THAP8 (THAP domain containing 8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: THAP8 (THAP domain containing 8) Homo sapiens
Analyze
Symbol: THAP8
Name: THAP domain containing 8
RGD ID: 1343379
HGNC Page HGNC:23191
Description: Predicted to enable DNA binding activity and metal ion binding activity.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ32891; THAP domain-containing protein 8
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381936,034,984 - 36,054,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1936,034,984 - 36,054,739 (-)EnsemblGRCh38hg38GRCh38
GRCh371936,525,886 - 36,545,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,217,727 - 41,237,504 (-)NCBINCBI36Build 36hg18NCBI36
Build 341941,217,726 - 41,237,504NCBI
Celera1933,240,067 - 33,259,840 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1933,031,437 - 33,051,189 (-)NCBIHuRef
CHM1_11936,527,238 - 36,547,020 (-)NCBICHM1_1
T2T-CHM13v2.01938,580,785 - 38,600,561 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12575992   PMID:14702039   PMID:15489334   PMID:16169070   PMID:17207965   PMID:19274049   PMID:21988832   PMID:25416956   PMID:26186194   PMID:26760575   PMID:28514442  
PMID:31515488   PMID:32296183   PMID:33961781   PMID:35748872  


Genomics

Comparative Map Data
THAP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381936,034,984 - 36,054,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1936,034,984 - 36,054,739 (-)EnsemblGRCh38hg38GRCh38
GRCh371936,525,886 - 36,545,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,217,727 - 41,237,504 (-)NCBINCBI36Build 36hg18NCBI36
Build 341941,217,726 - 41,237,504NCBI
Celera1933,240,067 - 33,259,840 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1933,031,437 - 33,051,189 (-)NCBIHuRef
CHM1_11936,527,238 - 36,547,020 (-)NCBICHM1_1
T2T-CHM13v2.01938,580,785 - 38,600,561 (-)NCBIT2T-CHM13v2.0
Thap8-ps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39729,988,527 - 29,988,721 (+)NCBIGRCm39GRCm39mm39
GRCm38730,289,102 - 30,289,296 (+)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map7B1NCBI
Thap8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0188,745,928 - 88,750,343 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Cytogenetic Map1q21NCBI
Thap8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554682,545,327 - 2,559,106 (+)NCBIChiLan1.0ChiLan1.0
THAP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22042,035,768 - 42,056,355 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11944,019,423 - 44,039,645 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,953,138 - 32,973,651 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,701,760 - 41,721,269 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,701,760 - 41,721,269 (-)Ensemblpanpan1.1panPan2
THAP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,641,648 - 116,657,258 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,641,945 - 116,655,654 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,047,266 - 116,061,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,244,793 - 117,259,359 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,245,396 - 117,259,368 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,811,981 - 116,823,398 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,432,409 - 116,446,975 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,487,568 - 117,502,125 (+)NCBIUU_Cfam_GSD_1.0
Thap8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,294,709 - 11,309,797 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493692264,838 - 80,015 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THAP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,406,742 - 45,418,856 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,407,145 - 45,418,848 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,810,985 - 40,820,902 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THAP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,946,361 - 30,964,104 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,946,290 - 30,963,628 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660738,741,412 - 8,758,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thap8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479410,296,683 - 10,309,612 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in THAP8
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19q12-13.13(chr19:29661858-38114723)x1 copy number loss See cases [RCV000135879] Chr19:29661858..38114723 [GRCh38]
Chr19:30152765..38605363 [GRCh37]
Chr19:34844605..43297203 [NCBI36]
Chr19:19q12-13.13		 pathogenic
GRCh38/hg38 19q12-13.13(chr19:29671324-37902990)x1 copy number loss See cases [RCV000136794] Chr19:29671324..37902990 [GRCh38]
Chr19:30162231..38393630 [GRCh37]
Chr19:34854071..43085470 [NCBI36]
Chr19:19q12-13.13		 pathogenic
GRCh37/hg19 19q13.12-13.13(chr19:36475577-38399402)x3 copy number gain See cases [RCV000240597] Chr19:36475577..38399402 [GRCh37]
Chr19:19q13.12-13.13		 uncertain significance
GRCh37/hg19 19q13.12(chr19:36147111-37249653)x1 copy number loss See cases [RCV000511504] Chr19:36147111..37249653 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
NM_152658.3(THAP8):c.82A>G (p.Lys28Glu) single nucleotide variant Inborn genetic diseases [RCV003261586] Chr19:36054136 [GRCh38]
Chr19:36545038 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.11-13.12(chr19:35111811-37744992) copy number loss Generalized epilepsy with febrile seizures plus, type 1 [RCV000767768] Chr19:35111811..37744992 [GRCh37]
Chr19:19q13.11-13.12		 pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33		 pathogenic
NM_152658.3(THAP8):c.386G>A (p.Arg129His) single nucleotide variant Inborn genetic diseases [RCV003248295] Chr19:36039609 [GRCh38]
Chr19:36530511 [GRCh37]
Chr19:19q13.12		 likely benign
NC_000019.9:g.(?_33167170)_(36643309_?)dup duplication Hereditary spastic paraplegia 75 [RCV003107659] Chr19:33167170..36643309 [GRCh37]
Chr19:19q13.11-13.12		 uncertain significance
GRCh37/hg19 19p13.11-q13.2(chr19:19546923-41313229)x3 copy number gain Specific learning disability [RCV001801194] Chr19:19546923..41313229 [GRCh37]
Chr19:19p13.11-q13.2		 pathogenic
NC_000019.9:g.(?_35521725)_(36643309_?)del deletion Brugada syndrome 5 [RCV001910265] Chr19:35521725..36643309 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.44G>A (p.Gly15Asp) single nucleotide variant Inborn genetic diseases [RCV003264413] Chr19:36054174 [GRCh38]
Chr19:36545076 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.43G>A (p.Gly15Ser) single nucleotide variant Inborn genetic diseases [RCV002727791] Chr19:36054175 [GRCh38]
Chr19:36545077 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.178G>A (p.Glu60Lys) single nucleotide variant Inborn genetic diseases [RCV002793956] Chr19:36040042 [GRCh38]
Chr19:36530944 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.229C>T (p.Arg77Trp) single nucleotide variant Inborn genetic diseases [RCV002981508] Chr19:36039991 [GRCh38]
Chr19:36530893 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.461C>T (p.Ala154Val) single nucleotide variant Inborn genetic diseases [RCV002977374] Chr19:36039534 [GRCh38]
Chr19:36530436 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.341C>T (p.Thr114Ile) single nucleotide variant Inborn genetic diseases [RCV002784205] Chr19:36039654 [GRCh38]
Chr19:36530556 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.84G>T (p.Lys28Asn) single nucleotide variant Inborn genetic diseases [RCV002668112] Chr19:36040136 [GRCh38]
Chr19:36531038 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.410C>T (p.Ser137Leu) single nucleotide variant Inborn genetic diseases [RCV002767618] Chr19:36039585 [GRCh38]
Chr19:36530487 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.739A>T (p.Ile247Leu) single nucleotide variant Inborn genetic diseases [RCV002827290] Chr19:36035526 [GRCh38]
Chr19:36526428 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.805A>G (p.Thr269Ala) single nucleotide variant Inborn genetic diseases [RCV002986878] Chr19:36035460 [GRCh38]
Chr19:36526362 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.22C>T (p.Pro8Ser) single nucleotide variant Inborn genetic diseases [RCV002892449] Chr19:36054196 [GRCh38]
Chr19:36545098 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.548G>A (p.Arg183Gln) single nucleotide variant Inborn genetic diseases [RCV002793113] Chr19:36039447 [GRCh38]
Chr19:36530349 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.652C>T (p.Arg218Cys) single nucleotide variant Inborn genetic diseases [RCV003188339] Chr19:36039343 [GRCh38]
Chr19:36530245 [GRCh37]
Chr19:19q13.12		 likely benign
NM_152658.3(THAP8):c.704C>T (p.Ser235Phe) single nucleotide variant Inborn genetic diseases [RCV003205514] Chr19:36035561 [GRCh38]
Chr19:36526463 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_152658.3(THAP8):c.95A>G (p.Lys32Arg) single nucleotide variant Inborn genetic diseases [RCV003348307] Chr19:36040125 [GRCh38]
Chr19:36531027 [GRCh37]
Chr19:19q13.12		 uncertain significance
Single allele deletion not provided [RCV003448708] Chr19:35225414..37357598 [GRCh37]
Chr19:19q13.11-13.12		 pathogenic
GRCh37/hg19 19q13.12(chr19:36312941-36751702)x3 copy number gain not provided [RCV003485199] Chr19:36312941..36751702 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19q13.12(chr19:36451071-36752221)x3 copy number gain not specified [RCV003986106] Chr19:36451071..36752221 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19q11-13.2(chr19:28271146-41508851)x3 copy number gain not specified [RCV003986115] Chr19:28271146..41508851 [GRCh37]
Chr19:19q11-13.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1727
Count of miRNA genes:653
Interacting mature miRNAs:728
Transcripts:ENST00000292894, ENST00000522483, ENST00000524106, ENST00000538849, ENST00000607730
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D19S224  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371936,528,072 - 36,528,329UniSTSGRCh37
GRCh371936,528,073 - 36,528,348UniSTSGRCh37
Build 361941,219,912 - 41,220,169RGDNCBI36
Celera1933,242,251 - 33,242,526UniSTS
Celera1933,242,250 - 33,242,507RGD
Cytogenetic Map19q13.12UniSTS
HuRef1933,033,621 - 33,033,860UniSTS
HuRef1933,033,622 - 33,033,879UniSTS
Marshfield Genetic Map1961.49UniSTS
Marshfield Genetic Map1961.49RGD
Genethon Genetic Map1960.9UniSTS
TNG Radiation Hybrid Map1913073.0UniSTS
GeneMap99-GB4 RH Map19216.14UniSTS
Whitehead-RH Map19267.0UniSTS
NCBI RH Map19362.9UniSTS
RH15953  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371936,525,975 - 36,526,101UniSTSGRCh37
Build 361941,217,815 - 41,217,941RGDNCBI36
Celera1933,240,155 - 33,240,281RGD
Cytogenetic Map19q13.12UniSTS
HuRef1933,031,525 - 33,031,651UniSTS
GeneMap99-GB4 RH Map19214.34UniSTS
THAP8__5251  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371936,525,868 - 36,526,458UniSTSGRCh37
Build 361941,217,708 - 41,218,298RGDNCBI36
Celera1933,240,048 - 33,240,635RGD
HuRef1933,031,418 - 33,032,005UniSTS
D19S224  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.12UniSTS
TNG Radiation Hybrid Map1913073.0UniSTS
GeneMap99-GB4 RH Map19216.14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1306 215 191 59 400 60 1235 700 1097 125 863 287 3 158 790
Low 1132 2750 1533 564 1540 404 3119 1482 2636 294 597 1323 171 1 1046 1995 6 2
Below cutoff 26 2 1 9 1 3 15 1 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000292894   ⟹   ENSP00000292894
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1936,034,984 - 36,054,285 (-)Ensembl
RefSeq Acc Id: ENST00000522483   ⟹   ENSP00000429629
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1936,035,148 - 36,054,377 (-)Ensembl
RefSeq Acc Id: ENST00000524106
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1936,039,961 - 36,054,739 (-)Ensembl
RefSeq Acc Id: ENST00000607730   ⟹   ENSP00000475450
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1936,039,323 - 36,054,401 (-)Ensembl
RefSeq Acc Id: NM_001331102   ⟹   NP_001318031
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381936,034,984 - 36,054,285 (-)NCBI
T2T-CHM13v2.01938,580,785 - 38,600,084 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001331103   ⟹   NP_001318032
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381936,034,984 - 36,054,285 (-)NCBI
T2T-CHM13v2.01938,580,785 - 38,600,084 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001331104   ⟹   NP_001318033
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381936,034,985 - 36,054,762 (-)NCBI
T2T-CHM13v2.01938,580,786 - 38,600,561 (-)NCBI
Sequence:
RefSeq Acc Id: NM_152658   ⟹   NP_689871
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381936,034,984 - 36,054,285 (-)NCBI
GRCh371936,525,886 - 36,545,664 (-)NCBI
Build 361941,217,727 - 41,237,504 (-)NCBI Archive
Celera1933,240,067 - 33,259,840 (-)RGD
HuRef1933,031,437 - 33,051,189 (-)RGD
CHM1_11936,527,238 - 36,547,020 (-)NCBI
T2T-CHM13v2.01938,580,785 - 38,600,084 (-)NCBI
Sequence:
RefSeq Acc Id: NR_138539
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381936,034,984 - 36,054,285 (-)NCBI
T2T-CHM13v2.01938,580,785 - 38,600,084 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_689871   ⟸   NM_152658
- Peptide Label: isoform a
- UniProtKB: Q0P5Z7 (UniProtKB/Swiss-Prot),   Q96M21 (UniProtKB/Swiss-Prot),   Q8NA92 (UniProtKB/Swiss-Prot),   H9CWI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001318033   ⟸   NM_001331104
- Peptide Label: isoform c
- UniProtKB: B4DKM9 (UniProtKB/TrEMBL),   H9CWI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001318032   ⟸   NM_001331103
- Peptide Label: isoform c
- UniProtKB: B4DKM9 (UniProtKB/TrEMBL),   H9CWI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001318031   ⟸   NM_001331102
- Peptide Label: isoform b
- UniProtKB: H9CWI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000292894   ⟸   ENST00000292894
RefSeq Acc Id: ENSP00000429629   ⟸   ENST00000522483
RefSeq Acc Id: ENSP00000475450   ⟸   ENST00000607730
Protein Domains
THAP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8NA92-F1-model_v2 AlphaFold Q8NA92 1-274 view protein structure

Promoters
RGD ID:7239635
Promoter ID:EPDNEW_H25562
Type:initiation region
Name:THAP8_2
Description:THAP domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25563  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381936,054,271 - 36,054,331EPDNEW
RGD ID:7239633
Promoter ID:EPDNEW_H25563
Type:initiation region
Name:THAP8_1
Description:THAP domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25562  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381936,054,755 - 36,054,815EPDNEW
RGD ID:6795397
Promoter ID:HG_KWN:29708
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000388999,   ENST00000392182,   NM_001083961,   NM_152658,   NM_173636,   OTTHUMT00000109534,   UC002ODB.2,   UC010EER.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361941,236,846 - 41,237,802 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23191 AgrOrtholog
COSMIC THAP8 COSMIC
Ensembl Genes ENSG00000161277 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000292894 ENTREZGENE
  ENST00000292894.2 UniProtKB/Swiss-Prot
  ENST00000522483.2 UniProtKB/TrEMBL
  ENST00000607730.1 UniProtKB/TrEMBL
GTEx ENSG00000161277 GTEx
HGNC ID HGNC:23191 ENTREZGENE
Human Proteome Map THAP8 Human Proteome Map
InterPro THAP_Znf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:199745 UniProtKB/Swiss-Prot
NCBI Gene 199745 ENTREZGENE
OMIM 612536 OMIM
PANTHER AGAP005574-PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46927:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam THAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134973337 PharmGKB
PROSITE ZF_THAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DM3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DKM9 ENTREZGENE, UniProtKB/TrEMBL
  E5RHW1_HUMAN UniProtKB/TrEMBL
  H9CWI5 ENTREZGENE, UniProtKB/TrEMBL
  Q0P5Z7 ENTREZGENE
  Q8NA92 ENTREZGENE
  Q96M21 ENTREZGENE
  THAP8_HUMAN UniProtKB/Swiss-Prot
  U3KQ16_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q0P5Z7 UniProtKB/Swiss-Prot
  Q96M21 UniProtKB/Swiss-Prot