ORC5 (origin recognition complex subunit 5) - Rat Genome Database

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Gene: ORC5 (origin recognition complex subunit 5) Homo sapiens
Analyze
Symbol: ORC5
Name: origin recognition complex subunit 5
RGD ID: 1320971
HGNC Page HGNC:8491
Description: Predicted to enable DNA replication origin binding activity. Involved in DNA replication initiation and regulation of DNA replication. Located in cytosol and nucleoplasm. Part of chromatin and nuclear origin of replication recognition complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ORC5L; ORC5P; ORC5T; origin recognition complex, subunit 5 homolog; origin recognition complex, subunit 5-like; PPP1R117
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387104,126,341 - 104,208,013 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7104,126,341 - 104,208,047 (-)EnsemblGRCh38hg38GRCh38
GRCh377103,766,788 - 103,848,461 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367103,554,024 - 103,635,699 (-)NCBINCBI36Build 36hg18NCBI36
Build 347103,402,575 - 103,442,414NCBI
Celera798,572,731 - 98,654,418 (-)NCBICelera
Cytogenetic Map7q22.1-q22.2NCBI
HuRef798,126,653 - 98,208,348 (-)NCBIHuRef
CHM1_17103,700,117 - 103,781,841 (-)NCBICHM1_1
T2T-CHM13v2.07105,440,576 - 105,522,271 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27103,127,226 - 103,208,947 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:9038340   PMID:9417919   PMID:9765232   PMID:9829972   PMID:10402192   PMID:10436018   PMID:10523313   PMID:10954718   PMID:11095689   PMID:11125146   PMID:11323433  
PMID:11379876   PMID:11395502   PMID:11931757   PMID:12004060   PMID:12045100   PMID:12477932   PMID:12614612   PMID:12690205   PMID:12853948   PMID:15226314   PMID:15232106   PMID:15489334  
PMID:15684404   PMID:15707391   PMID:16549788   PMID:17716973   PMID:18029348   PMID:19135898   PMID:19240061   PMID:19389623   PMID:19454010   PMID:20360068   PMID:20467437   PMID:20677014  
PMID:20850016   PMID:20932478   PMID:21873635   PMID:21988832   PMID:22398447   PMID:22939629   PMID:24797263   PMID:25416956   PMID:25609649   PMID:26186194   PMID:26264872   PMID:26496610  
PMID:26644179   PMID:28514442   PMID:29117863   PMID:29180619   PMID:29509190   PMID:29844126   PMID:30154076   PMID:30260704   PMID:30804502   PMID:30890647   PMID:31091453   PMID:31160578  
PMID:31527615   PMID:31678930   PMID:32780723   PMID:32808929   PMID:32989049   PMID:33961781   PMID:34079125   PMID:34189442   PMID:34373451   PMID:35241646   PMID:35256949   PMID:35509820  
PMID:35831314   PMID:36089195   PMID:36538041   PMID:37827155  


Genomics

Comparative Map Data
ORC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387104,126,341 - 104,208,013 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7104,126,341 - 104,208,047 (-)EnsemblGRCh38hg38GRCh38
GRCh377103,766,788 - 103,848,461 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367103,554,024 - 103,635,699 (-)NCBINCBI36Build 36hg18NCBI36
Build 347103,402,575 - 103,442,414NCBI
Celera798,572,731 - 98,654,418 (-)NCBICelera
Cytogenetic Map7q22.1-q22.2NCBI
HuRef798,126,653 - 98,208,348 (-)NCBIHuRef
CHM1_17103,700,117 - 103,781,841 (-)NCBICHM1_1
T2T-CHM13v2.07105,440,576 - 105,522,271 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27103,127,226 - 103,208,947 (-)NCBI
Orc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39522,691,478 - 22,755,358 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl522,691,483 - 22,755,427 (-)EnsemblGRCm39 Ensembl
GRCm38522,486,480 - 22,550,338 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl522,486,485 - 22,550,429 (-)EnsemblGRCm38mm10GRCm38
MGSCv37521,992,307 - 22,056,149 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36521,998,313 - 22,062,155 (-)NCBIMGSCv36mm8
Celera519,444,097 - 19,506,665 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.07NCBI
Orc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8413,440,264 - 13,504,888 (+)NCBIGRCr8
mRatBN7.2412,548,007 - 12,612,611 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl412,548,007 - 12,612,568 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx417,687,440 - 17,751,780 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0413,513,109 - 13,577,448 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0411,859,849 - 11,917,847 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,160,050 - 9,223,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,160,067 - 9,223,997 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.049,162,439 - 9,226,335 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.447,957,156 - 8,025,958 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera48,148,976 - 8,210,383 (+)NCBICelera
Cytogenetic Map4q11NCBI
Orc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,969,290 - 9,024,542 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554108,969,353 - 9,024,525 (-)NCBIChiLan1.0ChiLan1.0
ORC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26140,986,589 - 141,068,175 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17189,256,557 - 189,339,517 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0796,118,272 - 96,197,216 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17108,861,281 - 108,939,389 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,861,281 - 108,939,389 (-)Ensemblpanpan1.1panPan2
ORC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,088,143 - 16,183,813 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,088,184 - 16,166,718 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1815,732,833 - 15,812,126 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01816,392,659 - 16,471,208 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1816,392,671 - 16,487,890 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11816,161,839 - 16,241,089 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01816,094,737 - 16,173,996 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01816,367,381 - 16,446,657 (+)NCBIUU_Cfam_GSD_1.0
Orc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511858,326,313 - 58,393,209 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647919,450,070 - 19,517,160 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647919,450,087 - 19,516,976 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ORC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9104,083,830 - 104,166,541 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19104,078,792 - 104,166,530 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29114,841,154 - 114,888,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ORC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12173,082,527 - 73,148,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2173,083,032 - 73,148,647 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604230,845,981 - 30,912,118 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Orc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473925,271,477 - 25,335,718 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473925,271,474 - 25,335,737 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ORC5
22 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q22.1-31.1(chr7:101807149-112414850)x1 copy number loss See cases [RCV000050924] Chr7:101807149..112414850 [GRCh38]
Chr7:101450429..112054905 [GRCh37]
Chr7:101237149..111842141 [NCBI36]
Chr7:7q22.1-31.1		 pathogenic
GRCh38/hg38 7q22.1-22.3(chr7:101525795-105432462)x3 copy number gain See cases [RCV000050705] Chr7:101525795..105432462 [GRCh38]
Chr7:101169076..105072909 [GRCh37]
Chr7:100955796..104860145 [NCBI36]
Chr7:7q22.1-22.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q22.1-22.3(chr7:101700341-105162893)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054156]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054156]|See cases [RCV000054156] Chr7:101700341..105162893 [GRCh38]
Chr7:101343621..104803340 [GRCh37]
Chr7:101130341..104590576 [NCBI36]
Chr7:7q22.1-22.3		 pathogenic
GRCh38/hg38 7q22.1-22.3(chr7:102808199-105701108)x1 copy number loss See cases [RCV000054157] Chr7:102808199..105701108 [GRCh38]
Chr7:102448646..105341555 [GRCh37]
Chr7:102235882..105128791 [NCBI36]
Chr7:7q22.1-22.3		 pathogenic
NM_002553.3(ORC5):c.1033G>A (p.Glu345Lys) single nucleotide variant Malignant melanoma [RCV000067562] Chr7:104165240 [GRCh38]
Chr7:103805688 [GRCh37]
Chr7:103592924 [NCBI36]
Chr7:7q22.1		 not provided
NM_002553.3(ORC5):c.685-193G>T single nucleotide variant Lung cancer [RCV000097359] Chr7:104184364 [GRCh38]
Chr7:103824812 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q22.1-31.31(chr7:102196924-121278641)x1 copy number loss See cases [RCV000137522] Chr7:102196924..121278641 [GRCh38]
Chr7:101912320..120918695 [GRCh37]
Chr7:101626924..120705931 [NCBI36]
Chr7:7q22.1-31.31		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-22.3(chr7:102910570-105104800)x1 copy number loss not provided [RCV000682896] Chr7:102910570..105104800 [GRCh37]
Chr7:7q22.1-22.3		 likely pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1(chr7:103772610-103773849)x1 copy number loss not provided [RCV000746952] Chr7:103772610..103773849 [GRCh37]
Chr7:7q22.1		 benign
GRCh37/hg19 7q22.2(chr7:103813499-103870718)x3 copy number gain not provided [RCV000746953] Chr7:103813499..103870718 [GRCh37]
Chr7:7q22.2		 benign
GRCh37/hg19 7q22.1-22.3(chr7:103354482-105407628) copy number loss See cases [RCV000993742] Chr7:103354482..105407628 [GRCh37]
Chr7:7q22.1-22.3		 likely pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-22.3(chr7:103679146-105547471) copy number loss See cases [RCV000993744] Chr7:103679146..105547471 [GRCh37]
Chr7:7q22.1-22.3		 likely pathogenic
GRCh37/hg19 7q22.1-31.31(chr7:100676872-119156160) copy number loss not specified [RCV002053712] Chr7:100676872..119156160 [GRCh37]
Chr7:7q22.1-31.31		 pathogenic
GRCh37/hg19 7q22.1-31.1(chr7:99417471-111586308) copy number loss not specified [RCV002053711] Chr7:99417471..111586308 [GRCh37]
Chr7:7q22.1-31.1		 pathogenic
NC_000007.13:g.(?_102937907)_(107643330_?)dup duplication not provided [RCV003113939] Chr7:102937907..107643330 [GRCh37]
Chr7:7q22.1-31.1		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
NM_002553.4(ORC5):c.863C>T (p.Pro288Leu) single nucleotide variant not specified [RCV004306270] Chr7:104168487 [GRCh38]
Chr7:103808935 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7q22.1-22.2(chr7:103746409-104002334)x3 copy number gain not provided [RCV002473444] Chr7:103746409..104002334 [GRCh37]
Chr7:7q22.1-22.2		 uncertain significance
NM_002553.4(ORC5):c.1028A>T (p.Lys343Ile) single nucleotide variant not specified [RCV004210055] Chr7:104165245 [GRCh38]
Chr7:103805693 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.43G>C (p.Val15Leu) single nucleotide variant not specified [RCV004136801] Chr7:104207862 [GRCh38]
Chr7:103848310 [GRCh37]
Chr7:7q22.2		 uncertain significance
NM_002553.4(ORC5):c.611A>G (p.Tyr204Cys) single nucleotide variant not specified [RCV004189808] Chr7:104188324 [GRCh38]
Chr7:103828772 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.806A>G (p.Tyr269Cys) single nucleotide variant not specified [RCV004098874] Chr7:104183961 [GRCh38]
Chr7:103824409 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.223C>G (p.Gln75Glu) single nucleotide variant not specified [RCV004086764] Chr7:104200901 [GRCh38]
Chr7:103841349 [GRCh37]
Chr7:7q22.2		 uncertain significance
NM_002553.4(ORC5):c.1166C>T (p.Thr389Ile) single nucleotide variant not specified [RCV004151288] Chr7:104136877 [GRCh38]
Chr7:103777324 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.1100A>G (p.Tyr367Cys) single nucleotide variant not specified [RCV004122233] Chr7:104161121 [GRCh38]
Chr7:103801569 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.1136A>G (p.Asn379Ser) single nucleotide variant not specified [RCV004199109] Chr7:104161085 [GRCh38]
Chr7:103801533 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.895C>T (p.His299Tyr) single nucleotide variant not specified [RCV004260467] Chr7:104166867 [GRCh38]
Chr7:103807315 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.263A>T (p.Asp88Val) single nucleotide variant not specified [RCV004352150] Chr7:104200861 [GRCh38]
Chr7:103841309 [GRCh37]
Chr7:7q22.2		 uncertain significance
NM_002553.4(ORC5):c.898G>T (p.Val300Leu) single nucleotide variant not specified [RCV004502352] Chr7:104166864 [GRCh38]
Chr7:103807312 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.911A>G (p.Tyr304Cys) single nucleotide variant not specified [RCV004502353] Chr7:104166851 [GRCh38]
Chr7:103807299 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.542A>G (p.Asp181Gly) single nucleotide variant not specified [RCV004502351] Chr7:104195154 [GRCh38]
Chr7:103835602 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.1093A>G (p.Ile365Val) single nucleotide variant not specified [RCV004502349] Chr7:104161128 [GRCh38]
Chr7:103801576 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.1198G>C (p.Asp400His) single nucleotide variant not specified [RCV004502350] Chr7:104136845 [GRCh38]
Chr7:103777292 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.262G>T (p.Asp88Tyr) single nucleotide variant not specified [RCV004352149] Chr7:104200862 [GRCh38]
Chr7:103841310 [GRCh37]
Chr7:7q22.2		 uncertain significance
NM_002553.4(ORC5):c.849A>C (p.Lys283Asn) single nucleotide variant not specified [RCV004124655] Chr7:104168501 [GRCh38]
Chr7:103808949 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_002553.4(ORC5):c.497G>A (p.Arg166His) single nucleotide variant not specified [RCV004338710] Chr7:104195199 [GRCh38]
Chr7:103835647 [GRCh37]
Chr7:7q22.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1841
Count of miRNA genes:713
Interacting mature miRNAs:804
Transcripts:ENST00000297431, ENST00000422497, ENST00000447452, ENST00000448563, ENST00000463152, ENST00000477223, ENST00000485726, ENST00000545943
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-143604  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377103,828,063 - 103,828,411UniSTSGRCh37
Build 367103,615,299 - 103,615,647RGDNCBI36
Celera798,634,012 - 98,634,360RGD
Cytogenetic Map7q22.1UniSTS
HuRef798,187,937 - 98,188,285UniSTS
CRA_TCAGchr7v27103,188,508 - 103,188,856UniSTS
TNG Radiation Hybrid Map744891.0UniSTS
csnporc5l-pcr1-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377103,848,121 - 103,848,571UniSTSGRCh37
Build 367103,635,357 - 103,635,807RGDNCBI36
Celera798,654,076 - 98,654,526RGD
Cytogenetic Map7q22.1UniSTS
HuRef798,207,974 - 98,208,424UniSTS
CRA_TCAGchr7v27103,208,573 - 103,209,023UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 877 632 542 143 784 122 2592 333 1477 191 1276 695 35 1 504 1577 3
Low 1562 2325 1184 481 1142 343 1765 1855 2256 228 184 918 140 700 1211 3 2
Below cutoff 34 25 9 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_181747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC002067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF047599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF049127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF678849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U92538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000297431   ⟹   ENSP00000297431
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7104,126,341 - 104,208,013 (-)Ensembl
RefSeq Acc Id: ENST00000422497   ⟹   ENSP00000393208
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7104,126,343 - 104,208,000 (-)Ensembl
RefSeq Acc Id: ENST00000447452   ⟹   ENSP00000395747
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7104,167,994 - 104,207,957 (-)Ensembl
RefSeq Acc Id: ENST00000448563   ⟹   ENSP00000387465
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7104,200,821 - 104,208,000 (-)Ensembl
RefSeq Acc Id: ENST00000463152
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7104,184,220 - 104,197,767 (-)Ensembl
RefSeq Acc Id: ENST00000477223
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7104,126,838 - 104,165,734 (-)Ensembl
RefSeq Acc Id: ENST00000485726
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7104,187,543 - 104,208,009 (-)Ensembl
RefSeq Acc Id: ENST00000626700   ⟹   ENSP00000486840
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7104,202,509 - 104,208,047 (-)Ensembl
RefSeq Acc Id: NM_002553   ⟹   NP_002544
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387104,126,341 - 104,208,013 (-)NCBI
GRCh377103,766,788 - 103,848,495 (-)ENTREZGENE
Build 367103,554,024 - 103,635,699 (-)NCBI Archive
HuRef798,126,653 - 98,208,348 (-)ENTREZGENE
CHM1_17103,700,117 - 103,781,841 (-)NCBI
T2T-CHM13v2.07105,440,576 - 105,522,271 (-)NCBI
CRA_TCAGchr7v27103,127,226 - 103,208,947 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_181747   ⟹   NP_859531
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387104,168,189 - 104,208,013 (-)NCBI
GRCh377103,766,788 - 103,848,495 (-)ENTREZGENE
Build 367103,595,860 - 103,635,699 (-)NCBI Archive
HuRef798,126,653 - 98,208,348 (-)ENTREZGENE
CHM1_17103,741,956 - 103,781,841 (-)NCBI
T2T-CHM13v2.07105,482,424 - 105,522,271 (-)NCBI
CRA_TCAGchr7v27103,127,226 - 103,208,947 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011516273   ⟹   XP_011514575
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387104,184,213 - 104,208,013 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047420431   ⟹   XP_047276387
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387104,166,828 - 104,208,013 (-)NCBI
RefSeq Acc Id: XM_054358313   ⟹   XP_054214288
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.07105,498,371 - 105,522,271 (-)NCBI
RefSeq Acc Id: XM_054358314   ⟹   XP_054214289
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.07105,481,063 - 105,522,271 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_002544   ⟸   NM_002553
- Peptide Label: isoform 1
- UniProtKB: O60590 (UniProtKB/Swiss-Prot),   A4D0P8 (UniProtKB/Swiss-Prot),   O95268 (UniProtKB/Swiss-Prot),   O43913 (UniProtKB/Swiss-Prot),   A4D0P7 (UniProtKB/TrEMBL),   Q53FC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_859531   ⟸   NM_181747
- Peptide Label: isoform 2
- UniProtKB: O43913 (UniProtKB/Swiss-Prot),   Q53FC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011514575   ⟸   XM_011516273
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000297431   ⟸   ENST00000297431
RefSeq Acc Id: ENSP00000486840   ⟸   ENST00000626700
RefSeq Acc Id: ENSP00000395747   ⟸   ENST00000447452
RefSeq Acc Id: ENSP00000387465   ⟸   ENST00000448563
RefSeq Acc Id: ENSP00000393208   ⟸   ENST00000422497
RefSeq Acc Id: XP_047276387   ⟸   XM_047420431
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054214289   ⟸   XM_054358314
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054214288   ⟸   XM_054358313
- Peptide Label: isoform X1
Protein Domains
Orc1-like AAA ATPase   ORC5 lid   Origin recognition complex subunit 5 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O43913-F1-model_v2 AlphaFold O43913 1-435 view protein structure

Promoters
RGD ID:6806000
Promoter ID:HG_KWN:59153
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000348286,   OTTHUMT00000348287,   OTTHUMT00000348288,   OTTHUMT00000348291,   UC003VCD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367103,635,431 - 103,636,447 (-)MPROMDB
RGD ID:7211569
Promoter ID:EPDNEW_H11531
Type:initiation region
Name:ORC5_1
Description:origin recognition complex subunit 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387104,208,013 - 104,208,073EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8491 AgrOrtholog
COSMIC ORC5 COSMIC
Ensembl Genes ENSG00000164815 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000297431 ENTREZGENE
  ENST00000297431.9 UniProtKB/Swiss-Prot
  ENST00000422497.5 UniProtKB/TrEMBL
  ENST00000447452 ENTREZGENE
  ENST00000447452.6 UniProtKB/Swiss-Prot
  ENST00000448563.3 UniProtKB/TrEMBL
  ENST00000626700.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000164815 GTEx
HGNC ID HGNC:8491 ENTREZGENE
Human Proteome Map ORC5 Human Proteome Map
InterPro AAA_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORC5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORC5_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORC5_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5001 ENTREZGENE
OMIM 602331 OMIM
PANTHER ORIGIN RECOGNITION COMPLEX SUBUNIT 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12705 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORC5_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORC5_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32812 PharmGKB
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4D0P7 ENTREZGENE, UniProtKB/TrEMBL
  A4D0P8 ENTREZGENE
  G3V0H0_HUMAN UniProtKB/TrEMBL
  O43913 ENTREZGENE
  O60590 ENTREZGENE
  O95268 ENTREZGENE
  ORC5_HUMAN UniProtKB/Swiss-Prot
  Q53FC8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A4D0P8 UniProtKB/Swiss-Prot
  O60590 UniProtKB/Swiss-Prot
  O95268 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 ORC5  origin recognition complex subunit 5  ORC5  origin recognition complex, subunit 5  Symbol and/or name change 5135510 APPROVED
2011-07-27 ORC5  origin recognition complex, subunit 5  ORC5L  origin recognition complex, subunit 5-like (yeast)  Symbol and/or name change 5135510 APPROVED