177995759)x1 copy number loss See cases [RCV000053127] Chr5:176043476..177995759 [GRCh38]
Chr5:175470479..177422760 [GRCh37]
Chr5:175403085..177355366 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:176115257-177646633)x1 copy number loss See cases [RCV000053128] Chr5:176115257..177646633 [GRCh38]
Chr5:175542260..177073634 [GRCh37]
Chr5:175474866..177006240 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:176152073-177986213)x1 copy number loss See cases [RCV000053129] Chr5:176152073..177986213 [GRCh38]
Chr5:175579076..177413214 [GRCh37]
Chr5:175511682..177345820 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:176152073-177646633)x1 copy number loss See cases [RCV000053131] Chr5:176152073..177646633 [GRCh38]
Chr5:175579076..177073634 [GRCh37]
Chr5:175511682..177006240 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:176149599-177716401)x3 copy number gain See cases [RCV000053481] Chr5:176149599..177716401 [GRCh38]
Chr5:175576602..177143402 [GRCh37]
Chr5:175509208..177076008 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic|uncertain significance
GRCh38/hg38 5q35.2-35.3(chr5:176043476-177452489)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053860]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053860]|See cases [RCV000053860] Chr5:176043476..177452489 [GRCh38]
Chr5:175470479..176879490 [GRCh37]
Chr5:175403085..176812096 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic|uncertain significance
GRCh38/hg38 5q33.3-35.3(chr5:156825512-181269805)x3 copy number gain See cases [RCV000133847] Chr5:156825512..181269805 [GRCh38]
Chr5:156252523..180696806 [GRCh37]
Chr5:156185101..180629412 [NCBI36]
Chr5:5q33.3-35.3		 pathogenic
GRCh38/hg38 5q34-35.3(chr5:164386701-181269805)x3 copy number gain See cases [RCV000135546] Chr5:164386701..181269805 [GRCh38]
Chr5:163813707..180696806 [GRCh37]
Chr5:163746285..180629412 [NCBI36]
Chr5:5q34-35.3		 pathogenic
GRCh38/hg38 5q35.1-35.3(chr5:169334755-181285301)x3 copy number gain See cases [RCV000141249] Chr5:169334755..181285301 [GRCh38]
Chr5:168761759..180712302 [GRCh37]
Chr5:168694337..180644908 [NCBI36]
Chr5:5q35.1-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:175536771-181292788)x1 copy number loss See cases [RCV000141987] Chr5:175536771..181292788 [GRCh38]
Chr5:174963774..180719789 [GRCh37]
Chr5:174896380..180652395 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:175989092-178009412)x1 copy number loss See cases [RCV000142365] Chr5:175989092..178009412 [GRCh38]
Chr5:175416095..177436413 [GRCh37]
Chr5:175348701..177369019 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:176132340-177995759)x1 copy number loss See cases [RCV000142510] Chr5:176132340..177995759 [GRCh38]
Chr5:175559343..177422760 [GRCh37]
Chr5:175491949..177355366 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:176291838-178662699)x1 copy number loss See cases [RCV000142047] Chr5:176291838..178662699 [GRCh38]
Chr5:175718841..178089700 [GRCh37]
Chr5:175651447..178022306 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.1-35.2(chr5:173237772-176614618)x3 copy number gain See cases [RCV000142647] Chr5:173237772..176614618 [GRCh38]
Chr5:172664775..176041619 [GRCh37]
Chr5:172597381..175974225 [NCBI36]
Chr5:5q35.1-35.2		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:176143674-178009412)x1 copy number loss See cases [RCV000143463] Chr5:176143674..178009412 [GRCh38]
Chr5:175570677..177436413 [GRCh37]
Chr5:175503283..177369019 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:174397487-180686444)x1 copy number loss See cases [RCV000167565] Chr5:174397487..180686444 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
GRCh37/hg19 5q35.2-35.3(chr5:174990352-180690937) copy number gain not provided [RCV000767711] Chr5:174990352..180690937 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175722788-177423091)x3 copy number gain See cases [RCV000445774] Chr5:175722788..177423091 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:174427052-180719789)x1 copy number loss See cases [RCV000448611] Chr5:174427052..180719789 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175601473-180100378)x1 copy number loss See cases [RCV000448793] Chr5:175601473..180100378 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.1-35.3(chr5:171396359-180719789)x3 copy number gain See cases [RCV000448458] Chr5:171396359..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
GRCh37/hg19 5q35.1-35.3(chr5:172031248-180719789)x3 copy number gain See cases [RCV000512068] Chr5:172031248..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175438045-177392885)x1 copy number loss See cases [RCV000511974] Chr5:175438045..177392885 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175570677-177439550)x3 copy number gain See cases [RCV000511393] Chr5:175570677..177439550 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175570677-180719789)x1 copy number loss See cases [RCV000510785] Chr5:175570677..180719789 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175570678-177437340)x1 copy number loss See cases [RCV000512405] Chr5:175570678..177437340 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175570677-177436413)x1 copy number loss not provided [RCV000682615] Chr5:175570677..177436413 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2(chr5:175668563-176401296)x1 copy number loss not provided [RCV000682617] Chr5:175668563..176401296 [GRCh37]
Chr5:5q35.2		 uncertain significance
GRCh37/hg19 5q35.2-35.3(chr5:175438045-177481250)x1 copy number loss not provided [RCV000682614] Chr5:175438045..177481250 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2(chr5:175615624-175822818)x1 copy number loss not provided [RCV000682616] Chr5:175615624..175822818 [GRCh37]
Chr5:5q35.2		 likely benign
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q33.2-35.3(chr5:155344802-180693344)x3 copy number gain not provided [RCV000745284] Chr5:155344802..180693344 [GRCh37]
Chr5:5q33.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:174832617-180693344)x3 copy number gain not provided [RCV000745336] Chr5:174832617..180693344 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175346223-177423236)x1 copy number loss not provided [RCV000745338] Chr5:175346223..177423236 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175433876-177441189)x1 copy number loss not provided [RCV000745339] Chr5:175433876..177441189 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q32-35.3(chr5:149010383-180719789) copy number gain Hunter-McAlpine craniosynostosis [RCV002280612] Chr5:149010383..180719789 [GRCh37]
Chr5:5q32-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175570677-177439550)x3 copy number gain not provided [RCV000846148] Chr5:175570677..177439550 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2(chr5:175601473-175814860)x1 copy number loss not provided [RCV000847200] Chr5:175601473..175814860 [GRCh37]
Chr5:5q35.2		 uncertain significance
GRCh37/hg19 5q35.1-35.3(chr5:170805664-180719789)x3 copy number gain 5q35 microduplication syndrome [RCV001263227] Chr5:170805664..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175346695-177469711)x1 copy number loss Sotos syndrome [RCV003232270] Chr5:175346695..177469711 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175570677-177114151)x3 copy number gain not provided [RCV001258712] Chr5:175570677..177114151 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175394616-177436413)x3 copy number gain not provided [RCV001258713] Chr5:175394616..177436413 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2(chr5:175668563-176182615)x3 copy number gain not provided [RCV001836523] Chr5:175668563..176182615 [GRCh37]
Chr5:5q35.2		 uncertain significance
NC_000005.9:g.(?_175158654)_(179263593_?)dup duplication Ehlers-Danlos syndrome, dermatosparaxis type [RCV003116717]|Sotos syndrome [RCV003232857]|not provided [RCV003154288] Chr5:175158654..179263593 [GRCh37]
Chr5:5q35.2-35.3		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 5q35.1-35.3(chr5:170350336-180719789)x3 copy number gain See cases [RCV002292398] Chr5:170350336..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
NM_173664.6(ARL10):c.413A>G (p.Tyr138Cys) single nucleotide variant not specified [RCV004141345] Chr5:176368834 [GRCh38]
Chr5:175795837 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_007097.5(CLTB):c.259T>C (p.Tyr87His) single nucleotide variant not specified [RCV004123990] Chr5:176398023 [GRCh38]
Chr5:175825024 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.367G>C (p.Glu123Gln) single nucleotide variant not specified [RCV004186665] Chr5:176366563 [GRCh38]
Chr5:175793566 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.278T>G (p.Phe93Cys) single nucleotide variant not specified [RCV004115608] Chr5:176366474 [GRCh38]
Chr5:175793477 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.148C>T (p.Arg50Trp) single nucleotide variant not specified [RCV004108463] Chr5:176388303 [GRCh38]
Chr5:175815304 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.359G>A (p.Arg120His) single nucleotide variant not specified [RCV004240937] Chr5:176385255 [GRCh38]
Chr5:175812256 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.125G>C (p.Arg42Pro) single nucleotide variant not specified [RCV004206160] Chr5:176365688 [GRCh38]
Chr5:175792691 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.407A>G (p.Asp136Gly) single nucleotide variant not specified [RCV004147630] Chr5:176384361 [GRCh38]
Chr5:175811362 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_138820.4(HIGD2A):c.140C>T (p.Pro47Leu) single nucleotide variant not specified [RCV004069182] Chr5:176388959 [GRCh38]
Chr5:175815960 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.433G>A (p.Glu145Lys) single nucleotide variant not specified [RCV004069149] Chr5:176368854 [GRCh38]
Chr5:175795857 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_007097.5(CLTB):c.586G>A (p.Ala196Thr) single nucleotide variant not specified [RCV004133427] Chr5:176392878 [GRCh38]
Chr5:175819879 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.658A>G (p.Ile220Val) single nucleotide variant not specified [RCV004178335] Chr5:176371818 [GRCh38]
Chr5:175798821 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_138820.4(HIGD2A):c.74G>A (p.Ser25Asn) single nucleotide variant not specified [RCV004222436] Chr5:176388893 [GRCh38]
Chr5:175815894 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.25T>G (p.Leu9Val) single nucleotide variant not specified [RCV004093768] Chr5:176365588 [GRCh38]
Chr5:175792591 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.439C>G (p.Gln147Glu) single nucleotide variant not specified [RCV004264719] Chr5:176384329 [GRCh38]
Chr5:175811330 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.445C>T (p.Arg149Trp) single nucleotide variant not specified [RCV004310089] Chr5:176384323 [GRCh38]
Chr5:175811324 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_138820.4(HIGD2A):c.90G>C (p.Arg30Ser) single nucleotide variant not specified [RCV004273717] Chr5:176388909 [GRCh38]
Chr5:175815910 [GRCh37]
Chr5:5q35.2		 likely benign
NM_016391.8(NOP16):c.318G>C (p.Lys106Asn) single nucleotide variant not specified [RCV004260248] Chr5:176385296 [GRCh38]
Chr5:175812297 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_007097.5(CLTB):c.311G>A (p.Arg104His) single nucleotide variant not specified [RCV004262100] Chr5:176397971 [GRCh38]
Chr5:175824972 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_138820.4(HIGD2A):c.131G>A (p.Arg44His) single nucleotide variant not specified [RCV004338312] Chr5:176388950 [GRCh38]
Chr5:175815951 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.578T>G (p.Met193Arg) single nucleotide variant not specified [RCV004356243] Chr5:176371738 [GRCh38]
Chr5:175798741 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.206G>T (p.Arg69Leu) single nucleotide variant not specified [RCV004337881] Chr5:176388245 [GRCh38]
Chr5:175815246 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.541G>A (p.Val181Ile) single nucleotide variant not specified [RCV004338601] Chr5:176368962 [GRCh38]
Chr5:175795965 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.209C>T (p.Pro70Leu) single nucleotide variant not specified [RCV004346293] Chr5:176366405 [GRCh38]
Chr5:175793408 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.132G>C (p.Glu44Asp) single nucleotide variant not specified [RCV004362128] Chr5:176365695 [GRCh38]
Chr5:175792698 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.366G>A (p.Met122Ile) single nucleotide variant not specified [RCV004349882] Chr5:176385248 [GRCh38]
Chr5:175812249 [GRCh37]
Chr5:5q35.2		 uncertain significance
GRCh37/hg19 5q35.1-35.2(chr5:171836503-176517734)x1 copy number loss not provided [RCV003485492] Chr5:171836503..176517734 [GRCh37]
Chr5:5q35.1-35.2		 pathogenic
Single allele deletion not provided [RCV003448669] Chr5:175559209..177430432 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:175332333-177469711)x1 copy number loss not provided [RCV003485494] Chr5:175332333..177469711 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
NM_016391.8(NOP16):c.508T>G (p.Leu170Val) single nucleotide variant not specified [RCV004488071] Chr5:176384260 [GRCh38]
Chr5:175811261 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.520A>C (p.Lys174Gln) single nucleotide variant not specified [RCV004488072] Chr5:176384248 [GRCh38]
Chr5:175811249 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.386T>C (p.Ile129Thr) single nucleotide variant not specified [RCV004417862] Chr5:176368807 [GRCh38]
Chr5:175795810 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.506C>A (p.Ser169Tyr) single nucleotide variant not specified [RCV004488070] Chr5:176384262 [GRCh38]
Chr5:175811263 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.244G>A (p.Val82Met) single nucleotide variant not specified [RCV004417861] Chr5:176366440 [GRCh38]
Chr5:175793443 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.281T>C (p.Leu94Pro) single nucleotide variant not specified [RCV004488068] Chr5:176386845 [GRCh38]
Chr5:175813846 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_173664.6(ARL10):c.238G>A (p.Val80Met) single nucleotide variant not specified [RCV004417860] Chr5:176366434 [GRCh38]
Chr5:175793437 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_016391.8(NOP16):c.404G>A (p.Arg135His) single nucleotide variant not specified [RCV004488069] Chr5:176384364 [GRCh38]
Chr5:175811365 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_138820.4(HIGD2A):c.133G>C (p.Glu45Gln) single nucleotide variant not specified [RCV004397170] Chr5:176388952 [GRCh38]
Chr5:175815953 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_138820.4(HIGD2A):c.25C>A (p.Pro9Thr) single nucleotide variant not specified [RCV004397171] Chr5:176388844 [GRCh38]
Chr5:175815845 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_138820.4(HIGD2A):c.98A>C (p.Glu33Ala) single nucleotide variant not specified [RCV004397172] Chr5:176388917 [GRCh38]
Chr5:175815918 [GRCh37]
Chr5:5q35.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4868
Count of miRNA genes:1438
Interacting mature miRNAs:1915
Transcripts:ENST00000310389, ENST00000503175, ENST00000507151, ENST00000514533
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH92676  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375175,797,920 - 175,798,005UniSTSGRCh37
Build 365175,730,526 - 175,730,611RGDNCBI36
Celera5172,704,441 - 172,704,526RGD
Cytogenetic Map5q35.2UniSTS
HuRef5170,722,431 - 170,722,516UniSTS
GeneMap99-GB4 RH Map5644.61UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 86 106 6 2 160 2 423 74 532 34 262 64 3 3 394
Low 2221 2413 1580 492 1270 331 3900 2073 3188 342 1160 1480 172 1 1201 2385 4 2
Below cutoff 130 472 140 130 521 132 32 50 14 42 38 68 9 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001317948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC138956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF086071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR001833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF459629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000310389   ⟹   ENSP00000308496
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5176,365,487 - 176,381,909 (+)Ensembl
RefSeq Acc Id: ENST00000503175   ⟹   ENSP00000424831
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5176,368,947 - 176,388,638 (+)Ensembl
RefSeq Acc Id: ENST00000507151
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5176,366,538 - 176,369,127 (+)Ensembl
RefSeq Acc Id: ENST00000514533   ⟹   ENSP00000421449
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5176,368,850 - 176,401,865 (+)Ensembl
RefSeq Acc Id: NM_001317948   ⟹   NP_001304877
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385176,365,487 - 176,369,956 (+)NCBI
CHM1_15175,225,420 - 175,229,909 (+)NCBI
T2T-CHM13v2.05176,909,834 - 176,914,303 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173664   ⟹   NP_775935
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385176,365,487 - 176,381,909 (+)NCBI
GRCh375175,792,477 - 175,800,934 (+)NCBI
Build 365175,725,108 - 175,733,109 (+)NCBI Archive
Celera5172,701,905 - 172,709,953 (-)RGD
HuRef5170,717,012 - 170,725,052 (+)ENTREZGENE
CHM1_15175,225,420 - 175,233,453 (+)NCBI
T2T-CHM13v2.05176,909,834 - 176,926,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011534529   ⟹   XP_011532831
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385176,365,487 - 176,415,063 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011534530   ⟹   XP_011532832
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385176,365,487 - 176,414,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011534531   ⟹   XP_011532833
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385176,365,487 - 176,380,380 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054352417   ⟹   XP_054208392
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05176,909,834 - 176,959,829 (+)NCBI
RefSeq Acc Id: XM_054352418   ⟹   XP_054208393
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05176,909,834 - 176,959,062 (+)NCBI
RefSeq Acc Id: XM_054352419   ⟹   XP_054208394
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05176,909,834 - 176,924,745 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_775935   ⟸   NM_173664
- Peptide Label: isoform 2
- UniProtKB: Q8N8L6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011532831   ⟸   XM_011534529
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011532832   ⟸   XM_011534530
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011532833   ⟸   XM_011534531
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001304877   ⟸   NM_001317948
- Peptide Label: isoform 1
- UniProtKB: Q6PCE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000424831   ⟸   ENST00000503175
RefSeq Acc Id: ENSP00000308496   ⟸   ENST00000310389
RefSeq Acc Id: ENSP00000421449   ⟸   ENST00000514533
RefSeq Acc Id: XP_054208392   ⟸   XM_054352417
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054208393   ⟸   XM_054352418
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054208394   ⟸   XM_054352419
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8N8L6-F1-model_v2 AlphaFold Q8N8L6 1-244 view protein structure

Promoters
RGD ID:6802870
Promoter ID:HG_KWN:51860
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000253145,   UC003MEB.2
Position:
Human AssemblyChrPosition (strand)Source
Build 365175,724,896 - 175,725,562 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:22042 AgrOrtholog
COSMIC ARL10 COSMIC
Ensembl Genes ENSG00000175414 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000310389 ENTREZGENE
  ENST00000310389.6 UniProtKB/Swiss-Prot
  ENST00000503175.1 UniProtKB/TrEMBL
  ENST00000514533.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000175414 GTEx
HGNC ID HGNC:22042 ENTREZGENE
Human Proteome Map ARL10 Human Proteome Map
InterPro ARL10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_ARF/SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:285598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 285598 ENTREZGENE
PANTHER ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47575 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134871031 PharmGKB
PRINTS SAR1GTPBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ARL10_HUMAN UniProtKB/Swiss-Prot
  H0Y8L6_HUMAN UniProtKB/TrEMBL
  H0Y9R6_HUMAN UniProtKB/TrEMBL
  L0R582_HUMAN UniProtKB/TrEMBL
  Q6PCE2 ENTREZGENE, UniProtKB/TrEMBL
  Q8N8L6 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 ARL10  ADP ribosylation factor like GTPase 10    ADP-ribosylation factor like GTPase 10  Symbol and/or name change 5135510 APPROVED
2015-12-08 ARL10  ADP-ribosylation factor like GTPase 10    ADP-ribosylation factor-like 10  Symbol and/or name change 5135510 APPROVED