TWF2 (twinfilin actin binding protein 2)

Gene: TWF2 (twinfilin actin binding protein 2) Canis lupus familiaris

Analyze

Symbol:

TWF2

Name:

twinfilin actin binding protein 2

RGD ID:

13307307

Description:

ENCODES a protein that exhibits actin monomer binding (ortholog); ATP binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN barbed-end actin filament capping (ortholog); cellular response to growth factor stimulus (ortholog); cellular response to retinoic acid (ortholog); ASSOCIATED WITH congenital disorder of glycosylation In (ortholog); COVID-19 (ortholog); FOUND IN filopodium (ortholog); growth cone (ortholog); lamellipodium (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

TLR9; toll like receptor 9; twinfilin, actin-binding protein, homolog 2; twinfilin-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

NCBI Annotation Information:

Genome Annotation Status: not in current annotation release

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	37,529,322 - 37,539,955 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	37,529,401 - 37,539,957 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital disorder of glycosylation In (ISO)

COVID-19 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

barbed-end actin filament capping (ISO)

cellular response to growth factor stimulus (ISO)

cellular response to retinoic acid (ISO)

negative regulation of actin filament polymerization (IEA)

positive regulation of axon extension (ISO)

positive regulation of lamellipodium assembly (ISO)

positive regulation of neuron projection development (ISO)

regulation of actin cytoskeleton organization (IEA)

sequestering of actin monomers (ISO)

Cellular Component

cytoplasm (IEA)

cytoskeleton (IEA)

filopodium (ISO)

growth cone (ISO)

lamellipodium (ISO)

myofibril (ISO)

perinuclear region of cytoplasm (IEA)

stereocilium (ISO)

Molecular Function

actin binding (IEA)

actin monomer binding (ISO)

ATP binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (ISO)

protein binding (ISO)

protein kinase C binding (ISO)

References

Genomics

Comparative Map Data

TWF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	37,529,322 - 37,539,955 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	37,529,401 - 37,539,957 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1

TWF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	52,228,612 - 52,239,158 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	52,228,612 - 52,246,788 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	52,262,628 - 52,273,174 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	52,237,666 - 52,248,223 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	52,237,666 - 52,248,223	NCBI
Celera	3	52,241,938 - 52,252,496 (-)	NCBI		Celera
Cytogenetic Map	3	p21.2	NCBI
HuRef	3	52,324,788 - 52,335,347 (-)	NCBI		HuRef
CHM1_1	3	52,215,154 - 52,225,723 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	52,261,498 - 52,272,045 (-)	NCBI		T2T-CHM13v2.0

Twf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	106,080,307 - 106,092,586 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	106,080,307 - 106,092,588 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	106,203,108 - 106,215,387 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	106,203,108 - 106,215,389 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	106,105,439 - 106,117,718 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	106,061,209 - 106,073,488 (+)	NCBI		MGSCv36	mm8
Celera	9	105,828,685 - 105,841,171 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	57.46	NCBI

Twf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	115,723,980 - 115,737,025 (+)	NCBI		GRCr8
mRatBN7.2	8	106,845,253 - 106,858,298 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	106,845,253 - 106,858,298 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	112,469,873 - 112,482,740 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	110,669,034 - 110,681,905 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	108,511,834 - 108,524,701 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	114,897,011 - 114,909,531 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	114,897,011 - 114,909,531 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	114,259,815 - 114,272,429 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	8	106,167,478 - 106,179,370 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Twf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	3,834,579 - 3,844,760 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	3,835,620 - 3,844,760 (-)	NCBI	ChiLan1.0	ChiLan1.0

TWF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	34,361,297 - 34,371,277 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	34,361,294 - 34,370,997 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	37,634,368 - 37,644,046 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Variants

Variants in TWF2
120 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5	5	15		6		6	6	12		10	6
Low			7	6		6				8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001410696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022406645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000015648 ⟹ ENSCAFP00000014482

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	20	37,529,401 - 37,539,957 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000069694 ⟹ ENSCAFP00000046732

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	20	37,529,401 - 37,539,378 (+)	Ensembl

RefSeq Acc Id:

XM_022406645 ⟹ XP_022262353

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	20	37,529,322 - 37,539,955 (+)	NCBI

Sequence:

show sequence

GGTCCTGCGGCACCGCCCGGGAAGCTGCGCGAGGCTGGGCGGCCGCCGCCACATCCTCCTCCTC
CTCCGGGGCCGGGCGAGCGGAGCGGGTCCAGGGCTCGGCTGAGGGCGCTGAGGGCGCGGGCGGA
GCGCGGCACGGAGCCATGGCGCACCAGACGGGCATCCACGCCACCGAGGAGCTGAAGGAGTTCT
TCGCCAAGGCACGGGCTGGCTCTGTCCGGCTCATCAAAGTCGTCATCGAGGATGAGCAGCTTGT
GCTGGGTGCCTCACGGGAGCTGGCGGGCTGCTGGGACCAGGACTATGACAGGACCGTACTGCCG
CTGCTGGACGCCCAGGAGCCCTGTTACCTGCTCTACCGCCTGGACTCACAGAATGCCCAGGGCT
TCGAGTGGCTCTTCCTTGCTTGGTCACCTGACAATTCTCCCGTGCGGCTGAAGATGCTGTATGC
GGCCACACGGGCCACAGTGAAGAAGGAGTTTGGGGGCGGCCACATCAAGGATGAGCTCTTTGGG
ACTGTGAAGGACGACCTCTCCTTTGCTGGGTACCAGAAGCATCTGTCGTCCTGTGCAGCGCCCG
CCCCACTGACGTCGGCTGAGAGAGAGCTTCAGCAGATCCGTATTAATGAGGTGAAGACAGAGAT
CAGCGTGGAGAGCAAGCACCAGACCCTGCAGGGCCTCAACTTCCCACTGCAGCCGGCAGCCCAG
AGGGCACTTCAGCAGCTCAAACAGAAGGCCGTCAACTACATCCAGCTGAAGCTGGACCTGGAGC
GGGAGACAATTGAGCTGGTGCACACAGAGCCCACGGAAGTGGCCCAGCTGCCCTCAAGGGTTCC
CCGAGATGCTGCCCGCTACCACTTCTTCCTCTACAAGCATACTCATGAGGGTGACCCCCTCGAG
TCTGTGGTGTTCATCTACTCGATGCCAGGGTACAAGTGCAGCATCAAGGAGCGCATGCTCTATT
CCAGCTGCAAGAGTCGCCTCCTCGACTCTGTGGAGCAGGACTTCCAGCTGGAGATCTCCAAGAA
GATTGAGATTGGCGATGGGGCGGAGCTGACAGCCGAGTTCCTCTACGACGAGGTGCACCCCAAA
CAACATGCCTTCAAGCAGGCCTTCGCCAAGCCCAAGGGCCCAGGGGGCAAGCGGGGTCACAAGC
GCCTCATCCGCGGCCCTGGCGAGAATGGGGATGACAGCTAGGTGGCCGGACCTGAGCCGTGCCG
GCGTGTGGACTGTGTGCGTCCCACTGCTCCCGGCCACCTGCCTCATTCCCAGCCTGGGCTCCAG
GGGAGGGTTGCTTCCTGTGGGGCAGGAGGGCTGGTGACAGAACATTCTTGCAGCTTCTGAAGGC
CACTGGGCTGGAATTTTGTGACCTTCCCCTGTTGCTGTTCCTGCCTCTCATCTGTGTGCCCAAG
GGGGTCTGGGAACCCTGCCTGGCTGGCTCAAGGGGGCTGGGTAGGAAGCCTGGAATGAGCTTTC
CCCCCAGGGGTCCTAGCACAGCCCAGGAGCCTTTGGACACAGGAGTGGGTTCAGTCAGGGCTGG
GATAGGGGGTCACTGAAAGATAAGATGGTTGAATGCTGTATTTTTTAAAGAATAAAATATTTTT
AAATCAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001397625	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000014482.3
	ENSCAFP00000046732.1
	ENSCAFP00030012691.1
	ENSCAFP00040035473.1

RefSeq Acc Id:

XP_022262353 ⟸ XM_022406645

- Sequence:

show sequence

MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASRELAGCWDQDYDRTVLPLLDAQ
EPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDD
LSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLNFPLQPAAQRALQQ
LKQKAVNYIQLKLDLERETIELVHTEPTEVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFI
YSMPGYKCSIKERMLYSSCKSRLLDSVEQDFQLEISKKIEIGDGAELTAEFLYDEVHPKQHAFK
QAFAKPKGPGGKRGHKRLIRGPGENGDDS

hide sequence

RefSeq Acc Id:

ENSCAFP00000014482 ⟸ ENSCAFT00000015648

RefSeq Acc Id:

ENSCAFP00000046732 ⟸ ENSCAFT00000069694

Protein Domains

ADF-H

Promoters

RGD ID:

13686851

Promoter ID:

EPDNEW_C4919

Type:

initiation region

Name:

TWF2_1

Description:

twinfilin actin binding protein 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	20	37,529,369 - 37,529,429	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000023309	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030007878	UniProtKB/TrEMBL
	ENSCAFG00040021877	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000015648.5	UniProtKB/TrEMBL
	ENSCAFT00000069694.2	UniProtKB/TrEMBL
	ENSCAFT00030014550.1	UniProtKB/TrEMBL
	ENSCAFT00040040673.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.20.10	UniProtKB/TrEMBL
InterPro	ADF-H	UniProtKB/TrEMBL
	ADF-H/Gelsolin-like_dom_sf	UniProtKB/TrEMBL
	Twinfilin	UniProtKB/TrEMBL
NCBI Gene	TWF2	ENTREZGENE
PANTHER	PTHR13759	UniProtKB/TrEMBL
	TWINFILIN-2	UniProtKB/TrEMBL
Pfam	Cofilin_ADF	UniProtKB/TrEMBL
PROSITE	ADF_H	UniProtKB/TrEMBL
SMART	ADF	UniProtKB/TrEMBL
Superfamily-SCOP	Actin depolymerizing proteins	UniProtKB/TrEMBL
UniProt	A0A8C0JGU7	ENTREZGENE
	A0A8C0Z492_CANLF	UniProtKB/TrEMBL
	A0A8P0SF09	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:49952	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-08-29	TWF2	twinfilin actin binding protein 2	TLR9	toll like receptor 9	Symbol and/or name change	19259463	PROVISIONAL
2022-08-22	TLR9	toll like receptor 9	TWF2	twinfilin actin binding protein 2	Symbol and/or name change	19259463	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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