Nfatc4 (nuclear factor of activated T cells 4) - Rat Genome Database

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Gene: Nfatc4 (nuclear factor of activated T cells 4) Ictidomys tridecemlineatus
Analyze
Symbol: Nfatc4
Name: nuclear factor of activated T cells 4
RGD ID: 12736020
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); peroxisome proliferator activated receptor binding (ortholog); transcription factor binding (ortholog); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); calcineurin-NFAT signaling cascade (ortholog); cellular respiration (ortholog); PARTICIPATES IN calcineurin signaling pathway; nuclear factor of activated T-cells signaling pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); Chemical and Drug Induced Liver Injury (ortholog); dilated cardiomyopathy (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear factor of activated T-cells 4; nuclear factor of activated T-cells 4, transcript variant X1; nuclear factor of activated T-cells 4, transcript variant X2; nuclear factor of activated T-cells 4, transcript variant X3; nuclear factor of activated T-cells, cytoplasmic 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,201,144 - 36,210,126 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722179,200 - 187,800 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722178,866 - 187,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
branching involved in blood vessel morphogenesis  (IEA,ISO)
calcineurin-NFAT signaling cascade  (IEA,ISO)
cellular respiration  (IEA,ISO)
cellular response to ionomycin  (ISO)
cellular response to lithium ion  (IEA,ISO)
cellular response to UV  (IEA,ISO)
dendrite morphogenesis  (IEA,ISO)
heart development  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
long-term memory  (IEA)
long-term synaptic potentiation  (IEA)
negative regulation of dendrite morphogenesis  (IEA,ISO)
negative regulation of miRNA transcription  (IEA)
negative regulation of neuron apoptotic process  (IEA)
negative regulation of synapse maturation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of Wnt signaling pathway  (IEA)
neuron apoptotic process  (IEA,ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of synaptic plasticity  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
synapse maturation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
vascular associated smooth muscle cell development  (IEA,ISO)
vascular associated smooth muscle cell differentiation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Nfatc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,201,144 - 36,210,126 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722179,200 - 187,800 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722178,866 - 187,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,366,911 - 24,379,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,365,673 - 24,379,604 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,836,117 - 24,848,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,907,094 - 23,918,650 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,907,093 - 23,918,648NCBI
Celera144,700,788 - 4,713,452 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,950,950 - 4,963,469 (+)NCBIHuRef
CHM1_11424,834,722 - 24,847,385 (+)NCBICHM1_1
T2T-CHM13v2.01418,565,666 - 18,578,358 (+)NCBIT2T-CHM13v2.0
Nfatc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,062,252 - 56,071,400 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,060,601 - 56,071,400 (+)EnsemblGRCm39 Ensembl
GRCm381455,824,795 - 55,833,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,823,144 - 55,833,943 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,443,632 - 56,452,780 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,779,079 - 54,788,014 (+)NCBIMGSCv36mm8
Celera1453,626,552 - 53,635,649 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Nfatc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,256,912 - 33,284,522 (+)NCBIGRCr8
mRatBN7.21529,286,998 - 29,314,610 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,305,535 - 29,314,610 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,151,202 - 31,160,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,298,412 - 32,307,487 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,540,765 - 30,549,840 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,493,163 - 34,502,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,493,138 - 34,504,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,381,669 - 38,390,744 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,969,774 - 33,978,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,985,319 - 33,994,626 (+)NCBI
Celera1528,880,299 - 28,889,401 (+)NCBICelera
Cytogenetic Map15p13NCBI
Nfatc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,931,173 - 35,940,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540935,931,208 - 35,941,555 (-)NCBIChiLan1.0ChiLan1.0
NFATC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,722,011 - 25,733,084 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,936,780 - 24,949,576 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,141,699 - 5,156,021 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,267,667 - 23,279,249 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,266,702 - 23,279,249 (+)Ensemblpanpan1.1panPan2
NFATC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,337,098 - 4,346,409 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,336,450 - 4,346,100 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,259,072 - 4,268,379 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,448,860 - 4,458,168 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,448,341 - 4,458,173 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,138,640 - 4,147,945 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,201,033 - 4,210,339 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,463,303 - 4,472,610 (+)NCBIUU_Cfam_GSD_1.0
NFATC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,918,984 - 74,929,600 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1774,918,982 - 74,929,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,189,893 - 80,200,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,352,173 - 1,362,150 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,352,291 - 1,362,680 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603613,036,667 - 13,046,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfatc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,136,156 - 8,146,312 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,136,231 - 8,145,395 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000002875   ⟹   ENSSTOP00000002571
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936722179,200 - 187,800 (-)Ensembl
RefSeq Acc Id: XM_005338710   ⟹   XP_005338767
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,201,144 - 36,210,126 (+)NCBI
SpeTri2.0NW_004936722178,866 - 187,847 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013364513   ⟹   XP_013219967
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,202,366 - 36,210,126 (+)NCBI
SpeTri2.0NW_004936722178,866 - 186,547 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005338767 (Get FASTA)   NCBI Sequence Viewer  
  XP_013219967 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002571.3
GenBank Protein KAG3261003 (Get FASTA)   NCBI Sequence Viewer  
  KAG3261004 (Get FASTA)   NCBI Sequence Viewer  
  KAG3261005 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005338767   ⟸   XM_005338710
- Peptide Label: isoform X2
- UniProtKB: I3M1A0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013219967   ⟸   XM_013364513
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSTOP00000002571   ⟸   ENSSTOT00000002875
Protein Domains
RHD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002871 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002875.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_dom UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
NCBI Gene Nfatc4 ENTREZGENE
PANTHER NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4 UniProtKB/TrEMBL
  PTHR12533 UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/TrEMBL
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt I3M1A0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-19 Nfatc4  nuclear factor of activated T cells 4    nuclear factor of activated T-cells 4  Symbol and/or name change 5135510 APPROVED