SLIRP (SRA stem-loop interacting RNA binding protein) - Rat Genome Database

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Gene: SLIRP (SRA stem-loop interacting RNA binding protein) Homo sapiens
Analyze
Symbol: SLIRP
Name: SRA stem-loop interacting RNA binding protein
RGD ID: 1323602
HGNC Page HGNC:20495
Description: Enables RNA binding activity. Predicted to be involved in RNA splicing; positive regulation of mRNA splicing, via spliceosome; and spermatogenesis. Predicted to act upstream of or within several processes, including flagellated sperm motility; negative regulation of mitochondrial RNA catabolic process; and spermatid development. Located in mitochondrion.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C14orf156; DC50; PD04872; SRA stem-loop-interacting RNA-binding protein, mitochondrial
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: SLIRPP1   SLIRPP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381477,708,071 - 77,717,598 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1477,708,071 - 77,761,104 (+)EnsemblGRCh38hg38GRCh38
GRCh371478,174,414 - 78,183,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361477,244,188 - 77,253,694 (+)NCBINCBI36Build 36hg18NCBI36
Build 341477,244,187 - 77,253,692NCBI
Celera1458,212,937 - 58,222,439 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1458,340,405 - 58,349,918 (+)NCBIHuRef
CHM1_11478,113,886 - 78,123,414 (+)NCBICHM1_1
T2T-CHM13v2.01471,917,426 - 71,926,933 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15342556   PMID:15489334   PMID:16341674   PMID:16762838   PMID:17081983   PMID:18029348   PMID:19596235   PMID:19615732   PMID:19680543   PMID:20186120  
PMID:20200222   PMID:20833797   PMID:20877624   PMID:21873635   PMID:22045337   PMID:22113938   PMID:22190034   PMID:22658674   PMID:22661577   PMID:22681889   PMID:22810586   PMID:22939629  
PMID:23362268   PMID:23443559   PMID:23798571   PMID:24189400   PMID:24337577   PMID:25416956   PMID:25959826   PMID:26186194   PMID:26209609   PMID:26496610   PMID:26618866   PMID:26631746  
PMID:26866271   PMID:26972000   PMID:27353330   PMID:27432908   PMID:27609421   PMID:28330616   PMID:28514442   PMID:28515276   PMID:28859475   PMID:28892042   PMID:29146908   PMID:29229926  
PMID:29395067   PMID:29449217   PMID:29507755   PMID:29509190   PMID:29568061   PMID:29987050   PMID:30209976   PMID:30833792   PMID:30948266   PMID:30997501   PMID:31046837   PMID:31056398  
PMID:31091453   PMID:31363146   PMID:31409639   PMID:31536960   PMID:31586073   PMID:31617661   PMID:31819114   PMID:31822558   PMID:31871319   PMID:31980649   PMID:32041737   PMID:32203420  
PMID:32296183   PMID:32329962   PMID:32457219   PMID:32552912   PMID:32628020   PMID:32665550   PMID:32807901   PMID:32811647   PMID:32877691   PMID:32989298   PMID:33022573   PMID:33150185  
PMID:33306668   PMID:33957083   PMID:33961781   PMID:34133714   PMID:34426662   PMID:34709727   PMID:35013218   PMID:35032548   PMID:35256949   PMID:35271311   PMID:35337019   PMID:35338135  
PMID:35777956   PMID:35944360   PMID:36215168   PMID:36244648   PMID:36273042   PMID:36604567   PMID:36758106   PMID:37931956   PMID:38113892   PMID:38203264  


Genomics

Comparative Map Data
SLIRP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381477,708,071 - 77,717,598 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1477,708,071 - 77,761,104 (+)EnsemblGRCh38hg38GRCh38
GRCh371478,174,414 - 78,183,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361477,244,188 - 77,253,694 (+)NCBINCBI36Build 36hg18NCBI36
Build 341477,244,187 - 77,253,692NCBI
Celera1458,212,937 - 58,222,439 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1458,340,405 - 58,349,918 (+)NCBIHuRef
CHM1_11478,113,886 - 78,123,414 (+)NCBICHM1_1
T2T-CHM13v2.01471,917,426 - 71,926,933 (+)NCBIT2T-CHM13v2.0
Slirp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391287,490,666 - 87,496,694 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1287,490,666 - 87,498,976 (+)EnsemblGRCm39 Ensembl
GRCm381287,443,896 - 87,449,924 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1287,443,896 - 87,452,206 (+)EnsemblGRCm38mm10GRCm38
MGSCv371288,784,846 - 88,790,874 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361288,333,015 - 88,339,021 (+)NCBIMGSCv36mm8
Celera1288,908,518 - 88,914,546 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1241.67NCBI
Slirp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,819,684 - 112,828,715 (+)NCBIGRCr8
mRatBN7.26107,088,760 - 107,097,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6107,088,403 - 107,097,791 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6107,257,674 - 107,266,700 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06107,556,491 - 107,565,517 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06106,926,189 - 106,935,215 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06111,476,768 - 111,486,039 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,476,768 - 111,486,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,757,482 - 120,766,753 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46111,682,052 - 111,691,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6104,908,488 - 104,917,534 (+)NCBICelera
Cytogenetic Map6q31NCBI
Slirp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554381,556,462 - 1,561,561 (+)NCBIChiLan1.0ChiLan1.0
SLIRP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21578,794,056 - 78,803,744 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11478,010,561 - 78,020,249 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01458,262,126 - 58,271,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11477,462,870 - 77,472,380 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1477,462,875 - 77,516,882 (+)Ensemblpanpan1.1panPan2
SLIRP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1850,471,175 - 50,478,923 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl850,471,228 - 50,481,268 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha850,158,600 - 50,166,343 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0850,705,481 - 50,713,228 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl850,705,533 - 50,715,572 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1850,367,496 - 50,375,211 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0850,390,405 - 50,398,346 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0850,789,298 - 50,797,024 (+)NCBIUU_Cfam_GSD_1.0
Slirp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864025,574,410 - 25,582,177 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364886,485,981 - 6,495,522 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364886,486,807 - 6,494,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLIRP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7100,710,234 - 100,720,374 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17100,710,472 - 100,718,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLIRP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12454,967,400 - 54,976,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2454,966,605 - 54,978,597 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605343,154,008 - 43,163,502 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slirp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473424,191,979 - 24,197,680 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473424,191,944 - 24,196,944 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLIRP
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q24.3(chr14:73877072-78042422)x1 copy number loss See cases [RCV000051548] Chr14:73877072..78042422 [GRCh38]
Chr14:74343775..78508765 [GRCh37]
Chr14:73413528..77578518 [NCBI36]
Chr14:14q24.3		 pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:75489052-79610332)x1 copy number loss See cases [RCV000051549] Chr14:75489052..79610332 [GRCh38]
Chr14:75955395..80076675 [GRCh37]
Chr14:75025148..79146428 [NCBI36]
Chr14:14q24.3-31.1		 pathogenic
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2		 pathogenic
GRCh38/hg38 14q24.1-31.1(chr14:69562099-81975384)x1 copy number loss See cases [RCV000134154] Chr14:69562099..81975384 [GRCh38]
Chr14:70028816..82441728 [GRCh37]
Chr14:69098569..81511481 [NCBI36]
Chr14:14q24.1-31.1		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:77193005-80476132)x1 copy number loss See cases [RCV000137421] Chr14:77193005..80476132 [GRCh38]
Chr14:77659348..80942475 [GRCh37]
Chr14:76729101..80012228 [NCBI36]
Chr14:14q24.3-31.1		 likely pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:73343213-78835059)x1 copy number loss See cases [RCV000143265] Chr14:73343213..78835059 [GRCh38]
Chr14:73809921..79301402 [GRCh37]
Chr14:72879674..78371155 [NCBI36]
Chr14:14q24.3-31.1		 pathogenic|likely pathogenic
GRCh37/hg19 14q24.3(chr14:78146198-78504237)x3 copy number gain See cases [RCV000240255] Chr14:78146198..78504237 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q24.3-31.1(chr14:78146198-79579273)x4 copy number gain See cases [RCV000240478] Chr14:78146198..79579273 [GRCh37]
Chr14:14q24.3-31.1		 uncertain significance
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q24.3-31.1(chr14:78146198-79579214)x3 copy number gain See cases [RCV000445984] Chr14:78146198..79579214 [GRCh37]
Chr14:14q24.3-31.1		 uncertain significance
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33		 pathogenic
GRCh37/hg19 14q24.3(chr14:78146198-78205077)x3 copy number gain See cases [RCV000448305] Chr14:78146198..78205077 [GRCh37]
Chr14:14q24.3		 benign
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q24.3(chr14:76082940-78372356)x1 copy number loss See cases [RCV000511668] Chr14:76082940..78372356 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3 copy number gain See cases [RCV000512497] Chr14:73750741..107285437 [GRCh37]
Chr14:14q24.2-32.33		 pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
NM_031210.6(SLIRP):c.248_252del (p.Ile83fs) deletion Mitochondrial encephalomyopathy [RCV001647258] Chr14:77715860..77715864 [GRCh38]
Chr14:78182203..78182207 [GRCh37]
Chr14:14q24.3		 likely pathogenic
GRCh37/hg19 14q24.3-32.11(chr14:77274990-89803137)x1 copy number loss not provided [RCV000847566] Chr14:77274990..89803137 [GRCh37]
Chr14:14q24.3-32.11		 pathogenic
NM_031210.6(SLIRP):c.98-178A>G single nucleotide variant Mitochondrial encephalomyopathy [RCV001647259] Chr14:77710660 [GRCh38]
Chr14:78177003 [GRCh37]
Chr14:14q24.3		 likely pathogenic
GRCh37/hg19 14q24.3-31.1(chr14:78075661-79605863)x4 copy number gain not provided [RCV001259789] Chr14:78075661..79605863 [GRCh37]
Chr14:14q24.3-31.1		 uncertain significance
GRCh37/hg19 14q24.3(chr14:77862909-78274607) copy number gain not specified [RCV002053114] Chr14:77862909..78274607 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33		 pathogenic
NM_031210.6(SLIRP):c.230T>A (p.Leu77Gln) single nucleotide variant not specified [RCV004212446] Chr14:77715845 [GRCh38]
Chr14:78182188 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_031210.6(SLIRP):c.212A>G (p.Glu71Gly) single nucleotide variant not specified [RCV004186685] Chr14:77715827 [GRCh38]
Chr14:78182170 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_031210.6(SLIRP):c.254A>G (p.Asp85Gly) single nucleotide variant not specified [RCV004194816] Chr14:77715869 [GRCh38]
Chr14:78182212 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_031210.6(SLIRP):c.58G>C (p.Val20Leu) single nucleotide variant not specified [RCV004194260] Chr14:77708169 [GRCh38]
Chr14:78174512 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_031210.6(SLIRP):c.16G>T (p.Ala6Ser) single nucleotide variant not specified [RCV004333968] Chr14:77708127 [GRCh38]
Chr14:78174470 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q24.3(chr14:77885734-78292290)x3 copy number gain not provided [RCV003485045] Chr14:77885734..78292290 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q24.3-31.1(chr14:78078206-79605613)x3 copy number gain not provided [RCV003485046] Chr14:78078206..79605613 [GRCh37]
Chr14:14q24.3-31.1		 uncertain significance
GRCh37/hg19 14q24.3(chr14:78152921-78505776)x3 copy number gain not provided [RCV003485047] Chr14:78152921..78505776 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3 copy number gain not provided [RCV003485036] Chr14:58894502..107227240 [GRCh37]
Chr14:14q23.1-32.33		 pathogenic
NM_031210.6(SLIRP):c.320A>G (p.Lys107Arg) single nucleotide variant not specified [RCV004457329] Chr14:77717551 [GRCh38]
Chr14:78183894 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1808
Count of miRNA genes:816
Interacting mature miRNAs:929
Transcripts:ENST00000238688, ENST00000553981, ENST00000554074, ENST00000555890, ENST00000556310, ENST00000556375, ENST00000556831, ENST00000556956, ENST00000557342, ENST00000557431, ENST00000557623
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D14S857  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371478,183,973 - 78,184,247UniSTSGRCh37
Build 361477,253,726 - 77,254,000RGDNCBI36
Celera1458,222,471 - 58,222,745RGD
Cytogenetic Map14q24.3UniSTS
HuRef1458,349,950 - 58,350,224UniSTS
Whitehead-YAC Contig Map14 UniSTS
G36014  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371478,182,121 - 78,182,191UniSTSGRCh37
Build 361477,251,874 - 77,251,944RGDNCBI36
Celera1458,220,625 - 58,220,695RGD
Cytogenetic Map14q24.3UniSTS
HuRef1458,348,104 - 58,348,174UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2434 2162 1703 601 1189 443 4331 2137 3625 415 1459 1610 175 1 1202 2775 6 2
Low 5 809 23 23 742 22 26 60 109 4 1 3 2 13
Below cutoff 20 20

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001267863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001267864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_052025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF253980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF271779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ272055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY860853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM685909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP289922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ083727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU944910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU955571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU960115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EL951262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000238688   ⟹   ENSP00000238688
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,079 - 77,717,598 (+)Ensembl
RefSeq Acc Id: ENST00000553981   ⟹   ENSP00000450587
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,178 - 77,717,598 (+)Ensembl
RefSeq Acc Id: ENST00000554074
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,121 - 77,712,038 (+)Ensembl
RefSeq Acc Id: ENST00000555890   ⟹   ENSP00000451606
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,114 - 77,717,593 (+)Ensembl
RefSeq Acc Id: ENST00000556310   ⟹   ENSP00000452329
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,160 - 77,760,952 (+)Ensembl
RefSeq Acc Id: ENST00000556375   ⟹   ENSP00000452162
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,160 - 77,760,952 (+)Ensembl
RefSeq Acc Id: ENST00000556831   ⟹   ENSP00000450770
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,119 - 77,716,351 (+)Ensembl
RefSeq Acc Id: ENST00000556956
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,710,644 - 77,717,584 (+)Ensembl
RefSeq Acc Id: ENST00000557342   ⟹   ENSP00000450909
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,103 - 77,717,598 (+)Ensembl
RefSeq Acc Id: ENST00000557431   ⟹   ENSP00000450849
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,103 - 77,761,104 (+)Ensembl
RefSeq Acc Id: ENST00000557623   ⟹   ENSP00000452057
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,103 - 77,721,107 (+)Ensembl
RefSeq Acc Id: ENST00000613856   ⟹   ENSP00000478794
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,708,071 - 77,717,594 (+)Ensembl
RefSeq Acc Id: NM_001267863   ⟹   NP_001254792
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,708,071 - 77,717,598 (+)NCBI
GRCh371478,174,414 - 78,183,941 (+)NCBI
HuRef1458,340,405 - 58,349,918 (+)NCBI
CHM1_11478,113,886 - 78,123,414 (+)NCBI
T2T-CHM13v2.01471,917,426 - 71,926,933 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001267864   ⟹   NP_001254793
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,708,071 - 77,717,598 (+)NCBI
GRCh371478,174,414 - 78,183,941 (+)NCBI
HuRef1458,340,405 - 58,349,918 (+)NCBI
CHM1_11478,113,886 - 78,123,414 (+)NCBI
T2T-CHM13v2.01471,917,426 - 71,926,933 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031210   ⟹   NP_112487
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,708,103 - 77,717,598 (+)NCBI
GRCh371478,174,414 - 78,183,941 (+)NCBI
Build 361477,244,188 - 77,253,694 (+)NCBI Archive
Celera1458,212,937 - 58,222,439 (+)RGD
HuRef1458,340,405 - 58,349,918 (+)NCBI
CHM1_11478,113,886 - 78,123,414 (+)NCBI
T2T-CHM13v2.01471,917,458 - 71,926,933 (+)NCBI
Sequence:
RefSeq Acc Id: NR_052025
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,708,103 - 77,717,598 (+)NCBI
GRCh371478,174,414 - 78,183,941 (+)NCBI
HuRef1458,340,405 - 58,349,918 (+)NCBI
CHM1_11478,113,886 - 78,123,414 (+)NCBI
T2T-CHM13v2.01471,917,458 - 71,926,933 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_112487   ⟸   NM_031210
- Peptide Label: isoform 1 precursor
- UniProtKB: J3KMY7 (UniProtKB/Swiss-Prot),   Q9GZT3 (UniProtKB/Swiss-Prot),   H0YJ40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001254793   ⟸   NM_001267864
- Peptide Label: isoform 3 precursor
- UniProtKB: A0A087WUN7 (UniProtKB/TrEMBL),   G3V4X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001254792   ⟸   NM_001267863
- Peptide Label: isoform 2 precursor
- UniProtKB: G3V4X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000451606   ⟸   ENST00000555890
RefSeq Acc Id: ENSP00000452329   ⟸   ENST00000556310
RefSeq Acc Id: ENSP00000452162   ⟸   ENST00000556375
RefSeq Acc Id: ENSP00000450770   ⟸   ENST00000556831
RefSeq Acc Id: ENSP00000450909   ⟸   ENST00000557342
RefSeq Acc Id: ENSP00000452057   ⟸   ENST00000557623
RefSeq Acc Id: ENSP00000450849   ⟸   ENST00000557431
RefSeq Acc Id: ENSP00000478794   ⟸   ENST00000613856
RefSeq Acc Id: ENSP00000238688   ⟸   ENST00000238688
RefSeq Acc Id: ENSP00000450587   ⟸   ENST00000553981
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9GZT3-F1-model_v2 AlphaFold Q9GZT3 1-109 view protein structure

Promoters
RGD ID:6791330
Promoter ID:HG_KWN:19871
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_006020,   NM_031210,   UC001XUD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361477,243,821 - 77,244,321 (+)MPROMDB
RGD ID:6852132
Promoter ID:EP73872
Type:initiation region
Name:HS_DC50
Description:Hypothetical protein DC50.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361477,244,199 - 77,244,259EPD
RGD ID:7228259
Promoter ID:EPDNEW_H19875
Type:initiation region
Name:C14orf156_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,708,103 - 77,708,163EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:20495 AgrOrtholog
COSMIC SLIRP COSMIC
Ensembl Genes ENSG00000119705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000238688 ENTREZGENE
  ENST00000238688.9 UniProtKB/Swiss-Prot
  ENST00000553981.1 UniProtKB/TrEMBL
  ENST00000555890 ENTREZGENE
  ENST00000555890.5 UniProtKB/TrEMBL
  ENST00000556310.1 UniProtKB/TrEMBL
  ENST00000556375.5 UniProtKB/TrEMBL
  ENST00000556831.5 UniProtKB/TrEMBL
  ENST00000557342 ENTREZGENE
  ENST00000557342.6 UniProtKB/Swiss-Prot
  ENST00000557431.5 UniProtKB/TrEMBL
  ENST00000557623.5 UniProtKB/TrEMBL
  ENST00000613856 ENTREZGENE
  ENST00000613856.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000119705 GTEx
HGNC ID HGNC:20495 ENTREZGENE
Human Proteome Map SLIRP Human Proteome Map
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLIRP_RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:81892 UniProtKB/Swiss-Prot
NCBI Gene 81892 ENTREZGENE
OMIM 610211 OMIM
PANTHER GEO13361P1 UniProtKB/TrEMBL
  GEO13361P1-RELATED UniProtKB/TrEMBL
  HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134892132 PharmGKB
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WUN7 ENTREZGENE, UniProtKB/TrEMBL
  G3V2S9_HUMAN UniProtKB/TrEMBL
  G3V4X6 ENTREZGENE, UniProtKB/TrEMBL
  H0YJ07_HUMAN UniProtKB/TrEMBL
  H0YJ40 ENTREZGENE, UniProtKB/TrEMBL
  H0YJI1_HUMAN UniProtKB/TrEMBL
  H0YJU7_HUMAN UniProtKB/TrEMBL
  H0YJW7_HUMAN UniProtKB/TrEMBL
  J3KMY7 ENTREZGENE
  Q9GZT3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary J3KMY7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 SLIRP  SRA stem-loop interacting RNA binding protein  C14orf156  chromosome 14 open reading frame 156  Symbol and/or name change 5135510 APPROVED