MMP17 (matrix metallopeptidase 17) - Rat Genome Database

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Gene: MMP17 (matrix metallopeptidase 17) Homo sapiens
Analyze
Symbol: MMP17
Name: matrix metallopeptidase 17
RGD ID: 1323053
HGNC Page HGNC:7163
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within drinking behavior and kidney development. Predicted to be located in several cellular components, including extracellular matrix; extracellular region; and side of membrane. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: matrix metallopeptidase 17 (membrane-inserted); matrix metalloproteinase 17 (membrane-inserted); matrix metalloproteinase-17; membrane-type matrix metalloproteinase 4; membrane-type-4 matrix metalloproteinase; MMP-17; MT-MMP 4; MT4-MMP; MT4MMP; MTMMP4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812131,828,393 - 131,851,771 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12131,828,393 - 131,851,783 (+)EnsemblGRCh38hg38GRCh38
GRCh3712132,312,938 - 132,336,316 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612130,878,894 - 130,902,272 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412130,979,170 - 131,002,546NCBI
Celera12131,939,471 - 131,953,072 (+)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12129,198,895 - 129,222,033 (+)NCBIHuRef
CHM1_112132,133,920 - 132,157,125 (+)NCBICHM1_1
T2T-CHM13v2.012131,872,417 - 131,895,761 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8640782   PMID:9878265   PMID:10419448   PMID:10471807   PMID:10543448   PMID:10551873   PMID:10567400   PMID:10640822   PMID:10799478   PMID:10949161   PMID:12477932   PMID:12661033  
PMID:12962706   PMID:14645246   PMID:14701864   PMID:16686598   PMID:19426156   PMID:20019845   PMID:20452482   PMID:20587546   PMID:20673868   PMID:21828052   PMID:21873635   PMID:22262494  
PMID:22674854   PMID:22683712   PMID:25320013   PMID:25963716   PMID:26663028   PMID:28196064   PMID:28531887   PMID:29117863   PMID:29500407   PMID:30792164   PMID:31813546   PMID:34857952  
PMID:35748872   PMID:36042626   PMID:36543142   PMID:38310435  


Genomics

Comparative Map Data
MMP17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812131,828,393 - 131,851,771 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12131,828,393 - 131,851,783 (+)EnsemblGRCh38hg38GRCh38
GRCh3712132,312,938 - 132,336,316 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612130,878,894 - 130,902,272 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412130,979,170 - 131,002,546NCBI
Celera12131,939,471 - 131,953,072 (+)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12129,198,895 - 129,222,033 (+)NCBIHuRef
CHM1_112132,133,920 - 132,157,125 (+)NCBICHM1_1
T2T-CHM13v2.012131,872,417 - 131,895,761 (+)NCBIT2T-CHM13v2.0
Mmp17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395129,661,215 - 129,688,163 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5129,661,233 - 129,688,163 (+)EnsemblGRCm39 Ensembl
GRCm385129,584,151 - 129,611,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5129,584,169 - 129,611,099 (+)EnsemblGRCm38mm10GRCm38
MGSCv375130,090,089 - 130,114,086 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365129,898,922 - 129,922,919 (+)NCBIMGSCv36mm8
Celera5126,627,110 - 126,651,274 (+)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.18NCBI
Mmp17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,710,504 - 32,735,418 (-)NCBIGRCr8
mRatBN7.21227,074,398 - 27,099,317 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,074,409 - 27,099,316 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1228,210,833 - 28,235,729 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,821,391 - 28,846,290 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,882,871 - 27,907,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,701,900 - 30,728,683 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01230,353,874 - 30,356,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,702,571 - 30,728,655 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,636,484 - 32,663,678 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,142,947 - 28,168,483 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11228,007,827 - 28,031,804 (-)NCBI
Celera1228,778,275 - 28,803,185 (-)NCBICelera
Cytogenetic Map12q13NCBI
Mmp17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955482789,968 - 797,301 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955482788,921 - 797,301 (-)NCBIChiLan1.0ChiLan1.0
MMP17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210139,918,156 - 139,943,785 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112139,914,706 - 139,940,301 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012129,481,501 - 129,505,696 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112133,922,882 - 133,936,152 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12133,922,882 - 133,936,152 (+)Ensemblpanpan1.1panPan2
MMP17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1261,008,651 - 1,019,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl261,009,109 - 1,018,662 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,054,484 - 1,073,216 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,072,479 - 1,091,195 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,072,934 - 1,091,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1261,009,626 - 1,028,354 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0261,106,771 - 1,124,956 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0261,029,400 - 1,048,084 (-)NCBIUU_Cfam_GSD_1.0
Mmp17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118122,568,921 - 122,590,193 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366602,139,129 - 2,150,741 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366602,139,777 - 2,152,159 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1423,481,227 - 23,506,919 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11423,481,220 - 23,506,936 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21424,946,584 - 24,972,449 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111127,204,811 - 127,229,202 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11127,214,890 - 127,230,731 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037117,730,300 - 117,813,072 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474727,659,060 - 27,670,447 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474727,658,997 - 27,671,377 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MMP17
59 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q24.23-24.33(chr12:118165459-133182322)x3 copy number gain See cases [RCV000050866] Chr12:118165459..133182322 [GRCh38]
Chr12:118603264..133758908 [GRCh37]
Chr12:117087647..132268981 [NCBI36]
Chr12:12q24.23-24.33		 pathogenic
GRCh38/hg38 12q24.31-24.33(chr12:123444758-133191400)x3 copy number gain See cases [RCV000051151] Chr12:123444758..133191400 [GRCh38]
Chr12:123929305..133767986 [GRCh37]
Chr12:122495258..132278059 [NCBI36]
Chr12:12q24.31-24.33		 pathogenic
GRCh38/hg38 12q24.32-24.33(chr12:126403612-133166920)x3 copy number gain See cases [RCV000053715] Chr12:126403612..133166920 [GRCh38]
Chr12:126888158..133743506 [GRCh37]
Chr12:125454111..132253579 [NCBI36]
Chr12:12q24.32-24.33		 pathogenic
GRCh38/hg38 12q24.33(chr12:131049491-133191400)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053717]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053717]|See cases [RCV000053717] Chr12:131049491..133191400 [GRCh38]
Chr12:131534036..133767986 [GRCh37]
Chr12:130099989..132278059 [NCBI36]
Chr12:12q24.33		 pathogenic
GRCh38/hg38 12q24.21-24.33(chr12:115131583-133166920)x3 copy number gain See cases [RCV000053689] Chr12:115131583..133166920 [GRCh38]
Chr12:115569388..133743506 [GRCh37]
Chr12:114053771..132253579 [NCBI36]
Chr12:12q24.21-24.33		 pathogenic
GRCh38/hg38 12q24.23-24.33(chr12:119417382-133191400)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053691]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053691]|See cases [RCV000053691] Chr12:119417382..133191400 [GRCh38]
Chr12:119855187..133767986 [GRCh37]
Chr12:118339570..132278059 [NCBI36]
Chr12:12q24.23-24.33		 pathogenic
GRCh38/hg38 12q24.31-24.33(chr12:123365769-133191400)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053693]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053693]|See cases [RCV000053693] Chr12:123365769..133191400 [GRCh38]
Chr12:123850316..133767986 [GRCh37]
Chr12:122416269..132278059 [NCBI36]
Chr12:12q24.31-24.33		 pathogenic
NM_016155.4(MMP17):c.346C>T (p.Pro116Ser) single nucleotide variant Malignant melanoma [RCV000069898] Chr12:131838665 [GRCh38]
Chr12:132323210 [GRCh37]
Chr12:130889163 [NCBI36]
Chr12:12q24.33		 not provided
NM_016155.4(MMP17):c.347C>T (p.Pro116Leu) single nucleotide variant Malignant melanoma [RCV000069899] Chr12:131838666 [GRCh38]
Chr12:132323211 [GRCh37]
Chr12:130889164 [NCBI36]
Chr12:12q24.33		 not provided
GRCh38/hg38 12q24.33(chr12:131650542-133191400)x1 copy number loss See cases [RCV000134173] Chr12:131650542..133191400 [GRCh38]
Chr12:132135087..133767986 [GRCh37]
Chr12:130701040..132278059 [NCBI36]
Chr12:12q24.33		 pathogenic
GRCh38/hg38 12q24.31-24.33(chr12:123509825-133191400)x3 copy number gain See cases [RCV000135535] Chr12:123509825..133191400 [GRCh38]
Chr12:123994372..133767986 [GRCh37]
Chr12:122560325..132278059 [NCBI36]
Chr12:12q24.31-24.33		 pathogenic
GRCh38/hg38 12q24.31-24.33(chr12:120697672-133202490)x3 copy number gain See cases [RCV000137651] Chr12:120697672..133202490 [GRCh38]
Chr12:121135475..133779076 [GRCh37]
Chr12:119619858..132289149 [NCBI36]
Chr12:12q24.31-24.33		 pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q24.21-24.33(chr12:114268403-133201316)x3 copy number gain See cases [RCV000143656] Chr12:114268403..133201316 [GRCh38]
Chr12:114706208..133777902 [GRCh37]
Chr12:113190591..132287975 [NCBI36]
Chr12:12q24.21-24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12q24.33(chr12:131749518-133777902)x1 copy number loss See cases [RCV000449052] Chr12:131749518..133777902 [GRCh37]
Chr12:12q24.33		 pathogenic
GRCh37/hg19 12q24.33(chr12:132073314-132457696)x3 copy number gain See cases [RCV000446039] Chr12:132073314..132457696 [GRCh37]
Chr12:12q24.33		 uncertain significance
GRCh37/hg19 12q24.33(chr12:131862310-133777902)x1 copy number loss See cases [RCV000447834] Chr12:131862310..133777902 [GRCh37]
Chr12:12q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12q24.33(chr12:130973400-133777902)x3 copy number gain not provided [RCV000683469] Chr12:130973400..133777902 [GRCh37]
Chr12:12q24.33		 likely pathogenic
GRCh37/hg19 12q24.33(chr12:131808459-132623611)x3 copy number gain not provided [RCV000683450] Chr12:131808459..132623611 [GRCh37]
Chr12:12q24.33		 uncertain significance
GRCh37/hg19 12q24.23-24.33(chr12:120367241-133777645)x3 copy number gain not provided [RCV000738070] Chr12:120367241..133777645 [GRCh37]
Chr12:12q24.23-24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12q24.33(chr12:132335572-132404616)x3 copy number gain not provided [RCV000738098] Chr12:132335572..132404616 [GRCh37]
Chr12:12q24.33		 benign
GRCh37/hg19 12q24.33(chr12:132335572-132405765)x3 copy number gain not provided [RCV000738099] Chr12:132335572..132405765 [GRCh37]
Chr12:12q24.33		 benign
GRCh37/hg19 12q24.33(chr12:132239542-132424944)x3 copy number gain not provided [RCV000750628] Chr12:132239542..132424944 [GRCh37]
Chr12:12q24.33		 benign
GRCh37/hg19 12q24.33(chr12:132306125-132405748)x3 copy number gain not provided [RCV000750629] Chr12:132306125..132405748 [GRCh37]
Chr12:12q24.33		 benign
NM_016155.7(MMP17):c.1553G>T (p.Arg518Leu) single nucleotide variant not specified [RCV004317806] Chr12:131851015 [GRCh38]
Chr12:132335560 [GRCh37]
Chr12:12q24.33		 uncertain significance
GRCh37/hg19 12q24.33(chr12:131363916-133777645)x3 copy number gain See cases [RCV000790570] Chr12:131363916..133777645 [GRCh37]
Chr12:12q24.33		 pathogenic
NM_016155.7(MMP17):c.819G>A (p.Pro273=) single nucleotide variant not provided [RCV000883229] Chr12:131841736 [GRCh38]
Chr12:132326281 [GRCh37]
Chr12:12q24.33		 benign
NM_016155.7(MMP17):c.174G>T (p.Arg58Ser) single nucleotide variant not specified [RCV004296077] Chr12:131838209 [GRCh38]
Chr12:132322754 [GRCh37]
Chr12:12q24.33		 uncertain significance
GRCh37/hg19 12q24.31-24.33(chr12:125451405-133810935) copy number gain not provided [RCV000767827] Chr12:125451405..133810935 [GRCh37]
Chr12:12q24.31-24.33		 pathogenic
GRCh37/hg19 12q24.32-24.33(chr12:126470636-133777902)x1 copy number loss not provided [RCV000848702] Chr12:126470636..133777902 [GRCh37]
Chr12:12q24.32-24.33		 uncertain significance
GRCh37/hg19 12q24.33(chr12:131505849-132681966)x3 copy number gain not provided [RCV000848354] Chr12:131505849..132681966 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1318A>G (p.Asn440Asp) single nucleotide variant not provided [RCV000887936] Chr12:131849915 [GRCh38]
Chr12:132334460 [GRCh37]
Chr12:12q24.33		 benign
NM_016155.7(MMP17):c.232C>A (p.Leu78Met) single nucleotide variant not provided [RCV000963481] Chr12:131838267 [GRCh38]
Chr12:132322812 [GRCh37]
Chr12:12q24.33		 likely benign
NM_016155.7(MMP17):c.744C>T (p.His248=) single nucleotide variant not provided [RCV000958200] Chr12:131841661 [GRCh38]
Chr12:132326206 [GRCh37]
Chr12:12q24.33		 benign
NM_016155.7(MMP17):c.597C>A (p.Pro199=) single nucleotide variant not provided [RCV000957153] Chr12:131840747 [GRCh38]
Chr12:132325292 [GRCh37]
Chr12:12q24.33		 benign
NM_016155.7(MMP17):c.757G>A (p.Ala253Thr) single nucleotide variant not specified [RCV004310445] Chr12:131841674 [GRCh38]
Chr12:132326219 [GRCh37]
Chr12:12q24.33		 uncertain significance
GRCh37/hg19 12q24.33(chr12:132230559-132545601)x3 copy number gain not provided [RCV001260181] Chr12:132230559..132545601 [GRCh37]
Chr12:12q24.33		 uncertain significance
GRCh37/hg19 12q24.22-24.33(chr12:117461902-133841395)x3 copy number gain Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures [RCV001801213] Chr12:117461902..133841395 [GRCh37]
Chr12:12q24.22-24.33		 likely pathogenic
GRCh37/hg19 12q24.33(chr12:131657203-133227428) copy number loss not specified [RCV002053033] Chr12:131657203..133227428 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1661C>T (p.Ser554Leu) single nucleotide variant not specified [RCV004089970] Chr12:131851123 [GRCh38]
Chr12:132335668 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.276G>C (p.Glu92Asp) single nucleotide variant not specified [RCV004240246] Chr12:131838311 [GRCh38]
Chr12:132322856 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.589G>A (p.Gly197Ser) single nucleotide variant not specified [RCV004098163] Chr12:131840739 [GRCh38]
Chr12:132325284 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1480C>T (p.Arg494Cys) single nucleotide variant not specified [RCV004131135] Chr12:131850942 [GRCh38]
Chr12:132335487 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.463A>T (p.Thr155Ser) single nucleotide variant not specified [RCV004128998] Chr12:131840613 [GRCh38]
Chr12:132325158 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.26C>A (p.Pro9His) single nucleotide variant not specified [RCV004233983] Chr12:131828520 [GRCh38]
Chr12:132313065 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1073C>T (p.Thr358Met) single nucleotide variant not specified [RCV004239069] Chr12:131845318 [GRCh38]
Chr12:132329863 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.490C>T (p.Leu164Phe) single nucleotide variant not specified [RCV004119377] Chr12:131840640 [GRCh38]
Chr12:132325185 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.413T>C (p.Leu138Pro) single nucleotide variant not specified [RCV004228936] Chr12:131838732 [GRCh38]
Chr12:132323277 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1669G>A (p.Gly557Ser) single nucleotide variant not specified [RCV004135695] Chr12:131851131 [GRCh38]
Chr12:132335676 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.841G>A (p.Gly281Arg) single nucleotide variant not specified [RCV004136154] Chr12:131841758 [GRCh38]
Chr12:132326303 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.685G>C (p.Ala229Pro) single nucleotide variant not specified [RCV004240353] Chr12:131840835 [GRCh38]
Chr12:132325380 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.617C>T (p.Thr206Ile) single nucleotide variant not specified [RCV004224412] Chr12:131840767 [GRCh38]
Chr12:132325312 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.938C>T (p.Pro313Leu) single nucleotide variant not specified [RCV004205775] Chr12:131844051 [GRCh38]
Chr12:132328596 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.178G>C (p.Gly60Arg) single nucleotide variant not specified [RCV004093279] Chr12:131838213 [GRCh38]
Chr12:132322758 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.562G>A (p.Asp188Asn) single nucleotide variant not specified [RCV004201913] Chr12:131840712 [GRCh38]
Chr12:132325257 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.464C>T (p.Thr155Met) single nucleotide variant not specified [RCV004178323] Chr12:131840614 [GRCh38]
Chr12:132325159 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.955C>T (p.Arg319Trp) single nucleotide variant not specified [RCV004225042] Chr12:131844068 [GRCh38]
Chr12:132328613 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1450C>T (p.Arg484Cys) single nucleotide variant not specified [RCV004162454] Chr12:131850047 [GRCh38]
Chr12:132334592 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.220A>G (p.Thr74Ala) single nucleotide variant not specified [RCV004112993] Chr12:131838255 [GRCh38]
Chr12:132322800 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.889C>T (p.Arg297Trp) single nucleotide variant not specified [RCV004103946] Chr12:131844002 [GRCh38]
Chr12:132328547 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1636C>T (p.Pro546Ser) single nucleotide variant not specified [RCV004230609] Chr12:131851098 [GRCh38]
Chr12:132335643 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.509T>G (p.Ile170Ser) single nucleotide variant not specified [RCV004167765] Chr12:131840659 [GRCh38]
Chr12:132325204 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1732G>C (p.Val578Leu) single nucleotide variant not specified [RCV004146452] Chr12:131851194 [GRCh38]
Chr12:132335739 [GRCh37]
Chr12:12q24.33		 likely benign
NM_016155.7(MMP17):c.427C>T (p.Arg143Trp) single nucleotide variant not specified [RCV004197880] Chr12:131840577 [GRCh38]
Chr12:132325122 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.412C>G (p.Leu138Val) single nucleotide variant not specified [RCV004169822] Chr12:131838731 [GRCh38]
Chr12:132323276 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.228G>C (p.Glu76Asp) single nucleotide variant not specified [RCV004146453] Chr12:131838263 [GRCh38]
Chr12:132322808 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.17C>G (p.Ala6Gly) single nucleotide variant not specified [RCV004169555] Chr12:131828511 [GRCh38]
Chr12:132313056 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1294G>A (p.Asp432Asn) single nucleotide variant not specified [RCV004127561] Chr12:131849891 [GRCh38]
Chr12:132334436 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.256C>G (p.Gln86Glu) single nucleotide variant not specified [RCV004146338] Chr12:131838291 [GRCh38]
Chr12:132322836 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1738G>A (p.Ala580Thr) single nucleotide variant not specified [RCV004184715] Chr12:131851200 [GRCh38]
Chr12:132335745 [GRCh37]
Chr12:12q24.33		 likely benign
NM_016155.7(MMP17):c.674A>T (p.Asp225Val) single nucleotide variant not specified [RCV004216814] Chr12:131840824 [GRCh38]
Chr12:132325369 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.25C>G (p.Pro9Ala) single nucleotide variant not specified [RCV004091286] Chr12:131828519 [GRCh38]
Chr12:132313064 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1103C>T (p.Pro368Leu) single nucleotide variant not specified [RCV004258124] Chr12:131845348 [GRCh38]
Chr12:132329893 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1805C>T (p.Thr602Met) single nucleotide variant not specified [RCV004270766] Chr12:131851267 [GRCh38]
Chr12:132335812 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.662A>C (p.Asp221Ala) single nucleotide variant not specified [RCV004329258] Chr12:131840812 [GRCh38]
Chr12:132325357 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1796A>G (p.Gln599Arg) single nucleotide variant not specified [RCV004329816] Chr12:131851258 [GRCh38]
Chr12:132335803 [GRCh37]
Chr12:12q24.33		 likely benign
NM_016155.7(MMP17):c.619G>A (p.Val207Met) single nucleotide variant not specified [RCV004344121] Chr12:131840769 [GRCh38]
Chr12:132325314 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.221C>A (p.Thr74Lys) single nucleotide variant not specified [RCV004336643] Chr12:131838256 [GRCh38]
Chr12:132322801 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.911C>T (p.Ala304Val) single nucleotide variant not specified [RCV004361848] Chr12:131844024 [GRCh38]
Chr12:132328569 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1613C>T (p.Ala538Val) single nucleotide variant not specified [RCV004345760] Chr12:131851075 [GRCh38]
Chr12:132335620 [GRCh37]
Chr12:12q24.33		 uncertain significance
GRCh37/hg19 12q24.31-24.33(chr12:121551496-133777902)x3 copy number gain not provided [RCV003484881] Chr12:121551496..133777902 [GRCh37]
Chr12:12q24.31-24.33		 pathogenic
GRCh37/hg19 12q24.31-24.33(chr12:120880079-133777902)x3 copy number gain not provided [RCV003484880] Chr12:120880079..133777902 [GRCh37]
Chr12:12q24.31-24.33		 pathogenic
NM_016155.7(MMP17):c.1602G>A (p.Ala534=) single nucleotide variant not provided [RCV003398280] Chr12:131851064 [GRCh38]
Chr12:132335609 [GRCh37]
Chr12:12q24.33		 likely benign
NM_016155.7(MMP17):c.780C>T (p.Ala260=) single nucleotide variant not provided [RCV003398279] Chr12:131841697 [GRCh38]
Chr12:132326242 [GRCh37]
Chr12:12q24.33		 likely benign
NM_016155.7(MMP17):c.283G>A (p.Gly95Ser) single nucleotide variant not specified [RCV004447036] Chr12:131838318 [GRCh38]
Chr12:132322863 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.397T>C (p.Trp133Arg) single nucleotide variant not specified [RCV004447081] Chr12:131838716 [GRCh38]
Chr12:132323261 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.326G>A (p.Arg109His) single nucleotide variant not specified [RCV004447062] Chr12:131838645 [GRCh38]
Chr12:132323190 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.460G>A (p.Asp154Asn) single nucleotide variant not specified [RCV004447181] Chr12:131840610 [GRCh38]
Chr12:132325155 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1076G>A (p.Arg359Gln) single nucleotide variant not specified [RCV004452030] Chr12:131845321 [GRCh38]
Chr12:132329866 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.112G>C (p.Ala38Pro) single nucleotide variant not specified [RCV004452085] Chr12:131828606 [GRCh38]
Chr12:132313151 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1228G>A (p.Asp410Asn) single nucleotide variant not specified [RCV004452117] Chr12:131849825 [GRCh38]
Chr12:132334370 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1288G>A (p.Gly430Ser) single nucleotide variant not specified [RCV004452184] Chr12:131849885 [GRCh38]
Chr12:132334430 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.19C>T (p.Arg7Trp) single nucleotide variant not specified [RCV004454841] Chr12:131828513 [GRCh38]
Chr12:132313058 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1237G>A (p.Val413Ile) single nucleotide variant not specified [RCV004452145] Chr12:131849834 [GRCh38]
Chr12:132334379 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.835C>T (p.Arg279Cys) single nucleotide variant not specified [RCV004449950] Chr12:131841752 [GRCh38]
Chr12:132326297 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1075C>T (p.Arg359Trp) single nucleotide variant not specified [RCV004452008] Chr12:131845320 [GRCh38]
Chr12:132329865 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1461C>A (p.Asp487Glu) single nucleotide variant not specified [RCV004452339] Chr12:131850058 [GRCh38]
Chr12:132334603 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.77T>C (p.Leu26Pro) single nucleotide variant not specified [RCV004449926] Chr12:131828571 [GRCh38]
Chr12:132313116 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1451G>A (p.Arg484His) single nucleotide variant not specified [RCV004452303] Chr12:131850048 [GRCh38]
Chr12:132334593 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.1717G>A (p.Ala573Thr) single nucleotide variant not specified [RCV004326040] Chr12:131851179 [GRCh38]
Chr12:132335724 [GRCh37]
Chr12:12q24.33		 uncertain significance
NM_016155.7(MMP17):c.585C>T (p.Asn195=) single nucleotide variant not provided [RCV003410969] Chr12:131840735 [GRCh38]
Chr12:132325280 [GRCh37]
Chr12:12q24.33		 likely benign
NM_016155.7(MMP17):c.1357C>A (p.Arg453Ser) single nucleotide variant not specified [RCV004452254] Chr12:131849954 [GRCh38]
Chr12:132334499 [GRCh37]
Chr12:12q24.33		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4239
Count of miRNA genes:924
Interacting mature miRNAs:1166
Transcripts:ENST00000360564, ENST00000534865, ENST00000535004, ENST00000535182, ENST00000535271, ENST00000535291, ENST00000537848, ENST00000542142, ENST00000542648, ENST00000545671, ENST00000545790
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH80241  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712132,335,831 - 132,336,022UniSTSGRCh37
Build 3612130,901,784 - 130,901,975RGDNCBI36
Celera12131,952,584 - 131,952,775RGD
Cytogenetic Map12q24.3UniSTS
HuRef12129,221,545 - 129,221,736UniSTS
GeneMap99-GB4 RH Map12499.71UniSTS
RH91194  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712132,336,007 - 132,336,170UniSTSGRCh37
Build 3612130,901,960 - 130,902,123RGDNCBI36
Celera12131,952,760 - 131,952,923RGD
Cytogenetic Map12q24.3UniSTS
HuRef12129,221,721 - 129,221,884UniSTS
GeneMap99-GB4 RH Map12499.71UniSTS
RH48667  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712132,324,654 - 132,324,797UniSTSGRCh37
Build 3612130,890,607 - 130,890,750RGDNCBI36
Celera12131,941,386 - 131,941,529RGD
Cytogenetic Map12q24.3UniSTS
HuRef12129,210,370 - 129,210,513UniSTS
GeneMap99-GB4 RH Map12499.71UniSTS
RH46995  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712132,331,412 - 132,331,532UniSTSGRCh37
Build 3612130,897,365 - 130,897,485RGDNCBI36
Celera12131,948,163 - 131,948,283RGD
Cytogenetic Map12q24.3UniSTS
HuRef12129,217,125 - 129,217,245UniSTS
GeneMap99-GB4 RH Map12500.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 350 26 21 4 102 5 964 164 2326 11 323 87 2 105 612
Low 1945 2692 1335 367 1585 208 3011 1536 1398 174 1073 1451 169 1 1099 1795 2 2
Below cutoff 112 265 352 239 144 237 381 494 9 191 56 71 3 381 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001411000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_944550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_944551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_944552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB021225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC045610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ227546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX389435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA489162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000360564   ⟹   ENSP00000353767
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,828,393 - 131,851,771 (+)Ensembl
RefSeq Acc Id: ENST00000534865   ⟹   ENSP00000442104
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,840,025 - 131,849,981 (+)Ensembl
RefSeq Acc Id: ENST00000535004   ⟹   ENSP00000445620
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,828,393 - 131,851,367 (+)Ensembl
RefSeq Acc Id: ENST00000535182
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,840,736 - 131,845,391 (+)Ensembl
RefSeq Acc Id: ENST00000535271
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,849,835 - 131,851,332 (+)Ensembl
RefSeq Acc Id: ENST00000535291   ⟹   ENSP00000441106
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,838,056 - 131,851,783 (+)Ensembl
RefSeq Acc Id: ENST00000537848   ⟹   ENSP00000443727
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,844,870 - 131,851,030 (+)Ensembl
RefSeq Acc Id: ENST00000542142
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,841,768 - 131,844,721 (+)Ensembl
RefSeq Acc Id: ENST00000542648   ⟹   ENSP00000439542
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,844,961 - 131,850,062 (+)Ensembl
RefSeq Acc Id: ENST00000545671   ⟹   ENSP00000444603
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,828,406 - 131,841,736 (+)Ensembl
RefSeq Acc Id: ENST00000545790   ⟹   ENSP00000441710
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12131,828,495 - 131,851,274 (+)Ensembl
RefSeq Acc Id: NM_001411000   ⟹   NP_001397929
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,830,624 - 131,851,771 (+)NCBI
T2T-CHM13v2.012131,874,657 - 131,895,761 (+)NCBI
RefSeq Acc Id: NM_016155   ⟹   NP_057239
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,828,393 - 131,851,771 (+)NCBI
GRCh3712132,312,941 - 132,336,316 (+)ENTREZGENE
Build 3612130,878,894 - 130,902,272 (+)NCBI Archive
HuRef12129,198,895 - 129,222,033 (+)ENTREZGENE
CHM1_112132,133,917 - 132,157,125 (+)NCBI
T2T-CHM13v2.012131,872,417 - 131,895,761 (+)NCBI
Sequence:
RefSeq Acc Id: NR_182296
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,828,393 - 131,851,771 (+)NCBI
T2T-CHM13v2.012131,872,417 - 131,895,761 (+)NCBI
RefSeq Acc Id: NR_182297
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,828,393 - 131,851,771 (+)NCBI
T2T-CHM13v2.012131,872,417 - 131,895,761 (+)NCBI
RefSeq Acc Id: XM_011538355   ⟹   XP_011536657
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,834,396 - 131,851,771 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011538356   ⟹   XP_011536658
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,834,396 - 131,851,771 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017019307   ⟹   XP_016874796
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,828,393 - 131,849,275 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047428860   ⟹   XP_047284816
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,840,771 - 131,851,771 (+)NCBI
RefSeq Acc Id: XM_047428861   ⟹   XP_047284817
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,828,393 - 131,845,165 (+)NCBI
RefSeq Acc Id: XM_047428862   ⟹   XP_047284818
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,848,278 - 131,851,771 (+)NCBI
RefSeq Acc Id: XM_054372070   ⟹   XP_054228045
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012131,878,391 - 131,895,761 (+)NCBI
RefSeq Acc Id: XM_054372071   ⟹   XP_054228046
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012131,878,391 - 131,895,761 (+)NCBI
RefSeq Acc Id: XM_054372072   ⟹   XP_054228047
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012131,872,417 - 131,893,266 (+)NCBI
RefSeq Acc Id: XM_054372073   ⟹   XP_054228048
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012131,884,763 - 131,895,761 (+)NCBI
RefSeq Acc Id: XM_054372074   ⟹   XP_054228049
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012131,872,417 - 131,889,154 (+)NCBI
RefSeq Acc Id: XM_054372075   ⟹   XP_054228050
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012131,892,268 - 131,895,761 (+)NCBI
RefSeq Acc Id: XR_008488586
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012131,872,417 - 131,889,189 (+)NCBI
RefSeq Acc Id: XR_008488587
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012131,872,417 - 131,889,190 (+)NCBI
RefSeq Acc Id: XR_944551
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,828,393 - 131,845,200 (+)NCBI
Sequence:
RefSeq Acc Id: XR_944552
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,828,393 - 131,845,201 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_057239   ⟸   NM_016155
- Peptide Label: isoform 1 precursor
- UniProtKB: Q14850 (UniProtKB/Swiss-Prot),   Q9ULZ9 (UniProtKB/Swiss-Prot),   Q8IWC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011536657   ⟸   XM_011538355
- Peptide Label: isoform X1
- UniProtKB: Q8IWC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011536658   ⟸   XM_011538356
- Peptide Label: isoform X1
- UniProtKB: Q8IWC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016874796   ⟸   XM_017019307
- Peptide Label: isoform X2
- UniProtKB: F5H209 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000439542   ⟸   ENST00000542648
RefSeq Acc Id: ENSP00000353767   ⟸   ENST00000360564
RefSeq Acc Id: ENSP00000441710   ⟸   ENST00000545790
RefSeq Acc Id: ENSP00000444603   ⟸   ENST00000545671
RefSeq Acc Id: ENSP00000442104   ⟸   ENST00000534865
RefSeq Acc Id: ENSP00000441106   ⟸   ENST00000535291
RefSeq Acc Id: ENSP00000445620   ⟸   ENST00000535004
RefSeq Acc Id: ENSP00000443727   ⟸   ENST00000537848
RefSeq Acc Id: XP_047284817   ⟸   XM_047428861
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047284816   ⟸   XM_047428860
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047284818   ⟸   XM_047428862
- Peptide Label: isoform X5
RefSeq Acc Id: NP_001397929   ⟸   NM_001411000
- Peptide Label: isoform 2
RefSeq Acc Id: XP_054228047   ⟸   XM_054372072
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054228049   ⟸   XM_054372074
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054228046   ⟸   XM_054372071
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054228045   ⟸   XM_054372070
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054228048   ⟸   XM_054372073
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054228050   ⟸   XM_054372075
- Peptide Label: isoform X5
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ULZ9-F1-model_v2 AlphaFold Q9ULZ9 1-603 view protein structure

Promoters
RGD ID:6790267
Promoter ID:HG_KWN:17070
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000360564
Position:
Human AssemblyChrPosition (strand)Source
Build 3612130,878,691 - 130,879,191 (+)MPROMDB
RGD ID:7225865
Promoter ID:EPDNEW_H18679
Type:initiation region
Name:MMP17_1
Description:matrix metallopeptidase 17
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812131,828,393 - 131,828,453EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7163 AgrOrtholog
COSMIC MMP17 COSMIC
Ensembl Genes ENSG00000198598 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000360564 ENTREZGENE
  ENST00000360564.5 UniProtKB/Swiss-Prot
  ENST00000535004 ENTREZGENE
  ENST00000535004.2 UniProtKB/TrEMBL
  ENST00000535291 ENTREZGENE
  ENST00000535291.5 UniProtKB/Swiss-Prot
  ENST00000545671.6 UniProtKB/TrEMBL
  ENST00000545790 ENTREZGENE
  ENST00000545790.6 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000198598 GTEx
HGNC ID HGNC:7163 ENTREZGENE
Human Proteome Map MMP17 Human Proteome Map
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4326 UniProtKB/Swiss-Prot
NCBI Gene 4326 ENTREZGENE
OMIM 602285 OMIM
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10201:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30875 PharmGKB
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F5GWR3_HUMAN UniProtKB/TrEMBL
  F5GZA7_HUMAN UniProtKB/TrEMBL
  F5H209 ENTREZGENE, UniProtKB/TrEMBL
  MMP17_HUMAN UniProtKB/Swiss-Prot
  Q14850 ENTREZGENE
  Q5U5M0_HUMAN UniProtKB/TrEMBL
  Q8IWC3 ENTREZGENE, UniProtKB/TrEMBL
  Q9ULZ9 ENTREZGENE
UniProt Secondary Q14850 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 MMP17  matrix metallopeptidase 17  MMP17  matrix metallopeptidase 17 (membrane-inserted)  Symbol and/or name change 5135510 APPROVED