Dph5 (diphthamide biosynthesis 5)

Gene: Dph5 (diphthamide biosynthesis 5) Ictidomys tridecemlineatus

Analyze

Symbol:

Dph5

Name:

diphthamide biosynthesis 5

RGD ID:

12703305

Description:

ENCODES a protein that exhibits diphthine methyl ester synthase activity (inferred); methyltransferase activity (inferred); INVOLVED IN methylation (inferred); protein histidyl modification to diphthamide (inferred); ASSOCIATED WITH epilepsy (ortholog); genetic disease (ortholog); maple syrup urine disease (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

diphthamide biosynthesis 5, transcript variant X1; diphthamide biosynthesis 5, transcript variant X2; diphthine methyl ester synthase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	111,194,838 - 111,227,850 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936748	996,321 - 1,033,533 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936748	1,000,247 - 1,032,966 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (ISO)

genetic disease (ISO)

maple syrup urine disease (ISO)

neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

methylation (IEA)

protein histidyl modification to diphthamide (IEA)

Molecular Function

diphthine methyl ester synthase activity (IEA)

methyltransferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Dph5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	111,194,838 - 111,227,850 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936748	996,321 - 1,033,533 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936748	1,000,247 - 1,032,966 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DPH5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	100,989,623 - 101,025,784 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	100,989,623 - 101,026,088 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	101,455,179 - 101,491,340 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	101,227,767 - 101,263,950 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	99,716,901 - 99,753,082 (-)	NCBI		Celera
Cytogenetic Map	1	p21.2	NCBI
HuRef	1	99,580,318 - 99,617,487 (-)	NCBI		HuRef
CHM1_1	1	101,571,005 - 101,607,193 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	100,838,455 - 100,874,670 (-)	NCBI		T2T-CHM13v2.0

Dph5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	115,681,785 - 115,728,010 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	115,681,486 - 115,728,010 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	115,888,116 - 115,934,361 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	115,887,837 - 115,934,361 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	115,591,101 - 115,632,241 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	115,880,187 - 115,921,327 (+)	NCBI		MGSCv36	mm8
Celera	3	122,321,079 - 122,353,898 (+)	NCBI		Celera
Cytogenetic Map	3	G1	NCBI
cM Map	3	50.13	NCBI

Dph5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	206,489,556 - 206,540,590 (+)	NCBI		GRCr8
mRatBN7.2	2	203,804,620 - 203,858,196 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	203,804,936 - 203,840,433 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	211,461,774 - 211,495,760 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	209,352,166 - 209,386,152 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	204,169,193 - 204,203,179 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	218,834,034 - 218,866,763 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	218,834,034 - 218,866,761 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	236,920,286 - 236,953,015 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	212,033,229 - 212,067,023 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	211,995,982 - 212,029,777 (+)	NCBI
Celera	2	196,307,200 - 196,340,118 (+)	NCBI		Celera
Cytogenetic Map	2	q42	NCBI

Dph5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	5,615,143 - 5,659,125 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955435	5,618,646 - 5,659,403 (-)	NCBI	ChiLan1.0	ChiLan1.0

DPH5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	126,003,324 - 126,039,151 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	125,161,515 - 125,197,331 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	103,646,182 - 103,682,551 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	102,358,876 - 102,394,857 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	102,358,882 - 102,394,816 (-)	Ensembl	panpan1.1		panPan2

DPH5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	49,095,188 - 49,131,427 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	49,095,895 - 49,130,484 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	51,766,585 - 51,802,807 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	49,439,930 - 49,476,172 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	49,440,179 - 49,476,384 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	49,132,953 - 49,169,201 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	49,112,572 - 49,148,764 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	49,542,108 - 49,578,350 (+)	NCBI		UU_Cfam_GSD_1.0

DPH5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	117,269,074 - 117,306,188 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	117,269,030 - 117,307,803 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	128,811,920 - 128,847,187 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DPH5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	32,328,708 - 32,362,786 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	32,328,206 - 32,361,353 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	25,706,055 - 25,741,711 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dph5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624857	3,867,544 - 3,903,834 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624857	3,864,142 - 3,904,158 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005339693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013364910	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000005377 ⟹ ENSSTOP00000004816

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936748	996,321 - 1,033,533 (-)	Ensembl

RefSeq Acc Id:

XM_005339693 ⟹ XP_005339750

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	111,194,838 - 111,227,807 (-)	NCBI
SpeTri2.0	NW_004936748	1,000,247 - 1,032,966 (-)	NCBI

Sequence:

show sequence

GCGCCGTAGGTGAGGCCGGCAGCGTGGGACCTGCTTCACCGGAAAGGCCAGCTGCAATTAGGAC
TTGGTGGAGCATAGGGGACCAGCTAGCATTCTCTCATCGGGTAATTGGACCCAACTGTCACCCA
GTTCGAAATGCTTTACCTGATCGGCTTGGGCCTGGGAGATGCCAAGGACATCACAGTGAAGGGA
CTGGAAGTTGTAAGACGCTGCAGTCGAGTGTATCTGGAAGCCTACACCTCAGTCCTGACTGTAG
GGAAGGAATCCCTGGAAGACTTTTATGGAAGAAAATTGATTCTTGCTGATAGAGAAGAAGTGGA
ACAAGAAGCAGATAATATTTTAAAGGATGCTGATATCAGTGATGTTGCATTCCTTGTGGTTGGT
GATCCATTTGGAGCTACGACACATAGCGATCTCATTCTGAGAGCAGCAAAGTTGGGCATCCCTT
ATCGTGTTATACATAATGCCTCCATCATGAATGCTGTAGGCTGCTGTGGTTTACAGTTATATAA
ATTTGGCGAGACAGTTTCTATTGTTTTTTGGACAGACACTTGGAGACCAGAAAGCTTTTTTGAC
AAAGTCAAAAAGAACAGACAGAATGGCATGCACACATTATGCTTACTAGACATCAAAGTAAAGG
AGCAGTCTTTGGAAAATCTAATCAAGGGCAGGAAGATTTATGAACCTCCTCGCTATATGCATGT
AAACCAAGCAGCCCAGCAACTTCTGGAAATTGTTCAAAATCAAAGATTACGAGGAGAAGAACCA
GCAATCACAGAGGAGACACTCTGTGTTGGCTTAGCCAGGGTTGGAGCTGAAGACCAAAAAATAG
TAGCAGGCACTTTACAACAGATGTGTACTGTGGACTTGGGAGAACCATTGCATTCCTTGGTTAT
CACAGGAGGCAGCTTGCATCCACTTGAGATGGAGATGTTAAGTCTGTTTTCCATACCAGAAAAC
ACCTCAGAATCCCAAAGCATCGATGGACTCTGAACATGGACATTTTCTACTCTGGCACATTAAT
TTCAGTTAGATATGGATATACACATCTTTGTATAACAAATTAAGCAGGTCTTTTGTTTTAACTG
GTAAGTATAAAACAAATAAGCAAGAAGAAAGAAACCAACAATGCTTGATTTCCGGTGGCAATAA
ATTTTCCCCATGTTA

hide sequence

RefSeq Acc Id:

XM_013364910 ⟹ XP_013220364

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	111,194,838 - 111,227,850 (-)	NCBI
SpeTri2.0	NW_004936748	1,000,247 - 1,032,966 (-)	NCBI

Sequence:

show sequence

GCGCCGTAGGTGAGGCCGGCAGCGTGGGACCTGCTTCACCGGAAAGGCCAGCTGCAATTAGGAC
TTGGTGGAGCATAGGGGACCAGCTAGCATTCTCTCATCGGTCACCCAGTTCGAAATGCTTTACC
TGATCGGCTTGGGCCTGGGAGATGCCAAGGACATCACAGTGAAGGGACTGGAAGTTGTAAGACG
CTGCAGTCGAGTGTATCTGGAAGCCTACACCTCAGTCCTGACTGTAGGGAAGGAATCCCTGGAA
GACTTTTATGGAAGAAAATTGATTCTTGCTGATAGAGAAGAAGTGGAACAAGAAGCAGATAATA
TTTTAAAGGATGCTGATATCAGTGATGTTGCATTCCTTGTGGTTGGTGATCCATTTGGAGCTAC
GACACATAGCGATCTCATTCTGAGAGCAGCAAAGTTGGGCATCCCTTATCGTGTTATACATAAT
GCCTCCATCATGAATGCTGTAGGCTGCTGTGGTTTACAGTTATATAAATTTGGCGAGACAGTTT
CTATTGTTTTTTGGACAGACACTTGGAGACCAGAAAGCTTTTTTGACAAAGTCAAAAAGAACAG
ACAGAATGGCATGCACACATTATGCTTACTAGACATCAAAGTAAAGGAGCAGTCTTTGGAAAAT
CTAATCAAGGGCAGGAAGATTTATGAACCTCCTCGCTATATGCATGTAAACCAAGCAGCCCAGC
AACTTCTGGAAATTGTTCAAAATCAAAGATTACGAGGAGAAGAACCAGCAATCACAGAGGAGAC
ACTCTGTGTTGGCTTAGCCAGGGTTGGAGCTGAAGACCAAAAAATAGTAGCAGGCACTTTACAA
CAGATGTGTACTGTGGACTTGGGAGAACCATTGCATTCCTTGGTTATCACAGGAGGCAGCTTGC
ATCCACTTGAGATGGAGATGTTAAGTCTGTTTTCCATACCAGAAAACACCTCAGAATCCCAAAG
CATCGATGGACTCTGAACATGGACATTTTCTACTCTGGCACATTAATTTCAGTTAGATATGGAT
ATACACATCTTTGTATAACAAATTAAGCAGGTCTTTTGTTTTAACTGGTAAGTATAAAACAAAT
AAGCAAGAAGAAAGAAACCAACAATGCTTGATTTCCGGTGGCAATAAATTTTCCCCATGTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005339750	(Get FASTA)	NCBI Sequence Viewer
	XP_013220364	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004816.3
GenBank Protein	KAG3283684	(Get FASTA)	NCBI Sequence Viewer
	KAG3283685	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005339750 ⟸ XM_005339693

- UniProtKB:

I3M5Z0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKESLEDFYGRKLILADREEVEQE
ADNILKDADISDVAFLVVGDPFGATTHSDLILRAAKLGIPYRVIHNASIMNAVGCCGLQLYKFG
ETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMHVNQ
AAQQLLEIVQNQRLRGEEPAITEETLCVGLARVGAEDQKIVAGTLQQMCTVDLGEPLHSLVITG
GSLHPLEMEMLSLFSIPENTSESQSIDGL

hide sequence

RefSeq Acc Id:

XP_013220364 ⟸ XM_013364910

- UniProtKB:

I3M5Z0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKESLEDFYGRKLILADREEVEQE
ADNILKDADISDVAFLVVGDPFGATTHSDLILRAAKLGIPYRVIHNASIMNAVGCCGLQLYKFG
ETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMHVNQ
AAQQLLEIVQNQRLRGEEPAITEETLCVGLARVGAEDQKIVAGTLQQMCTVDLGEPLHSLVITG
GSLHPLEMEMLSLFSIPENTSESQSIDGL

hide sequence

RefSeq Acc Id:

ENSSTOP00000004816 ⟸ ENSSTOT00000005377

Protein Domains

Tetrapyrrole methylase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000005381	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000005377.3	UniProtKB/TrEMBL
InterPro	4pyrrol_Mease	UniProtKB/TrEMBL
	4pyrrol_Methylase_sf	UniProtKB/TrEMBL
	4pyrrole_Mease_sub1	UniProtKB/TrEMBL
	4pyrrole_Mease_sub2	UniProtKB/TrEMBL
	Dphthn_synthase	UniProtKB/TrEMBL
NCBI Gene	Dph5	ENTREZGENE
PANTHER	DIPHTHINE METHYL ESTER SYNTHASE	UniProtKB/TrEMBL
	PTHR10882	UniProtKB/TrEMBL
Pfam	TP_methylase	UniProtKB/TrEMBL
PIRSF	Diphthine_synth	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53790	UniProtKB/TrEMBL
UniProt	I3M5Z0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM