LACTB (lactamase beta) - Rat Genome Database

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Gene: LACTB (lactamase beta) Homo sapiens
Analyze
Symbol: LACTB
Name: lactamase beta
RGD ID: 1312433
HGNC Page HGNC:16468
Description: Enables peptidase activity. Involved in proteolysis and regulation of lipid metabolic process. Located in cytosol and mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ14902; G24; lactamase, beta; mitochondrial 39S ribosomal protein L56; mitochondrial ribosomal protein L56; MRPL56; serine beta lactamase-like protein LACTB; serine beta-lactamase-like protein LACTB, mitochondrial; serine beta-lactamase-like protein, mitochondrial
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381563,121,861 - 63,142,061 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1563,121,833 - 63,142,061 (+)EnsemblGRCh38hg38GRCh38
GRCh371563,414,060 - 63,434,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,201,085 - 61,221,313 (+)NCBINCBI36Build 36hg18NCBI36
Build 341561,201,084 - 61,209,078NCBI
Celera1540,293,752 - 40,313,875 (+)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1540,237,097 - 40,257,359 (+)NCBIHuRef
CHM1_11563,533,208 - 63,553,467 (+)NCBICHM1_1
T2T-CHM13v2.01560,926,721 - 60,946,916 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IDA)
mitochondrion  (HDA,IBA,IDA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889549   PMID:11551941   PMID:11707067   PMID:12164938   PMID:12477932   PMID:12975309   PMID:14702039   PMID:15489334   PMID:15840729   PMID:17081983   PMID:18029348   PMID:18226203  
PMID:18344982   PMID:18538381   PMID:19322201   PMID:19858488   PMID:20686565   PMID:20833797   PMID:20877624   PMID:21280222   PMID:21873635   PMID:21886157   PMID:22990118   PMID:23042605  
PMID:24097068   PMID:24816252   PMID:25458010   PMID:25476789   PMID:25544563   PMID:25609649   PMID:26389662   PMID:26496610   PMID:26603571   PMID:27025967   PMID:27499296   PMID:27545878  
PMID:27609421   PMID:28190767   PMID:28329758   PMID:28380382   PMID:28514442   PMID:28835318   PMID:29229926   PMID:29478914   PMID:29509190   PMID:29564676   PMID:29568061   PMID:29899406  
PMID:30021884   PMID:30471916   PMID:31048545   PMID:31536960   PMID:31586073   PMID:31617661   PMID:32235678   PMID:32614325   PMID:32807901   PMID:32877691   PMID:32994395   PMID:33152401  
PMID:33259719   PMID:33462405   PMID:33507917   PMID:33675985   PMID:33957083   PMID:33961781   PMID:34079125   PMID:34315543   PMID:34316702   PMID:34362477   PMID:34709727   PMID:35013218  
PMID:35247327   PMID:35264565   PMID:35676659   PMID:36088805   PMID:36215168   PMID:36232890   PMID:36244648   PMID:36282364   PMID:36375842   PMID:36526897   PMID:36534696   PMID:36543142  
PMID:37157950   PMID:38176415  


Genomics

Comparative Map Data
LACTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381563,121,861 - 63,142,061 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1563,121,833 - 63,142,061 (+)EnsemblGRCh38hg38GRCh38
GRCh371563,414,060 - 63,434,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,201,085 - 61,221,313 (+)NCBINCBI36Build 36hg18NCBI36
Build 341561,201,084 - 61,209,078NCBI
Celera1540,293,752 - 40,313,875 (+)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1540,237,097 - 40,257,359 (+)NCBIHuRef
CHM1_11563,533,208 - 63,553,467 (+)NCBICHM1_1
T2T-CHM13v2.01560,926,721 - 60,946,916 (+)NCBIT2T-CHM13v2.0
Lactb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39966,862,668 - 66,882,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl966,862,670 - 66,882,766 (-)EnsemblGRCm39 Ensembl
GRCm38966,955,382 - 66,975,484 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl966,955,388 - 66,975,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv37966,803,200 - 66,823,291 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36966,754,537 - 66,774,628 (-)NCBIMGSCv36mm8
MGSCv36967,552,232 - 67,572,323 (-)NCBIMGSCv36mm8
Celera964,189,769 - 64,209,813 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map936.23NCBI
Lactb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8876,452,679 - 76,469,986 (-)NCBIGRCr8
mRatBN7.2867,571,504 - 67,587,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl867,571,500 - 67,587,539 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx873,103,000 - 73,118,974 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0871,375,937 - 71,391,911 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0869,213,247 - 69,229,261 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0872,750,174 - 72,766,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl872,750,171 - 72,766,389 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0877,083,026 - 77,099,150 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4871,266,865 - 71,283,398 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1871,285,914 - 71,302,363 (-)NCBI
Celera874,117,191 - 74,133,164 (+)NCBICelera
Cytogenetic Map8q24NCBI
Lactb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545012,140,404 - 12,155,898 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545012,140,049 - 12,155,600 (-)NCBIChiLan1.0ChiLan1.0
LACTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21652,370,439 - 52,390,787 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11556,546,640 - 56,566,900 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01542,069,069 - 42,089,329 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11560,365,427 - 60,385,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1560,365,427 - 60,385,179 (+)Ensemblpanpan1.1panPan2
LACTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13027,720,255 - 27,738,213 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3027,719,821 - 27,737,959 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3027,639,728 - 27,657,290 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03027,892,759 - 27,909,935 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3027,892,149 - 27,909,681 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13027,829,724 - 27,847,276 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03027,891,999 - 27,909,143 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03028,136,004 - 28,153,251 (+)NCBIUU_Cfam_GSD_1.0
Lactb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640105,865,069 - 105,886,865 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647123,713,100 - 23,732,216 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647123,713,144 - 23,732,214 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LACTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1108,909,693 - 108,924,511 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11108,909,690 - 108,924,509 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21120,133,394 - 120,148,202 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LACTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12620,399,882 - 20,419,422 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2620,399,858 - 20,419,369 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048120,980,651 - 121,000,249 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lactb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247819,365,472 - 9,381,580 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247819,365,231 - 9,381,639 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LACTB
26 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
NM_032857.5(LACTB):c.46G>C (p.Gly16Arg) single nucleotide variant Abnormality of neuronal migration [RCV000201410] Chr15:63121917 [GRCh38]
Chr15:63414116 [GRCh37]
Chr15:15q22.2		 pathogenic|benign
Single allele deletion Nemaline myopathy 6 [RCV000677940] Chr15:63414894..66439797 [GRCh37]
Chr15:15q22.2-22.31		 likely pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3		 likely pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
NM_032857.5(LACTB):c.324C>G (p.Ile108Met) single nucleotide variant not specified [RCV004292998] Chr15:63122195 [GRCh38]
Chr15:63414394 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.682A>G (p.Lys228Glu) single nucleotide variant not specified [RCV004292748] Chr15:63127419 [GRCh38]
Chr15:63419618 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.269C>G (p.Pro90Arg) single nucleotide variant not specified [RCV004328863] Chr15:63122140 [GRCh38]
Chr15:63414339 [GRCh37]
Chr15:15q22.2		 uncertain significance
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
NM_032857.5(LACTB):c.616-7C>A single nucleotide variant not provided [RCV000879873] Chr15:63127346 [GRCh38]
Chr15:63419545 [GRCh37]
Chr15:15q22.2		 benign
NC_000015.10:g.(?_63042820)_(63869153_?)dup duplication Hypertrophic cardiomyopathy [RCV001033641] Chr15:63335019..64161352 [GRCh37]
Chr15:15q22.2-22.31		 uncertain significance
NM_032857.5(LACTB):c.1343C>T (p.Pro448Leu) single nucleotide variant not specified [RCV004291622] Chr15:63141504 [GRCh38]
Chr15:63433703 [GRCh37]
Chr15:15q22.2		 uncertain significance
NC_000015.9:g.(?_62146656)_(64747263_?)del deletion not provided [RCV003107781] Chr15:62146656..64747263 [GRCh37]
Chr15:15q22.2-22.31		 pathogenic
NM_032857.5(LACTB):c.1440G>A (p.Arg480=) single nucleotide variant not provided [RCV000880890] Chr15:63141601 [GRCh38]
Chr15:63433800 [GRCh37]
Chr15:15q22.2		 benign
NM_032857.5(LACTB):c.46G>A (p.Gly16Arg) single nucleotide variant not provided [RCV000957298] Chr15:63121917 [GRCh38]
Chr15:63414116 [GRCh37]
Chr15:15q22.2		 benign
NM_032857.5(LACTB):c.73C>T (p.Arg25Cys) single nucleotide variant not provided [RCV000957299] Chr15:63121944 [GRCh38]
Chr15:63414143 [GRCh37]
Chr15:15q22.2		 benign
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1		 uncertain significance
NC_000015.9:g.(?_63335019)_(64161352_?)dup duplication Hypertrophic cardiomyopathy [RCV001304134] Chr15:63335019..64161352 [GRCh37]
Chr15:15q22.2-22.31		 uncertain significance
GRCh37/hg19 15q21.1-22.2(chr15:48589845-63543438)x3 copy number gain not provided [RCV002472512] Chr15:48589845..63543438 [GRCh37]
Chr15:15q21.1-22.2		 pathogenic
NM_032857.5(LACTB):c.529T>G (p.Leu177Val) single nucleotide variant not specified [RCV004117131] Chr15:63126963 [GRCh38]
Chr15:63419162 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.921A>T (p.Leu307Phe) single nucleotide variant not specified [RCV004139082] Chr15:63127658 [GRCh38]
Chr15:63419857 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1238C>T (p.Ala413Val) single nucleotide variant not specified [RCV004100760] Chr15:63141399 [GRCh38]
Chr15:63433598 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.827G>A (p.Arg276Gln) single nucleotide variant not specified [RCV004137373] Chr15:63127564 [GRCh38]
Chr15:63419763 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.471G>C (p.Glu157Asp) single nucleotide variant not specified [RCV004127721] Chr15:63126905 [GRCh38]
Chr15:63419104 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1438C>T (p.Arg480Trp) single nucleotide variant not specified [RCV004118838] Chr15:63141599 [GRCh38]
Chr15:63433798 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.185G>T (p.Gly62Val) single nucleotide variant not specified [RCV004155802] Chr15:63122056 [GRCh38]
Chr15:63414255 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.440A>T (p.Asp147Val) single nucleotide variant not specified [RCV004178475] Chr15:63126874 [GRCh38]
Chr15:63419073 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.50G>C (p.Gly17Ala) single nucleotide variant not specified [RCV004106513] Chr15:63121921 [GRCh38]
Chr15:63414120 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1534G>A (p.Val512Ile) single nucleotide variant not specified [RCV004074681] Chr15:63141695 [GRCh38]
Chr15:63433894 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.569A>C (p.Gln190Pro) single nucleotide variant not specified [RCV004272658] Chr15:63127003 [GRCh38]
Chr15:63419202 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1522A>G (p.Ile508Val) single nucleotide variant not specified [RCV004271584] Chr15:63141683 [GRCh38]
Chr15:63433882 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1012G>A (p.Ala338Thr) single nucleotide variant not specified [RCV004407140] Chr15:63129544 [GRCh38]
Chr15:63421743 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1055A>T (p.His352Leu) single nucleotide variant not specified [RCV004407141] Chr15:63129587 [GRCh38]
Chr15:63421786 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1145G>A (p.Arg382His) single nucleotide variant not specified [RCV004407142] Chr15:63141306 [GRCh38]
Chr15:63433505 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1259T>C (p.Val420Ala) single nucleotide variant not specified [RCV004407143] Chr15:63141420 [GRCh38]
Chr15:63433619 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1415C>T (p.Thr472Met) single nucleotide variant not specified [RCV004407144] Chr15:63141576 [GRCh38]
Chr15:63433775 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1427G>A (p.Cys476Tyr) single nucleotide variant not specified [RCV004407145] Chr15:63141588 [GRCh38]
Chr15:63433787 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.1511A>G (p.Asp504Gly) single nucleotide variant not specified [RCV004407146] Chr15:63141672 [GRCh38]
Chr15:63433871 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.184G>C (p.Gly62Arg) single nucleotide variant not specified [RCV004407147] Chr15:63122055 [GRCh38]
Chr15:63414254 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.206C>T (p.Pro69Leu) single nucleotide variant not specified [RCV004407148] Chr15:63122077 [GRCh38]
Chr15:63414276 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.277C>A (p.Pro93Thr) single nucleotide variant not specified [RCV004407149] Chr15:63122148 [GRCh38]
Chr15:63414347 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.376G>A (p.Gly126Ser) single nucleotide variant not specified [RCV004407150] Chr15:63122654 [GRCh38]
Chr15:63414853 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.520C>T (p.Leu174Phe) single nucleotide variant not specified [RCV004407152] Chr15:63126954 [GRCh38]
Chr15:63419153 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.7C>T (p.Arg3Trp) single nucleotide variant not specified [RCV004407153] Chr15:63121878 [GRCh38]
Chr15:63414077 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.806A>C (p.Gln269Pro) single nucleotide variant not specified [RCV004407154] Chr15:63127543 [GRCh38]
Chr15:63419742 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.904A>G (p.Ile302Val) single nucleotide variant not specified [RCV004407155] Chr15:63127641 [GRCh38]
Chr15:63419840 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_032857.5(LACTB):c.904A>T (p.Ile302Phe) single nucleotide variant not specified [RCV004407156] Chr15:63127641 [GRCh38]
Chr15:63419840 [GRCh37]
Chr15:15q22.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:485
Count of miRNA genes:402
Interacting mature miRNAs:425
Transcripts:ENST00000261893, ENST00000413507, ENST00000557972, ENST00000559782
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D15S159  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371563,426,963 - 63,427,125UniSTSGRCh37
GRCh371563,426,884 - 63,427,126UniSTSGRCh37
Build 361561,213,937 - 61,214,179RGDNCBI36
Celera1540,306,500 - 40,306,742RGD
Celera1540,306,579 - 40,306,741UniSTS
Cytogenetic Map15q22.1UniSTS
HuRef1540,250,063 - 40,250,225UniSTS
HuRef1540,249,984 - 40,250,226UniSTS
Marshfield Genetic Map1559.05UniSTS
Marshfield Genetic Map1559.05RGD
Genethon Genetic Map1558.8UniSTS
TNG Radiation Hybrid Map1523266.0UniSTS
deCODE Assembly Map1565.68UniSTS
Stanford-G3 RH Map151964.0UniSTS
GeneMap99-GB4 RH Map15224.23UniSTS
Whitehead-RH Map15221.3UniSTS
Whitehead-YAC Contig Map15 UniSTS
NCBI RH Map15360.5UniSTS
GeneMap99-G3 RH Map151964.0UniSTS
G20855  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371563,432,502 - 63,432,709UniSTSGRCh37
Build 361561,219,555 - 61,219,762RGDNCBI36
Celera1540,312,117 - 40,312,324RGD
Cytogenetic Map15q22.1UniSTS
HuRef1540,255,601 - 40,255,808UniSTS
A006I36  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371563,432,502 - 63,432,709UniSTSGRCh37
Build 361561,219,555 - 61,219,762RGDNCBI36
Celera1540,312,117 - 40,312,324RGD
Cytogenetic Map15q22.1UniSTS
HuRef1540,255,601 - 40,255,808UniSTS
GeneMap99-GB4 RH Map15224.23UniSTS
RH91565  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371563,433,926 - 63,434,027UniSTSGRCh37
Build 361561,220,979 - 61,221,080RGDNCBI36
Celera1540,313,541 - 40,313,642RGD
Cytogenetic Map15q22.1UniSTS
HuRef1540,257,025 - 40,257,126UniSTS
GeneMap99-GB4 RH Map15222.22UniSTS
G31564  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371563,421,952 - 63,422,101UniSTSGRCh37
Build 361561,209,005 - 61,209,154RGDNCBI36
Celera1540,301,567 - 40,301,716RGD
Cytogenetic Map15q22.1UniSTS
HuRef1540,245,051 - 40,245,200UniSTS
G20452  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371563,433,984 - 63,434,188UniSTSGRCh37
Build 361561,221,037 - 61,221,241RGDNCBI36
Celera1540,313,599 - 40,313,803RGD
Cytogenetic Map15q22.1UniSTS
HuRef1540,257,083 - 40,257,287UniSTS
A005R42  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371563,433,984 - 63,434,188UniSTSGRCh37
Build 361561,221,037 - 61,221,241RGDNCBI36
Celera1540,313,599 - 40,313,803RGD
Cytogenetic Map15q22.1UniSTS
HuRef1540,257,083 - 40,257,287UniSTS
GeneMap99-GB4 RH Map15224.23UniSTS
D15S159  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q22.1UniSTS
TNG Radiation Hybrid Map1523266.0UniSTS
Stanford-G3 RH Map151964.0UniSTS
GeneMap99-G3 RH Map151964.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 826 1365 806 391 1276 356 3081 1262 600 306 785 1032 47 923 1953 2
Low 1613 1617 919 232 671 109 1274 926 3130 113 673 579 127 281 835 3 1
Below cutoff 9 1 4 8 3 2 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_050565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_171846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054377234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_429442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_931745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA186367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC087612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI621121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG250900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU624474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000261893   ⟹   ENSP00000261893
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1563,121,861 - 63,142,061 (+)Ensembl
RefSeq Acc Id: ENST00000413507   ⟹   ENSP00000392956
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1563,121,833 - 63,131,471 (+)Ensembl
RefSeq Acc Id: ENST00000557972   ⟹   ENSP00000454085
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1563,122,583 - 63,127,593 (+)Ensembl
RefSeq Acc Id: ENST00000559782
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1563,129,359 - 63,141,346 (+)Ensembl
RefSeq Acc Id: NM_001288585   ⟹   NP_001275514
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381563,121,861 - 63,131,467 (+)NCBI
HuRef1540,237,097 - 40,257,363 (+)NCBI
CHM1_11563,533,208 - 63,542,882 (+)NCBI
T2T-CHM13v2.01560,926,721 - 60,936,331 (+)NCBI
Sequence:
RefSeq Acc Id: NM_032857   ⟹   NP_116246
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381563,121,861 - 63,142,061 (+)NCBI
GRCh371563,413,999 - 63,434,260 (+)ENTREZGENE
GRCh371563,413,999 - 63,434,260 (+)NCBI
Build 361561,201,085 - 61,221,313 (+)NCBI Archive
Celera1540,293,752 - 40,313,875 (+)RGD
HuRef1540,237,097 - 40,257,363 (+)NCBI
CHM1_11563,533,208 - 63,553,471 (+)NCBI
T2T-CHM13v2.01560,926,721 - 60,946,916 (+)NCBI
Sequence:
RefSeq Acc Id: NM_171846   ⟹   NP_741982
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381563,121,861 - 63,131,467 (+)NCBI
GRCh371563,413,999 - 63,434,260 (+)ENTREZGENE
Build 361561,201,085 - 61,209,079 (+)NCBI Archive
Celera1540,293,752 - 40,313,875 (+)RGD
HuRef1540,237,097 - 40,257,363 (+)NCBI
CHM1_11563,533,208 - 63,542,882 (+)NCBI
T2T-CHM13v2.01560,926,721 - 60,936,331 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047432128   ⟹   XP_047288084
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381563,121,861 - 63,131,467 (+)NCBI
RefSeq Acc Id: XM_054377234   ⟹   XP_054233209
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01560,926,721 - 60,943,514 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_116246   ⟸   NM_032857
- Peptide Label: isoform a precursor
- UniProtKB: P83096 (UniProtKB/Swiss-Prot),   P83111 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_741982   ⟸   NM_171846
- Peptide Label: isoform b precursor
- UniProtKB: P83111 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001275514   ⟸   NM_001288585
- Peptide Label: isoform c precursor
- UniProtKB: P83111 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000454085   ⟸   ENST00000557972
RefSeq Acc Id: ENSP00000392956   ⟸   ENST00000413507
RefSeq Acc Id: ENSP00000261893   ⟸   ENST00000261893
RefSeq Acc Id: XP_047288084   ⟸   XM_047432128
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054233209   ⟸   XM_054377234
- Peptide Label: isoform X1
Protein Domains
Beta-lactamase-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P83111-F1-model_v2 AlphaFold P83111 1-547 view protein structure

Promoters
RGD ID:6792412
Promoter ID:HG_KWN:21621
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_171846,   OTTHUMT00000256224
Position:
Human AssemblyChrPosition (strand)Source
Build 361561,200,856 - 61,201,356 (+)MPROMDB
RGD ID:7229727
Promoter ID:EPDNEW_H20609
Type:initiation region
Name:LACTB_1
Description:lactamase beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381563,121,863 - 63,121,923EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16468 AgrOrtholog
COSMIC LACTB COSMIC
Ensembl Genes ENSG00000103642 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000261893 ENTREZGENE
  ENST00000261893.9 UniProtKB/Swiss-Prot
  ENST00000413507 ENTREZGENE
  ENST00000413507.3 UniProtKB/Swiss-Prot
  ENST00000557972.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.710.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000103642 GTEx
HGNC ID HGNC:16468 ENTREZGENE
Human Proteome Map LACTB Human Proteome Map
InterPro Beta-lactam-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-lactam/transpept-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:114294 UniProtKB/Swiss-Prot
NCBI Gene 114294 ENTREZGENE
OMIM 608440 OMIM
PANTHER SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL UniProtKB/Swiss-Prot
  SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL UniProtKB/Swiss-Prot
  SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL UniProtKB/TrEMBL
  SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Beta-lactamase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30262 PharmGKB
Superfamily-SCOP SSF56601 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H0YNN5_HUMAN UniProtKB/TrEMBL
  LACTB_HUMAN UniProtKB/Swiss-Prot
  P83096 ENTREZGENE
  P83111 ENTREZGENE
UniProt Secondary P83096 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 LACTB  lactamase beta    lactamase, beta  Symbol and/or name change 5135510 APPROVED