Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | PSCA | Human | 1-naphthyl isothiocyanate | increases expression | ISO | Psca (Rattus norvegicus) | 6480464 | 1-Naphthylisothiocyanate results in increased expression of PSCA mRNA | CTD | PMID:30723492 | PSCA | Human | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PSCA mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of PSCA mRNA | CTD | PMID:19619570 and PMID:30165855 | PSCA | Human | 17beta-estradiol | increases expression | ISO | Psca (Mus musculus) | 6480464 | Estradiol results in increased expression of PSCA mRNA | CTD | PMID:30077407 | PSCA | Human | 17beta-estradiol | multiple interactions | ISO | Psca (Mus musculus) | 6480464 | [Polyphenols co-treated with Estradiol] results in decreased expression of PSCA mRNA | CTD | PMID:30077407 | PSCA | Human | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PSCA mRNA | CTD | PMID:19619570 more ... | PSCA | Human | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PSCA mRNA more ... | CTD | PMID:14761676 and PMID:19619570 | PSCA | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Psca (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PSCA mRNA | CTD | PMID:21570461 | PSCA | Human | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PSCA mRNA | CTD | PMID:19619570 and PMID:20106945 | PSCA | Human | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Psca (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PSCA mRNA | CTD | PMID:17035482 | PSCA | Human | 3,3',5-triiodo-L-thyronine | multiple interactions | EXP | | 6480464 | 4-OH-2' more ... | CTD | PMID:14761676 | PSCA | Human | 3,3',5-triiodo-L-thyronine | increases expression | EXP | | 6480464 | Triiodothyronine results in increased expression of PSCA mRNA and Triiodothyronine results in increased expression of PSCA protein | CTD | PMID:14761676 | PSCA | Human | 4,4'-diaminodiphenylmethane | increases expression | ISO | Psca (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of PSCA mRNA | CTD | PMID:18648102 | PSCA | Human | 4,4'-sulfonyldiphenol | decreases expression | EXP | | 6480464 | bisphenol S results in decreased expression of PSCA mRNA | CTD | PMID:28591870 | PSCA | Human | 4,4'-sulfonyldiphenol | increases expression | ISO | Psca (Mus musculus) | 6480464 | bisphenol S results in increased expression of PSCA mRNA | CTD | PMID:30951980 | PSCA | Human | acetamide | increases expression | ISO | Psca (Rattus norvegicus) | 6480464 | acetamide results in increased expression of PSCA mRNA | CTD | PMID:31881176 | PSCA | Human | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of PSCA promoter | CTD | PMID:30157460 | PSCA | Human | Aflatoxin B2 alpha | increases methylation | EXP | | 6480464 | aflatoxin B2 results in increased methylation of PSCA intron | CTD | PMID:30157460 | PSCA | Human | amiodarone | decreases expression | ISO | Psca (Rattus norvegicus) | 6480464 | Amiodarone results in decreased expression of PSCA mRNA | CTD | PMID:17991464 | PSCA | Human | apigenin | decreases expression | EXP | | 6480464 | Apigenin results in decreased expression of PSCA mRNA | CTD | PMID:18331776 | PSCA | Human | aristolochic acid A | increases expression | EXP | | 6480464 | aristolochic acid I results in increased expression of PSCA mRNA | CTD | PMID:33212167 | PSCA | Human | arsenite(3-) | decreases methylation | EXP | | 6480464 | arsenite results in decreased methylation of PSCA promoter | CTD | PMID:23974009 | PSCA | Human | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of PSCA intron and Benzo(a)pyrene affects the methylation of PSCA promoter | CTD | PMID:27901495 and PMID:30157460 | PSCA | Human | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of PSCA mRNA | CTD | PMID:35870112 | PSCA | Human | benzo[a]pyrene diol epoxide I | increases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:19150397 | PSCA | Human | benzo[e]pyrene | increases methylation | EXP | | 6480464 | benzo(e)pyrene results in increased methylation of PSCA intron | CTD | PMID:30157460 | PSCA | Human | bis(2-ethylhexyl) phthalate | increases expression | ISO | Psca (Rattus norvegicus) | 6480464 | Diethylhexyl Phthalate results in increased expression of PSCA mRNA | CTD | PMID:29689378 | PSCA | Human | bis(2-ethylhexyl) phthalate | decreases methylation | ISO | Psca (Rattus norvegicus) | 6480464 | Diethylhexyl Phthalate results in decreased methylation of PSCA gene and Diethylhexyl Phthalate results in decreased methylation of PSCA promoter | CTD | PMID:29689378 | PSCA | Human | bisphenol A | decreases expression | ISO | Psca (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PSCA mRNA | CTD | PMID:22687993 | PSCA | Human | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PSCA protein | CTD | PMID:33376534 | PSCA | Human | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PSCA mRNA | CTD | PMID:28591870 and PMID:28711546 | PSCA | Human | Bisphenol B | decreases expression | EXP | | 6480464 | bisphenol B results in decreased expression of PSCA mRNA | CTD | PMID:28591870 | PSCA | Human | bisphenol F | decreases expression | EXP | | 6480464 | bisphenol F results in decreased expression of PSCA mRNA | CTD | PMID:28591870 | PSCA | Human | bisphenol F | increases expression | ISO | Psca (Mus musculus) | 6480464 | bisphenol F results in increased expression of PSCA mRNA | CTD | PMID:30951980 | PSCA | Human | cantharidin | increases expression | ISO | Psca (Mus musculus) | 6480464 | Cantharidin results in increased expression of PSCA mRNA | CTD | PMID:36907384 | PSCA | Human | carbon nanotube | increases expression | ISO | Psca (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of PSCA mRNA | CTD | PMID:25554681 | PSCA | Human | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PSCA gene] | CTD | PMID:28238834 | PSCA | Human | chlordecone | increases expression | ISO | Psca (Mus musculus) | 6480464 | Chlordecone results in increased expression of PSCA mRNA | CTD | PMID:33711761 | PSCA | Human | chrysin | decreases expression | EXP | | 6480464 | chrysin results in decreased expression of PSCA mRNA | CTD | PMID:18331776 | PSCA | Human | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of PSCA mRNA | CTD | PMID:27392435 | PSCA | Human | cobalt dichloride | decreases expression | ISO | Psca (Rattus norvegicus) | 6480464 | cobaltous chloride results in decreased expression of PSCA mRNA | CTD | PMID:24386269 | PSCA | Human | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of PSCA mRNA | CTD | PMID:20106945 | PSCA | Human | dimethylarsinic acid | increases expression | ISO | Psca (Mus musculus) | 6480464 | Cacodylic Acid results in increased expression of PSCA mRNA | CTD | PMID:32052077 | PSCA | Human | dioxygen | multiple interactions | ISO | Psca (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PSCA mRNA | CTD | PMID:30529165 | PSCA | Human | ethylparaben | increases expression | EXP | | 6480464 | ethyl-p-hydroxybenzoate results in increased expression of PSCA mRNA | CTD | PMID:37690743 | PSCA | Human | flurbiprofen | multiple interactions | ISO | Psca (Mus musculus) | 6480464 | [Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein more ... | CTD | PMID:16949054 | PSCA | Human | flurbiprofen | increases expression | ISO | Psca (Mus musculus) | 6480464 | Flurbiprofen results in increased expression of PSCA mRNA | CTD | PMID:16949054 | PSCA | Human | glycidol | increases expression | ISO | Psca (Mus musculus) | 6480464 | glycidol results in increased expression of PSCA mRNA | CTD | PMID:33187795 | PSCA | Human | hydrogen peroxide | affects expression | EXP | | 6480464 | Hydrogen Peroxide affects the expression of PSCA mRNA | CTD | PMID:20044591 | PSCA | Human | kaempferol | decreases expression | EXP | | 6480464 | kaempferol results in decreased expression of PSCA mRNA | CTD | PMID:18331776 | PSCA | Human | lipopolysaccharide | multiple interactions | EXP | | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PSCA mRNA | CTD | PMID:35811015 | PSCA | Human | luteolin | decreases expression | EXP | | 6480464 | Luteolin results in decreased expression of PSCA mRNA | CTD | PMID:18331776 and PMID:19397994 | PSCA | Human | methapyrilene | increases methylation | EXP | | 6480464 | Methapyrilene results in increased methylation of PSCA intron | CTD | PMID:30157460 | PSCA | Human | myricetin | decreases expression | EXP | | 6480464 | myricetin results in decreased expression of PSCA mRNA | CTD | PMID:18331776 | PSCA | Human | ozone | increases expression | ISO | Psca (Mus musculus) | 6480464 | Ozone results in increased expression of PSCA mRNA | CTD | PMID:25658374 more ... | PSCA | Human | ozone | multiple interactions | ISO | Psca (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of PSCA mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of PSCA mRNA | CTD | PMID:34911549 | PSCA | Human | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PSCA mRNA | CTD | PMID:29067470 | PSCA | Human | perfluorohexanesulfonic acid | increases expression | ISO | Psca (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of PSCA mRNA | CTD | PMID:37995155 | PSCA | Human | propanal | increases expression | EXP | | 6480464 | propionaldehyde results in increased expression of PSCA mRNA | CTD | PMID:26079696 | PSCA | Human | quercetin | decreases expression | EXP | | 6480464 | Quercetin results in decreased expression of PSCA mRNA | CTD | PMID:18331776 | PSCA | Human | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | EXP | | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PSCA mRNA | CTD | PMID:35811015 | PSCA | Human | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide analog results in increased expression of PSCA mRNA | CTD | PMID:25895662 | PSCA | Human | sodium arsenate | decreases expression | EXP | | 6480464 | sodium arsenate results in decreased expression of PSCA mRNA | CTD | PMID:12727804 | PSCA | Human | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of PSCA mRNA | CTD | PMID:12727804 | PSCA | Human | sodium arsenite | decreases expression | ISO | Psca (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of PSCA mRNA | CTD | PMID:37682722 | PSCA | Human | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of PSCA mRNA | CTD | PMID:29301061 | PSCA | Human | sodium dichromate | decreases expression | ISO | Psca (Mus musculus) | 6480464 | sodium bichromate results in decreased expression of PSCA mRNA | CTD | PMID:22155349 | PSCA | Human | sulindac sulfone | increases expression | ISO | Psca (Mus musculus) | 6480464 | sulindac sulfone results in increased expression of PSCA mRNA | CTD | PMID:16949054 | PSCA | Human | tert-butyl hydroperoxide | increases expression | ISO | Psca (Mus musculus) | 6480464 | tert-Butylhydroperoxide results in increased expression of PSCA mRNA | CTD | PMID:14729362 and PMID:15003993 | PSCA | Human | tetrachloromethane | increases expression | ISO | Psca (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of PSCA mRNA | CTD | PMID:30723492 | PSCA | Human | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of PSCA gene | CTD | PMID:29154799 | |