LANCL2 (LanC like glutathione S-transferase 2) - Rat Genome Database

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Gene: LANCL2 (LanC like glutathione S-transferase 2) Homo sapiens
Analyze
Symbol: LANCL2
Name: LanC like glutathione S-transferase 2
RGD ID: 1321926
HGNC Page HGNC:6509
Description: Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of DNA-templated transcription and positive regulation of abscisic acid-activated signaling pathway. Located in several cellular components, including cortical actin cytoskeleton; cytosol; and nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 69B; GPR69B; LanC (bacterial lantibiotic synthetase component C)-like 2; LanC lantibiotic synthetase component C-like 2; LanC like 2; lanC-like protein 2; MGC87139; TASP; testis-specific adriamycin sensitivity protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38755,365,337 - 55,433,737 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl755,365,337 - 55,433,737 (+)EnsemblGRCh38hg38GRCh38
GRCh37755,433,030 - 55,501,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36755,400,635 - 55,468,929 (+)NCBINCBI36Build 36hg18NCBI36
Build 34755,207,349 - 55,275,644NCBI
Celera755,536,348 - 55,604,629 (+)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef755,268,359 - 55,336,642 (+)NCBIHuRef
CHM1_1755,435,807 - 55,504,119 (+)NCBICHM1_1
T2T-CHM13v2.0755,525,667 - 55,594,061 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2755,437,426 - 55,505,717 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cortical actin cytoskeleton  (IDA)
cytoplasm  (IEA)
cytosol  (IDA)
nucleoplasm  (IDA)
nucleus  (HDA,IDA,IEA)
plasma membrane  (IBA,IDA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:11762191   PMID:12477932   PMID:12566319   PMID:12690205   PMID:12853948   PMID:14702039   PMID:15489334   PMID:16979580   PMID:18029348   PMID:19165527   PMID:19615732  
PMID:19667068   PMID:20512604   PMID:21044950   PMID:21630459   PMID:21832049   PMID:21873635   PMID:22037458   PMID:22354994   PMID:22658674   PMID:22939629   PMID:23956138   PMID:24981860  
PMID:25273559   PMID:25416956   PMID:25963833   PMID:26186194   PMID:26439863   PMID:26549023   PMID:26598620   PMID:27222287   PMID:27365398   PMID:27684187   PMID:28514442   PMID:28515276  
PMID:28675297   PMID:29229926   PMID:29421190   PMID:29564676   PMID:30196744   PMID:30948266   PMID:31048545   PMID:31091453   PMID:31871319   PMID:32296183   PMID:32552912   PMID:32591558  
PMID:32812023   PMID:32963011   PMID:33545068   PMID:33568630   PMID:33961781   PMID:34349018   PMID:34461927   PMID:34591877   PMID:35256949   PMID:35509820   PMID:35563538   PMID:35831314  
PMID:35944360   PMID:36089195   PMID:36114006   PMID:36215168   PMID:36526897   PMID:36929488   PMID:37499664   PMID:37689310   PMID:38113892   PMID:38624012  


Genomics

Comparative Map Data
LANCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38755,365,337 - 55,433,737 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl755,365,337 - 55,433,737 (+)EnsemblGRCh38hg38GRCh38
GRCh37755,433,030 - 55,501,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36755,400,635 - 55,468,929 (+)NCBINCBI36Build 36hg18NCBI36
Build 34755,207,349 - 55,275,644NCBI
Celera755,536,348 - 55,604,629 (+)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef755,268,359 - 55,336,642 (+)NCBIHuRef
CHM1_1755,435,807 - 55,504,119 (+)NCBICHM1_1
T2T-CHM13v2.0755,525,667 - 55,594,061 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2755,437,426 - 55,505,717 (+)NCBI
Lancl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39657,679,440 - 57,716,434 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl657,679,525 - 57,716,424 (+)EnsemblGRCm39 Ensembl
GRCm38657,702,455 - 57,739,449 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl657,702,540 - 57,739,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv37657,652,449 - 57,689,443 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36657,632,214 - 57,668,060 (+)NCBIMGSCv36mm8
Celera658,446,120 - 58,483,175 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.82NCBI
Lancl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8488,771,974 - 88,813,920 (-)NCBIGRCr8
mRatBN7.2487,441,821 - 87,483,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl487,441,823 - 87,482,800 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx492,665,021 - 92,704,609 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0488,440,426 - 88,480,014 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0486,803,501 - 86,843,013 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0488,524,212 - 88,565,113 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl488,525,695 - 88,565,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04153,346,850 - 153,387,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4487,197,364 - 87,236,803 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1487,439,372 - 87,480,274 (-)NCBI
Celera482,209,185 - 82,248,518 (-)NCBICelera
Cytogenetic Map4q24NCBI
Lancl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955456204,434 - 229,371 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955456204,434 - 250,143 (-)NCBIChiLan1.0ChiLan1.0
LANCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2660,198,037 - 60,264,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17108,522,754 - 108,589,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0755,958,850 - 56,025,166 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1756,268,426 - 56,335,549 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl756,268,426 - 56,335,549 (+)Ensemblpanpan1.1panPan2
LANCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1186,131,536 - 6,237,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl186,197,989 - 6,234,856 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha186,035,458 - 6,082,375 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0186,232,306 - 6,279,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl186,231,806 - 6,280,793 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1186,222,155 - 6,269,095 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0186,196,304 - 6,243,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0186,302,518 - 6,349,674 (+)NCBIUU_Cfam_GSD_1.0
Lancl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118109,623,089 - 109,672,284 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936678219,991 - 265,627 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936678217,272 - 268,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LANCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1848,550,944 - 48,593,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11848,550,752 - 48,593,055 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LANCL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,435,435 - 3,503,802 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,434,909 - 3,501,335 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606219,087,225 - 19,155,311 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lancl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624740485,874 - 514,638 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624740487,173 - 514,484 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LANCL2
28 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p12.1-11.2(chr7:52114454-57434735)x1 copy number loss See cases [RCV000052656] Chr7:52114454..57434735 [GRCh38]
Chr7:52182150..57493216 [GRCh37]
Chr7:52149644..57498383 [NCBI36]
Chr7:7p12.1-11.2		 uncertain significance
GRCh38/hg38 7p12.1-11.2(chr7:52192528-57823293)x3 copy number gain See cases [RCV000053439] Chr7:52192528..57823293 [GRCh38]
Chr7:52260224..57882999 [GRCh37]
Chr7:52227718..57886941 [NCBI36]
Chr7:7p12.1-11.2		 uncertain significance
GRCh38/hg38 7p12.1-11.2(chr7:53450330-56107195)x3 copy number gain See cases [RCV000053440] Chr7:53450330..56107195 [GRCh38]
Chr7:53518023..56174888 [GRCh37]
Chr7:53485517..56142382 [NCBI36]
Chr7:7p12.1-11.2		 uncertain significance
GRCh38/hg38 7p14.3-q11.21(chr7:33328312-62377476)x3 copy number gain See cases [RCV000053532] Chr7:33328312..62377476 [GRCh38]
Chr7:33367924..61831899 [GRCh37]
Chr7:33334449..61469334 [NCBI36]
Chr7:7p14.3-q11.21		 pathogenic
GRCh38/hg38 7p12.1-q11.22(chr7:53274059-68576213)x3 copy number gain See cases [RCV000053534] Chr7:53274059..68576213 [GRCh38]
Chr7:53341752..68041200 [GRCh37]
Chr7:53309246..67679136 [NCBI36]
Chr7:7p12.1-q11.22		 pathogenic
NM_018697.3(LANCL2):c.643G>A (p.Gly215Ser) single nucleotide variant Malignant melanoma [RCV000067912] Chr7:55400069 [GRCh38]
Chr7:55467762 [GRCh37]
Chr7:55435256 [NCBI36]
Chr7:7p11.2		 not provided
NM_018697.3(LANCL2):c.1127C>T (p.Ser376Phe) single nucleotide variant Malignant melanoma [RCV000061659] Chr7:55425372 [GRCh38]
Chr7:55493065 [GRCh37]
Chr7:55460559 [NCBI36]
Chr7:7p11.2		 not provided
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p14.1-11.2(chr7:40534157-56107122)x1 copy number loss See cases [RCV000136092] Chr7:40534157..56107122 [GRCh38]
Chr7:40573756..56174815 [GRCh37]
Chr7:40540281..56142309 [NCBI36]
Chr7:7p14.1-11.2		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p11.2(chr7:54972516-56172165)x1 copy number loss See cases [RCV000445658] Chr7:54972516..56172165 [GRCh37]
Chr7:7p11.2		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_018697.4(LANCL2):c.1313G>A (p.Arg438Gln) single nucleotide variant not specified [RCV004298717] Chr7:55431280 [GRCh38]
Chr7:55498973 [GRCh37]
Chr7:7p11.2		 uncertain significance
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
Single allele duplication Autism [RCV000754332] Chr7:52551984..56315037 [GRCh38]
Chr7:7p12.1-11.2		 likely pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_018697.4(LANCL2):c.924A>G (p.Ser308=) single nucleotide variant not provided [RCV000963204] Chr7:55412005 [GRCh38]
Chr7:55479698 [GRCh37]
Chr7:7p11.2		 benign
GRCh37/hg19 7p12.1-11.1(chr7:52809787-58025873)x1 copy number loss not provided [RCV000846150] Chr7:52809787..58025873 [GRCh37]
Chr7:7p12.1-11.1		 uncertain significance
NM_018697.4(LANCL2):c.7G>A (p.Glu3Lys) single nucleotide variant not specified [RCV004324684] Chr7:55366032 [GRCh38]
Chr7:55433725 [GRCh37]
Chr7:7p11.2		 uncertain significance
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
NM_018697.4(LANCL2):c.1168C>T (p.Leu390Phe) single nucleotide variant not specified [RCV004320660] Chr7:55425413 [GRCh38]
Chr7:55493106 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.131C>T (p.Ala44Val) single nucleotide variant not specified [RCV004236257] Chr7:55366156 [GRCh38]
Chr7:55433849 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.1081C>T (p.Arg361Trp) single nucleotide variant not specified [RCV004151956] Chr7:55425326 [GRCh38]
Chr7:55493019 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.935A>G (p.Asn312Ser) single nucleotide variant not specified [RCV004223736] Chr7:55412016 [GRCh38]
Chr7:55479709 [GRCh37]
Chr7:7p11.2		 uncertain significance
GRCh37/hg19 7p12.1-11.2(chr7:53991820-56148011)x3 copy number gain not provided [RCV002475815] Chr7:53991820..56148011 [GRCh37]
Chr7:7p12.1-11.2		 uncertain significance
NM_018697.4(LANCL2):c.830C>T (p.Ala277Val) single nucleotide variant not specified [RCV004117178] Chr7:55411911 [GRCh38]
Chr7:55479604 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.92A>G (p.Tyr31Cys) single nucleotide variant not specified [RCV004164595] Chr7:55366117 [GRCh38]
Chr7:55433810 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.655G>A (p.Val219Met) single nucleotide variant not specified [RCV004138085] Chr7:55400081 [GRCh38]
Chr7:55467774 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.391G>T (p.Asp131Tyr) single nucleotide variant not specified [RCV004150546] Chr7:55398491 [GRCh38]
Chr7:55466184 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.86C>T (p.Pro29Leu) single nucleotide variant not specified [RCV004124491] Chr7:55366111 [GRCh38]
Chr7:55433804 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.397G>A (p.Val133Ile) single nucleotide variant not specified [RCV004238747] Chr7:55398497 [GRCh38]
Chr7:55466190 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.103G>C (p.Ala35Pro) single nucleotide variant not specified [RCV004107946] Chr7:55366128 [GRCh38]
Chr7:55433821 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.563A>G (p.Gln188Arg) single nucleotide variant not specified [RCV004164092] Chr7:55399989 [GRCh38]
Chr7:55467682 [GRCh37]
Chr7:7p11.2		 likely benign
NM_018697.4(LANCL2):c.548G>T (p.Arg183Ile) single nucleotide variant not specified [RCV004214914] Chr7:55399974 [GRCh38]
Chr7:55467667 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.192T>G (p.His64Gln) single nucleotide variant not specified [RCV004231529] Chr7:55366217 [GRCh38]
Chr7:55433910 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.1219G>A (p.Gly407Arg) single nucleotide variant not specified [RCV004203928] Chr7:55428408 [GRCh38]
Chr7:55496101 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.1175G>A (p.Arg392Gln) single nucleotide variant not specified [RCV004084374] Chr7:55425420 [GRCh38]
Chr7:55493113 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.190C>T (p.His64Tyr) single nucleotide variant not specified [RCV004240002] Chr7:55366215 [GRCh38]
Chr7:55433908 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.11C>T (p.Thr4Ile) single nucleotide variant not specified [RCV004252337] Chr7:55366036 [GRCh38]
Chr7:55433729 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.122C>T (p.Ser41Phe) single nucleotide variant not specified [RCV004287507] Chr7:55366147 [GRCh38]
Chr7:55433840 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.1270G>A (p.Ala424Thr) single nucleotide variant not specified [RCV004328269] Chr7:55431237 [GRCh38]
Chr7:55498930 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.433G>T (p.Val145Phe) single nucleotide variant not specified [RCV004355976] Chr7:55398533 [GRCh38]
Chr7:55466226 [GRCh37]
Chr7:7p11.2		 uncertain significance
GRCh37/hg19 7p11.2-11.1(chr7:55498635-58025873)x3 copy number gain not provided [RCV003484683] Chr7:55498635..58025873 [GRCh37]
Chr7:7p11.2-11.1		 uncertain significance
NM_018697.4(LANCL2):c.1093G>A (p.Gly365Arg) single nucleotide variant not specified [RCV004410087] Chr7:55425338 [GRCh38]
Chr7:55493031 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.110C>A (p.Ala37Glu) single nucleotide variant not specified [RCV004410088] Chr7:55366135 [GRCh38]
Chr7:55433828 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.149T>C (p.Val50Ala) single nucleotide variant not specified [RCV004410090] Chr7:55366174 [GRCh38]
Chr7:55433867 [GRCh37]
Chr7:7p11.2		 likely benign
NM_018697.4(LANCL2):c.163A>C (p.Thr55Pro) single nucleotide variant not specified [RCV004410091] Chr7:55366188 [GRCh38]
Chr7:55433881 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.386C>G (p.Ser129Cys) single nucleotide variant not specified [RCV004410092] Chr7:55398486 [GRCh38]
Chr7:55466179 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.680T>C (p.Val227Ala) single nucleotide variant not specified [RCV004410093] Chr7:55401175 [GRCh38]
Chr7:55468868 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.782G>C (p.Gly261Ala) single nucleotide variant not specified [RCV004410094] Chr7:55401277 [GRCh38]
Chr7:55468970 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.839T>C (p.Val280Ala) single nucleotide variant not specified [RCV004410095] Chr7:55411920 [GRCh38]
Chr7:55479613 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.847G>A (p.Glu283Lys) single nucleotide variant not specified [RCV004410096] Chr7:55411928 [GRCh38]
Chr7:55479621 [GRCh37]
Chr7:7p11.2		 uncertain significance
NM_018697.4(LANCL2):c.905G>A (p.Arg302Gln) single nucleotide variant not specified [RCV004353945] Chr7:55411986 [GRCh38]
Chr7:55479679 [GRCh37]
Chr7:7p11.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1963
Count of miRNA genes:966
Interacting mature miRNAs:1148
Transcripts:ENST00000254770, ENST00000452107, ENST00000466041, ENST00000476479, ENST00000486376
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
GDB:1317264  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37755,444,321 - 55,444,431UniSTSGRCh37
Build 36755,411,815 - 55,411,925RGDNCBI36
Celera755,547,518 - 55,547,628RGD
Cytogenetic Map7q31.1-q31.33UniSTS
HuRef755,279,530 - 55,279,640UniSTS
CRA_TCAGchr7v2755,448,597 - 55,448,707UniSTS
WIAF-2178  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37755,501,186 - 55,501,372UniSTSGRCh37
Build 36755,468,680 - 55,468,866RGDNCBI36
Celera755,604,380 - 55,604,566RGD
Cytogenetic Map7q31.1-q31.33UniSTS
HuRef755,336,393 - 55,336,579UniSTS
CRA_TCAGchr7v2755,505,468 - 55,505,654UniSTS
GeneMap99-GB4 RH Map7256.75UniSTS
RH79715  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37755,498,954 - 55,499,174UniSTSGRCh37
Build 36755,466,448 - 55,466,668RGDNCBI36
Celera755,602,148 - 55,602,368RGD
Cytogenetic Map7q31.1-q31.33UniSTS
HuRef755,334,161 - 55,334,381UniSTS
CRA_TCAGchr7v2755,503,236 - 55,503,456UniSTS
GeneMap99-GB4 RH Map7257.79UniSTS
D7S2156E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37755,499,712 - 55,499,859UniSTSGRCh37
Build 36755,467,206 - 55,467,353RGDNCBI36
Celera755,602,906 - 55,603,053RGD
Cytogenetic Map7q31.1-q31.33UniSTS
HuRef755,334,919 - 55,335,066UniSTS
CRA_TCAGchr7v2755,503,994 - 55,504,141UniSTS
D7S2128E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37755,501,107 - 55,501,214UniSTSGRCh37
Build 36755,468,601 - 55,468,708RGDNCBI36
Celera755,604,301 - 55,604,408RGD
Cytogenetic Map7q31.1-q31.33UniSTS
HuRef755,336,314 - 55,336,421UniSTS
CRA_TCAGchr7v2755,505,389 - 55,505,496UniSTS
Stanford-G3 RH Map72469.0UniSTS
GeneMap99-GB4 RH Map7261.97UniSTS
GeneMap99-G3 RH Map72469.0UniSTS
WI-16990  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37755,463,159 - 55,463,262UniSTSGRCh37
Build 36755,430,653 - 55,430,756RGDNCBI36
Celera755,566,346 - 55,566,449RGD
Cytogenetic Map7q31.1-q31.33UniSTS
HuRef755,298,433 - 55,298,536UniSTS
CRA_TCAGchr7v2755,467,422 - 55,467,525UniSTS
GeneMap99-GB4 RH Map7250.82UniSTS
Whitehead-RH Map7224.6UniSTS
NCBI RH Map7774.7UniSTS
WI-18503  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37755,500,212 - 55,500,361UniSTSGRCh37
Build 36755,467,706 - 55,467,855RGDNCBI36
Celera755,603,406 - 55,603,555RGD
Cytogenetic Map7q31.1-q31.33UniSTS
HuRef755,335,419 - 55,335,568UniSTS
CRA_TCAGchr7v2755,504,494 - 55,504,643UniSTS
GeneMap99-GB4 RH Map7257.72UniSTS
Whitehead-RH Map7225.4UniSTS
NCBI RH Map7770.8UniSTS
GDB:4585065  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37755,499,076 - 55,499,177UniSTSGRCh37
Build 36755,466,570 - 55,466,671RGDNCBI36
Celera755,602,270 - 55,602,371RGD
Cytogenetic Map7q31.1-q31.33UniSTS
HuRef755,334,283 - 55,334,384UniSTS
CRA_TCAGchr7v2755,503,358 - 55,503,459UniSTS
GDB:4585709  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37755,437,780 - 55,437,868UniSTSGRCh37
Build 36755,405,274 - 55,405,362RGDNCBI36
Celera755,540,994 - 55,541,082RGD
Cytogenetic Map7q31.1-q31.33UniSTS
HuRef755,273,005 - 55,273,093UniSTS
CRA_TCAGchr7v2755,442,072 - 55,442,160UniSTS
SHGC-32070  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37755,500,192 - 55,500,341UniSTSGRCh37
Build 36755,467,686 - 55,467,835RGDNCBI36
Celera755,603,386 - 55,603,535RGD
Cytogenetic Map7q31.1-q31.33UniSTS
HuRef755,335,399 - 55,335,548UniSTS
CRA_TCAGchr7v2755,504,474 - 55,504,623UniSTS
TNG Radiation Hybrid Map726697.0UniSTS
Stanford-G3 RH Map72462.0UniSTS
GeneMap99-GB4 RH Map7257.72UniSTS
Whitehead-RH Map7229.1UniSTS
GeneMap99-G3 RH Map72462.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 1 2
Medium 304 41 838 89 624 76 1065 104 2702 238 1063 756 23 120 539 2
Low 2127 2856 885 533 1265 388 3289 2061 1013 180 386 852 149 1084 2248 2
Below cutoff 2 87 59 1 28 13 1 5 1 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_018697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA994905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB035966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC073347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF353942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ278245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL713665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF590020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI869599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000254770   ⟹   ENSP00000254770
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl755,365,337 - 55,433,737 (+)Ensembl
RefSeq Acc Id: ENST00000452107   ⟹   ENSP00000387598
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl755,366,111 - 55,431,528 (+)Ensembl
RefSeq Acc Id: ENST00000466041
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl755,428,056 - 55,431,406 (+)Ensembl
RefSeq Acc Id: ENST00000476479
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl755,411,360 - 55,431,322 (+)Ensembl
RefSeq Acc Id: ENST00000486376
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl755,394,069 - 55,400,107 (+)Ensembl
RefSeq Acc Id: NM_018697   ⟹   NP_061167
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38755,365,337 - 55,433,737 (+)NCBI
GRCh37755,433,141 - 55,501,435 (+)RGD
Build 36755,400,635 - 55,468,929 (+)NCBI Archive
Celera755,536,348 - 55,604,629 (+)RGD
HuRef755,268,359 - 55,336,642 (+)RGD
CHM1_1755,435,807 - 55,504,119 (+)NCBI
T2T-CHM13v2.0755,525,667 - 55,594,061 (+)NCBI
CRA_TCAGchr7v2755,437,426 - 55,505,717 (+)RGD
Sequence:
RefSeq Acc Id: XM_047420614   ⟹   XP_047276570
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38755,366,355 - 55,433,737 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_061167   ⟸   NM_018697
- UniProtKB: Q8TCQ3 (UniProtKB/Swiss-Prot),   Q6NSL4 (UniProtKB/Swiss-Prot),   B2R8D4 (UniProtKB/Swiss-Prot),   Q9BSR1 (UniProtKB/Swiss-Prot),   Q9NS86 (UniProtKB/Swiss-Prot),   B3KTN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000254770   ⟸   ENST00000254770
RefSeq Acc Id: ENSP00000387598   ⟸   ENST00000452107
RefSeq Acc Id: XP_047276570   ⟸   XM_047420614
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NS86-F1-model_v2 AlphaFold Q9NS86 1-450 view protein structure

Promoters
RGD ID:7210619
Promoter ID:EPDNEW_H11055
Type:initiation region
Name:LANCL2_1
Description:LanC like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11056  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38755,365,337 - 55,365,397EPDNEW
RGD ID:7210621
Promoter ID:EPDNEW_H11056
Type:initiation region
Name:LANCL2_2
Description:LanC like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11055  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38755,365,531 - 55,365,591EPDNEW
RGD ID:6805860
Promoter ID:HG_KWN:57476
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   Jurkat,   K562,   Lymphoblastoid
Transcripts:NM_018697,   OTTHUMT00000343064
Position:
Human AssemblyChrPosition (strand)Source
Build 36755,400,026 - 55,401,382 (+)MPROMDB
RGD ID:6813301
Promoter ID:HG_ACW:72299
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:LANCL2.HAPR07-UNSPLICED,   SNORBLORBY.AAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 36755,401,246 - 55,401,746 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6509 AgrOrtholog
COSMIC LANCL2 COSMIC
Ensembl Genes ENSG00000132434 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000254770 ENTREZGENE
  ENST00000254770.3 UniProtKB/Swiss-Prot
  ENST00000452107.6 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000132434 GTEx
HGNC ID HGNC:6509 ENTREZGENE
Human Proteome Map LANCL2 Human Proteome Map
InterPro 6hp_glycosidase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LANC-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LanC-like_prot_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:55915 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 55915 ENTREZGENE
OMIM 612919 OMIM
PANTHER LANC-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LANC-LIKE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LANC_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30294 PharmGKB
PRINTS LANCEUKARYTE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LANCSUPER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LANC_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP LanC-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R8D4 ENTREZGENE
  B3KTN5 ENTREZGENE, UniProtKB/TrEMBL
  H7BZ40_HUMAN UniProtKB/TrEMBL
  LANC2_HUMAN UniProtKB/Swiss-Prot
  Q6NSL4 ENTREZGENE
  Q8TCQ3 ENTREZGENE
  Q9BSR1 ENTREZGENE
  Q9NS86 ENTREZGENE
UniProt Secondary B2R8D4 UniProtKB/Swiss-Prot
  Q6NSL4 UniProtKB/Swiss-Prot
  Q8TCQ3 UniProtKB/Swiss-Prot
  Q9BSR1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-20 LANCL2  LanC like glutathione S-transferase 2  LANCL2  LanC like 2  Symbol and/or name change 19259463 PROVISIONAL
2016-01-12 LANCL2  LanC like 2    LanC lantibiotic synthetase component C-like 2 (bacterial)  Symbol and/or name change 5135510 APPROVED