KLK12 (kallikrein related peptidase 12) - Rat Genome Database

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Gene: KLK12 (kallikrein related peptidase 12) Homo sapiens
Analyze
Symbol: KLK12
Name: kallikrein related peptidase 12
RGD ID: 1319061
HGNC Page HGNC:6360
Description: Enables serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in secretory granule.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DKFZp686H1078; kallikrein 12; kallikrein-12; kallikrein-like protein 5; kallikrein-related peptidase 12; KLK-L5; KLKL5; MGC42603
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,029,094 - 51,035,002 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,029,092 - 51,035,230 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,532,350 - 51,538,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,224,160 - 56,229,960 (-)NCBINCBI36Build 36hg18NCBI36
Celera1948,584,407 - 48,590,207 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1947,864,957 - 47,870,784 (-)NCBIHuRef
CHM1_11951,534,321 - 51,540,123 (-)NCBICHM1_1
T2T-CHM13v2.01954,117,609 - 54,123,558 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IDA,IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10652563   PMID:10675891   PMID:10969073   PMID:11006094   PMID:11054574   PMID:11056051   PMID:12477932   PMID:12975309   PMID:15057824   PMID:15300858   PMID:16800723   PMID:16800724  
PMID:17391064   PMID:18976975   PMID:20424135   PMID:21439340   PMID:21628462   PMID:21741862   PMID:21873635   PMID:22344438   PMID:22351561   PMID:23152405   PMID:23236234   PMID:23376485  
PMID:23612974   PMID:27706634   PMID:29807016   PMID:29874189   PMID:31485623   PMID:32028882   PMID:32461654   PMID:32487729   PMID:33961781  


Genomics

Comparative Map Data
KLK12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,029,094 - 51,035,002 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,029,092 - 51,035,230 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,532,350 - 51,538,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,224,160 - 56,229,960 (-)NCBINCBI36Build 36hg18NCBI36
Celera1948,584,407 - 48,590,207 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1947,864,957 - 47,870,784 (-)NCBIHuRef
CHM1_11951,534,321 - 51,540,123 (-)NCBICHM1_1
T2T-CHM13v2.01954,117,609 - 54,123,558 (-)NCBIT2T-CHM13v2.0
Klk12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,418,346 - 43,423,005 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,418,321 - 43,423,009 (+)EnsemblGRCm39 Ensembl
GRCm38743,768,891 - 43,773,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,768,897 - 43,773,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv37751,024,470 - 51,028,851 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,637,241 - 43,641,625 (+)NCBIMGSCv36mm8
Celera739,235,763 - 39,240,146 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.26NCBI
Klk12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,359,274 - 103,364,186 (+)NCBIGRCr8
mRatBN7.2194,222,778 - 94,227,637 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,223,045 - 94,227,637 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,608,934 - 99,613,051 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,081,605 - 108,085,722 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,371,488 - 101,375,612 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,706,148 - 99,711,004 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,706,780 - 99,711,004 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,774,715 - 100,779,762 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,198,530 - 94,203,133 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,276,165 - 94,281,244 (+)NCBI
Celera188,492,207 - 88,496,322 (+)NCBICelera
Cytogenetic Map1q22NCBI
Klk12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555581,454,615 - 1,458,928 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555581,454,512 - 1,459,105 (+)NCBIChiLan1.0ChiLan1.0
KLK12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,098,830 - 57,104,583 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11959,020,338 - 59,026,083 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,996,689 - 48,002,335 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,885,704 - 56,891,516 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,885,704 - 56,891,516 (-)Ensemblpanpan1.1panPan2
KLK12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,845,579 - 105,853,192 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,848,940 - 105,853,204 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,421,223 - 105,425,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,357,630 - 106,362,011 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,357,758 - 106,362,013 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,029,093 - 106,033,469 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,670,479 - 105,674,857 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,465,946 - 106,470,325 (+)NCBIUU_Cfam_GSD_1.0
LOC101957019
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,798,459 - 22,804,411 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889674,458 - 677,695 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889674,449 - 677,695 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLK12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,686,623 - 55,692,671 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,686,666 - 55,692,706 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KLK12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,048,992 - 44,055,570 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,049,073 - 44,054,433 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607324,094,987 - 24,100,842 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klk12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248323,738,677 - 3,744,091 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KLK12
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
NM_144947.1(KLK11):c.83C>T (p.Ser28Phe) single nucleotide variant Malignant melanoma [RCV000072274] Chr19:51025645 [GRCh38]
Chr19:51528901 [GRCh37]
Chr19:56220713 [NCBI36]
Chr19:19q13.41		 not provided
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:50489390-59095359)x3 copy number gain See cases [RCV000445925] Chr19:50489390..59095359 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:50740074-59097160)x3 copy number gain not provided [RCV000740208] Chr19:50740074..59097160 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
NM_001370125.1(KLK12):c.75C>T (p.Gly25=) single nucleotide variant not provided [RCV000967537] Chr19:51034102 [GRCh38]
Chr19:51537358 [GRCh37]
Chr19:19q13.41		 benign
NM_001370125.1(KLK12):c.306G>A (p.Ser102=) single nucleotide variant not provided [RCV000968395] Chr19:51032027 [GRCh38]
Chr19:51535283 [GRCh37]
Chr19:19q13.41		 benign
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42		 not provided
GRCh37/hg19 19q13.33-13.41(chr19:50469730-51916485)x3 copy number gain not provided [RCV001007055] Chr19:50469730..51916485 [GRCh37]
Chr19:19q13.33-13.41		 uncertain significance
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.33-13.41(chr19:49911081-53127438) copy number gain not specified [RCV002052689] Chr19:49911081..53127438 [GRCh37]
Chr19:19q13.33-13.41		 likely pathogenic
NM_001370125.1(KLK12):c.112G>A (p.Gly38Arg) single nucleotide variant not specified [RCV004161106] Chr19:51034065 [GRCh38]
Chr19:51537321 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.592G>T (p.Gly198Cys) single nucleotide variant not specified [RCV004237697] Chr19:51029457 [GRCh38]
Chr19:51532713 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.724C>T (p.Arg242Trp) single nucleotide variant not specified [RCV004195075] Chr19:51029325 [GRCh38]
Chr19:51532581 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.392A>G (p.Asn131Ser) single nucleotide variant not specified [RCV004164594] Chr19:51031941 [GRCh38]
Chr19:51535197 [GRCh37]
Chr19:19q13.41		 likely benign
NM_001370125.1(KLK12):c.324C>G (p.Asp108Glu) single nucleotide variant not specified [RCV004107839] Chr19:51032009 [GRCh38]
Chr19:51535265 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.241G>A (p.Asp81Asn) single nucleotide variant not specified [RCV004172580] Chr19:51032092 [GRCh38]
Chr19:51535348 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.412A>T (p.Thr138Ser) single nucleotide variant not specified [RCV004231544] Chr19:51031921 [GRCh38]
Chr19:51535177 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.352G>A (p.Val118Ile) single nucleotide variant not specified [RCV004185568] Chr19:51031981 [GRCh38]
Chr19:51535237 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.454C>T (p.Arg152Trp) single nucleotide variant not specified [RCV004178976] Chr19:51031879 [GRCh38]
Chr19:51535135 [GRCh37]
Chr19:19q13.41		 likely benign
NM_001370125.1(KLK12):c.316G>A (p.Glu106Lys) single nucleotide variant not specified [RCV004081590] Chr19:51032017 [GRCh38]
Chr19:51535273 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.401C>A (p.Ala134Glu) single nucleotide variant not specified [RCV004073734] Chr19:51031932 [GRCh38]
Chr19:51535188 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.169G>A (p.Val57Ile) single nucleotide variant not specified [RCV004075153] Chr19:51034008 [GRCh38]
Chr19:51537264 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.267C>A (p.Ser89Arg) single nucleotide variant not specified [RCV004249536] Chr19:51032066 [GRCh38]
Chr19:51535322 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.120T>G (p.Phe40Leu) single nucleotide variant not specified [RCV004355637] Chr19:51034057 [GRCh38]
Chr19:51537313 [GRCh37]
Chr19:19q13.41		 uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:49625130-57647352)x3 copy number gain not provided [RCV003485200] Chr19:49625130..57647352 [GRCh37]
Chr19:19q13.33-13.43		 likely pathogenic
GRCh37/hg19 19q13.33-13.41(chr19:48905537-51614930)x3 copy number gain not specified [RCV003986127] Chr19:48905537..51614930 [GRCh37]
Chr19:19q13.33-13.41		 likely pathogenic
NM_001370125.1(KLK12):c.124G>T (p.Gly42Cys) single nucleotide variant not specified [RCV004409608] Chr19:51034053 [GRCh38]
Chr19:51537309 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.178G>T (p.Ala60Ser) single nucleotide variant not specified [RCV004409609] Chr19:51033999 [GRCh38]
Chr19:51537255 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.179C>T (p.Ala60Val) single nucleotide variant not specified [RCV004409610] Chr19:51033998 [GRCh38]
Chr19:51537254 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.226A>G (p.Ser76Gly) single nucleotide variant not specified [RCV004409611] Chr19:51032107 [GRCh38]
Chr19:51535363 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.343C>T (p.Arg115Cys) single nucleotide variant not specified [RCV004409612] Chr19:51031990 [GRCh38]
Chr19:51535246 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.415G>A (p.Glu139Lys) single nucleotide variant not specified [RCV004409613] Chr19:51031918 [GRCh38]
Chr19:51535174 [GRCh37]
Chr19:19q13.41		 likely benign
NM_001370125.1(KLK12):c.455G>A (p.Arg152Gln) single nucleotide variant not specified [RCV004409614] Chr19:51031878 [GRCh38]
Chr19:51535134 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.5G>A (p.Gly2Glu) single nucleotide variant not specified [RCV004409615] Chr19:51034617 [GRCh38]
Chr19:51537873 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.674A>T (p.Asp225Val) single nucleotide variant not specified [RCV004409616] Chr19:51029375 [GRCh38]
Chr19:51532631 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_001370125.1(KLK12):c.725G>A (p.Arg242Gln) single nucleotide variant not specified [RCV004409617] Chr19:51029324 [GRCh38]
Chr19:51532580 [GRCh37]
Chr19:19q13.41		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2412
Count of miRNA genes:616
Interacting mature miRNAs:706
Transcripts:ENST00000250351, ENST00000250352, ENST00000319590, ENST00000525263, ENST00000526824, ENST00000529888, ENST00000530943, ENST00000531374
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
KLK12_8032  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371951,532,251 - 51,532,678UniSTSGRCh37
Build 361956,224,063 - 56,224,490RGDNCBI36
Celera1948,584,310 - 48,584,737RGD
HuRef1947,864,860 - 47,865,287UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage pharyngeal arch
High 3
Medium 47 19 85 17 3 9 18 2 110 29 85 1 1
Low 498 10 305 77 145 2 784 104 248 3 680 251 77 61 442 1
Below cutoff 1212 1100 604 134 497 132 1695 1094 1121 63 439 727 9 551 1155

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001370125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005258951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC011473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF135025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF243527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY697987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000250351   ⟹   ENSP00000250351
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,029,155 - 51,034,892 (-)Ensembl
RefSeq Acc Id: ENST00000319590   ⟹   ENSP00000324181
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,029,092 - 51,034,892 (-)Ensembl
RefSeq Acc Id: ENST00000525263   ⟹   ENSP00000436458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,029,092 - 51,034,741 (-)Ensembl
RefSeq Acc Id: ENST00000526824   ⟹   ENSP00000434604
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,029,094 - 51,035,230 (-)Ensembl
RefSeq Acc Id: ENST00000529888   ⟹   ENSP00000434036
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,029,130 - 51,034,862 (-)Ensembl
RefSeq Acc Id: ENST00000530943   ⟹   ENSP00000434339
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,029,094 - 51,034,862 (-)Ensembl
RefSeq Acc Id: ENST00000531374   ⟹   ENSP00000436121
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,029,130 - 51,034,862 (-)Ensembl
RefSeq Acc Id: ENST00000684732   ⟹   ENSP00000508282
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,029,094 - 51,035,002 (-)Ensembl
RefSeq Acc Id: NM_001370125   ⟹   NP_001357054
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,029,094 - 51,035,002 (-)NCBI
T2T-CHM13v2.01954,117,609 - 54,123,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001370126   ⟹   NP_001357055
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,029,094 - 51,035,002 (-)NCBI
T2T-CHM13v2.01954,117,609 - 54,123,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001370127   ⟹   NP_001357056
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,029,094 - 51,035,002 (-)NCBI
T2T-CHM13v2.01954,117,609 - 54,123,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001370128   ⟹   NP_001357057
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,029,094 - 51,035,002 (-)NCBI
T2T-CHM13v2.01954,117,609 - 54,123,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019598   ⟹   NP_062544
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,029,094 - 51,035,002 (-)NCBI
GRCh371951,532,348 - 51,538,486 (-)NCBI
Build 361956,224,160 - 56,229,960 (-)NCBI Archive
Celera1948,584,407 - 48,590,207 (-)RGD
HuRef1947,864,957 - 47,870,784 (-)ENTREZGENE
CHM1_11951,534,321 - 51,540,123 (-)NCBI
T2T-CHM13v2.01954,117,609 - 54,123,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_145894   ⟹   NP_665901
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,029,094 - 51,035,002 (-)NCBI
GRCh371951,532,348 - 51,538,486 (-)NCBI
Build 361956,224,160 - 56,229,960 (-)NCBI Archive
Celera1948,584,407 - 48,590,207 (-)RGD
HuRef1947,864,957 - 47,870,784 (-)ENTREZGENE
CHM1_11951,534,321 - 51,540,123 (-)NCBI
T2T-CHM13v2.01954,117,609 - 54,123,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_145895   ⟹   NP_665902
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,029,094 - 51,035,002 (-)NCBI
GRCh371951,532,348 - 51,538,486 (-)NCBI
Build 361956,224,160 - 56,229,960 (-)NCBI Archive
Celera1948,584,407 - 48,590,207 (-)RGD
HuRef1947,864,957 - 47,870,784 (-)ENTREZGENE
CHM1_11951,534,321 - 51,540,123 (-)NCBI
T2T-CHM13v2.01954,117,609 - 54,123,558 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001357054 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357055 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357056 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357057 (Get FASTA)   NCBI Sequence Viewer  
  NP_062544 (Get FASTA)   NCBI Sequence Viewer  
  NP_665901 (Get FASTA)   NCBI Sequence Viewer  
  NP_665902 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD26426 (Get FASTA)   NCBI Sequence Viewer  
  AAF06065 (Get FASTA)   NCBI Sequence Viewer  
  AAF06066 (Get FASTA)   NCBI Sequence Viewer  
  AAG23258 (Get FASTA)   NCBI Sequence Viewer  
  AAG33365 (Get FASTA)   NCBI Sequence Viewer  
  AAH35385 (Get FASTA)   NCBI Sequence Viewer  
  AAI36342 (Get FASTA)   NCBI Sequence Viewer  
  AAQ88888 (Get FASTA)   NCBI Sequence Viewer  
  AUS91425 (Get FASTA)   NCBI Sequence Viewer  
  EAW71973 (Get FASTA)   NCBI Sequence Viewer  
  EAW71974 (Get FASTA)   NCBI Sequence Viewer  
  EAW71975 (Get FASTA)   NCBI Sequence Viewer  
  EAW71976 (Get FASTA)   NCBI Sequence Viewer  
  EAW71977 (Get FASTA)   NCBI Sequence Viewer  
  EAW71978 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000250351
  ENSP00000250351.4
  ENSP00000324181
  ENSP00000324181.4
  ENSP00000434036.1
  ENSP00000434339.1
  ENSP00000434604.1
  ENSP00000436121.1
  ENSP00000436458.1
  ENSP00000508282
  ENSP00000508282.1
GenBank Protein Q9UKR0 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_062544   ⟸   NM_019598
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9UKR0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_665901   ⟸   NM_145894
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9UKR1 (UniProtKB/Swiss-Prot),   Q9UKR2 (UniProtKB/Swiss-Prot),   Q9UKR0 (UniProtKB/Swiss-Prot),   A0A024R4M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_665902   ⟸   NM_145895
- Peptide Label: isoform 3
- UniProtKB: B9EGA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001357056   ⟸   NM_001370127
- Peptide Label: isoform 3
- UniProtKB: B9EGA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357054   ⟸   NM_001370125
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9UKR1 (UniProtKB/Swiss-Prot),   Q9UKR0 (UniProtKB/Swiss-Prot),   Q9UKR2 (UniProtKB/Swiss-Prot),   A0A024R4M4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357055   ⟸   NM_001370126
- Peptide Label: isoform 4
- UniProtKB: A8MQ31 (UniProtKB/TrEMBL),   Q49AM7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357057   ⟸   NM_001370128
- Peptide Label: isoform 3
- UniProtKB: B9EGA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000434339   ⟸   ENST00000530943
RefSeq Acc Id: ENSP00000436121   ⟸   ENST00000531374
RefSeq Acc Id: ENSP00000436458   ⟸   ENST00000525263
RefSeq Acc Id: ENSP00000434604   ⟸   ENST00000526824
RefSeq Acc Id: ENSP00000250351   ⟸   ENST00000250351
RefSeq Acc Id: ENSP00000434036   ⟸   ENST00000529888
RefSeq Acc Id: ENSP00000324181   ⟸   ENST00000319590
RefSeq Acc Id: ENSP00000508282   ⟸   ENST00000684732
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UKR0-F1-model_v2 AlphaFold Q9UKR0 1-248 view protein structure

Promoters
RGD ID:13205337
Promoter ID:EPDNEW_H26249
Type:initiation region
Name:KLK12_2
Description:kallikrein related peptidase 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26250  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,034,767 - 51,034,827EPDNEW
RGD ID:13205339
Promoter ID:EPDNEW_H26250
Type:initiation region
Name:KLK12_1
Description:kallikrein related peptidase 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26249  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,034,906 - 51,034,966EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6360 AgrOrtholog
COSMIC KLK12 COSMIC
Ensembl Genes ENSG00000186474 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000250351 ENTREZGENE
  ENST00000250351.4 UniProtKB/Swiss-Prot
  ENST00000319590 ENTREZGENE
  ENST00000319590.8 UniProtKB/Swiss-Prot
  ENST00000525263.5 UniProtKB/Swiss-Prot
  ENST00000526824.5 UniProtKB/TrEMBL
  ENST00000529888.5 UniProtKB/Swiss-Prot
  ENST00000530943.6 UniProtKB/TrEMBL
  ENST00000531374.5 UniProtKB/TrEMBL
  ENST00000684732 ENTREZGENE
  ENST00000684732.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000186474 GTEx
HGNC ID HGNC:6360 ENTREZGENE
Human Proteome Map KLK12 Human Proteome Map
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:43849 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 43849 ENTREZGENE
OMIM 605539 OMIM
PANTHER KALLIKREIN-12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIKEN CDNA 2210010C04 GENE UniProtKB/TrEMBL
  TRYPSIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30149 PharmGKB
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R4M4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2I7ZG50_HUMAN UniProtKB/TrEMBL
  A8MQ31 ENTREZGENE
  B9EGA9 ENTREZGENE, UniProtKB/TrEMBL
  E9PPC6_HUMAN UniProtKB/TrEMBL
  E9PR22_HUMAN UniProtKB/TrEMBL
  KLK12_HUMAN UniProtKB/Swiss-Prot
  Q49AM7 ENTREZGENE, UniProtKB/TrEMBL
  Q9UKR0 ENTREZGENE
  Q9UKR1 ENTREZGENE
  Q9UKR2 ENTREZGENE
UniProt Secondary A8MQ31 UniProtKB/TrEMBL
  Q9UKR1 UniProtKB/Swiss-Prot
  Q9UKR2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 KLK12  kallikrein related peptidase 12  KLK12  kallikrein-related peptidase 12  Symbol and/or name change 5135510 APPROVED