TEX50 (testis expressed 50) - Rat Genome Database

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Gene: TEX50 (testis expressed 50) Homo sapiens
Analyze
Symbol: TEX50
Name: testis expressed 50
RGD ID: 12879508
HGNC Page HGNC:52382
Description: Predicted to be located in membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: testis-expressed protein 50; uncharacterized protein LOC730159
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,635,338 - 173,637,130 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,635,338 - 173,637,130 (+)EnsemblGRCh38hg38GRCh38
GRCh371173,604,477 - 173,606,269 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,871,359 - 171,872,896 (+)NCBINCBI36Build 36hg18NCBI36
Celera1146,714,150 - 146,715,687 (+)NCBICelera
Cytogenetic Map1q25.1NCBI
HuRef1144,829,583 - 144,831,195 (+)NCBIHuRef
CHM1_11175,027,094 - 175,028,706 (+)NCBICHM1_1
T2T-CHM13v2.01172,993,493 - 172,995,285 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Genomics

Comparative Map Data
TEX50
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,635,338 - 173,637,130 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,635,338 - 173,637,130 (+)EnsemblGRCh38hg38GRCh38
GRCh371173,604,477 - 173,606,269 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,871,359 - 171,872,896 (+)NCBINCBI36Build 36hg18NCBI36
Celera1146,714,150 - 146,715,687 (+)NCBICelera
Cytogenetic Map1q25.1NCBI
HuRef1144,829,583 - 144,831,195 (+)NCBIHuRef
CHM1_11175,027,094 - 175,028,706 (+)NCBICHM1_1
T2T-CHM13v2.01172,993,493 - 172,995,285 (+)NCBIT2T-CHM13v2.0
Tex50
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,984,413 - 160,986,883 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,982,128 - 160,986,884 (-)EnsemblGRCm39 Ensembl
GRCm381161,156,843 - 161,159,314 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,154,558 - 161,159,314 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,084,689 - 163,089,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361163,084,689 - 163,089,665 (-)NCBIMGSCv36mm8
Celera1163,597,837 - 163,602,580 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
Tex50
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81375,966,726 - 75,972,131 (-)NCBIGRCr8
mRatBN7.21373,433,375 - 73,438,787 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1373,433,384 - 73,438,792 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1376,028,379 - 76,031,072 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01377,312,595 - 77,315,285 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01374,572,491 - 74,575,181 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01378,982,272 - 78,987,682 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1378,982,261 - 78,988,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01383,877,514 - 83,882,768 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1373,221,748 - 73,227,158 (-)NCBICelera
Cytogenetic Map13q22NCBI
Tex50
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540613,859,967 - 13,864,308 (+)NCBIChiLan1.0ChiLan1.0
TEX50
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2176,088,463 - 76,090,581 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1175,760,629 - 75,764,782 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01149,153,114 - 149,155,115 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11152,858,370 - 152,860,204 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1152,858,593 - 152,860,204 (+)Ensemblpanpan1.1panPan2
TEX50
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1725,536,754 - 25,538,694 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl725,537,117 - 25,538,568 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha725,069,257 - 25,070,959 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0725,288,003 - 25,289,705 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl725,287,758 - 25,289,582 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1725,206,779 - 25,208,481 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0725,288,994 - 25,290,695 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0725,434,094 - 25,435,796 (-)NCBIUU_Cfam_GSD_1.0
Tex50
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,300,499 - 96,304,707 (-)NCBIHiC_Itri_2
TEX50
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9115,970,441 - 115,972,598 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19115,968,409 - 115,974,118 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29127,605,263 - 127,607,432 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TEX50
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12555,559,128 - 55,562,036 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605557,124,566 - 57,132,465 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tex50
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247718,149,931 - 8,154,483 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247718,150,058 - 8,154,556 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.3-25.2(chr1:164922655-180061589)x3 copy number gain See cases [RCV000051856] Chr1:164922655..180061589 [GRCh38]
Chr1:164891892..180030724 [GRCh37]
Chr1:163158516..178297347 [NCBI36]
Chr1:1q23.3-25.2		 pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:161740907-173965154)x1 copy number loss See cases [RCV000053914] Chr1:161740907..173965154 [GRCh38]
Chr1:161710697..173934292 [GRCh37]
Chr1:159977321..172200915 [NCBI36]
Chr1:1q23.3-25.1		 pathogenic
GRCh38/hg38 1q24.2-25.1(chr1:168314822-175299299)x1 copy number loss See cases [RCV000053918] Chr1:168314822..175299299 [GRCh38]
Chr1:168284060..175268435 [GRCh37]
Chr1:166550684..173535058 [NCBI36]
Chr1:1q24.2-25.1		 pathogenic
GRCh38/hg38 1q24.1-25.1(chr1:166762832-175327423)x1 copy number loss See cases [RCV000053917] Chr1:166762832..175327423 [GRCh38]
Chr1:166732069..175296559 [GRCh37]
Chr1:164998693..173563182 [NCBI36]
Chr1:1q24.1-25.1		 pathogenic
GRCh38/hg38 1q24.3-31.1(chr1:171039975-186875957)x3 copy number gain See cases [RCV000134876] Chr1:171039975..186875957 [GRCh38]
Chr1:171009116..186845089 [GRCh37]
Chr1:169275740..185111712 [NCBI36]
Chr1:1q24.3-31.1		 pathogenic
GRCh38/hg38 1q24.2-25.2(chr1:169218236-178075834)x1 copy number loss See cases [RCV000137128] Chr1:169218236..178075834 [GRCh38]
Chr1:169187474..178044969 [GRCh37]
Chr1:167454098..176311592 [NCBI36]
Chr1:1q24.2-25.2		 pathogenic
GRCh38/hg38 1q24.3-31.2(chr1:170929720-191065409)x1 copy number loss See cases [RCV000142369] Chr1:170929720..191065409 [GRCh38]
Chr1:170898861..191034539 [GRCh37]
Chr1:169165485..189301162 [NCBI36]
Chr1:1q24.3-31.2		 pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:163382523-175877022)x1 copy number loss See cases [RCV000143292] Chr1:163382523..175877022 [GRCh38]
Chr1:163352313..175846158 [GRCh37]
Chr1:161618937..174112781 [NCBI36]
Chr1:1q23.3-25.1		 pathogenic
GRCh38/hg38 1q24.2-31.1(chr1:170036068-187555148)x1 copy number loss See cases [RCV000143688] Chr1:170036068..187555148 [GRCh38]
Chr1:170005209..187524280 [GRCh37]
Chr1:168271833..185790903 [NCBI36]
Chr1:1q24.2-31.1		 pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1		 pathogenic
NC_000001.11:g.173501975_175305010del deletion Hereditary antithrombin deficiency [RCV001779970] Chr1:173501975..175305010 [GRCh38]
Chr1:1q25.1		 pathogenic
NC_000001.11:g.172987296_174843232del deletion Hereditary antithrombin deficiency [RCV001779981] Chr1:172987296..174843232 [GRCh38]
Chr1:1q24.3-25.1		 pathogenic
NM_001195190.3(TEX50):c.322A>C (p.Lys108Gln) single nucleotide variant not specified [RCV004472292] Chr1:173635843 [GRCh38]
Chr1:173604982 [GRCh37]
Chr1:1q25.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:89
Interacting mature miRNAs:90
Transcripts:ENST00000417563
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 351
Low 1 5 2 7 3 1 26 9 2 5
Below cutoff 103 131 90 30 62 21 166 77 186 14 65 70 11 53 98

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000417563   ⟹   ENSP00000489890
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1173,635,338 - 173,637,130 (+)Ensembl
RefSeq Acc Id: NM_001195190   ⟹   NP_001182119
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,635,338 - 173,637,130 (+)NCBI
CHM1_11175,027,094 - 175,028,706 (+)NCBI
T2T-CHM13v2.01172,993,493 - 172,995,285 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001182119 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0A1B0GTY4 (Get FASTA)   NCBI Sequence Viewer  
  CAI93509 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000489890
  ENSP00000489890.1
Reference Protein Sequences
RefSeq Acc Id: NP_001182119   ⟸   NM_001195190
- Peptide Label: precursor
- UniProtKB: A0A1B0GTY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000489890   ⟸   ENST00000417563

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A1B0GTY4-F1-model_v2 AlphaFold A0A1B0GTY4 1-177 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:52382 AgrOrtholog
COSMIC TEX50 COSMIC
Ensembl Genes ENSG00000232113 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000417563 ENTREZGENE
  ENST00000417563.3 UniProtKB/Swiss-Prot
GTEx ENSG00000232113 GTEx
HGNC ID HGNC:52382 ENTREZGENE
Human Proteome Map TEX50 Human Proteome Map
InterPro TEX50 UniProtKB/Swiss-Prot
KEGG Report hsa:730159 UniProtKB/Swiss-Prot
NCBI Gene TEX50 ENTREZGENE
PANTHER PTHR39232 UniProtKB/Swiss-Prot
  TESTIS-EXPRESSED PROTEIN 50 UniProtKB/Swiss-Prot
PharmGKB PA166181666 PharmGKB
UniProt A0A1B0GTY4 ENTREZGENE, UniProtKB/Swiss-Prot