TRDV2 (T cell receptor delta variable 2) - Rat Genome Database

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Gene: TRDV2 (T cell receptor delta variable 2) Homo sapiens
Analyze
Symbol: TRDV2
Name: T cell receptor delta variable 2
RGD ID: 1343000
HGNC Page HGNC:12263
Description: Predicted to be involved in adaptive immune response and innate immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex.
Type: gene (Ensembl: TR_V_gene)
RefSeq Status: REVIEWED
Previously known as: hDV102S1
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381422,422,546 - 22,423,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1422,422,371 - 22,423,042 (+)EnsemblGRCh38hg38GRCh38
GRCh371422,891,537 - 22,892,033 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361421,961,377 - 21,961,873 (+)NCBINCBI36Build 36hg18NCBI36
Celera142,754,484 - 2,754,980 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,009,794 - 3,010,290 (+)NCBIHuRef
CHM1_11422,890,448 - 22,890,944 (+)NCBICHM1_1
T2T-CHM13v2.01416,620,292 - 16,620,788 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:2526321   PMID:12477932   PMID:16210656   PMID:19465023   PMID:19494338   PMID:21873635  


Genomics

Comparative Map Data
TRDV2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381422,422,546 - 22,423,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1422,422,371 - 22,423,042 (+)EnsemblGRCh38hg38GRCh38
GRCh371422,891,537 - 22,892,033 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361421,961,377 - 21,961,873 (+)NCBINCBI36Build 36hg18NCBI36
Celera142,754,484 - 2,754,980 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,009,794 - 3,010,290 (+)NCBIHuRef
CHM1_11422,890,448 - 22,890,944 (+)NCBICHM1_1
T2T-CHM13v2.01416,620,292 - 16,620,788 (+)NCBIT2T-CHM13v2.0
Trdv4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,312,461 - 54,312,972 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,312,362 - 54,312,972 (+)EnsemblGRCm39 Ensembl
GRCm381454,075,004 - 54,075,515 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,074,905 - 54,075,515 (+)EnsemblGRCm38mm10GRCm38
MGSCv371454,694,679 - 54,695,190 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Cytogenetic Map14C2NCBI
cM Map1427.64NCBI


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q11.2(chr14:21919243-22511027)x1 copy number loss See cases [RCV000135132] Chr14:21919243..22511027 [GRCh38]
Chr14:22387418..22980010 [GRCh37]
Chr14:21457258..22049850 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2(chr14:21973760-22442515)x1 copy number loss See cases [RCV000135471] Chr14:21973760..22442515 [GRCh38]
Chr14:22441989..22911507 [GRCh37]
Chr14:21511829..21981347 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:21854413-22495939)x1 copy number loss See cases [RCV000135900] Chr14:21854413..22495939 [GRCh38]
Chr14:22322590..22964922 [GRCh37]
Chr14:21392430..22034762 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:22229069-22495939)x1 copy number loss See cases [RCV000136725] Chr14:22229069..22495939 [GRCh38]
Chr14:22696964..22964922 [GRCh37]
Chr14:21766804..22034762 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2-12(chr14:20412587-25018120)x3 copy number gain See cases [RCV000137725] Chr14:20412587..25018120 [GRCh38]
Chr14:20880746..25487326 [GRCh37]
Chr14:19950586..24557166 [NCBI36]
Chr14:14q11.2-12		 likely pathogenic
GRCh38/hg38 14q11.2(chr14:22021665-22428036)x3 copy number gain See cases [RCV000139203] Chr14:22021665..22428036 [GRCh38]
Chr14:22489905..22897028 [GRCh37]
Chr14:21559745..21966868 [NCBI36]
Chr14:14q11.2		 likely benign
GRCh38/hg38 14q11.2(chr14:21973759-22428036)x3 copy number gain See cases [RCV000139486] Chr14:21973759..22428036 [GRCh38]
Chr14:22441988..22897028 [GRCh37]
Chr14:21511828..21966868 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:21010790-22951814)x3 copy number gain See cases [RCV000140829] Chr14:21010790..22951814 [GRCh38]
Chr14:21478949..23421023 [GRCh37]
Chr14:20548789..22490863 [NCBI36]
Chr14:14q11.2		 uncertain significance
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20022693-44093672)x3 copy number gain See cases [RCV000143186] Chr14:20022693..44093672 [GRCh38]
Chr14:20490852..44562875 [GRCh37]
Chr14:19560692..43632625 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2-21.3(chr14:20043513-48642042)x3 copy number gain See cases [RCV000143748] Chr14:20043513..48642042 [GRCh38]
Chr14:20511672..49111245 [GRCh37]
Chr14:19581512..48180995 [NCBI36]
Chr14:14q11.2-21.3		 pathogenic
GRCh38/hg38 14q11.2(chr14:19755249-22741281)x1 copy number loss See cases [RCV000051483] Chr14:19755249..22741281 [GRCh38]
Chr14:20223408..23210490 [GRCh37]
Chr14:19293248..22280330 [NCBI36]
Chr14:14q11.2		 pathogenic
GRCh38/hg38 14q11.2-12(chr14:20151149-27723796)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|See cases [RCV000051484] Chr14:20151149..27723796 [GRCh38]
Chr14:20619308..28193002 [GRCh37]
Chr14:19689148..27262842 [NCBI36]
Chr14:14q11.2-12		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1 copy number loss See cases [RCV000051485] Chr14:20196945..45284802 [GRCh38]
Chr14:20665104..45754005 [GRCh37]
Chr14:19734944..44823755 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2(chr14:21919243-22442515)x1 copy number loss See cases [RCV000051207] Chr14:21919243..22442515 [GRCh38]
Chr14:22387418..22911507 [GRCh37]
Chr14:21457258..21981347 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:20151149-23442195)x3 copy number gain See cases [RCV000050914] Chr14:20151149..23442195 [GRCh38]
Chr14:20619308..23911404 [GRCh37]
Chr14:19689148..22981244 [NCBI36]
Chr14:14q11.2		 pathogenic
GRCh38/hg38 14q11.2(chr14:22021664-22592708)x1 copy number loss See cases [RCV000053682] Chr14:22021664..22592708 [GRCh38]
Chr14:22489904..23061615 [GRCh37]
Chr14:21559744..22131455 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3 copy number gain See cases [RCV000053803] Chr14:20000611..38984415 [GRCh38]
Chr14:20468770..39453619 [GRCh37]
Chr14:19538610..38523370 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|See cases [RCV000053806] Chr14:20150949..39746154 [GRCh38]
Chr14:20619108..40215358 [GRCh37]
Chr14:19688948..39285109 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:248
Interacting mature miRNAs:256
Transcripts:ENST00000390469
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D14S1325  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371423,020,621 - 23,020,788UniSTSGRCh37
Build 361422,090,461 - 22,090,628RGDNCBI36
Celera142,883,636 - 2,883,804RGD
Cytogenetic Map14q11UniSTS
Cytogenetic Map14q11.2UniSTS
HuRef143,138,836 - 3,139,004UniSTS
Stanford-G3 RH Map14204.0UniSTS
GeneMap99-G3 RH Map14204.0UniSTS
G43587  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371423,020,769 - 23,021,056UniSTSGRCh37
Build 361422,090,609 - 22,090,896RGDNCBI36
Celera142,883,785 - 2,884,073RGD
Cytogenetic Map14q11UniSTS
Cytogenetic Map14q11.2UniSTS
HuRef143,138,985 - 3,139,273UniSTS
GDB:210884  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371422,891,730 - 22,892,049UniSTSGRCh37
Build 361421,961,570 - 21,961,889RGDNCBI36
Celera142,754,677 - 2,754,996RGD
Cytogenetic Map14q11UniSTS
Cytogenetic Map14q11.2UniSTS
HuRef143,009,987 - 3,010,306UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 37 37 1 1 1 1
Low 92 454 59 31 734 32 66 7 18 41 46 149 1 60 21
Below cutoff 597 649 358 178 455 140 732 404 407 96 247 423 37 436 411

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000390469   ⟹   ENSP00000451578
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1422,422,371 - 22,423,042 (+)Ensembl
Protein Sequences
GenBank Protein A0JD36 (Get FASTA)   NCBI Sequence Viewer  
  AAB69040 (Get FASTA)   NCBI Sequence Viewer  
  CAA33277 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000451578.1
Reference Protein Sequences
RefSeq Acc Id: ENSP00000451578   ⟸   ENST00000390469
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0JD36-F1-model_v2 AlphaFold A0JD36 1-115 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12263 AgrOrtholog
COSMIC TRDV2 COSMIC
Ensembl Genes ENSG00000211821 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000390469.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000211821 GTEx
HGNC ID HGNC:12263 ENTREZGENE
Human Proteome Map TRDV2 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
NCBI Gene TRDV2 ENTREZGENE
PANTHER T CELL RECEPTOR GAMMA, VARIABLE 6 UniProtKB/Swiss-Prot
  T-CELL RECEPTOR GAMMA CHAIN UniProtKB/Swiss-Prot
Pfam V-set UniProtKB/Swiss-Prot
PharmGKB PA36943 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot
SMART IGv UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0JD36 ENTREZGENE, UniProtKB/Swiss-Prot