CRYZ (crystallin zeta) - Rat Genome Database

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Gene: CRYZ (crystallin zeta) Homo sapiens
Analyze
Symbol: CRYZ
Name: crystallin zeta
RGD ID: 1323202
HGNC Page HGNC:2419
Description: Enables several functions, including NADPH binding activity; NADPH:quinone reductase activity; and mRNA 3'-UTR binding activity. Involved in protein homotetramerization and xenobiotic catabolic process. Located in cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: crystallin, zeta (quinone reductase); DKFZp779E0834; FLJ41475; NADPH:quinone reductase; quinone oxidoreductase; zeta-crystallin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: CRYZP1   CRYZP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,705,486 - 74,733,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,705,482 - 74,733,408 (-)EnsemblGRCh38hg38GRCh38
GRCh37175,171,170 - 75,198,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,943,772 - 74,971,315 (-)NCBINCBI36Build 36hg18NCBI36
Build 34174,883,204 - 74,910,748NCBI
Celera173,416,409 - 73,444,324 (-)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef173,305,573 - 73,333,498 (-)NCBIHuRef
CHM1_1175,286,617 - 75,314,534 (-)NCBICHM1_1
T2T-CHM13v2.0174,547,169 - 74,574,691 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (EXP)
2,4-dinitrotoluene  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methylcholine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
aristolochic acid A  (EXP)
benzatropine  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzoyl peroxide  (ISO)
beta-ionone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (EXP)
carvacrol  (ISO)
CGP 52608  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (EXP,ISO)
cycloartenol  (ISO)
cyclosporin A  (EXP)
dicrotophos  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (EXP)
lead(0)  (ISO)
lupeol  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methidathion  (ISO)
methylmercury chloride  (EXP)
Monobutylphthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP)
picoxystrobin  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sanguinarine  (ISO)
SB 431542  (EXP)
sodium arsenite  (EXP)
streptozocin  (ISO)
sunitinib  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (EXP)
thapsigargin  (EXP)
thioacetamide  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
xanthohumol  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,IEA)
extracellular exosome  (HDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7835889   PMID:8088825   PMID:8125298   PMID:8466529   PMID:9698072   PMID:11295131   PMID:11672428   PMID:12477932   PMID:12714703   PMID:14702039   PMID:15146197   PMID:15489334  
PMID:16344560   PMID:17192395   PMID:17497241   PMID:18029348   PMID:19056867   PMID:20103721   PMID:20458337   PMID:20835842   PMID:21276778   PMID:21873635   PMID:22843503   PMID:22863883  
PMID:23376485   PMID:23533145   PMID:23898208   PMID:26344197   PMID:26496610   PMID:28514442   PMID:29128334   PMID:29987050   PMID:30021884   PMID:31536960   PMID:31563996   PMID:31586073  
PMID:32296183   PMID:32687490   PMID:32877691   PMID:33845483   PMID:33961781   PMID:34709727   PMID:35384245   PMID:35831314   PMID:35944360   PMID:36215168   PMID:36244648   PMID:37827155  
PMID:38297188  


Genomics

Comparative Map Data
CRYZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,705,486 - 74,733,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,705,482 - 74,733,408 (-)EnsemblGRCh38hg38GRCh38
GRCh37175,171,170 - 75,198,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,943,772 - 74,971,315 (-)NCBINCBI36Build 36hg18NCBI36
Build 34174,883,204 - 74,910,748NCBI
Celera173,416,409 - 73,444,324 (-)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef173,305,573 - 73,333,498 (-)NCBIHuRef
CHM1_1175,286,617 - 75,314,534 (-)NCBICHM1_1
T2T-CHM13v2.0174,547,169 - 74,574,691 (-)NCBIT2T-CHM13v2.0
Cryz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393154,302,348 - 154,328,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3154,302,348 - 154,328,819 (+)EnsemblGRCm39 Ensembl
GRCm383154,596,711 - 154,623,182 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3154,596,711 - 154,623,182 (+)EnsemblGRCm38mm10GRCm38
MGSCv373154,259,976 - 154,286,146 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363154,532,492 - 154,558,475 (+)NCBIMGSCv36mm8
Celera3161,056,174 - 161,081,722 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map379.25NCBI
Cryz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82246,211,707 - 246,239,472 (+)NCBIGRCr8
mRatBN7.22243,552,037 - 243,580,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2243,552,119 - 243,579,758 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2251,382,444 - 251,410,059 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02249,276,271 - 249,303,886 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02244,175,870 - 244,204,081 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02260,884,315 - 260,911,827 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,884,337 - 260,911,792 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02279,545,988 - 279,573,507 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42252,433,559 - 252,461,038 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12252,448,165 - 252,475,644 (+)NCBI
Celera2235,475,252 - 235,504,548 (+)NCBICelera
Cytogenetic Map2q45NCBI
Cryz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542317,955,222 - 17,975,982 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542317,952,783 - 17,975,982 (+)NCBIChiLan1.0ChiLan1.0
CRYZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21152,146,290 - 152,174,077 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11151,306,974 - 151,335,349 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,933,432 - 73,962,107 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,908,684 - 75,936,131 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,908,684 - 75,936,127 (-)Ensemblpanpan1.1panPan2
CRYZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1671,656,162 - 71,693,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl671,656,188 - 71,675,692 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha674,319,317 - 74,339,207 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0672,243,211 - 72,286,494 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl672,243,256 - 72,276,221 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1671,743,227 - 71,762,856 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0671,689,881 - 71,709,606 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0672,184,160 - 72,204,066 (+)NCBIUU_Cfam_GSD_1.0
Cryz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505886,491,899 - 86,523,098 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365712,001,273 - 2,024,974 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365712,002,388 - 2,033,423 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRYZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6138,435,392 - 138,460,975 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16138,434,960 - 138,461,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26128,301,994 - 128,327,414 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRYZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12058,427,281 - 58,456,370 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2058,435,671 - 58,456,408 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603358,998,854 - 59,027,683 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cryz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474221,955,368 - 21,990,402 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474221,951,389 - 21,974,134 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CRYZ
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p32.3-31.1(chr1:52595352-76767765)x3 copy number gain See cases [RCV000051822] Chr1:52595352..76767765 [GRCh38]
Chr1:53061024..77233450 [GRCh37]
Chr1:52833612..77006038 [NCBI36]
Chr1:1p32.3-31.1		 pathogenic
GRCh38/hg38 1p31.1-13.3(chr1:72661709-107456880)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|See cases [RCV000051825] Chr1:72661709..107456880 [GRCh38]
Chr1:73127392..107999502 [GRCh37]
Chr1:72899980..107801025 [NCBI36]
Chr1:1p31.1-13.3		 pathogenic
GRCh38/hg38 1p32.1-31.1(chr1:59632500-76730877)x1 copy number loss See cases [RCV000053842] Chr1:59632500..76730877 [GRCh38]
Chr1:60098172..77196562 [GRCh37]
Chr1:59870760..76969150 [NCBI36]
Chr1:1p32.1-31.1		 pathogenic
GRCh38/hg38 1p32.1-22.3(chr1:58819605-86098611)x1 copy number loss See cases [RCV000136913] Chr1:58819605..86098611 [GRCh38]
Chr1:59285277..86564294 [GRCh37]
Chr1:59057865..86336882 [NCBI36]
Chr1:1p32.1-22.3		 pathogenic
GRCh38/hg38 1p31.1(chr1:74320173-74823743)x3 copy number gain See cases [RCV000141222] Chr1:74320173..74823743 [GRCh38]
Chr1:74785857..75289427 [GRCh37]
Chr1:74558445..75062015 [NCBI36]
Chr1:1p31.1		 uncertain significance
GRCh38/hg38 1p31.1(chr1:74261660-75056208)x3 copy number gain See cases [RCV000142355] Chr1:74261660..75056208 [GRCh38]
Chr1:74727344..75521892 [GRCh37]
Chr1:74499932..75294480 [NCBI36]
Chr1:1p31.1		 uncertain significance
GRCh38/hg38 1p31.3-31.1(chr1:64072618-75518432)x3 copy number gain See cases [RCV000142452] Chr1:64072618..75518432 [GRCh38]
Chr1:64538290..75984117 [GRCh37]
Chr1:64310878..75756705 [NCBI36]
Chr1:1p31.3-31.1		 pathogenic
GRCh38/hg38 1p31.3-31.1(chr1:66865125-77123381)x1 copy number loss See cases [RCV000143129] Chr1:66865125..77123381 [GRCh38]
Chr1:67330808..77589066 [GRCh37]
Chr1:67103396..77361654 [NCBI36]
Chr1:1p31.3-31.1		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p31.3-31.1(chr1:63252828-77402595)x1 copy number loss See cases [RCV000446378] Chr1:63252828..77402595 [GRCh37]
Chr1:1p31.3-31.1		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p31.1-22.1(chr1:72044544-92505091)x1 copy number loss See cases [RCV000510161] Chr1:72044544..92505091 [GRCh37]
Chr1:1p31.1-22.1		 pathogenic
GRCh37/hg19 1p31.3-22.3(chr1:64321264-88153669)x1 copy number loss See cases [RCV000511392] Chr1:64321264..88153669 [GRCh37]
Chr1:1p31.3-22.3		 pathogenic|uncertain significance
GRCh37/hg19 1p31.1(chr1:74848936-80324850)x3 copy number gain See cases [RCV000510973] Chr1:74848936..80324850 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p31.1(chr1:72578280-77429541)x3 copy number gain not provided [RCV000585144] Chr1:72578280..77429541 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p31.3-31.1(chr1:61351024-79583933)x1 copy number loss See cases [RCV000512152] Chr1:61351024..79583933 [GRCh37]
Chr1:1p31.3-31.1		 pathogenic
GRCh37/hg19 1p31.1(chr1:72103442-77186974)x3 copy number gain not provided [RCV000684586] Chr1:72103442..77186974 [GRCh37]
Chr1:1p31.1		 likely pathogenic
GRCh37/hg19 1p31.1(chr1:72859282-75395703)x3 copy number gain not provided [RCV000684587] Chr1:72859282..75395703 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p31.1(chr1:74125095-75208561)x1 copy number loss not provided [RCV000684588] Chr1:74125095..75208561 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p31.1(chr1:75171751-75176418)x1 copy number loss not provided [RCV000749036] Chr1:75171751..75176418 [GRCh37]
Chr1:1p31.1		 benign
GRCh37/hg19 1p31.1(chr1:75197876-75202249)x1 copy number loss not provided [RCV000749037] Chr1:75197876..75202249 [GRCh37]
Chr1:1p31.1		 benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
NM_001889.4(CRYZ):c.913T>C (p.Leu305=) single nucleotide variant not provided [RCV000902480] Chr1:74706373 [GRCh38]
Chr1:75172057 [GRCh37]
Chr1:1p31.1		 benign
NM_001889.4(CRYZ):c.547G>A (p.Glu183Lys) single nucleotide variant CRYZ-related condition [RCV003926244]|not provided [RCV000964813] Chr1:74710181 [GRCh38]
Chr1:75175865 [GRCh37]
Chr1:1p31.1		 benign
GRCh37/hg19 1p31.1(chr1:71410579-78131158) copy number gain not provided [RCV000767771] Chr1:71410579..78131158 [GRCh37]
Chr1:1p31.1		 pathogenic
NM_001889.4(CRYZ):c.732+1G>A single nucleotide variant not provided [RCV000903566] Chr1:74707102 [GRCh38]
Chr1:75172786 [GRCh37]
Chr1:1p31.1		 likely benign
NM_001889.4(CRYZ):c.265-1G>A single nucleotide variant CRYZ-related condition [RCV003960624]|not provided [RCV000951049] Chr1:74719373 [GRCh38]
Chr1:75185057 [GRCh37]
Chr1:1p31.1		 likely benign
Single allele deletion not provided [RCV000844927] Chr1:66085524..88429789 [GRCh37]
Chr1:1p31.3-22.2		 not provided
GRCh37/hg19 1p31.3-31.1(chr1:66868168-77106425)x1 copy number loss not provided [RCV000847457] Chr1:66868168..77106425 [GRCh37]
Chr1:1p31.3-31.1		 pathogenic
GRCh37/hg19 1p31.3-22.3(chr1:67851233-86101340)x1 copy number loss not provided [RCV000846441] Chr1:67851233..86101340 [GRCh37]
Chr1:1p31.3-22.3		 pathogenic
GRCh37/hg19 1p31.1(chr1:74734130-75521892)x3 copy number gain not provided [RCV002473645] Chr1:74734130..75521892 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p31.1(chr1:74969395-75264251)x3 copy number gain not provided [RCV001005112] Chr1:74969395..75264251 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.1A>C (p.Met1Leu) single nucleotide variant not provided [RCV001300375] Chr1:74724821 [GRCh38]
Chr1:75190505 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p31.3-22.1(chr1:68180293-92731957) copy number loss not specified [RCV002053392] Chr1:68180293..92731957 [GRCh37]
Chr1:1p31.3-22.1		 pathogenic
Single allele duplication not specified [RCV002286371] Chr1:66885559..77949895 [GRCh38]
Chr1:1p31.3-31.1		 uncertain significance
NM_001889.4(CRYZ):c.617T>C (p.Ile206Thr) single nucleotide variant not specified [RCV004169505] Chr1:74710111 [GRCh38]
Chr1:75175795 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.215A>G (p.Asp72Gly) single nucleotide variant not specified [RCV004161609] Chr1:74723167 [GRCh38]
Chr1:75188851 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.164G>A (p.Arg55His) single nucleotide variant CRYZ-related condition [RCV003918949]|not specified [RCV004082420] Chr1:74723218 [GRCh38]
Chr1:75188902 [GRCh37]
Chr1:1p31.1		 likely benign|uncertain significance
NM_001889.4(CRYZ):c.689T>G (p.Leu230Arg) single nucleotide variant not specified [RCV004112347] Chr1:74707146 [GRCh38]
Chr1:75172830 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.730A>G (p.Ile244Val) single nucleotide variant not specified [RCV004166400] Chr1:74707105 [GRCh38]
Chr1:75172789 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.659T>C (p.Ile220Thr) single nucleotide variant not specified [RCV004092940] Chr1:74707176 [GRCh38]
Chr1:75172860 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.284C>G (p.Thr95Ser) single nucleotide variant not specified [RCV004085703] Chr1:74719353 [GRCh38]
Chr1:75185037 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.215A>T (p.Asp72Val) single nucleotide variant not specified [RCV004287453] Chr1:74723167 [GRCh38]
Chr1:75188851 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p31.1(chr1:74993063-75580191)x3 copy number gain not provided [RCV003484019] Chr1:74993063..75580191 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.290G>C (p.Ser97Thr) single nucleotide variant not specified [RCV004370257] Chr1:74719347 [GRCh38]
Chr1:75185031 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.443C>T (p.Ala148Val) single nucleotide variant not specified [RCV004370258] Chr1:74714616 [GRCh38]
Chr1:75180300 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.716A>G (p.His239Arg) single nucleotide variant not specified [RCV004370260] Chr1:74707119 [GRCh38]
Chr1:75172803 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001889.4(CRYZ):c.518G>T (p.Gly173Val) single nucleotide variant not specified [RCV004370259] Chr1:74710210 [GRCh38]
Chr1:75175894 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p31.1-22.3(chr1:73616197-87012961)x1 copy number loss not provided [RCV003885448] Chr1:73616197..87012961 [GRCh37]
Chr1:1p31.1-22.3		 likely pathogenic
NM_001889.4(CRYZ):c.120C>A (p.Ile40=) single nucleotide variant CRYZ-related condition [RCV003956844] Chr1:74723262 [GRCh38]
Chr1:75188946 [GRCh37]
Chr1:1p31.1		 likely benign
NM_001889.4(CRYZ):c.867A>C (p.Gly289=) single nucleotide variant CRYZ-related condition [RCV003931781] Chr1:74706419 [GRCh38]
Chr1:75172103 [GRCh37]
Chr1:1p31.1		 likely benign
NM_001889.4(CRYZ):c.615C>T (p.Tyr205=) single nucleotide variant CRYZ-related condition [RCV003914193] Chr1:74710113 [GRCh38]
Chr1:75175797 [GRCh37]
Chr1:1p31.1		 benign
NM_001889.4(CRYZ):c.839A>G (p.Gln280Arg) single nucleotide variant CRYZ-related condition [RCV003921990] Chr1:74706447 [GRCh38]
Chr1:75172131 [GRCh37]
Chr1:1p31.1		 likely benign
NM_001889.4(CRYZ):c.759A>G (p.Glu253=) single nucleotide variant CRYZ-related condition [RCV003974116] Chr1:74706968 [GRCh38]
Chr1:75172652 [GRCh37]
Chr1:1p31.1		 benign
NM_001889.4(CRYZ):c.353C>G (p.Pro118Arg) single nucleotide variant not specified [RCV004355372] Chr1:74719284 [GRCh38]
Chr1:75184968 [GRCh37]
Chr1:1p31.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1044
Count of miRNA genes:393
Interacting mature miRNAs:418
Transcripts:ENST00000340866, ENST00000370870, ENST00000370871, ENST00000370872, ENST00000417775, ENST00000441120, ENST00000492102
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D1S3201  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37175,171,626 - 75,171,933UniSTSGRCh37
Build 36174,944,214 - 74,944,521RGDNCBI36
Celera173,416,865 - 73,417,172RGD
Cytogenetic Map1p31.1UniSTS
HuRef173,306,029 - 73,306,336UniSTS
GeneMap99-GB4 RH Map1189.5UniSTS
RH69010  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37175,171,326 - 75,171,585UniSTSGRCh37
Build 36174,943,914 - 74,944,173RGDNCBI36
Celera173,416,565 - 73,416,824RGD
Cytogenetic Map1p31.1UniSTS
HuRef173,305,729 - 73,305,988UniSTS
GeneMap99-GB4 RH Map1197.22UniSTS
NCBI RH Map1518.0UniSTS
RH68052  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37175,171,394 - 75,171,524UniSTSGRCh37
Build 36174,943,982 - 74,944,112RGDNCBI36
Celera173,416,633 - 73,416,763RGD
Cytogenetic Map1p31.1UniSTS
HuRef173,305,797 - 73,305,927UniSTS
GeneMap99-GB4 RH Map1197.43UniSTS
NCBI RH Map1518.0UniSTS
CRYZ_4643  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37175,171,104 - 75,171,980UniSTSGRCh37
Build 36174,943,692 - 74,944,568RGDNCBI36
Celera173,416,343 - 73,417,219RGD
HuRef173,305,507 - 73,306,383UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2036 1724 1652 562 1001 462 2824 1065 1361 404 1111 1489 115 1 846 1721 5 2
Low 403 1122 74 62 809 3 1518 1125 2372 15 349 122 60 358 1067 1
Below cutoff 145 141 8 7 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001134759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005270491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011540747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC135803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX649061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN368109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA256305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000340866   ⟹   ENSP00000339399
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,705,486 - 74,733,050 (-)Ensembl
RefSeq Acc Id: ENST00000370870   ⟹   ENSP00000359907
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,707,105 - 74,733,061 (-)Ensembl
RefSeq Acc Id: ENST00000370871   ⟹   ENSP00000359908
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,705,972 - 74,733,022 (-)Ensembl
RefSeq Acc Id: ENST00000370872   ⟹   ENSP00000359909
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,705,482 - 74,733,018 (-)Ensembl
RefSeq Acc Id: ENST00000417775   ⟹   ENSP00000399805
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,705,490 - 74,733,408 (-)Ensembl
RefSeq Acc Id: ENST00000441120   ⟹   ENSP00000404289
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,109 - 74,732,811 (-)Ensembl
RefSeq Acc Id: ENST00000492102
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,705,488 - 74,708,827 (-)Ensembl
RefSeq Acc Id: NM_001130042   ⟹   NP_001123514
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,705,486 - 74,733,050 (-)NCBI
GRCh37175,171,170 - 75,199,092 (-)ENTREZGENE
HuRef173,305,573 - 73,333,498 (-)ENTREZGENE
CHM1_1175,286,617 - 75,314,534 (-)NCBI
T2T-CHM13v2.0174,547,169 - 74,574,691 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001130043   ⟹   NP_001123515
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,705,486 - 74,733,050 (-)NCBI
GRCh37175,171,170 - 75,199,092 (-)ENTREZGENE
HuRef173,305,573 - 73,333,498 (-)ENTREZGENE
CHM1_1175,286,617 - 75,314,534 (-)NCBI
T2T-CHM13v2.0174,547,169 - 74,574,691 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001134759   ⟹   NP_001128231
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,705,486 - 74,733,050 (-)NCBI
GRCh37175,171,170 - 75,199,092 (-)ENTREZGENE
HuRef173,305,573 - 73,333,498 (-)ENTREZGENE
CHM1_1175,286,617 - 75,314,534 (-)NCBI
T2T-CHM13v2.0174,547,169 - 74,574,691 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001889   ⟹   NP_001880
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,705,486 - 74,733,050 (-)NCBI
GRCh37175,171,170 - 75,199,092 (-)ENTREZGENE
Build 36174,943,772 - 74,971,315 (-)NCBI Archive
HuRef173,305,573 - 73,333,498 (-)ENTREZGENE
CHM1_1175,286,617 - 75,314,534 (-)NCBI
T2T-CHM13v2.0174,547,169 - 74,574,691 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011540747   ⟹   XP_011539049
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,705,486 - 74,733,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017000367   ⟹   XP_016855856
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,705,486 - 74,733,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047446751   ⟹   XP_047302707
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,705,486 - 74,733,050 (-)NCBI
RefSeq Acc Id: XM_054334536   ⟹   XP_054190511
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,547,169 - 74,574,685 (-)NCBI
RefSeq Acc Id: XM_054334537   ⟹   XP_054190512
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,547,169 - 74,574,691 (-)NCBI
RefSeq Acc Id: XM_054334538   ⟹   XP_054190513
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,547,169 - 74,574,532 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001123514 (Get FASTA)   NCBI Sequence Viewer  
  NP_001123515 (Get FASTA)   NCBI Sequence Viewer  
  NP_001128231 (Get FASTA)   NCBI Sequence Viewer  
  NP_001880 (Get FASTA)   NCBI Sequence Viewer  
  XP_011539049 (Get FASTA)   NCBI Sequence Viewer  
  XP_016855856 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302707 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190511 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190512 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190513 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36536 (Get FASTA)   NCBI Sequence Viewer  
  AAH39578 (Get FASTA)   NCBI Sequence Viewer  
  AAH70058 (Get FASTA)   NCBI Sequence Viewer  
  AAK40311 (Get FASTA)   NCBI Sequence Viewer  
  ADO22285 (Get FASTA)   NCBI Sequence Viewer  
  BAD92951 (Get FASTA)   NCBI Sequence Viewer  
  BAD96870 (Get FASTA)   NCBI Sequence Viewer  
  BAD96921 (Get FASTA)   NCBI Sequence Viewer  
  CAI46072 (Get FASTA)   NCBI Sequence Viewer  
  EAX06409 (Get FASTA)   NCBI Sequence Viewer  
  EAX06410 (Get FASTA)   NCBI Sequence Viewer  
  EAX06411 (Get FASTA)   NCBI Sequence Viewer  
  EAX06412 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000339399
  ENSP00000339399.5
  ENSP00000359907.1
  ENSP00000359908
  ENSP00000359908.3
  ENSP00000359909
  ENSP00000359909.3
  ENSP00000399805
  ENSP00000399805.1
  ENSP00000404289.1
GenBank Protein Q08257 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001128231   ⟸   NM_001134759
- Peptide Label: isoform c
- UniProtKB: Q08257 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001123515   ⟸   NM_001130043
- Peptide Label: isoform b
- UniProtKB: A0A384P5L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001880   ⟸   NM_001889
- Peptide Label: isoform a
- UniProtKB: Q5HYE7 (UniProtKB/Swiss-Prot),   Q59EU7 (UniProtKB/Swiss-Prot),   Q53FT0 (UniProtKB/Swiss-Prot),   D3DQ76 (UniProtKB/Swiss-Prot),   A6NN60 (UniProtKB/Swiss-Prot),   Q6NSK9 (UniProtKB/Swiss-Prot),   Q08257 (UniProtKB/Swiss-Prot),   A0A384P5L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001123514   ⟸   NM_001130042
- Peptide Label: isoform a
- UniProtKB: Q5HYE7 (UniProtKB/Swiss-Prot),   Q59EU7 (UniProtKB/Swiss-Prot),   Q53FT0 (UniProtKB/Swiss-Prot),   D3DQ76 (UniProtKB/Swiss-Prot),   A6NN60 (UniProtKB/Swiss-Prot),   Q6NSK9 (UniProtKB/Swiss-Prot),   Q08257 (UniProtKB/Swiss-Prot),   A0A384P5L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011539049   ⟸   XM_011540747
- Peptide Label: isoform X1
- UniProtKB: Q5HYE7 (UniProtKB/Swiss-Prot),   Q59EU7 (UniProtKB/Swiss-Prot),   Q53FT0 (UniProtKB/Swiss-Prot),   D3DQ76 (UniProtKB/Swiss-Prot),   A6NN60 (UniProtKB/Swiss-Prot),   Q6NSK9 (UniProtKB/Swiss-Prot),   Q08257 (UniProtKB/Swiss-Prot),   A0A384P5L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016855856   ⟸   XM_017000367
- Peptide Label: isoform X2
- UniProtKB: A0A384P5L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000359907   ⟸   ENST00000370870
RefSeq Acc Id: ENSP00000359908   ⟸   ENST00000370871
RefSeq Acc Id: ENSP00000359909   ⟸   ENST00000370872
RefSeq Acc Id: ENSP00000404289   ⟸   ENST00000441120
RefSeq Acc Id: ENSP00000399805   ⟸   ENST00000417775
RefSeq Acc Id: ENSP00000339399   ⟸   ENST00000340866
RefSeq Acc Id: XP_047302707   ⟸   XM_047446751
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054190512   ⟸   XM_054334537
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054190511   ⟸   XM_054334536
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054190513   ⟸   XM_054334538
- Peptide Label: isoform X2
Protein Domains
Enoyl reductase (ER)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08257-F1-model_v2 AlphaFold Q08257 1-329 view protein structure

Promoters
RGD ID:6855908
Promoter ID:EPDNEW_H1119
Type:initiation region
Name:CRYZ_1
Description:crystallin zeta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,733,048 - 74,733,108EPDNEW
RGD ID:6814440
Promoter ID:HG_XEF:301
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_174025
Position:
Human AssemblyChrPosition (strand)Source
Build 36174,969,671 - 74,970,171 (-)MPROMDB
RGD ID:6850444
Promoter ID:EP73013
Type:initiation region
Name:HS_CRYZ
Description:Crystallin, zeta (quinone reductase).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36174,971,312 - 74,971,372EPD
RGD ID:6784969
Promoter ID:HG_KWN:3277
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000370870,   ENST00000370872,   NM_001130042,   NM_001130043,   OTTHUMT00000026514,   OTTHUMT00000026563
Position:
Human AssemblyChrPosition (strand)Source
Build 36174,971,556 - 74,972,092 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2419 AgrOrtholog
COSMIC CRYZ COSMIC
Ensembl Genes ENSG00000116791 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000340866 ENTREZGENE
  ENST00000340866.10 UniProtKB/Swiss-Prot
  ENST00000370870.5 UniProtKB/TrEMBL
  ENST00000370871 ENTREZGENE
  ENST00000370871.7 UniProtKB/Swiss-Prot
  ENST00000370872 ENTREZGENE
  ENST00000370872.7 UniProtKB/Swiss-Prot
  ENST00000417775 ENTREZGENE
  ENST00000417775.5 UniProtKB/Swiss-Prot
  ENST00000441120.1 UniProtKB/TrEMBL
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000116791 GTEx
HGNC ID HGNC:2419 ENTREZGENE
Human Proteome Map CRYZ Human Proteome Map
InterPro ADH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKS_ER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Quin_OxRdtase/zeta-crystal_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1429 UniProtKB/Swiss-Prot
NCBI Gene 1429 ENTREZGENE
OMIM 123691 OMIM
PANTHER QUINONE OXIDOREDUCTASE UniProtKB/Swiss-Prot
  QUINONE OXIDOREDUCTASE UniProtKB/Swiss-Prot
  QUINONE OXIDOREDUCTASE UniProtKB/TrEMBL
  QUINONE OXIDOREDUCTASE UniProtKB/TrEMBL
Pfam ADH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CRYZ RGD, PharmGKB
PROSITE QOR_ZETA_CRYSTAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PKS_ER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A384P5L2 ENTREZGENE, UniProtKB/TrEMBL
  A6NN60 ENTREZGENE
  A6NP24_HUMAN UniProtKB/TrEMBL
  C9JH92_HUMAN UniProtKB/TrEMBL
  D3DQ76 ENTREZGENE
  Q08257 ENTREZGENE
  Q53FT0 ENTREZGENE
  Q59EU7 ENTREZGENE
  Q5HYE7 ENTREZGENE
  Q6NSK9 ENTREZGENE
  QOR_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A6NN60 UniProtKB/Swiss-Prot
  D3DQ76 UniProtKB/Swiss-Prot
  Q53FT0 UniProtKB/Swiss-Prot
  Q59EU7 UniProtKB/Swiss-Prot
  Q5HYE7 UniProtKB/Swiss-Prot
  Q6NSK9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 CRYZ  crystallin zeta  CRYZ  crystallin, zeta (quinone reductase)  Symbol and/or name change 5135510 APPROVED