LINGO1 (leucine rich repeat and Ig domain containing 1) - Rat Genome Database

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Gene: LINGO1 (leucine rich repeat and Ig domain containing 1) Homo sapiens
Analyze
Symbol: LINGO1
Name: leucine rich repeat and Ig domain containing 1
RGD ID: 1318574
HGNC Page HGNC:21205
Description: Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within negative regulation of oligodendrocyte differentiation; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and neuron development. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ14594; LERN1; leucine rich repeat neuronal 6A; leucine-rich repeat and immunoglobilin domain-containing protein 1; leucine-rich repeat and immunoglobulin domain-containing protein 1; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine-rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat neuronal protein 6A; LRRN6A; MGC17422; MRT64; UNQ201
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381577,613,027 - 77,820,900 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1577,613,027 - 77,820,900 (-)EnsemblGRCh38hg38GRCh38
GRCh371577,905,369 - 78,113,242 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361575,692,424 - 75,711,764 (-)NCBINCBI36Build 36hg18NCBI36
Build 341575,692,423 - 75,711,764NCBI
Celera1554,843,608 - 54,862,572 (-)NCBICelera
Cytogenetic Map15q24.3NCBI
HuRef1554,660,535 - 54,680,264 (-)NCBIHuRef
CHM1_11578,023,300 - 78,042,675 (-)NCBICHM1_1
T2T-CHM13v2.01575,473,724 - 75,683,106 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma. Fu QL, etal., Neuroscience. 2009 Aug 18;162(2):375-82. doi: 10.1016/j.neuroscience.2009.04.075. Epub 2009 May 5.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12975309   PMID:14686891   PMID:14702039   PMID:14966521   PMID:15694322   PMID:16169070   PMID:16189514   PMID:16344560   PMID:17005555   PMID:17239012   PMID:17726113  
PMID:19182806   PMID:19254717   PMID:19363035   PMID:19553813   PMID:19720553   PMID:19805735   PMID:19908305   PMID:20117178   PMID:20310002   PMID:20369371   PMID:20372186   PMID:20468067  
PMID:20600614   PMID:20659559   PMID:20951767   PMID:20957646   PMID:21158743   PMID:21219542   PMID:21264305   PMID:21506150   PMID:21653829   PMID:21741293   PMID:21752692   PMID:21873635  
PMID:21955595   PMID:22133804   PMID:22216198   PMID:22425540   PMID:22514275   PMID:22710005   PMID:23482566   PMID:23574883   PMID:23682623   PMID:23754655   PMID:24448210   PMID:24531928  
PMID:24583087   PMID:25416956   PMID:25666623   PMID:26186194   PMID:26254004   PMID:26979953   PMID:28514442   PMID:28837161   PMID:30064229   PMID:31932443   PMID:32296183   PMID:32814053  
PMID:33830473   PMID:33961781   PMID:34079125   PMID:35063084   PMID:36901909   PMID:37958608  


Genomics

Comparative Map Data
LINGO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381577,613,027 - 77,820,900 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1577,613,027 - 77,820,900 (-)EnsemblGRCh38hg38GRCh38
GRCh371577,905,369 - 78,113,242 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361575,692,424 - 75,711,764 (-)NCBINCBI36Build 36hg18NCBI36
Build 341575,692,423 - 75,711,764NCBI
Celera1554,843,608 - 54,862,572 (-)NCBICelera
Cytogenetic Map15q24.3NCBI
HuRef1554,660,535 - 54,680,264 (-)NCBIHuRef
CHM1_11578,023,300 - 78,042,675 (-)NCBICHM1_1
T2T-CHM13v2.01575,473,724 - 75,683,106 (-)NCBIT2T-CHM13v2.0
Lingo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39956,525,743 - 56,704,355 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl956,525,759 - 56,703,752 (-)EnsemblGRCm39 Ensembl
GRCm38956,618,460 - 56,796,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl956,618,475 - 56,796,468 (-)EnsemblGRCm38mm10GRCm38
MGSCv37956,466,282 - 56,533,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36956,416,612 - 56,483,390 (-)NCBIMGSCv36mm8
Celera953,844,163 - 53,910,841 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map930.28NCBI
Lingo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8865,907,275 - 66,089,485 (-)NCBIGRCr8
mRatBN7.2857,011,272 - 57,193,496 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,010,007 - 57,196,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx862,541,946 - 62,558,082 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0860,820,958 - 60,837,094 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0858,685,217 - 58,701,353 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0861,272,125 - 61,455,480 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl861,274,017 - 61,290,240 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0859,842,273 - 60,025,178 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4860,335,369 - 60,351,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1860,353,788 - 60,376,585 (-)NCBI
Celera856,482,212 - 56,498,460 (-)NCBICelera
Cytogenetic Map8q24NCBI
Lingo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554502,435,662 - 2,452,213 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554502,435,768 - 2,493,387 (-)NCBIChiLan1.0ChiLan1.0
LINGO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21666,708,662 - 67,030,680 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11570,874,422 - 71,196,329 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01556,424,422 - 56,747,075 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11572,328,076 - 72,534,429 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1572,328,079 - 72,347,016 (-)Ensemblpanpan1.1panPan2
LINGO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13038,668,199 - 38,738,178 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3038,721,394 - 38,737,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3038,590,466 - 38,611,287 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03038,873,710 - 38,942,658 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,866,779 - 38,942,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13038,718,990 - 38,892,481 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,870,129 - 38,939,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03039,107,012 - 39,176,028 (+)NCBIUU_Cfam_GSD_1.0
Lingo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640116,690,565 - 116,881,599 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647134,706,198 - 34,731,037 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647134,657,073 - 34,729,662 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LINGO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl757,684,589 - 57,890,126 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1757,684,591 - 57,890,121 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2762,376,757 - 62,583,077 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LINGO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,485,059 - 5,690,531 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl265,688,293 - 5,690,155 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048136,058,467 - 136,267,092 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lingo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624894648,785 - 791,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624894648,357 - 791,168 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LINGO1
77 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q24.2-26.3(chr15:75307767-101723215)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|See cases [RCV000052346] Chr15:75307767..101723215 [GRCh38]
Chr15:75600108..102263418 [GRCh37]
Chr15:73387161..100080941 [NCBI36]
Chr15:15q24.2-26.3		 pathogenic
GRCh38/hg38 15q24.3-26.3(chr15:77543797-101843411)x3 copy number gain See cases [RCV000052347] Chr15:77543797..101843411 [GRCh38]
Chr15:77836139..102383614 [GRCh37]
Chr15:75623194..100201137 [NCBI36]
Chr15:15q24.3-26.3		 pathogenic
GRCh38/hg38 15q24.2-25.1(chr15:76006154-79982417)x1 copy number loss See cases [RCV000137079] Chr15:76006154..79982417 [GRCh38]
Chr15:76298495..80274759 [GRCh37]
Chr15:74085550..78061814 [NCBI36]
Chr15:15q24.2-25.1		 pathogenic|uncertain significance
GRCh38/hg38 15q24.3(chr15:77193423-77828917)x3 copy number gain See cases [RCV000138994] Chr15:77193423..77828917 [GRCh38]
Chr15:77485765..78121259 [GRCh37]
Chr15:75272820..75908314 [NCBI36]
Chr15:15q24.3		 likely benign
GRCh38/hg38 15q23-25.1(chr15:70025300-78705993)x1 copy number loss See cases [RCV000141666] Chr15:70025300..78705993 [GRCh38]
Chr15:70317639..78998335 [GRCh37]
Chr15:68104693..76785390 [NCBI36]
Chr15:15q23-25.1		 pathogenic
GRCh38/hg38 15q23-26.3(chr15:72154949-101920998)x3 copy number gain See cases [RCV000143019] Chr15:72154949..101920998 [GRCh38]
Chr15:72447290..102461201 [GRCh37]
Chr15:70234344..100278724 [NCBI36]
Chr15:15q23-26.3		 pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
GRCh38/hg38 15q24.3-25.1(chr15:77640317-78459174)x3 copy number gain See cases [RCV000050915] Chr15:77640317..78459174 [GRCh38]
Chr15:77932659..78751516 [GRCh37]
Chr15:75719714..76538571 [NCBI36]
Chr15:15q24.3-25.1		 uncertain significance
GRCh37/hg19 15q24.2-26.3(chr15:76061144-102429112)x3 copy number gain See cases [RCV000511332] Chr15:76061144..102429112 [GRCh37]
Chr15:15q24.2-26.3		 pathogenic
GRCh37/hg19 15q24.1-24.3(chr15:74368270-78122737)x3 copy number gain See cases [RCV000240526] Chr15:74368270..78122737 [GRCh37]
Chr15:15q24.1-24.3		 uncertain significance
GRCh37/hg19 15q22.31-26.3(chr15:64637227-102509910)x3 copy number gain See cases [RCV000240602] Chr15:64637227..102509910 [GRCh37]
Chr15:15q22.31-26.3		 pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3		 likely pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3		 pathogenic
GRCh37/hg19 15q24.2-24.3(chr15:76061143-78265674)x3 copy number gain See cases [RCV000446527] Chr15:76061143..78265674 [GRCh37]
Chr15:15q24.2-24.3		 uncertain significance
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
NM_032808.7(LINGO1):c.1849A>T (p.Met617Leu) single nucleotide variant not specified [RCV004304442] Chr15:77614058 [GRCh38]
Chr15:77906400 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.461A>T (p.Lys154Met) single nucleotide variant not specified [RCV004298580] Chr15:77615446 [GRCh38]
Chr15:77907788 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1382C>A (p.Pro461His) single nucleotide variant not specified [RCV004311977] Chr15:77614525 [GRCh38]
Chr15:77906867 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1070C>T (p.Ser357Leu) single nucleotide variant not specified [RCV004319550] Chr15:77614837 [GRCh38]
Chr15:77907179 [GRCh37]
Chr15:15q24.3		 uncertain significance
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3		 pathogenic
NM_032808.7(LINGO1):c.869G>A (p.Arg290His) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV000678221] Chr15:77615038 [GRCh38]
Chr15:77907380 [GRCh37]
Chr15:15q24.3		 pathogenic
NM_032808.7(LINGO1):c.863A>G (p.Tyr288Cys) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV000678222] Chr15:77615044 [GRCh38]
Chr15:77907386 [GRCh37]
Chr15:15q24.3		 pathogenic
GRCh37/hg19 15q23-26.3(chr15:71329220-102270758)x3 copy number gain not provided [RCV000683703] Chr15:71329220..102270758 [GRCh37]
Chr15:15q23-26.3		 pathogenic
GRCh37/hg19 15q24.3-26.3(chr15:77479244-102429112)x3 copy number gain not provided [RCV000683710] Chr15:77479244..102429112 [GRCh37]
Chr15:15q24.3-26.3		 pathogenic
Single allele duplication Schizophrenia [RCV000754167] Chr15:74071509..77878298 [GRCh38]
Chr15:15q24.1-24.3		 likely pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q24.3(chr15:77684224-77992234)x3 copy number gain not provided [RCV000762708] Chr15:77684224..77992234 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.832G>A (p.Val278Met) single nucleotide variant not specified [RCV004296083] Chr15:77615075 [GRCh38]
Chr15:77907417 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1830C>T (p.Asp610=) single nucleotide variant not provided [RCV000960873] Chr15:77614077 [GRCh38]
Chr15:77906419 [GRCh37]
Chr15:15q24.3		 benign
NM_032808.7(LINGO1):c.474A>G (p.Leu158=) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV001730951]|not provided [RCV001686331] Chr15:77615433 [GRCh38]
Chr15:77907775 [GRCh37]
Chr15:15q24.3		 benign
NM_032808.7(LINGO1):c.465C>T (p.Ile155=) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV001730906]|not provided [RCV001652031] Chr15:77615442 [GRCh38]
Chr15:77907784 [GRCh37]
Chr15:15q24.3		 benign
NM_032808.7(LINGO1):c.1575C>T (p.Pro525=) single nucleotide variant LINGO1-related condition [RCV003935909]|not provided [RCV000959226] Chr15:77614332 [GRCh38]
Chr15:77906674 [GRCh37]
Chr15:15q24.3		 benign
NM_032808.7(LINGO1):c.1110G>A (p.Pro370=) single nucleotide variant not provided [RCV000950459] Chr15:77614797 [GRCh38]
Chr15:77907139 [GRCh37]
Chr15:15q24.3		 benign
NM_032808.7(LINGO1):c.1557C>T (p.Pro519=) single nucleotide variant LINGO1-related condition [RCV003915936]|not provided [RCV000957327] Chr15:77614350 [GRCh38]
Chr15:77906692 [GRCh37]
Chr15:15q24.3		 benign|likely benign
NM_032808.7(LINGO1):c.114G>A (p.Ser38=) single nucleotide variant not provided [RCV000934797] Chr15:77615793 [GRCh38]
Chr15:77908135 [GRCh37]
Chr15:15q24.3		 benign|likely benign
NM_032808.7(LINGO1):c.1104C>T (p.Ser368=) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV001731091] Chr15:77614803 [GRCh38]
Chr15:77907145 [GRCh37]
Chr15:15q24.3		 benign
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1		 uncertain significance
NM_032808.7(LINGO1):c.158G>A (p.Arg53His) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV002284059] Chr15:77615749 [GRCh38]
Chr15:77908091 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.70C>G (p.Gln24Glu) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV001332713] Chr15:77615837 [GRCh38]
Chr15:77908179 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.295G>A (p.Glu99Lys) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV001336797] Chr15:77615612 [GRCh38]
Chr15:77907954 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1406A>G (p.Lys469Arg) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV001332712] Chr15:77614501 [GRCh38]
Chr15:77906843 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.714G>C (p.Leu238=) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV001730958]|not provided [RCV001686852] Chr15:77615193 [GRCh38]
Chr15:77907535 [GRCh37]
Chr15:15q24.3		 benign
NM_032808.7(LINGO1):c.868C>T (p.Arg290Cys) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV002250092] Chr15:77615039 [GRCh38]
Chr15:77907381 [GRCh37]
Chr15:15q24.3		 pathogenic
NM_032808.7(LINGO1):c.1825G>A (p.Ala609Thr) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV001839246]|not specified [RCV004041038] Chr15:77614082 [GRCh38]
Chr15:77906424 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.244C>T (p.Arg82Cys) single nucleotide variant not provided [RCV002221909]   uncertain significance
NM_032808.7(LINGO1):c.1385G>A (p.Arg462Gln) single nucleotide variant not specified [RCV004324087] Chr15:77614522 [GRCh38]
Chr15:77906864 [GRCh37]
Chr15:15q24.3		 uncertain significance
GRCh37/hg19 15q24.3-26.3(chr15:77512817-102035027)x3 copy number gain not provided [RCV002475797] Chr15:77512817..102035027 [GRCh37]
Chr15:15q24.3-26.3		 pathogenic
NM_032808.7(LINGO1):c.668G>A (p.Arg223Gln) single nucleotide variant not specified [RCV004145520] Chr15:77615239 [GRCh38]
Chr15:77907581 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.484A>C (p.Met162Leu) single nucleotide variant not specified [RCV004092046] Chr15:77615423 [GRCh38]
Chr15:77907765 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.368C>T (p.Thr123Met) single nucleotide variant not specified [RCV004142126] Chr15:77615539 [GRCh38]
Chr15:77907881 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.119C>T (p.Thr40Met) single nucleotide variant not specified [RCV004085326] Chr15:77615788 [GRCh38]
Chr15:77908130 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1816A>G (p.Ile606Val) single nucleotide variant not specified [RCV004187176] Chr15:77614091 [GRCh38]
Chr15:77906433 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.146C>T (p.Ser49Phe) single nucleotide variant not specified [RCV004084525] Chr15:77615761 [GRCh38]
Chr15:77908103 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1358C>T (p.Pro453Leu) single nucleotide variant not specified [RCV004217654] Chr15:77614549 [GRCh38]
Chr15:77906891 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1274G>A (p.Arg425His) single nucleotide variant not specified [RCV004211495] Chr15:77614633 [GRCh38]
Chr15:77906975 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.452G>A (p.Ser151Asn) single nucleotide variant not specified [RCV004127616] Chr15:77615455 [GRCh38]
Chr15:77907797 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.997G>A (p.Gly333Ser) single nucleotide variant not specified [RCV004290379] Chr15:77614910 [GRCh38]
Chr15:77907252 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1322C>T (p.Thr441Met) single nucleotide variant not specified [RCV004275175] Chr15:77614585 [GRCh38]
Chr15:77906927 [GRCh37]
Chr15:15q24.3		 uncertain significance
GRCh37/hg19 15q22.33-26.1(chr15:67358491-91644328)x3 copy number gain not provided [RCV003222839] Chr15:67358491..91644328 [GRCh37]
Chr15:15q22.33-26.1		 pathogenic
NM_032808.7(LINGO1):c.220C>T (p.Arg74Cys) single nucleotide variant not specified [RCV004264951] Chr15:77615687 [GRCh38]
Chr15:77908029 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1711G>A (p.Val571Ile) single nucleotide variant not specified [RCV004266957] Chr15:77614196 [GRCh38]
Chr15:77906538 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1171C>T (p.Arg391Trp) single nucleotide variant not specified [RCV004260167] Chr15:77614736 [GRCh38]
Chr15:77907078 [GRCh37]
Chr15:15q24.3		 uncertain significance
GRCh37/hg19 15q24.1-26.3(chr15:75165490-102520892)x3 copy number gain See cases [RCV003329502] Chr15:75165490..102520892 [GRCh37]
Chr15:15q24.1-26.3		 pathogenic
NM_032808.7(LINGO1):c.1775A>C (p.Asn592Thr) single nucleotide variant not provided [RCV003326922] Chr15:77614132 [GRCh38]
Chr15:77906474 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1184C>T (p.Thr395Met) single nucleotide variant not specified [RCV004343672] Chr15:77614723 [GRCh38]
Chr15:77907065 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.821A>G (p.Asn274Ser) single nucleotide variant not specified [RCV004359974] Chr15:77615086 [GRCh38]
Chr15:77907428 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.895A>G (p.Ile299Val) single nucleotide variant not specified [RCV004359975] Chr15:77615012 [GRCh38]
Chr15:77907354 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.34G>A (p.Val12Met) single nucleotide variant not specified [RCV004348750] Chr15:77615873 [GRCh38]
Chr15:77908215 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1795C>G (p.Pro599Ala) single nucleotide variant not specified [RCV004357708] Chr15:77614112 [GRCh38]
Chr15:77906454 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.55C>T (p.Leu19Phe) single nucleotide variant not specified [RCV004352713] Chr15:77615852 [GRCh38]
Chr15:77908194 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.120G>A (p.Thr40=) single nucleotide variant not provided [RCV003400962] Chr15:77615787 [GRCh38]
Chr15:77908129 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1635C>A (p.Arg545=) single nucleotide variant not provided [RCV003400957] Chr15:77614272 [GRCh38]
Chr15:77906614 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1359G>A (p.Pro453=) single nucleotide variant LINGO1-related condition [RCV003919122]|not provided [RCV003400960] Chr15:77614548 [GRCh38]
Chr15:77906890 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1443G>A (p.Thr481=) single nucleotide variant not provided [RCV003411190] Chr15:77614464 [GRCh38]
Chr15:77906806 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1635C>T (p.Arg545=) single nucleotide variant not provided [RCV003411189] Chr15:77614272 [GRCh38]
Chr15:77906614 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1194G>A (p.Thr398=) single nucleotide variant LINGO1-related condition [RCV003901043]|not provided [RCV003400961] Chr15:77614713 [GRCh38]
Chr15:77907055 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1503C>T (p.Asn501=) single nucleotide variant not provided [RCV003400958] Chr15:77614404 [GRCh38]
Chr15:77906746 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1365C>T (p.Ala455=) single nucleotide variant not provided [RCV003400959] Chr15:77614542 [GRCh38]
Chr15:77906884 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1510G>A (p.Gly504Ser) single nucleotide variant not specified [RCV004415356] Chr15:77614397 [GRCh38]
Chr15:77906739 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1280G>A (p.Arg427Gln) single nucleotide variant not specified [RCV004415353] Chr15:77614627 [GRCh38]
Chr15:77906969 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.7-9C>T single nucleotide variant LINGO1-related condition [RCV003976624] Chr15:77615909 [GRCh38]
Chr15:77908251 [GRCh37]
Chr15:15q24.3		 benign
NM_032808.7(LINGO1):c.1496C>T (p.Ala499Val) single nucleotide variant not specified [RCV004415355] Chr15:77614411 [GRCh38]
Chr15:77906753 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.939G>T (p.Leu313=) single nucleotide variant LINGO1-related condition [RCV003914347] Chr15:77614968 [GRCh38]
Chr15:77907310 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.945G>A (p.Glu315=) single nucleotide variant LINGO1-related condition [RCV003969057] Chr15:77614962 [GRCh38]
Chr15:77907304 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.6+9G>A single nucleotide variant LINGO1-related condition [RCV003912189] Chr15:77632301 [GRCh38]
Chr15:77924643 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.486G>A (p.Met162Ile) single nucleotide variant Intellectual disability, autosomal recessive 64 [RCV003991792] Chr15:77615421 [GRCh38]
Chr15:77907763 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1458C>T (p.Tyr486=) single nucleotide variant not provided [RCV003884102] Chr15:77614449 [GRCh38]
Chr15:77906791 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1827C>T (p.Ala609=) single nucleotide variant LINGO1-related condition [RCV003964597] Chr15:77614080 [GRCh38]
Chr15:77906422 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1008C>T (p.Tyr336=) single nucleotide variant LINGO1-related condition [RCV003964607] Chr15:77614899 [GRCh38]
Chr15:77907241 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.274G>A (p.Ala92Thr) single nucleotide variant LINGO1-related condition [RCV003959852] Chr15:77615633 [GRCh38]
Chr15:77907975 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.147C>T (p.Ser49=) single nucleotide variant LINGO1-related condition [RCV003937159] Chr15:77615760 [GRCh38]
Chr15:77908102 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.1351G>A (p.Asp451Asn) single nucleotide variant not specified [RCV004415354] Chr15:77614556 [GRCh38]
Chr15:77906898 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.89T>C (p.Val30Ala) single nucleotide variant not specified [RCV004415358] Chr15:77615818 [GRCh38]
Chr15:77908160 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.798G>A (p.Thr266=) single nucleotide variant LINGO1-related condition [RCV003974026] Chr15:77615109 [GRCh38]
Chr15:77907451 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.739T>A (p.Ser247Thr) single nucleotide variant not specified [RCV004415357] Chr15:77615168 [GRCh38]
Chr15:77907510 [GRCh37]
Chr15:15q24.3		 uncertain significance
NM_032808.7(LINGO1):c.1668C>T (p.Thr556=) single nucleotide variant LINGO1-related condition [RCV003911771] Chr15:77614239 [GRCh38]
Chr15:77906581 [GRCh37]
Chr15:15q24.3		 likely benign
NM_032808.7(LINGO1):c.-4C>A single nucleotide variant LINGO1-related condition [RCV003944472] Chr15:77632319 [GRCh38]
Chr15:77924661 [GRCh37]
Chr15:15q24.3		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4792
Count of miRNA genes:983
Interacting mature miRNAs:1191
Transcripts:ENST00000355300, ENST00000557798, ENST00000559893, ENST00000561030, ENST00000561686, ENST00000562933, ENST00000563316, ENST00000564066, ENST00000564472, ENST00000566711, ENST00000567605, ENST00000567726, ENST00000568951, ENST00000570216
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
WI-21778  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371577,906,048 - 77,906,225UniSTSGRCh37
Build 361575,693,103 - 75,693,280RGDNCBI36
Celera1554,844,287 - 54,844,464RGD
Cytogenetic Map15q24.3UniSTS
HuRef1554,661,214 - 54,661,391UniSTS
GeneMap99-GB4 RH Map15272.4UniSTS
Whitehead-RH Map15285.3UniSTS
NCBI RH Map15513.2UniSTS
G59824  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371577,906,066 - 77,906,170UniSTSGRCh37
Build 361575,693,121 - 75,693,225RGDNCBI36
Celera1554,844,305 - 54,844,409RGD
Cytogenetic Map15q24.3UniSTS
HuRef1554,661,232 - 54,661,336UniSTS
TNG Radiation Hybrid Map1529048.0UniSTS
SHGC-146402  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371577,910,069 - 77,910,401UniSTSGRCh37
Build 361575,697,124 - 75,697,456RGDNCBI36
Celera1554,848,308 - 54,848,640RGD
Cytogenetic Map15q24.3UniSTS
HuRef1554,665,235 - 54,665,567UniSTS
TNG Radiation Hybrid Map1529052.0UniSTS
STS-H11343  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q24.3UniSTS
GeneMap99-GB4 RH Map15272.72UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 28 270 30 19 9 19 484 29 2314 52 178 62 1 30 221
Low 2100 1794 1258 328 539 168 3171 1320 1334 307 1187 1268 163 1 1155 1902 1
Below cutoff 260 747 419 267 906 266 693 831 62 31 61 231 6 19 664 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001301186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054379005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054379006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054379007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC046168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC105133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL109677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL834260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY324320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY324322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY324323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI523562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI669707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI825536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX355455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA150164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA182630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA183673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA232085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA328735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA410114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA483616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA494936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA525603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA787289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB165168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  H11343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY342106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000355300   ⟹   ENSP00000347451
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,613,027 - 77,632,912 (-)Ensembl
RefSeq Acc Id: ENST00000557798   ⟹   ENSP00000453780
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,614,944 - 77,634,353 (-)Ensembl
RefSeq Acc Id: ENST00000559893   ⟹   ENSP00000454051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,615,722 - 77,696,495 (-)Ensembl
RefSeq Acc Id: ENST00000561030   ⟹   ENSP00000453853
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,613,670 - 77,696,148 (-)Ensembl
RefSeq Acc Id: ENST00000561686   ⟹   ENSP00000455605
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,615,353 - 77,787,014 (-)Ensembl
RefSeq Acc Id: ENST00000562933   ⟹   ENSP00000456516
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,615,854 - 77,820,332 (-)Ensembl
RefSeq Acc Id: ENST00000563316   ⟹   ENSP00000457101
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,615,877 - 77,820,871 (-)Ensembl
RefSeq Acc Id: ENST00000564066
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,677,156 - 77,820,224 (-)Ensembl
RefSeq Acc Id: ENST00000564472   ⟹   ENSP00000454245
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,615,782 - 77,720,751 (-)Ensembl
RefSeq Acc Id: ENST00000566711   ⟹   ENSP00000454687
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,615,673 - 77,819,452 (-)Ensembl
RefSeq Acc Id: ENST00000567605
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,677,107 - 77,819,528 (-)Ensembl
RefSeq Acc Id: ENST00000567726   ⟹   ENSP00000454465
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,615,513 - 77,707,507 (-)Ensembl
RefSeq Acc Id: ENST00000568951
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,677,109 - 77,820,854 (-)Ensembl
RefSeq Acc Id: ENST00000570216   ⟹   ENSP00000454577
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1577,615,833 - 77,820,900 (-)Ensembl
RefSeq Acc Id: NM_001301186   ⟹   NP_001288115
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,820,900 (-)NCBI
CHM1_11578,023,297 - 78,231,113 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,683,106 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301187   ⟹   NP_001288116
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,820,332 (-)NCBI
CHM1_11578,023,297 - 78,230,545 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,682,538 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301189   ⟹   NP_001288118
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,820,201 (-)NCBI
CHM1_11578,023,297 - 78,230,315 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,682,407 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301191   ⟹   NP_001288120
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,819,452 (-)NCBI
CHM1_11578,023,297 - 78,229,747 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,681,668 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301192   ⟹   NP_001288121
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,819,452 (-)NCBI
CHM1_11578,023,297 - 78,229,747 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,681,668 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301194   ⟹   NP_001288123
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,819,452 (-)NCBI
CHM1_11578,023,297 - 78,229,747 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,681,668 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301195   ⟹   NP_001288124
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,787,049 (-)NCBI
CHM1_11578,023,297 - 78,197,346 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,649,389 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301197   ⟹   NP_001288126
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,720,751 (-)NCBI
CHM1_11578,023,297 - 78,131,094 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,583,109 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301198   ⟹   NP_001288127
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,707,507 (-)NCBI
CHM1_11578,023,297 - 78,117,814 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,569,871 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301199   ⟹   NP_001288128
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,696,495 (-)NCBI
CHM1_11578,023,297 - 78,106,802 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,556,812 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301200   ⟹   NP_001288129
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,696,148 (-)NCBI
CHM1_11578,023,297 - 78,106,455 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,556,465 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032808   ⟹   NP_116197
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,632,912 (-)NCBI
GRCh371577,905,369 - 77,988,490 (-)NCBI
Build 361575,692,424 - 75,711,764 (-)NCBI Archive
HuRef1554,660,535 - 54,680,264 (-)ENTREZGENE
CHM1_11578,023,297 - 78,042,835 (-)NCBI
T2T-CHM13v2.01575,473,724 - 75,493,239 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011522118   ⟹   XP_011520420
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,671,779 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017022682   ⟹   XP_016878171
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,819,452 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024450091   ⟹   XP_024305859
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,613,027 - 77,787,049 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054379005   ⟹   XP_054234980
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01575,473,724 - 75,649,390 (-)NCBI
RefSeq Acc Id: XM_054379006   ⟹   XP_054234981
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01575,473,724 - 75,681,668 (-)NCBI
RefSeq Acc Id: XM_054379007   ⟹   XP_054234982
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01575,473,724 - 75,532,146 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001288115 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288116 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288118 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288120 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288121 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288123 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288124 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288126 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288127 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288128 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288129 (Get FASTA)   NCBI Sequence Viewer  
  NP_116197 (Get FASTA)   NCBI Sequence Viewer  
  XP_011520420 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878171 (Get FASTA)   NCBI Sequence Viewer  
  XP_024305859 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234980 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234981 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234982 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH11057 (Get FASTA)   NCBI Sequence Viewer  
  AAH68558 (Get FASTA)   NCBI Sequence Viewer  
  AAQ88651 (Get FASTA)   NCBI Sequence Viewer  
  AAQ97216 (Get FASTA)   NCBI Sequence Viewer  
  AAQ97217 (Get FASTA)   NCBI Sequence Viewer  
  AAQ97218 (Get FASTA)   NCBI Sequence Viewer  
  BAB55157 (Get FASTA)   NCBI Sequence Viewer  
  BAF84052 (Get FASTA)   NCBI Sequence Viewer  
  CAD38935 (Get FASTA)   NCBI Sequence Viewer  
  EAW99195 (Get FASTA)   NCBI Sequence Viewer  
  EAW99196 (Get FASTA)   NCBI Sequence Viewer  
  EAW99197 (Get FASTA)   NCBI Sequence Viewer  
  EAW99198 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000347451
  ENSP00000347451.6
  ENSP00000453780.1
  ENSP00000453853
  ENSP00000453853.1
  ENSP00000454051.1
  ENSP00000454245.1
  ENSP00000454465.1
  ENSP00000454577.1
  ENSP00000454687.1
  ENSP00000455605.1
  ENSP00000456516.1
GenBank Protein Q96FE5 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_116197   ⟸   NM_032808
- Peptide Label: isoform a precursor
- UniProtKB: Q8N3K5 (UniProtKB/Swiss-Prot),   Q6VVG2 (UniProtKB/Swiss-Prot),   Q6VVG1 (UniProtKB/Swiss-Prot),   Q6VVG0 (UniProtKB/Swiss-Prot),   Q6UXM3 (UniProtKB/Swiss-Prot),   Q6NUK3 (UniProtKB/Swiss-Prot),   D3DW80 (UniProtKB/Swiss-Prot),   Q96K52 (UniProtKB/Swiss-Prot),   Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288115   ⟸   NM_001301186
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288116   ⟸   NM_001301187
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288118   ⟸   NM_001301189
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288123   ⟸   NM_001301194
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288121   ⟸   NM_001301192
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288120   ⟸   NM_001301191
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288124   ⟸   NM_001301195
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288126   ⟸   NM_001301197
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288127   ⟸   NM_001301198
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288128   ⟸   NM_001301199
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288129   ⟸   NM_001301200
- Peptide Label: isoform b precursor
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011520420   ⟸   XM_011522118
- Peptide Label: isoform X1
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016878171   ⟸   XM_017022682
- Peptide Label: isoform X1
- UniProtKB: Q96FE5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024305859   ⟸   XM_024450091
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000453780   ⟸   ENST00000557798
RefSeq Acc Id: ENSP00000454577   ⟸   ENST00000570216
RefSeq Acc Id: ENSP00000454051   ⟸   ENST00000559893
RefSeq Acc Id: ENSP00000455605   ⟸   ENST00000561686
RefSeq Acc Id: ENSP00000453853   ⟸   ENST00000561030
RefSeq Acc Id: ENSP00000456516   ⟸   ENST00000562933
RefSeq Acc Id: ENSP00000457101   ⟸   ENST00000563316
RefSeq Acc Id: ENSP00000454245   ⟸   ENST00000564472
RefSeq Acc Id: ENSP00000347451   ⟸   ENST00000355300
RefSeq Acc Id: ENSP00000454687   ⟸   ENST00000566711
RefSeq Acc Id: ENSP00000454465   ⟸   ENST00000567726
RefSeq Acc Id: XP_054234981   ⟸   XM_054379006
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054234980   ⟸   XM_054379005
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054234982   ⟸   XM_054379007
- Peptide Label: isoform X1
Protein Domains
Ig-like C2-type   LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96FE5-F1-model_v2 AlphaFold Q96FE5 1-620 view protein structure

Promoters
RGD ID:6792414
Promoter ID:HG_KWN:22007
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000355300
Position:
Human AssemblyChrPosition (strand)Source
Build 361575,712,611 - 75,713,111 (-)MPROMDB
RGD ID:7230213
Promoter ID:EPDNEW_H20852
Type:initiation region
Name:LINGO1_1
Description:leucine rich repeat and Ig domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381577,632,888 - 77,632,948EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21205 AgrOrtholog
COSMIC LINGO1 COSMIC
Ensembl Genes ENSG00000169783 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000355300 ENTREZGENE
  ENST00000355300.7 UniProtKB/Swiss-Prot
  ENST00000557798.1 UniProtKB/TrEMBL
  ENST00000559893.5 UniProtKB/TrEMBL
  ENST00000561030 ENTREZGENE
  ENST00000561030.5 UniProtKB/Swiss-Prot
  ENST00000561686.5 UniProtKB/TrEMBL
  ENST00000562933.5 UniProtKB/TrEMBL
  ENST00000564472.5 UniProtKB/TrEMBL
  ENST00000566711.5 UniProtKB/TrEMBL
  ENST00000567726.5 UniProtKB/TrEMBL
  ENST00000570216.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000169783 GTEx
HGNC ID HGNC:21205 ENTREZGENE
Human Proteome Map LINGO1 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_5 UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:84894 UniProtKB/Swiss-Prot
NCBI Gene 84894 ENTREZGENE
OMIM 609791 OMIM
PANTHER FI03225P UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot
  LRR_1 UniProtKB/TrEMBL
  LRR_5 UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162394087 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48726 UniProtKB/Swiss-Prot
UniProt D3DW80 ENTREZGENE
  H0YMX3_HUMAN UniProtKB/TrEMBL
  H0YNK7_HUMAN UniProtKB/TrEMBL
  H3BM59_HUMAN UniProtKB/TrEMBL
  H3BMN3_HUMAN UniProtKB/TrEMBL
  H3BMW2_HUMAN UniProtKB/TrEMBL
  H3BN48_HUMAN UniProtKB/TrEMBL
  H3BQ49_HUMAN UniProtKB/TrEMBL
  H3BS32_HUMAN UniProtKB/TrEMBL
  LIGO1_HUMAN UniProtKB/Swiss-Prot
  Q6NUK3 ENTREZGENE
  Q6UXM3 ENTREZGENE
  Q6VVG0 ENTREZGENE
  Q6VVG1 ENTREZGENE
  Q6VVG2 ENTREZGENE
  Q8N3K5 ENTREZGENE
  Q96FE5 ENTREZGENE
  Q96K52 ENTREZGENE
UniProt Secondary D3DW80 UniProtKB/Swiss-Prot
  Q6NUK3 UniProtKB/Swiss-Prot
  Q6UXM3 UniProtKB/Swiss-Prot
  Q6VVG0 UniProtKB/Swiss-Prot
  Q6VVG1 UniProtKB/Swiss-Prot
  Q6VVG2 UniProtKB/Swiss-Prot
  Q8N3K5 UniProtKB/Swiss-Prot
  Q96K52 UniProtKB/Swiss-Prot