FBXL12 (F-box and leucine rich repeat protein 12) - Rat Genome Database

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Gene: FBXL12 (F-box and leucine rich repeat protein 12) Homo sapiens
Analyze
Symbol: FBXL12
Name: F-box and leucine rich repeat protein 12
RGD ID: 1313605
HGNC Page HGNC:13611
Description: Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F-box and leucine-rich repeat protein 12; F-box protein FBL12; F-box/LRR-repeat protein 12; Fbl12; FLJ20188
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: FBXL12P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,810,270 - 9,819,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl199,810,267 - 9,827,816 (-)EnsemblGRCh38hg38GRCh38
GRCh37199,920,946 - 9,929,755 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36199,781,943 - 9,790,731 (-)NCBINCBI36Build 36hg18NCBI36
Build 34199,781,944 - 9,790,731NCBI
Celera199,816,349 - 9,825,137 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,501,726 - 9,510,514 (-)NCBIHuRef
CHM1_1199,920,639 - 9,929,427 (-)NCBICHM1_1
T2T-CHM13v2.0199,936,413 - 9,946,656 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Autism  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10531037   PMID:12477932   PMID:14702039   PMID:15146197   PMID:15342556   PMID:15489334   PMID:15520277   PMID:15761153   PMID:16169070   PMID:16344560   PMID:17207965   PMID:17704768  
PMID:18660753   PMID:19028597   PMID:21145461   PMID:21163940   PMID:21873635   PMID:22939624   PMID:23324393   PMID:23707388   PMID:24035498   PMID:25416956   PMID:26124079   PMID:26972000  
PMID:27107014   PMID:27215384   PMID:27432908   PMID:27609421   PMID:27705803   PMID:27880917   PMID:28675297   PMID:29103612   PMID:29124172   PMID:29892012   PMID:31240132   PMID:31257023  
PMID:32296183   PMID:32353859   PMID:32513696   PMID:33060197   PMID:33961781   PMID:35271311   PMID:35748872   PMID:35813202   PMID:36071039   PMID:36114006   PMID:36538041   PMID:37591242  


Genomics

Comparative Map Data
FBXL12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,810,270 - 9,819,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl199,810,267 - 9,827,816 (-)EnsemblGRCh38hg38GRCh38
GRCh37199,920,946 - 9,929,755 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36199,781,943 - 9,790,731 (-)NCBINCBI36Build 36hg18NCBI36
Build 34199,781,944 - 9,790,731NCBI
Celera199,816,349 - 9,825,137 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,501,726 - 9,510,514 (-)NCBIHuRef
CHM1_1199,920,639 - 9,929,427 (-)NCBICHM1_1
T2T-CHM13v2.0199,936,413 - 9,946,656 (-)NCBIT2T-CHM13v2.0
Fbxl12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,549,045 - 20,556,064 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,529,414 - 20,556,063 (-)EnsemblGRCm39 Ensembl
GRCm38920,637,749 - 20,644,768 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,618,118 - 20,644,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,442,230 - 20,449,211 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,388,188 - 20,395,169 (-)NCBIMGSCv36mm8
Celera917,908,225 - 17,915,212 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.59NCBI
Fbxl12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,453,042 - 27,459,136 (-)NCBIGRCr8
mRatBN7.2819,175,864 - 19,183,373 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,160,352 - 19,183,607 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,197,118 - 23,201,851 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08448,793 - 453,526 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,406,554 - 19,411,289 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,656,636 - 21,662,755 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,656,639 - 21,661,259 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,712,697 - 21,718,747 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,656,937 - 19,661,560 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1819,656,936 - 19,661,560 (-)NCBI
Celera820,572,113 - 20,576,736 (-)NCBICelera
Cytogenetic Map8q13NCBI
Fbxl12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,229,030 - 1,236,349 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,232,028 - 1,242,673 (-)NCBIChiLan1.0ChiLan1.0
FBXL12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22014,726,868 - 14,735,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11913,729,227 - 13,738,107 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,362,764 - 9,371,547 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,027,266 - 10,036,092 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,027,266 - 10,036,091 (-)Ensemblpanpan1.1panPan2
FBXL12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12051,183,064 - 51,187,605 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2051,183,285 - 51,187,738 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2051,046,830 - 51,051,154 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,704,430 - 51,708,761 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,704,211 - 51,726,983 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,912,024 - 50,916,339 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,337,013 - 51,341,338 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,578,289 - 51,582,631 (+)NCBIUU_Cfam_GSD_1.0
Fbxl12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118210,058,206 - 210,067,851 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659286,845 - 296,603 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659285,780 - 297,526 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXL12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,693,001 - 68,706,048 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1268,692,994 - 68,701,917 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2268,920,481 - 68,929,641 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBXL12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.168,905,168 - 8,911,659 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl68,904,921 - 8,911,795 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607411,196,865 - 11,206,367 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxl12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,100,053 - 2,105,845 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,100,124 - 2,105,712 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FBXL12
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-13.13(chr19:8831147-13331227)x3 copy number gain See cases [RCV000052908] Chr19:8831147..13331227 [GRCh38]
Chr19:8941823..13442041 [GRCh37]
Chr19:8802823..13303041 [NCBI36]
Chr19:19p13.2-13.13		 likely pathogenic
GRCh38/hg38 19p13.2(chr19:9735443-11228001)x1 copy number loss See cases [RCV000135403] Chr19:9735443..11228001 [GRCh38]
Chr19:9846119..11338677 [GRCh37]
Chr19:9707119..11199677 [NCBI36]
Chr19:19p13.2		 pathogenic
GRCh37/hg19 19p13.2(chr19:8661944-10104083)x1 copy number loss Breast ductal adenocarcinoma [RCV000207085] Chr19:8661944..10104083 [GRCh37]
Chr19:19p13.2		 uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207119] Chr19:9001833..10085054 [GRCh37]
Chr19:19p13.2		 likely pathogenic|uncertain significance
GRCh37/hg19 19p13.2-13.12(chr19:9678768-14853426) copy number gain See cases [RCV000446985] Chr19:9678768..14853426 [GRCh37]
Chr19:19p13.2-13.12		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
Single allele duplication Autism [RCV000754212] Chr19:7981357..10019383 [GRCh38]
Chr19:19p13.2		 likely pathogenic
GRCh37/hg19 19p13.2(chr19:8518395-10053298)x3 copy number gain not provided [RCV001259373] Chr19:8518395..10053298 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.896C>T (p.Ala299Val) single nucleotide variant not specified [RCV004330240] Chr19:9810981 [GRCh38]
Chr19:9921657 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.493C>T (p.Arg165Cys) single nucleotide variant not specified [RCV004084961] Chr19:9811384 [GRCh38]
Chr19:9922060 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.527G>A (p.Arg176Gln) single nucleotide variant not specified [RCV004196703] Chr19:9811350 [GRCh38]
Chr19:9922026 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.499G>A (p.Glu167Lys) single nucleotide variant not specified [RCV004086097] Chr19:9811378 [GRCh38]
Chr19:9922054 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.841A>G (p.Met281Val) single nucleotide variant not specified [RCV004237186] Chr19:9811036 [GRCh38]
Chr19:9921712 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.436G>A (p.Asp146Asn) single nucleotide variant not specified [RCV004194655] Chr19:9811441 [GRCh38]
Chr19:9922117 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.391C>G (p.Leu131Val) single nucleotide variant not specified [RCV004160591] Chr19:9811486 [GRCh38]
Chr19:9922162 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.910T>G (p.Cys304Gly) single nucleotide variant not specified [RCV004217590] Chr19:9810967 [GRCh38]
Chr19:9921643 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.515T>C (p.Leu172Pro) single nucleotide variant not specified [RCV004083479] Chr19:9811362 [GRCh38]
Chr19:9922038 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.469G>A (p.Val157Met) single nucleotide variant not specified [RCV004184686] Chr19:9811408 [GRCh38]
Chr19:9922084 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.551G>A (p.Gly184Asp) single nucleotide variant not specified [RCV004084967] Chr19:9811326 [GRCh38]
Chr19:9922002 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.61G>A (p.Val21Ile) single nucleotide variant not specified [RCV004331865] Chr19:9818753 [GRCh38]
Chr19:9929429 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.164G>A (p.Arg55Gln) single nucleotide variant not specified [RCV004260517] Chr19:9811713 [GRCh38]
Chr19:9922389 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.316C>T (p.Arg106Cys) single nucleotide variant not specified [RCV004254460] Chr19:9811561 [GRCh38]
Chr19:9922237 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.569C>T (p.Thr190Ile) single nucleotide variant not specified [RCV004284813] Chr19:9811308 [GRCh38]
Chr19:9921984 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.878G>T (p.Gly293Val) single nucleotide variant not specified [RCV004357233] Chr19:9810999 [GRCh38]
Chr19:9921675 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.255G>C (p.Gln85His) single nucleotide variant not specified [RCV004378846] Chr19:9811622 [GRCh38]
Chr19:9922298 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.61G>C (p.Val21Leu) single nucleotide variant not specified [RCV004378848] Chr19:9818753 [GRCh38]
Chr19:9929429 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.686A>T (p.Asp229Val) single nucleotide variant not specified [RCV004378851] Chr19:9811191 [GRCh38]
Chr19:9921867 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.940G>A (p.Val314Ile) single nucleotide variant not specified [RCV004378853] Chr19:9810937 [GRCh38]
Chr19:9921613 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.208C>T (p.Arg70Trp) single nucleotide variant not specified [RCV004386369] Chr19:9811669 [GRCh38]
Chr19:9922345 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.889C>A (p.Gln297Lys) single nucleotide variant not specified [RCV004378852] Chr19:9810988 [GRCh38]
Chr19:9921664 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.65G>C (p.Arg22Pro) single nucleotide variant not specified [RCV004378849] Chr19:9818749 [GRCh38]
Chr19:9929425 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.236A>T (p.Tyr79Phe) single nucleotide variant not specified [RCV004378845] Chr19:9811641 [GRCh38]
Chr19:9922317 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.518C>T (p.Thr173Met) single nucleotide variant not specified [RCV004378847] Chr19:9811359 [GRCh38]
Chr19:9922035 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_017703.3(FBXL12):c.683G>A (p.Arg228Gln) single nucleotide variant not specified [RCV004378850] Chr19:9811194 [GRCh38]
Chr19:9921870 [GRCh37]
Chr19:19p13.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5886
Count of miRNA genes:899
Interacting mature miRNAs:1056
Transcripts:ENST00000247977, ENST00000585379, ENST00000586073, ENST00000586469, ENST00000586651, ENST00000588922, ENST00000589438, ENST00000589626, ENST00000590277, ENST00000590808, ENST00000591009, ENST00000592067, ENST00000592732
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D19S698E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,921,484 - 9,921,583UniSTSGRCh37
Build 36199,782,484 - 9,782,583RGDNCBI36
Celera199,816,890 - 9,816,989RGD
Cytogenetic Map19p13.2UniSTS
HuRef199,502,267 - 9,502,366UniSTS
STS-R38103  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,920,991 - 9,921,220UniSTSGRCh37
Build 36199,781,991 - 9,782,220RGDNCBI36
Celera199,816,397 - 9,816,626RGD
Cytogenetic Map19p13.2UniSTS
HuRef199,501,774 - 9,502,003UniSTS
GeneMap99-GB4 RH Map1953.35UniSTS
NCBI RH Map1910.0UniSTS
SHGC-36605  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,920,991 - 9,921,094UniSTSGRCh37
Build 36199,781,991 - 9,782,094RGDNCBI36
Celera199,816,397 - 9,816,500RGD
Cytogenetic Map19p13.2UniSTS
Stanford-G3 RH Map1963.0UniSTS
NCBI RH Map1988.0UniSTS
GeneMap99-G3 RH Map1963.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2284 1483 1336 286 1201 181 3648 1094 1544 291 1438 1580 120 1201 2099 4
Low 155 1503 390 338 745 284 709 1103 2190 128 22 33 55 1 3 689 2 2
Below cutoff 5 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001316936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001316937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001316938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001316939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001316940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001316941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001316942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006722782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017026912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA524458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL389936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI760557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM019575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP367273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN427140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB127388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000247977   ⟹   ENSP00000247977
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,810,270 - 9,819,079 (-)Ensembl
RefSeq Acc Id: ENST00000585379   ⟹   ENSP00000467359
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,810,861 - 9,827,816 (-)Ensembl
RefSeq Acc Id: ENST00000586073   ⟹   ENSP00000465439
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,818,154 - 9,818,845 (-)Ensembl
RefSeq Acc Id: ENST00000586469   ⟹   ENSP00000467859
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,811,550 - 9,819,103 (-)Ensembl
RefSeq Acc Id: ENST00000586651   ⟹   ENSP00000467059
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,810,267 - 9,818,829 (-)Ensembl
RefSeq Acc Id: ENST00000588922   ⟹   ENSP00000468033
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,810,271 - 9,819,076 (-)Ensembl
RefSeq Acc Id: ENST00000589438   ⟹   ENSP00000467523
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,811,156 - 9,818,813 (-)Ensembl
RefSeq Acc Id: ENST00000589626   ⟹   ENSP00000464858
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,810,267 - 9,819,079 (-)Ensembl
RefSeq Acc Id: ENST00000590277   ⟹   ENSP00000467467
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,811,454 - 9,819,075 (-)Ensembl
RefSeq Acc Id: ENST00000590808   ⟹   ENSP00000466142
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,811,308 - 9,818,816 (-)Ensembl
RefSeq Acc Id: ENST00000591009   ⟹   ENSP00000468369
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,810,896 - 9,813,413 (-)Ensembl
RefSeq Acc Id: ENST00000592067   ⟹   ENSP00000464784
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,811,282 - 9,819,079 (-)Ensembl
RefSeq Acc Id: ENST00000592732   ⟹   ENSP00000468766
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,811,126 - 9,818,785 (-)Ensembl
RefSeq Acc Id: NM_001316936   ⟹   NP_001303865
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,810,270 - 9,819,079 (-)NCBI
CHM1_1199,920,639 - 9,929,475 (-)NCBI
T2T-CHM13v2.0199,936,413 - 9,945,223 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001316937   ⟹   NP_001303866
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,810,270 - 9,819,079 (-)NCBI
CHM1_1199,920,639 - 9,929,475 (-)NCBI
T2T-CHM13v2.0199,936,413 - 9,945,223 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001316938   ⟹   NP_001303867
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,810,270 - 9,819,079 (-)NCBI
CHM1_1199,920,639 - 9,929,475 (-)NCBI
T2T-CHM13v2.0199,936,413 - 9,945,223 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001316939   ⟹   NP_001303868
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,810,270 - 9,819,079 (-)NCBI
CHM1_1199,920,639 - 9,929,475 (-)NCBI
T2T-CHM13v2.0199,936,413 - 9,945,223 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001316940   ⟹   NP_001303869
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,810,270 - 9,819,079 (-)NCBI
CHM1_1199,920,639 - 9,929,475 (-)NCBI
T2T-CHM13v2.0199,936,413 - 9,945,223 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001316941   ⟹   NP_001303870
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,810,270 - 9,819,079 (-)NCBI
CHM1_1199,920,639 - 9,929,475 (-)NCBI
T2T-CHM13v2.0199,936,413 - 9,945,223 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001316942   ⟹   NP_001303871
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,810,270 - 9,819,079 (-)NCBI
CHM1_1199,920,639 - 9,929,475 (-)NCBI
T2T-CHM13v2.0199,936,413 - 9,945,223 (-)NCBI
Sequence:
RefSeq Acc Id: NM_017703   ⟹   NP_060173
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,810,270 - 9,819,079 (-)NCBI
GRCh37199,920,943 - 9,930,101 (-)NCBI
Build 36199,781,943 - 9,790,731 (-)NCBI Archive
Celera199,816,349 - 9,825,137 (-)RGD
HuRef199,501,726 - 9,510,514 (-)ENTREZGENE
CHM1_1199,920,639 - 9,929,475 (-)NCBI
T2T-CHM13v2.0199,936,413 - 9,945,223 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006722782   ⟹   XP_006722845
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,810,270 - 9,818,614 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054321327   ⟹   XP_054177302
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0199,936,413 - 9,946,656 (-)NCBI
RefSeq Acc Id: XM_054321328   ⟹   XP_054177303
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0199,936,413 - 9,944,678 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_060173   ⟸   NM_017703
- Peptide Label: isoform a
- UniProtKB: B3KSJ8 (UniProtKB/Swiss-Prot),   Q9H5K4 (UniProtKB/Swiss-Prot),   Q9NXK8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006722845   ⟸   XM_006722782
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001303869   ⟸   NM_001316940
- Peptide Label: isoform c
- UniProtKB: Q9NXK8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001303865   ⟸   NM_001316936
- Peptide Label: isoform b
- UniProtKB: Q9NXK8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001303866   ⟸   NM_001316937
- Peptide Label: isoform c
- UniProtKB: Q9NXK8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001303868   ⟸   NM_001316939
- Peptide Label: isoform c
- UniProtKB: Q9NXK8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001303871   ⟸   NM_001316942
- Peptide Label: isoform c
- UniProtKB: Q9NXK8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001303870   ⟸   NM_001316941
- Peptide Label: isoform c
- UniProtKB: Q9NXK8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001303867   ⟸   NM_001316938
- Peptide Label: isoform c
- UniProtKB: Q9NXK8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000467359   ⟸   ENST00000585379
RefSeq Acc Id: ENSP00000465439   ⟸   ENST00000586073
RefSeq Acc Id: ENSP00000467059   ⟸   ENST00000586651
RefSeq Acc Id: ENSP00000467859   ⟸   ENST00000586469
RefSeq Acc Id: ENSP00000468033   ⟸   ENST00000588922
RefSeq Acc Id: ENSP00000464858   ⟸   ENST00000589626
RefSeq Acc Id: ENSP00000467523   ⟸   ENST00000589438
RefSeq Acc Id: ENSP00000247977   ⟸   ENST00000247977
RefSeq Acc Id: ENSP00000467467   ⟸   ENST00000590277
RefSeq Acc Id: ENSP00000466142   ⟸   ENST00000590808
RefSeq Acc Id: ENSP00000468369   ⟸   ENST00000591009
RefSeq Acc Id: ENSP00000468766   ⟸   ENST00000592732
RefSeq Acc Id: ENSP00000464784   ⟸   ENST00000592067
RefSeq Acc Id: XP_054177302   ⟸   XM_054321327
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054177303   ⟸   XM_054321328
- Peptide Label: isoform X1
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NXK8-F1-model_v2 AlphaFold Q9NXK8 1-326 view protein structure

Promoters
RGD ID:6795546
Promoter ID:HG_KWN:28809
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_017703,   UC002MMD.1,   UC002MMF.1,   UC002MMG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36199,790,461 - 9,791,502 (-)MPROMDB
RGD ID:6796160
Promoter ID:HG_KWN:28811
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001048241,   NM_024292,   UC002MMH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36199,799,296 - 9,799,796 (+)MPROMDB
RGD ID:7238407
Promoter ID:EPDNEW_H24949
Type:multiple initiation site
Name:FBXL12_1
Description:F-box and leucine rich repeat protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24950  EPDNEW_H24951  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,818,819 - 9,818,879EPDNEW
RGD ID:7238409
Promoter ID:EPDNEW_H24950
Type:initiation region
Name:FBXL12_2
Description:F-box and leucine rich repeat protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24949  EPDNEW_H24951  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,819,078 - 9,819,138EPDNEW
RGD ID:7238411
Promoter ID:EPDNEW_H24951
Type:initiation region
Name:FBXL12_3
Description:F-box and leucine rich repeat protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24949  EPDNEW_H24950  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,827,817 - 9,827,877EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13611 AgrOrtholog
COSMIC FBXL12 COSMIC
Ensembl Genes ENSG00000127452 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000247977 ENTREZGENE
  ENST00000247977.9 UniProtKB/Swiss-Prot
  ENST00000585379 ENTREZGENE
  ENST00000585379.5 UniProtKB/Swiss-Prot
  ENST00000586073.1 UniProtKB/TrEMBL
  ENST00000586469.1 UniProtKB/TrEMBL
  ENST00000586651.5 UniProtKB/TrEMBL
  ENST00000588922.5 UniProtKB/TrEMBL
  ENST00000589438.1 UniProtKB/TrEMBL
  ENST00000589626.5 UniProtKB/TrEMBL
  ENST00000590277.1 UniProtKB/TrEMBL
  ENST00000590808.1 UniProtKB/TrEMBL
  ENST00000591009 ENTREZGENE
  ENST00000591009.1 UniProtKB/Swiss-Prot
  ENST00000592067.1 UniProtKB/TrEMBL
  ENST00000592732.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000127452 GTEx
HGNC ID HGNC:13611 ENTREZGENE
Human Proteome Map FBXL12 Human Proteome Map
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:54850 UniProtKB/Swiss-Prot
NCBI Gene 54850 ENTREZGENE
OMIM 609079 OMIM
PANTHER F-BOX ONLY PROTEIN 33 UniProtKB/TrEMBL
  F-BOX ONLY PROTEIN 33 UniProtKB/TrEMBL
  F-BOX/TPR REPEAT PROTEIN POF3 UniProtKB/Swiss-Prot
  F-BOX_LRR-REPEAT PROTEIN 12 UniProtKB/Swiss-Prot
Pfam F-box-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134934043 PharmGKB
PROSITE FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3KSJ8 ENTREZGENE
  FXL12_HUMAN UniProtKB/Swiss-Prot
  K7EIK3_HUMAN UniProtKB/TrEMBL
  K7EIR3_HUMAN UniProtKB/TrEMBL
  K7EK37_HUMAN UniProtKB/TrEMBL
  K7ELM5_HUMAN UniProtKB/TrEMBL
  K7EPN7_HUMAN UniProtKB/TrEMBL
  K7EPT3_HUMAN UniProtKB/TrEMBL
  K7EQJ7_HUMAN UniProtKB/TrEMBL
  K7EQY7_HUMAN UniProtKB/TrEMBL
  K7ESL6_HUMAN UniProtKB/TrEMBL
  L8E9B2_HUMAN UniProtKB/TrEMBL
  Q9H5K4 ENTREZGENE
  Q9NXK8 ENTREZGENE
UniProt Secondary B3KSJ8 UniProtKB/Swiss-Prot
  Q9H5K4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-14 FBXL12  F-box and leucine rich repeat protein 12  FBXL12  F-box and leucine-rich repeat protein 12  Symbol and/or name change 5135510 APPROVED