LACTB2 (lactamase beta 2) - Rat Genome Database

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Gene: LACTB2 (lactamase beta 2) Homo sapiens
Analyze
Symbol: LACTB2
Name: lactamase beta 2
RGD ID: 1317324
HGNC Page HGNC:18512
Description: Enables RNA endonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Predicted to be involved in secondary metabolite biosynthetic process. Located in mitochondrial matrix.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-lactamase-like protein 2; CGI-83; endoribonuclease LACTB2; lactamase, beta 2; testicular secretory protein Li 23
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38870,637,266 - 70,669,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl870,635,318 - 70,669,185 (-)EnsemblGRCh38hg38GRCh38
GRCh37871,549,501 - 71,581,420 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36871,712,045 - 71,743,946 (-)NCBINCBI36Build 36hg18NCBI36
Build 34871,712,044 - 71,743,946NCBI
Celera867,547,128 - 67,579,082 (-)NCBICelera
Cytogenetic Map8q13.3ENTREZGENE
HuRef867,042,341 - 67,074,194 (-)NCBIHuRef
CHM1_1871,605,012 - 71,636,965 (-)NCBICHM1_1
T2T-CHM13v2.0871,067,173 - 71,099,092 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
2-palmitoylglycerol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
benzatropine  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clozapine  (EXP)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP,ISO)
diuron  (ISO)
doxorubicin  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
finasteride  (ISO)
fipronil  (ISO)
flutamide  (ISO)
glafenine  (ISO)
glycidyl methacrylate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
isotretinoin  (EXP)
ivermectin  (EXP)
lipopolysaccharide  (EXP)
methidathion  (ISO)
methylmercury chloride  (EXP)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phorone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
Tesaglitazar  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)
vincristine  (EXP)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrial matrix  (IBA,IDA,IEA)
mitochondrion  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:10810093   PMID:12477932   PMID:20877624   PMID:21873635   PMID:21988832   PMID:22939629   PMID:25416956   PMID:25823027   PMID:26186194   PMID:26344197   PMID:26826708  
PMID:27005419   PMID:28514442   PMID:31536960   PMID:33961781   PMID:34159380   PMID:34271102   PMID:35562734   PMID:35831314   PMID:35944360   PMID:36215168  


Genomics

Comparative Map Data
LACTB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38870,637,266 - 70,669,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl870,635,318 - 70,669,185 (-)EnsemblGRCh38hg38GRCh38
GRCh37871,549,501 - 71,581,420 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36871,712,045 - 71,743,946 (-)NCBINCBI36Build 36hg18NCBI36
Build 34871,712,044 - 71,743,946NCBI
Celera867,547,128 - 67,579,082 (-)NCBICelera
Cytogenetic Map8q13.3ENTREZGENE
HuRef867,042,341 - 67,074,194 (-)NCBIHuRef
CHM1_1871,605,012 - 71,636,965 (-)NCBICHM1_1
T2T-CHM13v2.0871,067,173 - 71,099,092 (-)NCBIT2T-CHM13v2.0
Lactb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,695,069 - 13,730,749 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,693,554 - 13,730,770 (-)EnsemblGRCm39 Ensembl
GRCm38113,625,893 - 13,660,583 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,623,330 - 13,660,546 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,615,979 - 13,650,590 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,611,112 - 13,645,723 (-)NCBIMGSCv36mm8
Celera113,576,714 - 13,611,343 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.29NCBI
Lactb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8510,352,165 - 10,374,928 (+)NCBIGRCr8
mRatBN7.255,569,080 - 5,591,843 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl55,569,067 - 5,596,429 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx57,706,604 - 7,729,324 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.059,345,494 - 9,368,214 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.059,036,663 - 9,059,389 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.054,982,348 - 5,005,111 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl54,982,348 - 5,005,109 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.054,950,859 - 4,973,622 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.454,770,321 - 4,793,420 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.154,770,320 - 4,793,418 (+)NCBI
Celera55,153,652 - 5,176,439 (+)NCBICelera
Cytogenetic Map5q11NCBI
Lactb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554449,059,572 - 9,088,705 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554449,059,999 - 9,088,705 (+)NCBIChiLan1.0ChiLan1.0
LACTB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2786,371,145 - 86,402,722 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1862,000,310 - 62,032,123 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0867,162,667 - 67,194,560 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1868,823,061 - 68,854,992 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl868,824,302 - 68,854,833 (-)Ensemblpanpan1.1panPan2
LACTB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12919,723,155 - 19,749,147 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2919,720,144 - 19,749,387 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2919,982,569 - 20,008,565 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02919,820,428 - 19,846,653 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2919,820,990 - 19,846,640 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12919,857,861 - 19,883,845 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02919,924,490 - 19,950,473 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02920,205,437 - 20,231,448 (-)NCBIUU_Cfam_GSD_1.0
Lactb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530359,465,676 - 59,492,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649615,292,216 - 15,319,786 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649615,292,216 - 15,319,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LACTB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl464,710,771 - 64,748,936 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1464,710,777 - 64,748,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2470,341,257 - 70,379,434 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LACTB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1866,375,284 - 66,406,385 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl866,370,596 - 66,406,406 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603975,020,323 - 75,051,298 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lactb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474420,577,545 - 20,605,149 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LACTB2
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q13.2-13.3(chr8:68488015-71476177)x1 copy number loss See cases [RCV000050801] Chr8:68488015..71476177 [GRCh38]
Chr8:69400250..72388412 [GRCh37]
Chr8:69562804..72550966 [NCBI36]
Chr8:8q13.2-13.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q12.1-21.13(chr8:57361243-79170078)x3 copy number gain See cases [RCV000053653] Chr8:57361243..79170078 [GRCh38]
Chr8:58273802..80082313 [GRCh37]
Chr8:58436356..80244868 [NCBI36]
Chr8:8q12.1-21.13		 pathogenic
GRCh38/hg38 8q12.3-21.13(chr8:61691800-82537696)x3 copy number gain See cases [RCV000053654] Chr8:61691800..82537696 [GRCh38]
Chr8:62604359..83449931 [GRCh37]
Chr8:62766913..83612486 [NCBI36]
Chr8:8q12.3-21.13		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q12.3-21.11(chr8:62230636-73227786)x1 copy number loss See cases [RCV000054242] Chr8:62230636..73227786 [GRCh38]
Chr8:63143195..74140021 [GRCh37]
Chr8:63305749..74302575 [NCBI36]
Chr8:8q12.3-21.11		 pathogenic
GRCh38/hg38 8q13.2-13.3(chr8:68987881-71640028)x1 copy number loss See cases [RCV000134801] Chr8:68987881..71640028 [GRCh38]
Chr8:69900116..72552263 [GRCh37]
Chr8:70062670..72714817 [NCBI36]
Chr8:8q13.2-13.3		 pathogenic
GRCh38/hg38 8q13.1-22.1(chr8:66171669-93505509)x3 copy number gain See cases [RCV000137050] Chr8:66171669..93505509 [GRCh38]
Chr8:67083904..94517737 [GRCh37]
Chr8:67246458..94586913 [NCBI36]
Chr8:8q13.1-22.1		 pathogenic
GRCh38/hg38 8q13.3(chr8:70625656-70804655)x1 copy number loss See cases [RCV000137676] Chr8:70625656..70804655 [GRCh38]
Chr8:71537891..71716890 [GRCh37]
Chr8:71700445..71879444 [NCBI36]
Chr8:8q13.3		 uncertain significance
GRCh38/hg38 8q13.1-21.13(chr8:66633845-80100089)x3 copy number gain See cases [RCV000138027] Chr8:66633845..80100089 [GRCh38]
Chr8:67546080..81012324 [GRCh37]
Chr8:67708634..81174879 [NCBI36]
Chr8:8q13.1-21.13		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q13.2-13.3(chr8:68987835-71663466)x1 copy number loss See cases [RCV000138251] Chr8:68987835..71663466 [GRCh38]
Chr8:69900070..72575701 [GRCh37]
Chr8:70062624..72738255 [NCBI36]
Chr8:8q13.2-13.3		 pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8q13.2-13.3(chr8:69955127-72552241)x1 copy number loss See cases [RCV000240421] Chr8:69955127..72552241 [GRCh37]
Chr8:8q13.2-13.3		 pathogenic
GRCh37/hg19 8q13.3-21.13(chr8:70971013-82019151)x3 copy number gain See cases [RCV000240367] Chr8:70971013..82019151 [GRCh37]
Chr8:8q13.3-21.13		 likely pathogenic
GRCh37/hg19 8q13.2-13.3(chr8:69899336-72597645)x1 copy number loss See cases [RCV000446721] Chr8:69899336..72597645 [GRCh37]
Chr8:8q13.2-13.3		 pathogenic
GRCh37/hg19 8q13.3(chr8:71077789-72943097)x3 copy number gain See cases [RCV000446539] Chr8:71077789..72943097 [GRCh37]
Chr8:8q13.3		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8q13.3(chr8:71549662-71647145)x3 copy number gain See cases [RCV000448894] Chr8:71549662..71647145 [GRCh37]
Chr8:8q13.3		 likely benign
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8q13.2-13.3(chr8:69899336-72597645)x1 copy number loss See cases [RCV000510185] Chr8:69899336..72597645 [GRCh37]
Chr8:8q13.2-13.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8q13.3(chr8:71198990-71920676)x1 copy number loss See cases [RCV000512294] Chr8:71198990..71920676 [GRCh37]
Chr8:8q13.3		 uncertain significance
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3		 pathogenic
GRCh37/hg19 8q13.3(chr8:71525694-71835493)x3 copy number gain not provided [RCV000682969] Chr8:71525694..71835493 [GRCh37]
Chr8:8q13.3		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771) copy number gain Polydactyly [RCV002280629] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8q13.3(chr8:70848713-71632067)x3 copy number gain not provided [RCV001006112] Chr8:70848713..71632067 [GRCh37]
Chr8:8q13.3		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8q13.3(chr8:71475270-71849895)x1 copy number loss not provided [RCV000846385] Chr8:71475270..71849895 [GRCh37]
Chr8:8q13.3		 uncertain significance
GRCh37/hg19 8q13.3(chr8:71244655-71685822)x3 copy number gain not provided [RCV001258414] Chr8:71244655..71685822 [GRCh37]
Chr8:8q13.3		 uncertain significance
GRCh37/hg19 8q13.2-13.3(chr8:69894553-72597645)x1 copy number loss not provided [RCV001827961] Chr8:69894553..72597645 [GRCh37]
Chr8:8q13.2-13.3		 pathogenic
GRCh37/hg19 8q13.2-24.3(chr8:70382990-146295771) copy number gain not specified [RCV002053772] Chr8:70382990..146295771 [GRCh37]
Chr8:8q13.2-24.3		 pathogenic
GRCh37/hg19 8q13.2-13.3(chr8:69899336-72597645) copy number loss not specified [RCV002053771] Chr8:69899336..72597645 [GRCh37]
Chr8:8q13.2-13.3		 pathogenic
GRCh37/hg19 8q13.2-24.3(chr8:68912432-146295771)x2 copy number gain See cases [RCV002292707] Chr8:68912432..146295771 [GRCh37]
Chr8:8q13.2-24.3		 pathogenic
NM_016027.3(LACTB2):c.340A>G (p.Ile114Val) single nucleotide variant not specified [RCV004079230] Chr8:70657829 [GRCh38]
Chr8:71570064 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.571A>C (p.Lys191Gln) single nucleotide variant not specified [RCV004225277] Chr8:70644086 [GRCh38]
Chr8:71556321 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.430G>A (p.Gly144Ser) single nucleotide variant not specified [RCV004222889] Chr8:70644227 [GRCh38]
Chr8:71556462 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.656T>C (p.Ile219Thr) single nucleotide variant not specified [RCV004083376] Chr8:70640987 [GRCh38]
Chr8:71553222 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.296A>G (p.Tyr99Cys) single nucleotide variant not specified [RCV004206395] Chr8:70657873 [GRCh38]
Chr8:71570108 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.170G>T (p.Ser57Ile) single nucleotide variant not specified [RCV004159482] Chr8:70661850 [GRCh38]
Chr8:71574085 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.659G>A (p.Arg220Gln) single nucleotide variant not specified [RCV004232729] Chr8:70640984 [GRCh38]
Chr8:71553219 [GRCh37]
Chr8:8q13.3		 uncertain significance
GRCh37/hg19 8q13.3(chr8:71556060-71631858)x1 copy number loss not provided [RCV003483031] Chr8:71556060..71631858 [GRCh37]
Chr8:8q13.3		 uncertain significance
GRCh37/hg19 8p21.2-q21.3(chr8:27024288-89410121)x3 copy number gain not specified [RCV003986754] Chr8:27024288..89410121 [GRCh37]
Chr8:8p21.2-q21.3		 pathogenic
GRCh37/hg19 8q13.2-13.3(chr8:69889747-72597645)x1 copy number loss not specified [RCV003986732] Chr8:69889747..72597645 [GRCh37]
Chr8:8q13.2-13.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not specified [RCV003986742] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_016027.3(LACTB2):c.859C>T (p.His287Tyr) single nucleotide variant not specified [RCV004407163] Chr8:70637868 [GRCh38]
Chr8:71550103 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.107T>G (p.Val36Gly) single nucleotide variant not specified [RCV004407157] Chr8:70669014 [GRCh38]
Chr8:71581249 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.13C>G (p.Leu5Val) single nucleotide variant not specified [RCV004407158] Chr8:70669108 [GRCh38]
Chr8:71581343 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.210C>G (p.Ile70Met) single nucleotide variant not specified [RCV004407159] Chr8:70661810 [GRCh38]
Chr8:71574045 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.635A>T (p.Gln212Leu) single nucleotide variant not specified [RCV004407160] Chr8:70641008 [GRCh38]
Chr8:71553243 [GRCh37]
Chr8:8q13.3		 uncertain significance
NM_016027.3(LACTB2):c.686G>A (p.Arg229His) single nucleotide variant not specified [RCV004407162] Chr8:70640957 [GRCh38]
Chr8:71553192 [GRCh37]
Chr8:8q13.3		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:669
Count of miRNA genes:506
Interacting mature miRNAs:545
Transcripts:ENST00000276590, ENST00000517601, ENST00000522447, ENST00000522558
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-31052  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,570,453 - 71,570,602UniSTSGRCh37
Build 36871,733,007 - 71,733,156RGDNCBI36
Celera867,568,088 - 67,568,237RGD
Cytogenetic Map8q13.3UniSTS
HuRef867,063,199 - 67,063,348UniSTS
GeneMap99-GB4 RH Map8371.77UniSTS
Whitehead-RH Map8476.1UniSTS
NCBI RH Map8833.0UniSTS
GeneMap99-G3 RH Map82973.0UniSTS
SHGC-141879  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,550,434 - 71,550,731UniSTSGRCh37
Build 36871,712,988 - 71,713,285RGDNCBI36
Celera867,548,061 - 67,548,358RGD
Cytogenetic Map8q13.3UniSTS
HuRef867,043,274 - 67,043,571UniSTS
RH98763  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8q13.3UniSTS
GeneMap99-GB4 RH Map8371.67UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1025 751 1339 460 840 436 1889 692 804 386 888 1197 41 1 764 949 5 2
Low 1412 2111 387 164 971 29 2468 1496 2925 32 572 416 134 440 1839 1
Below cutoff 1 129 132 9 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000276590   ⟹   ENSP00000276590
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl870,637,266 - 70,669,185 (-)Ensembl
RefSeq Acc Id: ENST00000517601
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl870,638,551 - 70,644,252 (-)Ensembl
RefSeq Acc Id: ENST00000522447   ⟹   ENSP00000428801
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl870,635,318 - 70,669,174 (-)Ensembl
RefSeq Acc Id: ENST00000522558
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl870,640,573 - 70,644,128 (-)Ensembl
RefSeq Acc Id: NM_016027   ⟹   NP_057111
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,637,266 - 70,669,185 (-)NCBI
GRCh37871,549,501 - 71,581,447 (-)RGD
Build 36871,712,045 - 71,743,946 (-)NCBI Archive
Celera867,547,128 - 67,579,082 (-)RGD
HuRef867,042,341 - 67,074,194 (-)RGD
CHM1_1871,605,012 - 71,636,965 (-)NCBI
T2T-CHM13v2.0871,067,173 - 71,099,092 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_057111   ⟸   NM_016027
- UniProtKB: A8K2D6 (UniProtKB/Swiss-Prot),   Q9Y392 (UniProtKB/Swiss-Prot),   Q53H82 (UniProtKB/Swiss-Prot),   A0A024R811 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000428801   ⟸   ENST00000522447
RefSeq Acc Id: ENSP00000276590   ⟸   ENST00000276590

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q53H82-F1-model_v2 AlphaFold Q53H82 1-288 view protein structure

Promoters
RGD ID:7213499
Promoter ID:EPDNEW_H12495
Type:initiation region
Name:LACTB2_1
Description:lactamase beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,669,175 - 70,669,235EPDNEW
RGD ID:6806832
Promoter ID:HG_KWN:61489
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000276590,   NM_001011720,   UC010LZD.1,   UC010LZE.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36871,743,286 - 71,744,017 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18512 AgrOrtholog
COSMIC LACTB2 COSMIC
Ensembl Genes ENSG00000147592 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000276590 ENTREZGENE
  ENST00000276590.5 UniProtKB/Swiss-Prot
  ENST00000522447.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.60.15.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000147592 GTEx
HGNC ID HGNC:18512 ENTREZGENE
Human Proteome Map LACTB2 Human Proteome Map
InterPro LACTB2-like_MBL-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LACTB2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-B-lactamas UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RibonucZ/Hydroxyglut_hydro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:51110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 51110 ENTREZGENE
OMIM 618921 OMIM
PANTHER ENDORIBONUCLEASE LACTB2 UniProtKB/Swiss-Prot
  ENDORIBONUCLEASE LACTB2 UniProtKB/Swiss-Prot
  ENDORIBONUCLEASE LACTB2 UniProtKB/TrEMBL
  ENDORIBONUCLEASE LACTB2 UniProtKB/TrEMBL
Pfam BLACT_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactamase_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134952605 PharmGKB
SMART Lactamase_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R811 ENTREZGENE, UniProtKB/TrEMBL
  A8K2D6 ENTREZGENE
  LACB2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Y392 ENTREZGENE
UniProt Secondary A8K2D6 UniProtKB/Swiss-Prot
  Q9Y392 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 LACTB2  lactamase beta 2    lactamase, beta 2  Symbol and/or name change 5135510 APPROVED