MIR377 (microRNA 377) - Rat Genome Database

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Gene: MIR377 (microRNA 377) Homo sapiens
Analyze
Symbol: MIR377
Name: microRNA 377
RGD ID: 1342565
HGNC Page HGNC:31870
Description: Involved in negative regulation of sprouting angiogenesis. Predicted to be part of RISC complex. Biomarker of lung non-small cell carcinoma.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-377; mir-377; MIRN377
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,062,050 - 101,062,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,062,050 - 101,062,118 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,528,387 - 101,528,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,598,139 - 100,598,207 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,584,448 - 81,584,516 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,711,760 - 81,711,828 (+)NCBIHuRef
CHM1_114101,467,409 - 101,467,477 (+)NCBICHM1_1
T2T-CHM13v2.01495,297,436 - 95,297,504 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (IEA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. miR-377 inhibited tumorous behaviors of non-small cell lung cancer through directly targeting CDK6. Zhang J, etal., Eur Rev Med Pharmacol Sci. 2016 Nov;20(21):4494-4499.
Additional References at PubMed
PMID:15891114   PMID:16274478   PMID:16381832   PMID:17604727   PMID:18716028   PMID:21037258   PMID:21106538   PMID:24166498   PMID:24312401   PMID:24951112   PMID:25077964   PMID:25251394  
PMID:25577249   PMID:25776481   PMID:25889255   PMID:25998046   PMID:26823698   PMID:27222047   PMID:27351135   PMID:27638830   PMID:28081730   PMID:28267394   PMID:28277545   PMID:28288140  
PMID:28758420   PMID:28857252   PMID:28886272   PMID:29175120   PMID:29228421   PMID:29512715   PMID:29523224   PMID:29592872   PMID:29771432   PMID:29845236   PMID:29959592   PMID:30044046  
PMID:30372896   PMID:30618083   PMID:30706373   PMID:30958621   PMID:31041680   PMID:31152456   PMID:31368365   PMID:31479715   PMID:31608997   PMID:31746333   PMID:31831175   PMID:32100443  
PMID:32122143   PMID:32220639   PMID:32373927   PMID:32432732   PMID:32537941   PMID:32614236   PMID:32814765   PMID:33006200   PMID:33084522   PMID:33135071   PMID:33459391   PMID:33571038  
PMID:33667514   PMID:33818827   PMID:33906524   PMID:34014568   PMID:34133001   PMID:34445712   PMID:34668101   PMID:34779493   PMID:35039981   PMID:35461040   PMID:35598633   PMID:35622213  
PMID:36197580   PMID:36252156   PMID:36719624   PMID:36729977   PMID:37864623   PMID:38172743   PMID:38317146   PMID:38401467  


Genomics

Comparative Map Data
MIR377
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,062,050 - 101,062,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,062,050 - 101,062,118 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,528,387 - 101,528,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,598,139 - 100,598,207 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,584,448 - 81,584,516 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,711,760 - 81,711,828 (+)NCBIHuRef
CHM1_114101,467,409 - 101,467,477 (+)NCBICHM1_1
T2T-CHM13v2.01495,297,436 - 95,297,504 (+)NCBIT2T-CHM13v2.0
Mir377
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,706,944 - 109,707,011 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,706,944 - 109,707,011 (+)EnsemblGRCm39 Ensembl
GRCm3812109,740,510 - 109,740,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,740,510 - 109,740,577 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,978,720 - 110,978,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,937,740 - 110,937,807 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI
Mir377
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,576,456 - 134,576,527 (+)NCBIGRCr8
mRatBN7.26128,755,051 - 128,755,122 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6128,934,290 - 128,934,361 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,230,122 - 129,230,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,591,747 - 128,591,818 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,890,690 - 133,890,761 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,890,646 - 133,890,779 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,053,047 - 143,053,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,339,430 - 126,339,501 (+)NCBICelera
Cytogenetic Map6q32NCBI
MIR377
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,290,937 - 69,291,005 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,809,084 - 68,809,152 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,572,589 - 69,572,657 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,236,132 - 69,236,200 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,302,226 - 69,302,294 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,700,224 - 69,700,292 (+)NCBIUU_Cfam_GSD_1.0


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q32.2-32.33(chr14:99831655-106855263)x1 copy number loss See cases [RCV000133831] Chr14:99831655..106855263 [GRCh38]
Chr14:100297992..107263478 [GRCh37]
Chr14:99367745..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-105987610)x3 copy number gain See cases [RCV000135410] Chr14:100309382..105987610 [GRCh38]
Chr14:100775719..106453697 [GRCh37]
Chr14:99845472..105524742 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97638520-106855263)x3 copy number gain See cases [RCV000135400] Chr14:97638520..106855263 [GRCh38]
Chr14:98104857..107263478 [GRCh37]
Chr14:97174610..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99448012-106850609)x3 copy number gain See cases [RCV000135875] Chr14:99448012..106850609 [GRCh38]
Chr14:99914349..107258824 [GRCh37]
Chr14:98984102..106329869 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:95524407-106879501)x1 copy number loss See cases [RCV000136032] Chr14:95524407..106879501 [GRCh38]
Chr14:95990744..107287708 [GRCh37]
Chr14:95060497..106358753 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.31(chr14:100262836-102500697)x1 copy number loss See cases [RCV000139723] Chr14:100262836..102500697 [GRCh38]
Chr14:100729173..102967034 [GRCh37]
Chr14:99798926..102036787 [NCBI36]
Chr14:14q32.2-32.31		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100582059-106877229)x1 copy number loss See cases [RCV000143662] Chr14:100582059..106877229 [GRCh38]
Chr14:101048396..107285437 [GRCh37]
Chr14:100118149..106356482 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
NC_000014.9:g.100806482_101281031del474550 deletion Paternal uniparental disomy of chromosome 14 [RCV000149429] Chr14:100806482..101281031 [GRCh38]
Chr14:101272819..101747368 [GRCh37]
Chr14:14q32.2-32.31		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100590353-106855264)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|See cases [RCV000051553] Chr14:100590353..106855264 [GRCh38]
Chr14:101056690..107263479 [GRCh37]
Chr14:100126443..106334524 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97938637-106855263)x1 copy number loss See cases [RCV000050696] Chr14:97938637..106855263 [GRCh38]
Chr14:98404974..107263478 [GRCh37]
Chr14:97474727..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-106855263)x1 copy number loss See cases [RCV000050938] Chr14:100309382..106855263 [GRCh38]
Chr14:100775719..107263478 [GRCh37]
Chr14:99845472..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100808300-106855263)x1 copy number loss See cases [RCV000051113] Chr14:100808300..106855263 [GRCh38]
Chr14:101274637..107263478 [GRCh37]
Chr14:100344390..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33		 pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33		 pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
PPM1Ahsa-miR-377-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotNon-Functional MTI18716028
PAK1hsa-miR-377-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18716028
SOD1hsa-miR-377-3pMirtarbaseexternal_infoLuciferase reporter assay//Non-Functional MTI21203553
PAK1hsa-miR-377-3pMirecordsexternal_infoNANA18716028

Predicted Targets
Summary Value
Count of predictions:40315
Count of gene targets:13465
Count of transcripts:27392
Interacting mature miRNAs:hsa-miR-377-3p, hsa-miR-377-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 2 3 1 3 1 1 1
Low 2 14 8 13 8 15 7 42 1 20 22 3 2 1
Below cutoff 1 1 4 4 5 10 8 2 7 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000362145
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl14101,062,050 - 101,062,118 (+)Ensembl
RefSeq Acc Id: NR_029869
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3814101,062,050 - 101,062,118 (+)NCBI
GRCh3714101,528,387 - 101,528,455 (+)RGD
Celera1481,584,448 - 81,584,516 (+)RGD
HuRef1481,711,760 - 81,711,828 (+)ENTREZGENE
CHM1_114101,467,409 - 101,467,477 (+)NCBI
T2T-CHM13v2.01495,297,436 - 95,297,504 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31870 AgrOrtholog
COSMIC MIR377 COSMIC
Ensembl Genes ENSG00000199015 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362145 ENTREZGENE
GTEx ENSG00000199015 GTEx
HGNC ID HGNC:31870 ENTREZGENE
Human Proteome Map MIR377 Human Proteome Map
miRBase MI0000785 ENTREZGENE
NCBI Gene 494326 ENTREZGENE
PharmGKB PA164722696 PharmGKB
RNAcentral URS000007F792 RNACentral
  URS000036BEF1 RNACentral
  URS000075AF10 RNACentral