CAPG (capping actin protein, gelsolin like) - Rat Genome Database

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Gene: CAPG (capping actin protein, gelsolin like) Homo sapiens
Analyze
Symbol: CAPG
Name: capping actin protein, gelsolin like
RGD ID: 1323330
HGNC Page HGNC:1474
Description: Enables protein domain specific binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cellular response to type II interferon. Located in several cellular components, including Flemming body; microtubule cytoskeleton; and nuclear lumen.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: actin regulatory protein CAP-G; actin-regulatory protein CAP-G; AFCP; capping protein (actin filament), gelsolin-like; epididymis secretory protein Li 66; gelsolin-like capping protein; HEL-S-66; macrophage capping protein; macrophage-capping protein; MCP
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,391,602 - 85,419,540 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,394,753 - 85,418,432 (-)EnsemblGRCh38hg38GRCh38
GRCh37285,621,876 - 85,641,139 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,475,382 - 85,491,187 (-)NCBINCBI36Build 36hg18NCBI36
Build 34285,533,548 - 85,549,132NCBI
Celera285,450,057 - 85,465,950 (-)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,518,680 - 85,537,978 (-)NCBIHuRef
CHM1_1285,551,623 - 85,570,945 (-)NCBICHM1_1
T2T-CHM13v2.0285,393,613 - 85,421,559 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
amitrole  (ISO)
amphetamine  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
benzoates  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
butanal  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (ISO)
elemental selenium  (EXP)
entinostat  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
furan  (ISO)
genistein  (ISO)
glycidol  (ISO)
heparin  (ISO)
hexachlorobenzene  (ISO)
ivermectin  (EXP)
L-methionine  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methimazole  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
ozone  (EXP)
paracetamol  (ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
PhIP  (ISO)
piperonyl butoxide  (ISO)
piroxicam  (EXP)
potassium dichromate  (EXP)
propanal  (EXP)
quartz  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (EXP)
selenium atom  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
temozolomide  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
triclosan  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin E  (EXP)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:1322908   PMID:7814409   PMID:7851883   PMID:8125298   PMID:9160743   PMID:11337467   PMID:11694586   PMID:12477932   PMID:12637565   PMID:12754261   PMID:15454578   PMID:15489334  
PMID:16767159   PMID:17081065   PMID:18029348   PMID:18059028   PMID:18237446   PMID:18266911   PMID:18307271   PMID:18461482   PMID:18709641   PMID:18938132   PMID:19011242   PMID:19056867  
PMID:19166812   PMID:19188659   PMID:19242827   PMID:19439302   PMID:19454010   PMID:20458337   PMID:20467437   PMID:21768101   PMID:21873635   PMID:21908955   PMID:22155129   PMID:22190510  
PMID:23085225   PMID:23376485   PMID:23533145   PMID:23782053   PMID:23874603   PMID:24236012   PMID:24804218   PMID:25416956   PMID:25468996   PMID:26186194   PMID:26344197   PMID:26466680  
PMID:26496610   PMID:26634544   PMID:26663173   PMID:26757732   PMID:28514442   PMID:28790116   PMID:28986522   PMID:29399702   PMID:29721098   PMID:29970516   PMID:30021884   PMID:30155403  
PMID:31660072   PMID:31932471   PMID:32309867   PMID:32416067   PMID:32513696   PMID:32619075   PMID:32707033   PMID:32814053   PMID:33236143   PMID:33711419   PMID:33961781   PMID:34189442  
PMID:34316702   PMID:34551306   PMID:34732716   PMID:35562734   PMID:35831314   PMID:35833506   PMID:36215168   PMID:36244872   PMID:37232246   PMID:37468079   PMID:37774976  


Genomics

Comparative Map Data
CAPG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,391,602 - 85,419,540 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,394,753 - 85,418,432 (-)EnsemblGRCh38hg38GRCh38
GRCh37285,621,876 - 85,641,139 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,475,382 - 85,491,187 (-)NCBINCBI36Build 36hg18NCBI36
Build 34285,533,548 - 85,549,132NCBI
Celera285,450,057 - 85,465,950 (-)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,518,680 - 85,537,978 (-)NCBIHuRef
CHM1_1285,551,623 - 85,570,945 (-)NCBICHM1_1
T2T-CHM13v2.0285,393,613 - 85,421,559 (-)NCBIT2T-CHM13v2.0
Capg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,515,265 - 72,539,966 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,521,374 - 72,539,966 (+)EnsemblGRCm39 Ensembl
GRCm38672,538,282 - 72,562,983 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,544,391 - 72,562,983 (+)EnsemblGRCm38mm10GRCm38
MGSCv37672,494,433 - 72,512,974 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,474,046 - 72,492,482 (+)NCBIMGSCv36mm8
Celera674,642,688 - 74,661,043 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
Capg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,152,912 - 106,170,010 (+)NCBIGRCr8
mRatBN7.24104,594,743 - 104,611,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,594,753 - 104,611,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4109,978,942 - 109,990,693 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,754,064 - 105,765,815 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,367,824 - 104,379,611 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,395,693 - 100,419,447 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,407,658 - 100,419,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,172,664 - 165,189,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,850,321 - 105,862,109 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14106,094,801 - 106,106,589 (+)NCBI
Celera493,752,047 - 93,763,826 (+)NCBICelera
Cytogenetic Map4q32NCBI
Capg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554242,072,035 - 2,080,086 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554242,064,672 - 2,080,192 (+)NCBIChiLan1.0ChiLan1.0
CAPG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,964,633 - 40,988,660 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,967,382 - 40,991,422 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,447,296 - 85,466,677 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A86,997,891 - 87,022,494 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A86,997,891 - 87,016,263 (-)Ensemblpanpan1.1panPan2
CAPG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,619,429 - 39,640,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,619,248 - 39,640,942 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,299,850 - 39,312,556 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01740,437,759 - 40,450,697 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,428,690 - 40,569,097 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,504,989 - 39,517,906 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,576,662 - 39,589,513 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,976,517 - 39,989,441 (+)NCBIUU_Cfam_GSD_1.0
Capg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,054,827 - 79,081,310 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,793,480 - 1,806,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,793,666 - 1,803,621 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,339,966 - 59,366,846 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1359,335,483 - 59,366,855 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,357,527 - 62,374,580 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103219957
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,742,163 - 21,761,462 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,746,044 - 21,761,322 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604590,704,559 - 90,730,585 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Capg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,723,715 - 17,746,346 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,706,582 - 17,764,087 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CAPG
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001747.3(CAPG):c.574G>A (p.Asp192Asn) single nucleotide variant Malignant melanoma [RCV000065713] Chr2:85399228 [GRCh38]
Chr2:85626351 [GRCh37]
Chr2:85479862 [NCBI36]
Chr2:2p11.2
not provided
GRCh38/hg38 2p12-11.2(chr2:77025216-90282666)x3 copy number gain See cases [RCV000134786] Chr2:77025216..90282666 [GRCh38]
Chr2:77252342..91619262 [GRCh37]
Chr2:77105850..90982989 [NCBI36]
Chr2:2p12-11.2
pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2
uncertain significance
GRCh38/hg38 2p11.2(chr2:85014686-88826619)x1 copy number loss See cases [RCV000141948] Chr2:85014686..88826619 [GRCh38]
Chr2:85241809..89126132 [GRCh37]
Chr2:85095320..88907247 [NCBI36]
Chr2:2p11.2
pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2
benign
GRCh37/hg19 2p11.2(chr2:85598271-85843453)x3 copy number gain Breast ductal adenocarcinoma [RCV000207275] Chr2:85598271..85843453 [GRCh37]
Chr2:2p11.2
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p15-11.2(chr2:62245236-86978895)x3 copy number gain See cases [RCV000448688] Chr2:62245236..86978895 [GRCh37]
Chr2:2p15-11.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p13.1-11.2(chr2:74365484-89129064)x1 copy number loss See cases [RCV000510763] Chr2:74365484..89129064 [GRCh37]
Chr2:2p13.1-11.2
pathogenic
NM_001747.4(CAPG):c.781A>G (p.Met261Val) single nucleotide variant not specified [RCV004315811] Chr2:85398131 [GRCh38]
Chr2:85625254 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.286C>T (p.Arg96Cys) single nucleotide variant not specified [RCV004304081] Chr2:85401594 [GRCh38]
Chr2:85628717 [GRCh37]
Chr2:2p11.2
uncertain significance
GRCh37/hg19 2p12-11.2(chr2:82517612-86262705)x3 copy number gain not provided [RCV000682150] Chr2:82517612..86262705 [GRCh37]
Chr2:2p12-11.2
uncertain significance
GRCh37/hg19 2p13.1-11.2(chr2:74527522-89125488)x1 copy number loss not provided [RCV000682167] Chr2:74527522..89125488 [GRCh37]
Chr2:2p13.1-11.2
pathogenic
Single allele duplication not provided [RCV000677942] Chr2:63671346..85698002 [GRCh37]
Chr2:2p15-11.2
pathogenic
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_001747.4(CAPG):c.861C>T (p.Asn287=) single nucleotide variant not provided [RCV000923845] Chr2:85398051 [GRCh38]
Chr2:85625174 [GRCh37]
Chr2:2p11.2
benign
NM_001747.4(CAPG):c.332del (p.Pro111fs) deletion not provided [RCV000967958] Chr2:85401548 [GRCh38]
Chr2:85628671 [GRCh37]
Chr2:2p11.2
benign
NM_001747.4(CAPG):c.454G>T (p.Glu152Ter) single nucleotide variant not provided [RCV000845084] Chr2:85401227 [GRCh38]
Chr2:85628350 [GRCh37]
Chr2:2p11.2
not provided
GRCh37/hg19 2p12-11.2(chr2:77907114-87330965)x1 copy number loss not provided [RCV000846587] Chr2:77907114..87330965 [GRCh37]
Chr2:2p12-11.2
pathogenic
NM_001747.4(CAPG):c.680A>G (p.Lys227Arg) single nucleotide variant not provided [RCV000906123] Chr2:85398769 [GRCh38]
Chr2:85625892 [GRCh37]
Chr2:2p11.2
benign
GRCh37/hg19 2p11.2(chr2:85357332-85685465)x3 copy number gain not provided [RCV001005290] Chr2:85357332..85685465 [GRCh37]
Chr2:2p11.2
uncertain significance
GRCh37/hg19 2p12-11.2(chr2:81209244-86688030)x1 copy number loss not provided [RCV001537915] Chr2:81209244..86688030 [GRCh37]
Chr2:2p12-11.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p12-11.2(chr2:82486900-87322042) copy number loss not specified [RCV002053172] Chr2:82486900..87322042 [GRCh37]
Chr2:2p12-11.2
pathogenic
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13
pathogenic
NM_001747.4(CAPG):c.212G>A (p.Arg71Gln) single nucleotide variant not specified [RCV004237743] Chr2:85401668 [GRCh38]
Chr2:85628791 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.445C>T (p.Arg149Cys) single nucleotide variant not specified [RCV004240162] Chr2:85401236 [GRCh38]
Chr2:85628359 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.241G>C (p.Ala81Pro) single nucleotide variant not specified [RCV004242282] Chr2:85401639 [GRCh38]
Chr2:85628762 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.272G>A (p.Arg91Gln) single nucleotide variant not specified [RCV004211777] Chr2:85401608 [GRCh38]
Chr2:85628731 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.842A>G (p.Asp281Gly) single nucleotide variant not specified [RCV004089245] Chr2:85398070 [GRCh38]
Chr2:85625193 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.289G>C (p.Glu97Gln) single nucleotide variant not specified [RCV004155024] Chr2:85401591 [GRCh38]
Chr2:85628714 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.457C>T (p.Arg153Trp) single nucleotide variant not specified [RCV004261747] Chr2:85401224 [GRCh38]
Chr2:85628347 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.776G>A (p.Gly259Glu) single nucleotide variant not specified [RCV004338943] Chr2:85398136 [GRCh38]
Chr2:85625259 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.335G>A (p.Arg112Gln) single nucleotide variant not specified [RCV004434858] Chr2:85401545 [GRCh38]
Chr2:85628668 [GRCh37]
Chr2:2p11.2
likely benign
NM_001747.4(CAPG):c.92C>T (p.Pro31Leu) single nucleotide variant not specified [RCV004434860] Chr2:85401889 [GRCh38]
Chr2:85629012 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.733A>C (p.Asn245His) single nucleotide variant not specified [RCV004434859] Chr2:85398716 [GRCh38]
Chr2:85625839 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_001747.4(CAPG):c.107A>G (p.Gln36Arg) single nucleotide variant not specified [RCV004434857] Chr2:85401874 [GRCh38]
Chr2:85628997 [GRCh37]
Chr2:2p11.2
likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5235
Count of miRNA genes:909
Interacting mature miRNAs:1142
Transcripts:ENST00000263867, ENST00000409275, ENST00000409670, ENST00000409724, ENST00000409921, ENST00000415012, ENST00000439385, ENST00000447219, ENST00000449030, ENST00000453973, ENST00000459793, ENST00000471064, ENST00000479651, ENST00000483659, ENST00000491267
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
WI-17489  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37285,621,928 - 85,622,059UniSTSGRCh37
Build 36285,475,439 - 85,475,570RGDNCBI36
Celera285,450,114 - 85,450,245RGD
Cytogenetic Map2p11.2UniSTS
HuRef285,518,737 - 85,518,868UniSTS
GeneMap99-GB4 RH Map2295.38UniSTS
Whitehead-RH Map2377.1UniSTS
NCBI RH Map2460.4UniSTS
CAPG  
Human AssemblyChrPosition (strand)SourceJBrowse
Celera285,450,227 - 85,450,880UniSTS
HuRef285,518,850 - 85,519,503UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 5 5 2 15
Medium 2203 2166 1289 293 1842 136 3603 983 2583 409 1344 1538 170 1195 2078 2
Low 227 791 428 324 102 322 747 1182 1120 7 89 56 1 9 710 2 1
Below cutoff 1 26 7 6 1 7 1 30 14 1 8 16 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001256139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011533122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011533123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047445947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047445948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047445949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047445950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047445951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047445952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047445953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047445954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC062037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU099216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG762114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG762391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU172582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU626913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ224312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M94345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000263867   ⟹   ENSP00000263867
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,394,753 - 85,410,366 (-)Ensembl
RefSeq Acc Id: ENST00000409275   ⟹   ENSP00000386596
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,399,146 - 85,418,432 (-)Ensembl
RefSeq Acc Id: ENST00000409670   ⟹   ENSP00000386315
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,394,828 - 85,414,042 (-)Ensembl
RefSeq Acc Id: ENST00000409724   ⟹   ENSP00000386965
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,394,893 - 85,414,074 (-)Ensembl
RefSeq Acc Id: ENST00000409921   ⟹   ENSP00000387063
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,394,767 - 85,410,370 (-)Ensembl
RefSeq Acc Id: ENST00000415012
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,401,172 - 85,413,213 (-)Ensembl
RefSeq Acc Id: ENST00000439385   ⟹   ENSP00000391923
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,398,690 - 85,408,815 (-)Ensembl
RefSeq Acc Id: ENST00000447219   ⟹   ENSP00000398232
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,398,690 - 85,414,039 (-)Ensembl
RefSeq Acc Id: ENST00000449030   ⟹   ENSP00000403330
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,398,690 - 85,409,832 (-)Ensembl
RefSeq Acc Id: ENST00000453973   ⟹   ENSP00000397381
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,394,753 - 85,398,734 (-)Ensembl
RefSeq Acc Id: ENST00000459793
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,398,720 - 85,410,352 (-)Ensembl
RefSeq Acc Id: ENST00000471064
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,394,895 - 85,398,352 (-)Ensembl
RefSeq Acc Id: ENST00000479651
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,402,138 - 85,413,974 (-)Ensembl
RefSeq Acc Id: ENST00000483659
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,395,575 - 85,401,671 (-)Ensembl
RefSeq Acc Id: ENST00000491267
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,401,645 - 85,414,018 (-)Ensembl
RefSeq Acc Id: NM_001256139   ⟹   NP_001243068
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,394,753 - 85,414,016 (-)NCBI
HuRef285,518,680 - 85,537,978 (-)NCBI
CHM1_1285,551,623 - 85,570,945 (-)NCBI
T2T-CHM13v2.0285,396,765 - 85,416,030 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001256140   ⟹   NP_001243069
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,394,753 - 85,410,366 (-)NCBI
GRCh37285,621,871 - 85,641,197 (-)NCBI
HuRef285,518,680 - 85,537,978 (-)NCBI
CHM1_1285,551,623 - 85,567,568 (-)NCBI
T2T-CHM13v2.0285,396,765 - 85,412,380 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001320732   ⟹   NP_001307661
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,394,753 - 85,409,812 (-)NCBI
CHM1_1285,551,623 - 85,566,703 (-)NCBI
T2T-CHM13v2.0285,396,765 - 85,411,826 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001320733   ⟹   NP_001307662
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,394,753 - 85,410,309 (-)NCBI
CHM1_1285,551,623 - 85,567,180 (-)NCBI
T2T-CHM13v2.0285,396,765 - 85,412,323 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001320734   ⟹   NP_001307663
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,394,753 - 85,410,366 (-)NCBI
CHM1_1285,551,623 - 85,567,568 (-)NCBI
T2T-CHM13v2.0285,396,765 - 85,412,380 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001747   ⟹   NP_001738
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,394,753 - 85,410,366 (-)NCBI
GRCh37285,621,871 - 85,641,197 (-)NCBI
Build 36285,475,382 - 85,491,187 (-)NCBI Archive
HuRef285,518,680 - 85,537,978 (-)NCBI
CHM1_1285,551,623 - 85,567,568 (-)NCBI
T2T-CHM13v2.0285,396,765 - 85,412,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011533122   ⟹   XP_011531424
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,394,753 - 85,418,432 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011533123   ⟹   XP_011531425
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,394,753 - 85,413,249 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047445947   ⟹   XP_047301903
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,391,602 - 85,410,309 (-)NCBI
RefSeq Acc Id: XM_047445948   ⟹   XP_047301904
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,391,602 - 85,418,432 (-)NCBI
RefSeq Acc Id: XM_047445949   ⟹   XP_047301905
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,391,602 - 85,409,812 (-)NCBI
RefSeq Acc Id: XM_047445950   ⟹   XP_047301906
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,391,602 - 85,413,239 (-)NCBI
RefSeq Acc Id: XM_047445951   ⟹   XP_047301907
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,391,602 - 85,419,540 (-)NCBI
RefSeq Acc Id: XM_047445952   ⟹   XP_047301908
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,391,602 - 85,409,812 (-)NCBI
RefSeq Acc Id: XM_047445953   ⟹   XP_047301909
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,394,753 - 85,419,540 (-)NCBI
RefSeq Acc Id: XM_047445954   ⟹   XP_047301910
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,394,753 - 85,409,812 (-)NCBI
RefSeq Acc Id: XM_054344099   ⟹   XP_054200074
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,393,613 - 85,412,323 (-)NCBI
RefSeq Acc Id: XM_054344100   ⟹   XP_054200075
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,393,613 - 85,411,826 (-)NCBI
RefSeq Acc Id: XM_054344101   ⟹   XP_054200076
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,393,613 - 85,415,253 (-)NCBI
RefSeq Acc Id: XM_054344102   ⟹   XP_054200077
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,393,613 - 85,420,480 (-)NCBI
RefSeq Acc Id: XM_054344103   ⟹   XP_054200078
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,396,765 - 85,415,263 (-)NCBI
RefSeq Acc Id: XM_054344104   ⟹   XP_054200079
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,396,765 - 85,421,559 (-)NCBI
RefSeq Acc Id: XM_054344105   ⟹   XP_054200080
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,396,765 - 85,410,646 (-)NCBI
RefSeq Acc Id: XM_054344106   ⟹   XP_054200081
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,396,765 - 85,420,450 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001243068 (Get FASTA)   NCBI Sequence Viewer  
  NP_001243069 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307661 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307662 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307663 (Get FASTA)   NCBI Sequence Viewer  
  NP_001738 (Get FASTA)   NCBI Sequence Viewer  
  XP_011531424 (Get FASTA)   NCBI Sequence Viewer  
  XP_011531425 (Get FASTA)   NCBI Sequence Viewer  
  XP_047301903 (Get FASTA)   NCBI Sequence Viewer  
  XP_047301904 (Get FASTA)   NCBI Sequence Viewer  
  XP_047301905 (Get FASTA)   NCBI Sequence Viewer  
  XP_047301906 (Get FASTA)   NCBI Sequence Viewer  
  XP_047301907 (Get FASTA)   NCBI Sequence Viewer  
  XP_047301908 (Get FASTA)   NCBI Sequence Viewer  
  XP_047301909 (Get FASTA)   NCBI Sequence Viewer  
  XP_047301910 (Get FASTA)   NCBI Sequence Viewer  
  XP_054200074 (Get FASTA)   NCBI Sequence Viewer  
  XP_054200075 (Get FASTA)   NCBI Sequence Viewer  
  XP_054200076 (Get FASTA)   NCBI Sequence Viewer  
  XP_054200077 (Get FASTA)   NCBI Sequence Viewer  
  XP_054200078 (Get FASTA)   NCBI Sequence Viewer  
  XP_054200079 (Get FASTA)   NCBI Sequence Viewer  
  XP_054200080 (Get FASTA)   NCBI Sequence Viewer  
  XP_054200081 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA59570 (Get FASTA)   NCBI Sequence Viewer  
  AAA92670 (Get FASTA)   NCBI Sequence Viewer  
  AAH00728 (Get FASTA)   NCBI Sequence Viewer  
  AAH14549 (Get FASTA)   NCBI Sequence Viewer  
  AAY24128 (Get FASTA)   NCBI Sequence Viewer  
  ACI46004 (Get FASTA)   NCBI Sequence Viewer  
  BAG36621 (Get FASTA)   NCBI Sequence Viewer  
  BAG62220 (Get FASTA)   NCBI Sequence Viewer  
  EAW99517 (Get FASTA)   NCBI Sequence Viewer  
  EAW99518 (Get FASTA)   NCBI Sequence Viewer  
  EAW99519 (Get FASTA)   NCBI Sequence Viewer  
  EAW99520 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000263867
  ENSP00000263867.4
  ENSP00000386315.1
  ENSP00000386596.1
  ENSP00000386965
  ENSP00000386965.1
  ENSP00000387063
  ENSP00000387063.1
  ENSP00000391923.1
  ENSP00000397381.1
  ENSP00000398232.2
  ENSP00000403330.1
GenBank Protein P40121 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001738   ⟸   NM_001747
- Peptide Label: isoform 1
- UniProtKB: D6W5K8 (UniProtKB/Swiss-Prot),   B8ZZS7 (UniProtKB/Swiss-Prot),   Q53SA7 (UniProtKB/Swiss-Prot),   P40121 (UniProtKB/Swiss-Prot),   V9HW69 (UniProtKB/TrEMBL),   B2R9S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001243068   ⟸   NM_001256139
- Peptide Label: isoform 1
- UniProtKB: D6W5K8 (UniProtKB/Swiss-Prot),   B8ZZS7 (UniProtKB/Swiss-Prot),   Q53SA7 (UniProtKB/Swiss-Prot),   P40121 (UniProtKB/Swiss-Prot),   B2R9S4 (UniProtKB/TrEMBL),   V9HW69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001243069   ⟸   NM_001256140
- Peptide Label: isoform 2
- UniProtKB: B2R9S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011531424   ⟸   XM_011533122
- Peptide Label: isoform X2
- UniProtKB: D6W5K8 (UniProtKB/Swiss-Prot),   B8ZZS7 (UniProtKB/Swiss-Prot),   Q53SA7 (UniProtKB/Swiss-Prot),   P40121 (UniProtKB/Swiss-Prot),   V9HW69 (UniProtKB/TrEMBL),   B2R9S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011531425   ⟸   XM_011533123
- Peptide Label: isoform X2
- UniProtKB: D6W5K8 (UniProtKB/Swiss-Prot),   B8ZZS7 (UniProtKB/Swiss-Prot),   Q53SA7 (UniProtKB/Swiss-Prot),   P40121 (UniProtKB/Swiss-Prot),   V9HW69 (UniProtKB/TrEMBL),   B2R9S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307663   ⟸   NM_001320734
- Peptide Label: isoform 3
- UniProtKB: B2R9S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307662   ⟸   NM_001320733
- Peptide Label: isoform 1
- UniProtKB: D6W5K8 (UniProtKB/Swiss-Prot),   B8ZZS7 (UniProtKB/Swiss-Prot),   Q53SA7 (UniProtKB/Swiss-Prot),   P40121 (UniProtKB/Swiss-Prot),   V9HW69 (UniProtKB/TrEMBL),   B2R9S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307661   ⟸   NM_001320732
- Peptide Label: isoform 1
- UniProtKB: D6W5K8 (UniProtKB/Swiss-Prot),   B8ZZS7 (UniProtKB/Swiss-Prot),   Q53SA7 (UniProtKB/Swiss-Prot),   P40121 (UniProtKB/Swiss-Prot),   V9HW69 (UniProtKB/TrEMBL),   B2R9S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000391923   ⟸   ENST00000439385
RefSeq Acc Id: ENSP00000397381   ⟸   ENST00000453973
RefSeq Acc Id: ENSP00000398232   ⟸   ENST00000447219
RefSeq Acc Id: ENSP00000387063   ⟸   ENST00000409921
RefSeq Acc Id: ENSP00000386965   ⟸   ENST00000409724
RefSeq Acc Id: ENSP00000386315   ⟸   ENST00000409670
RefSeq Acc Id: ENSP00000386596   ⟸   ENST00000409275
RefSeq Acc Id: ENSP00000403330   ⟸   ENST00000449030
RefSeq Acc Id: ENSP00000263867   ⟸   ENST00000263867
RefSeq Acc Id: XP_047301907   ⟸   XM_047445951
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047301904   ⟸   XM_047445948
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047301906   ⟸   XM_047445950
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047301903   ⟸   XM_047445947
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047301905   ⟸   XM_047445949
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047301908   ⟸   XM_047445952
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047301909   ⟸   XM_047445953
- Peptide Label: isoform X2
- UniProtKB: P40121 (UniProtKB/Swiss-Prot),   D6W5K8 (UniProtKB/Swiss-Prot),   B8ZZS7 (UniProtKB/Swiss-Prot),   Q53SA7 (UniProtKB/Swiss-Prot),   V9HW69 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047301910   ⟸   XM_047445954
- Peptide Label: isoform X2
- UniProtKB: P40121 (UniProtKB/Swiss-Prot),   D6W5K8 (UniProtKB/Swiss-Prot),   B8ZZS7 (UniProtKB/Swiss-Prot),   Q53SA7 (UniProtKB/Swiss-Prot),   V9HW69 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054200077   ⟸   XM_054344102
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054200076   ⟸   XM_054344101
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054200074   ⟸   XM_054344099
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054200075   ⟸   XM_054344100
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054200079   ⟸   XM_054344104
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054200081   ⟸   XM_054344106
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054200078   ⟸   XM_054344103
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054200080   ⟸   XM_054344105
- Peptide Label: isoform X2
Protein Domains
Gelsolin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P40121-F1-model_v2 AlphaFold P40121 1-348 view protein structure

Promoters
RGD ID:6860882
Promoter ID:EPDNEW_H3606
Type:multiple initiation site
Name:CAPG_3
Description:capping actin protein, gelsolin like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3607  EPDNEW_H3608  EPDNEW_H3610  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,409,812 - 85,409,872EPDNEW
RGD ID:6860884
Promoter ID:EPDNEW_H3607
Type:initiation region
Name:CAPG_2
Description:capping actin protein, gelsolin like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3606  EPDNEW_H3608  EPDNEW_H3610  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,410,365 - 85,410,425EPDNEW
RGD ID:6860886
Promoter ID:EPDNEW_H3608
Type:initiation region
Name:CAPG_1
Description:capping actin protein, gelsolin like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3606  EPDNEW_H3607  EPDNEW_H3610  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,414,016 - 85,414,076EPDNEW
RGD ID:6860890
Promoter ID:EPDNEW_H3610
Type:initiation region
Name:CAPG_4
Description:capping actin protein, gelsolin like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3606  EPDNEW_H3607  EPDNEW_H3608  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,419,540 - 85,419,600EPDNEW
RGD ID:6796935
Promoter ID:HG_KWN:33534
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000329394,   OTTHUMT00000329395
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,479,486 - 85,479,986 (-)MPROMDB
RGD ID:6796931
Promoter ID:HG_KWN:33535
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:OTTHUMT00000329392,   OTTHUMT00000329393,   UC010FGJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,482,476 - 85,482,976 (-)MPROMDB
RGD ID:6796927
Promoter ID:HG_KWN:33536
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000329384
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,489,236 - 85,489,736 (-)MPROMDB
RGD ID:6796929
Promoter ID:HG_KWN:33537
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001747,   OTTHUMT00000329386,   OTTHUMT00000329390,   UC002SPM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,490,666 - 85,491,227 (-)MPROMDB
RGD ID:6851852
Promoter ID:EP73732
Type:multiple initiation site
Name:HS_CAPG
Description:Capping protein (actin filament), gelsolin-like.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,490,997 - 85,491,057EPD
RGD ID:6796928
Promoter ID:HG_KWN:33538
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:OTTHUMT00000329388
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,493,676 - 85,494,727 (-)MPROMDB
RGD ID:6797156
Promoter ID:HG_KWN:33539
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000409670,   OTTHUMT00000329385,   OTTHUMT00000329387,   OTTHUMT00000329389,   UC010FGI.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,494,576 - 85,495,667 (-)MPROMDB
RGD ID:6797163
Promoter ID:HG_KWN:33540
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000389938,   ENST00000409275,   OTTHUMT00000329396
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,499,081 - 85,500,162 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1474 AgrOrtholog
COSMIC CAPG COSMIC
Ensembl Genes ENSG00000042493 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000263867 ENTREZGENE
  ENST00000263867.9 UniProtKB/Swiss-Prot
  ENST00000409275.1 UniProtKB/TrEMBL
  ENST00000409670.5 UniProtKB/Swiss-Prot
  ENST00000409724 ENTREZGENE
  ENST00000409724.5 UniProtKB/Swiss-Prot
  ENST00000409921 ENTREZGENE
  ENST00000409921.5 UniProtKB/Swiss-Prot
  ENST00000439385.5 UniProtKB/TrEMBL
  ENST00000447219.6 UniProtKB/TrEMBL
  ENST00000449030.5 UniProtKB/TrEMBL
  ENST00000453973.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000042493 GTEx
HGNC ID HGNC:1474 ENTREZGENE
Human Proteome Map CAPG Human Proteome Map
InterPro ADF-H/Gelsolin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gelsolin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Villin/Gelsolin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 822 ENTREZGENE
OMIM 153615 OMIM
PANTHER MACROPHAGE-CAPPING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11977 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gelsolin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26056 PharmGKB
PRINTS GELSOLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Actin depolymerizing proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A979HLS1_HUMAN UniProtKB/TrEMBL
  A0A979HLS2_HUMAN UniProtKB/TrEMBL
  B2R9S4 ENTREZGENE, UniProtKB/TrEMBL
  B8ZZL6_HUMAN UniProtKB/TrEMBL
  B8ZZS7 ENTREZGENE
  CAPG_HUMAN UniProtKB/Swiss-Prot
  D6W5K8 ENTREZGENE
  E7ENU9_HUMAN UniProtKB/TrEMBL
  H7C0X8_HUMAN UniProtKB/TrEMBL
  P40121 ENTREZGENE
  Q53SA7 ENTREZGENE
  V9HW69 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B8ZZS7 UniProtKB/Swiss-Prot
  D6W5K8 UniProtKB/Swiss-Prot
  E7EUE9 UniProtKB/TrEMBL
  E7EUR2 UniProtKB/TrEMBL
  Q53SA7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 CAPG  capping actin protein, gelsolin like    capping protein (actin filament), gelsolin-like  Symbol and/or name change 5135510 APPROVED