VSTM2L (V-set and transmembrane domain containing 2 like)

Gene: VSTM2L (V-set and transmembrane domain containing 2 like) Homo sapiens

Analyze

Symbol:

VSTM2L

Name:

V-set and transmembrane domain containing 2 like

RGD ID:

1313925

HGNC Page

HGNC:16096

Description:

Involved in negative regulation of neuron apoptotic process. Located in cytoplasm and extracellular region.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

C20orf102; dJ1118M15.2; V-set and transmembrane domain-containing protein 2-like protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	37,903,127 - 37,945,350 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	37,903,111 - 37,945,350 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	36,531,529 - 36,573,752 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	35,964,913 - 36,007,166 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	35,964,919 - 36,007,159	NCBI
Celera	20	33,238,553 - 33,280,802 (+)	NCBI		Celera
Cytogenetic Map	20	q11.23	NCBI
HuRef	20	33,266,969 - 33,309,495 (+)	NCBI		HuRef
CHM1_1	20	36,434,291 - 36,476,782 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	39,627,202 - 39,669,657 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

focal epilepsy (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (EXP)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

cadmium atom (EXP)

calcitriol (EXP)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

cyclosporin A (EXP)

doxorubicin (EXP)

gentamycin (ISO)

lead(0) (EXP)

lipopolysaccharide (EXP)

methylmercury chloride (EXP)

mono(2-ethylhexyl) phthalate (ISO)

Nor-9-carboxy-delta9-THC (EXP)

paracetamol (ISO)

PCB138 (ISO)

pentanal (EXP)

pirinixic acid (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (EXP)

silicon dioxide (EXP)

sodium arsenite (EXP)

sunitinib (EXP)

testosterone (EXP,ISO)

trichloroethene (ISO)

triclosan (EXP)

tunicamycin (EXP)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of neuron apoptotic process (IDA,IEA)

Cellular Component

cytoplasm (IDA,IEA)

extracellular region (IDA,IEA)

membrane (IBA)

Molecular Function

protein binding (IPI)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Focal-onset seizure (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11553796	PMID:11780052	PMID:12477932	PMID:14702039	PMID:15489334	PMID:16713569	PMID:21393573	PMID:21873635	PMID:25814554	PMID:26167880	PMID:28611215	PMID:32814053
PMID:33506057	PMID:37030064

Genomics

Comparative Map Data

VSTM2L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	37,903,127 - 37,945,350 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	37,903,111 - 37,945,350 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	36,531,529 - 36,573,752 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	35,964,913 - 36,007,166 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	35,964,919 - 36,007,159	NCBI
Celera	20	33,238,553 - 33,280,802 (+)	NCBI		Celera
Cytogenetic Map	20	q11.23	NCBI
HuRef	20	33,266,969 - 33,309,495 (+)	NCBI		HuRef
CHM1_1	20	36,434,291 - 36,476,782 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	39,627,202 - 39,669,657 (+)	NCBI		T2T-CHM13v2.0

Vstm2l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	157,756,573 - 157,786,639 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	157,756,573 - 157,786,639 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	157,914,653 - 157,944,719 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	157,914,653 - 157,944,719 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	157,740,389 - 157,770,455 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	157,606,206 - 157,636,160 (+)	NCBI		MGSCv36	mm8
Celera	2	163,855,451 - 163,885,751 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	78.48	NCBI

Vstm2l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	166,991,035 - 167,020,869 (+)	NCBI		GRCr8
mRatBN7.2	3	146,571,099 - 146,600,930 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	146,571,278 - 146,600,325 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	154,395,014 - 154,424,482 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	154,395,187 - 154,424,625 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	161,177,818 - 161,206,967 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	148,624,668 - 148,651,409 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	148,530,610 - 148,557,362 (+)	NCBI
Celera	3	145,271,667 - 145,301,640 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Vstm2l
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	18,756,411 - 18,786,358 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	18,756,458 - 18,786,310 (-)	NCBI	ChiLan1.0	ChiLan1.0

VSTM2L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	43,629,437 - 43,670,812 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	43,622,543 - 43,663,906 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	34,223,796 - 34,266,260 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	35,365,536 - 35,379,672 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	35,362,246 - 35,378,574 (+)	Ensembl	panpan1.1		panPan2

VSTM2L
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	26,442,608 - 26,479,466 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	26,442,678 - 26,478,325 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	26,088,275 - 26,125,046 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	27,139,005 - 27,175,860 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	24	26,413,832 - 26,450,646 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	26,521,426 - 26,558,214 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	27,009,225 - 27,046,032 (+)	NCBI		UU_Cfam_GSD_1.0

Vstm2l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	175,338,530 - 175,371,324 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	3,378,124 - 3,411,206 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	3,378,160 - 3,410,957 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VSTM2L
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	40,978,794 - 41,019,845 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	40,978,558 - 41,019,847 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	46,335,428 - 46,433,682 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VSTM2L
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	25,804,501 - 25,847,371 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	25,804,439 - 25,847,194 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	74,652,262 - 74,695,019 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Vstm2l
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	1,708,665 - 1,740,393 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	1,708,658 - 1,740,438 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in VSTM2L
18 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 20q11.22-12(chr20:34541747-39663219)x1	copy number loss	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052766]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052766]\|See cases [RCV000052766]	Chr20:34541747..39663219 [GRCh38] Chr20:33129551..38291861 [GRCh37] Chr20:32593212..37725275 [NCBI36] Chr20:20q11.22-12	pathogenic
GRCh38/hg38 20p12.2-q12(chr20:9811433-39316956)x3	copy number gain	See cases [RCV000052999]	Chr20:9811433..39316956 [GRCh38] Chr20:9792081..37945599 [GRCh37] Chr20:9740081..37379013 [NCBI36] Chr20:20p12.2-q12	pathogenic
GRCh38/hg38 20q11.22-13.11(chr20:34249453-43359749)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053002]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053002]\|See cases [RCV000053002]	Chr20:34249453..43359749 [GRCh38] Chr20:32837259..41988389 [GRCh37] Chr20:32300920..41421803 [NCBI36] Chr20:20q11.22-13.11	pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3	copy number gain	See cases [RCV000135859]	Chr20:99557..64277321 [GRCh38] Chr20:80198..62908674 [GRCh37] Chr20:28198..62379118 [NCBI36] Chr20:20p13-q13.33	pathogenic
GRCh38/hg38 20q11.22-13.12(chr20:35237946-47631818)x1	copy number loss	See cases [RCV000140816]	Chr20:35237946..47631818 [GRCh38] Chr20:33825749..46260562 [GRCh37] Chr20:33289165..45693969 [NCBI36] Chr20:20q11.22-13.12	pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3	copy number gain	See cases [RCV000510832]	Chr20:61569..62915555 [GRCh37] Chr20:20p13-q13.33	pathogenic
NM_080607.3(VSTM2L):c.404C>T (p.Thr135Met)	single nucleotide variant	not specified [RCV004332083]	Chr20:37944042 [GRCh38] Chr20:36572444 [GRCh37] Chr20:20q11.23	uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)	copy number gain	See cases [RCV000512450]	Chr20:61569..62915555 [GRCh37] Chr20:20p13-q13.33	pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3	copy number gain	not provided [RCV000741059]	Chr20:63244..62961294 [GRCh37] Chr20:20p13-q13.33	pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3	copy number gain	not provided [RCV000741057]	Chr20:63244..62912463 [GRCh37] Chr20:20p13-q13.33	pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3	copy number gain	not provided [RCV000741058]	Chr20:63244..62948788 [GRCh37] Chr20:20p13-q13.33	pathogenic
NM_080607.3(VSTM2L):c.605G>A (p.Cys202Tyr)	single nucleotide variant	not specified [RCV004321182]	Chr20:37944243 [GRCh38] Chr20:36572645 [GRCh37] Chr20:20q11.23	uncertain significance
Single allele	deletion	Focal-onset seizure [RCV001004039]	Chr20:34980430..46806549 [GRCh37] Chr20:20q11.23-13.13	likely pathogenic
NM_080607.3(VSTM2L):c.241G>A (p.Val81Ile)	single nucleotide variant	not specified [RCV004325614]	Chr20:37931754 [GRCh38] Chr20:36560156 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.535G>A (p.Ala179Thr)	single nucleotide variant	not specified [RCV004282182]	Chr20:37944173 [GRCh38] Chr20:36572575 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.435C>G (p.Ile145Met)	single nucleotide variant	not specified [RCV004331042]	Chr20:37944073 [GRCh38] Chr20:36572475 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.502A>G (p.Asn168Asp)	single nucleotide variant	not specified [RCV004088372]	Chr20:37944140 [GRCh38] Chr20:36572542 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.421G>A (p.Glu141Lys)	single nucleotide variant	not specified [RCV004161799]	Chr20:37944059 [GRCh38] Chr20:36572461 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.535G>C (p.Ala179Pro)	single nucleotide variant	not specified [RCV004200789]	Chr20:37944173 [GRCh38] Chr20:36572575 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.355G>A (p.Val119Met)	single nucleotide variant	not specified [RCV004124107]	Chr20:37943993 [GRCh38] Chr20:36572395 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.245G>A (p.Arg82Gln)	single nucleotide variant	not specified [RCV004160897]	Chr20:37931758 [GRCh38] Chr20:36560160 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.157C>T (p.Arg53Trp)	single nucleotide variant	not specified [RCV004185741]	Chr20:37931670 [GRCh38] Chr20:36560072 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.316G>T (p.Ala106Ser)	single nucleotide variant	not specified [RCV004267557]	Chr20:37933563 [GRCh38] Chr20:36561965 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.8C>T (p.Ala3Val)	single nucleotide variant	not specified [RCV004266067]	Chr20:37903358 [GRCh38] Chr20:36531760 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.20T>C (p.Val7Ala)	single nucleotide variant	not specified [RCV004279875]	Chr20:37903370 [GRCh38] Chr20:36531772 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.584G>A (p.Arg195His)	single nucleotide variant	not specified [RCV004248197]	Chr20:37944222 [GRCh38] Chr20:36572624 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.389C>T (p.Ser130Phe)	single nucleotide variant	not specified [RCV004264732]	Chr20:37944027 [GRCh38] Chr20:36572429 [GRCh37] Chr20:20q11.23	uncertain significance
GRCh37/hg19 20q11.23(chr20:36112920-36787057)x1	copy number loss	not provided [RCV003483362]	Chr20:36112920..36787057 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.540G>A (p.Ala180=)	single nucleotide variant	not provided [RCV003431316]	Chr20:37944178 [GRCh38] Chr20:36572580 [GRCh37] Chr20:20q11.23	likely benign
NM_080607.3(VSTM2L):c.583C>T (p.Arg195Cys)	single nucleotide variant	not specified [RCV004485042]	Chr20:37944221 [GRCh38] Chr20:36572623 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.476C>T (p.Ala159Val)	single nucleotide variant	not specified [RCV004485041]	Chr20:37944114 [GRCh38] Chr20:36572516 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.265G>C (p.Asp89His)	single nucleotide variant	not specified [RCV004485040]	Chr20:37931778 [GRCh38] Chr20:36560180 [GRCh37] Chr20:20q11.23	uncertain significance
NM_080607.3(VSTM2L):c.82G>A (p.Ala28Thr)	single nucleotide variant	not specified [RCV004485043]	Chr20:37903432 [GRCh38] Chr20:36531834 [GRCh37] Chr20:20q11.23	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	2482
Count of miRNA genes:	707
Interacting mature miRNAs:	786
Transcripts:	ENST00000373458, ENST00000373459, ENST00000373461, ENST00000448944
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

D20S429

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	20	36,552,999 - 36,553,149	UniSTS	GRCh37
Build 36	20	35,986,413 - 35,986,563	RGD	NCBI36
Celera	20	33,260,049 - 33,260,199	RGD
Cytogenetic Map	20	q11.23	UniSTS
HuRef	20	33,288,742 - 33,288,892	UniSTS

STS-R38512

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	20	36,573,522 - 36,573,726	UniSTS	GRCh37
Build 36	20	36,006,936 - 36,007,140	RGD	NCBI36
Celera	20	33,280,572 - 33,280,776	RGD
Cytogenetic Map	20	q11.23	UniSTS
HuRef	20	33,309,265 - 33,309,469	UniSTS
GeneMap99-GB4 RH Map	20	213.05	UniSTS
NCBI RH Map	20	315.7	UniSTS

SHGC-77954

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	20	36,558,621 - 36,558,937	UniSTS	GRCh37
Build 36	20	35,992,035 - 35,992,351	RGD	NCBI36
Celera	20	33,265,671 - 33,265,987	RGD
Cytogenetic Map	20	q11.23	UniSTS
HuRef	20	33,294,364 - 33,294,680	UniSTS
TNG Radiation Hybrid Map	20	16886.0	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

579

567

359

247

603

2651

395

617

Low

1753

1124

1265

443

572

355

2982

1085

1006

216

795

950

707

1860

Below cutoff

1229

929

1316

495

137

234

494

909

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_080607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011528530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054322941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK056177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL109964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL834410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC033818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE905791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000373459 ⟹ ENSP00000362558

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	20	37,903,111 - 37,944,450 (+)	Ensembl

RefSeq Acc Id:

ENST00000373461 ⟹ ENSP00000362560

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	20	37,903,127 - 37,945,350 (+)	Ensembl

RefSeq Acc Id:

ENST00000448944 ⟹ ENSP00000406537

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	20	37,903,142 - 37,944,136 (+)	Ensembl

RefSeq Acc Id:

NM_080607 ⟹ NP_542174

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	20	37,903,127 - 37,945,350 (+)	NCBI
GRCh37	20	36,531,499 - 36,573,752 (+)	RGD
Build 36	20	35,964,913 - 36,007,166 (+)	NCBI Archive
Celera	20	33,238,553 - 33,280,802 (+)	RGD
HuRef	20	33,266,969 - 33,309,495 (+)	RGD
CHM1_1	20	36,434,291 - 36,476,782 (+)	NCBI
T2T-CHM13v2.0	20	39,627,202 - 39,669,657 (+)	NCBI

Sequence:

show sequence

GCAGTCGGAGGCGGCCGGCTGGGCGTGCGCTCGCTCCCCGAAGCCGGGGCTGGGCCGGAGCCGG
GCGAGGGCTGGGAGCTGGGCCGGGTCCGGGGACAGCGGGCGAGGGGCAGCTGCCGGAGCCGGGC
AGCCAGGCCGCTCAGGGCAGGGGACAGCTGGCGCCGGTTCTGCGGTCTCCGGGGCCCAGATGTG
AGGCGGCGGCGCCCCCGGCCCGAGAGCGCACGATGGGGGCCCCGCTCGCCGTAGCGCTGGGCGC
CCTCCACTACCTGGCACTTTTCCTGCAACTCGGCGGCGCCACGCGGCCCGCCGGCCACGCGCCC
TGGGACAACCACGTCTCCGGCCACGCCCTGTTCACAGAGACACCCCATGACATGACAGCACGGA
CGGGCGAGGACGTGGAGATGGCCTGCTCCTTCCGCGGCAGCGGCTCCCCCTCCTACTCGCTGGA
GATCCAGTGGTGGTATGTACGGAGCCACCGGGACTGGACCGACAAGCAGGCGTGGGCCTCGAAC
CAGCTAAAAGCATCTCAGCAGGAAGACGCAGGGAAGGAGGCAACCAAAATAAGTGTGGTCAAGG
TGGTGGGCAGCAACATCTCCCACAAGCTGCGCCTGTCCCGGGTGAAGCCCACGGACGAAGGCAC
CTACGAGTGCCGCGTCATCGACTTCAGCGACGGCAAGGCCCGGCACCACAAGGTCAAGGCCTAC
CTGCGGGTGCAGCCAGGGGAGAACTCCGTCCTGCATCTGCCCGAAGCCCCTCCCGCCGCGCCCG
CCCCGCCGCCCCCCAAGCCAGGCAAGGAGCTGAGGAAGCGCTCGGTGGACCAGGAGGCCTGCAG
CCTCTAGACTGATGCCCCTGCCCCCGCCCATCCGCCCCCACGCTGTACAGAGTGCATGAGGAGC
CGCCGGACCACCGGGGACCGACTGCCTGCGTCCAGCCGCGCCCCATCCCCGAGGCCGCCTGTGG
CCACCATGTCGGCCCTCTTTCCACCACCCCTTGCTCAGCATGTAAGCCCCACCCACCCCTGCCC
TTTCAGACCCCTGCGGTGACCTGGCTCGGAGAAGGTGGCCCTGGGCACCAAGGGGCCAACCGCC
CTGAACACTGGGGCAGGGACCATGCTGGGGCCCGGGGCCACCCCCTTCCTGTCACCAGCTTCTG
TGGAGTCCAGTGTTTTGCTTTGCTTGCTTGTCCCCCATCCTGTCCTGAGCCGGGGCCCCCCAGC
CTCGCCTCCCTCCTCCTACCATCCCTCACTTGGACCTGGGGGTGTGGACAGTGACCCCTCCCTG
AATATGGACTTGAATCTTCTGAGCAGAACTAGGGCCTCTCCCCTGGTGAAGACCCAGGGAACCC
AGGAGGGCCCTTCTGGGGCAGTGGCTCTGCAGGGTCACTCATGGAGGCCTAGGGGAACAGCGAG
ATGCCCCACCACCTCCTGGCGAGTCCTTCCTGTTCAGCTCCCTGTGCGACCCTCCAGGGATGCA
GGGGATCCAGGATTCTCTGCCCTGTCACACGGCGAGTCAGAAGGGAGGGGCCTTTCCCTCGGAC
CCATGGCCCCAGGCAGAGTTTTGCACCAGCAGGACCCCTTTGAGGGCCTTCAAGGCTCTCCCAG
GAGTCCCCCTCTGCCGGCCCCCCAATGCCCCAGCTCCCTCTTGGGTCCTGTGCCAAGTCCGCCC
CAGGGCCTGGGGCTGTTGGGAGCCAAGGGCCCCCTGGTACTCAGTTCCCTCACGATTCCCGATC
ACGGGCACACCTGCCCCCTGGTTATTTGTAAATATTTCTATTGGACCCAATTCTCCTCGGAATT
GGCTGGCACCTCTGGCTGCCGCAGCTCAGTGATGACGTGGGGGAGGTGGGAGAGGCCGAGGGCT
TTGCCTAGGGGTGGGTTGCCCTGTATACATGATCCAGTCTGTGACTACCAGCCAACCTGAATAA
AGCGGTTTTAAAAAAA

hide sequence

RefSeq Acc Id:

XM_011528530 ⟹ XP_011526832

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	20	37,903,127 - 37,945,350 (+)	NCBI

Sequence:

show sequence

CTTCCGCGGAAGGGAAGAGTCCCGCAGTCGGAGGCGGCCGGCTGGGCGTGCGCTCGCTCCCCGA
AGCCGGGGCTGGGCCGGAGCCGGGCGAGGGCTGGGAGCTGGGCCGGGTCCGGGGACAGCGGGCG
AGGGGCAGCTGCCGGAGCCGGGCAGCCAGGCCGCTCAGGGCAGGGGACAGCTGGCGCCGGTTCT
GCGGTCTCCGGGGCCCAGATGTGAGGCGGCGGCGCCCCCGGCCCGAGAGCGCACGATGGGGGCC
CCGCTCGCCGTAGCGCTGGGCGCCCTCCACTACCTGGCACTTTTCCTGCAACTCGGCGGCGCCA
CGCGGCCCGCCGGCCACGCGCCCTGGGACAACCACGTCTCCGGCCACGCCCTGTTCACAGAGAC
ACCCCATGACATGACAGCACGGACGGGCGAGGACGTGGAGATGGCCTGCTCCTTCCGCGGCAGC
GGCTCCCCCTCCTACTCGCTGGAGATCCAGTGGTGGTATGTACGGAGCCACCGGGACTGGACCG
ACAAGCAGGCGTGGGCCTCGAACCAGGTGGTCAAGGTGGTGGGCAGCAACATCTCCCACAAGCT
GCGCCTGTCCCGGGTGAAGCCCACGGACGAAGGCACCTACGAGTGCCGCGTCATCGACTTCAGC
GACGGCAAGGCCCGGCACCACAAGGTCAAGGCCTACCTGCGGGTGCAGCCAGGGGAGAACTCCG
TCCTGCATCTGCCCGAAGCCCCTCCCGCCGCGCCCGCCCCGCCGCCCCCCAAGCCAGGCAAGGA
GCTGAGGAAGCGCTCGGTGGACCAGGAGGCCTGCAGCCTCTAGACTGATGCCCCTGCCCCCGCC
CATCCGCCCCCACGCTGTACAGAGTGCATGAGGAGCCGCCGGACCACCGGGGACCGACTGCCTG
CGTCCAGCCGCGCCCCATCCCCGAGGCCGCCTGTGGCCACCATGTCGGCCCTCTTTCCACCACC
CCTTGCTCAGCATGTAAGCCCCACCCACCCCTGCCCTTTCAGACCCCTGCGGTGACCTGGCTCG
GAGAAGGTGGCCCTGGGCACCAAGGGGCCAACCGCCCTGAACACTGGGGCAGGGACCATGCTGG
GGCCCGGGGCCACCCCCTTCCTGTCACCAGCTTCTGTGGAGTCCAGTGTTTTGCTTTGCTTGCT
TGTCCCCCATCCTGTCCTGAGCCGGGGCCCCCCAGCCTCGCCTCCCTCCTCCTACCATCCCTCA
CTTGGACCTGGGGGTGTGGACAGTGACCCCTCCCTGAATATGGACTTGAATCTTCTGAGCAGAA
CTAGGGCCTCTCCCCTGGTGAAGACCCAGGGAACCCAGGAGGGCCCTTCTGGGGCAGTGGCTCT
GCAGGGTCACTCATGGAGGCCTAGGGGAACAGCGAGATGCCCCACCACCTCCTGGCGAGTCCTT
CCTGTTCAGCTCCCTGTGCGACCCTCCAGGGATGCAGGGGATCCAGGATTCTCTGCCCTGTCAC
ACGGCGAGTCAGAAGGGAGGGGCCTTTCCCTCGGACCCATGGCCCCAGGCAGAGTTTTGCACCA
GCAGGACCCCTTTGAGGGCCTTCAAGGCTCTCCCAGGAGTCCCCCTCTGCCGGCCCCCCAATGC
CCCAGCTCCCTCTTGGGTCCTGTGCCAAGTCCGCCCCAGGGCCTGGGGCTGTTGGGAGCCAAGG
GCCCCCTGGTACTCAGTTCCCTCACGATTCCCGATCACGGGCACACCTGCCCCCTGGTTATTTG
TAAATATTTCTATTGGACCCAATTCTCCTCGGAATTGGCTGGCACCTCTGGCTGCCGCAGCTCA
GTGATGACGTGGGGGAGGTGGGAGAGGCCGAGGGCTTTGCCTAGGGGTGGGTTGCCCTGTATAC
ATGATCCAGTCTGTGACTACCAGCCAACCTGAATAAAGCGGTTTTAAAAAAA

hide sequence

RefSeq Acc Id:

XM_054322941 ⟹ XP_054178916

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	20	39,627,202 - 39,669,657 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_542174	(Get FASTA)	NCBI Sequence Viewer
	XP_011526832	(Get FASTA)	NCBI Sequence Viewer
	XP_054178916	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH33818	(Get FASTA)	NCBI Sequence Viewer
	BAB71113	(Get FASTA)	NCBI Sequence Viewer
	CAD39072	(Get FASTA)	NCBI Sequence Viewer
	EAW76051	(Get FASTA)	NCBI Sequence Viewer
	EAW76053	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000362558.4
	ENSP00000362560
	ENSP00000362560.4
	ENSP00000406537.1
GenBank Protein	Q96N03	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_542174 ⟸ NM_080607
- Peptide Label:	precursor
- UniProtKB:	Q8ND45 (UniProtKB/Swiss-Prot), Q5JWZ5 (UniProtKB/Swiss-Prot), Q5JWZ4 (UniProtKB/Swiss-Prot), E1P5V7 (UniProtKB/Swiss-Prot), Q9BR37 (UniProtKB/Swiss-Prot), Q96N03 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGAPLAVALGALHYLALFLQLGGATRPAGHAPWDNHVSGHALFTETPHDMTARTGEDVEMACSF RGSGSPSYSLEIQWWYVRSHRDWTDKQAWASNQLKASQQEDAGKEATKISVVKVVGSNISHKLR LSRVKPTDEGTYECRVIDFSDGKARHHKVKAYLRVQPGENSVLHLPEAPPAAPAPPPPKPGKEL RKRSVDQEACSL hide sequence

RefSeq Acc Id:	XP_011526832 ⟸ XM_011528530
- Peptide Label:	isoform X1
- Sequence:	show sequence MGAPLAVALGALHYLALFLQLGGATRPAGHAPWDNHVSGHALFTETPHDMTARTGEDVEMACSF RGSGSPSYSLEIQWWYVRSHRDWTDKQAWASNQVVKVVGSNISHKLRLSRVKPTDEGTYECRVI DFSDGKARHHKVKAYLRVQPGENSVLHLPEAPPAAPAPPPPKPGKELRKRSVDQEACSL hide sequence

RefSeq Acc Id:

ENSP00000362558 ⟸ ENST00000373459

RefSeq Acc Id:

ENSP00000362560 ⟸ ENST00000373461

RefSeq Acc Id:

ENSP00000406537 ⟸ ENST00000448944

RefSeq Acc Id:	XP_054178916 ⟸ XM_054322941
- Peptide Label:	isoform X1

Protein Domains

Ig-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q96N03-F1-model_v2	AlphaFold	Q96N03	1-204	view protein structure

Promoters

RGD ID:

6799178

Promoter ID:

HG_KWN:39360

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Lymphoblastoid

Transcripts:

ENST00000373458, ENST00000373459, OTTHUMT00000079133

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	20	35,964,296 - 35,965,097 (+)	MPROMDB

RGD ID:

13206899

Promoter ID:

EPDNEW_H27030

Type:

initiation region

Name:

VSTM2L_1

Description:

V-set and transmembrane domain containing 2 like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H27029

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	20	37,903,129 - 37,903,189	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:16096	AgrOrtholog
COSMIC	VSTM2L	COSMIC
Ensembl Genes	ENSG00000132821	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000373459.4	UniProtKB/Swiss-Prot
	ENST00000373461	ENTREZGENE
	ENST00000373461.9	UniProtKB/Swiss-Prot
	ENST00000448944.1	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000132821	GTEx
HGNC ID	HGNC:16096	ENTREZGENE
Human Proteome Map	VSTM2L	Human Proteome Map
InterPro	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_sub	UniProtKB/Swiss-Prot
	Ig_V-set	UniProtKB/Swiss-Prot
KEGG Report	hsa:128434	UniProtKB/Swiss-Prot
NCBI Gene	128434	ENTREZGENE
OMIM	616537	OMIM
PANTHER	V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
	V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN	UniProtKB/Swiss-Prot
Pfam	V-set	UniProtKB/Swiss-Prot
PharmGKB	PA162408904	PharmGKB
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot
SMART	SM00409	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot
UniProt	E1P5V7	ENTREZGENE
	Q5JWZ4	ENTREZGENE
	Q5JWZ5	ENTREZGENE
	Q8ND45	ENTREZGENE
	Q96N03	ENTREZGENE
	Q9BR37	ENTREZGENE
	VTM2L_HUMAN	UniProtKB/Swiss-Prot
UniProt Secondary	E1P5V7	UniProtKB/Swiss-Prot
	Q5JWZ4	UniProtKB/Swiss-Prot
	Q5JWZ5	UniProtKB/Swiss-Prot
	Q8ND45	UniProtKB/Swiss-Prot
	Q9BR37	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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