Tmem120a (transmembrane protein 120A)

Gene: Tmem120a (transmembrane protein 120A) Ictidomys tridecemlineatus

Analyze

Symbol:

Tmem120a

Name:

transmembrane protein 120A

RGD ID:

12696994

Description:

ENCODES a protein that exhibits monoatomic ion channel activity (inferred); INVOLVED IN detection of mechanical stimulus involved in sensory perception of pain (inferred); fat cell differentiation (inferred); monoatomic ion transmembrane transport (inferred); ASSOCIATED WITH Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB (ortholog); cytochrome P450 oxidoreductase deficiency (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN membrane (inferred); nuclear inner membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ion channel TACAN

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,760,568 - 131,766,176 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	2,270,609 - 2,275,679 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	2,270,444 - 2,275,999 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB (ISO)

cytochrome P450 oxidoreductase deficiency (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of mechanical stimulus involved in sensory perception of pain (IEA)

fat cell differentiation (IEA)

monoatomic ion transmembrane transport (IEA)

protein heterooligomerization (IEA)

protein homooligomerization (IEA)

Cellular Component

membrane (IEA)

nuclear inner membrane (IEA)

plasma membrane (IEA)

Molecular Function

monoatomic ion channel activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Tmem120a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,760,568 - 131,766,176 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	2,270,609 - 2,275,679 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	2,270,444 - 2,275,999 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM120A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	75,986,831 - 75,994,595 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	75,986,831 - 75,994,656 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	75,616,149 - 75,623,913 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	75,454,243 - 75,461,889 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	70,484,699 - 70,492,531 (-)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	70,702,967 - 70,710,827 (-)	NCBI		HuRef
CHM1_1	7	75,546,225 - 75,554,037 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	77,274,487 - 77,282,162 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	74,949,219 - 74,957,056 (-)	NCBI

Tmem120a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	135,764,344 - 135,773,026 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	135,764,339 - 135,773,302 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	135,735,490 - 135,744,172 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	135,735,485 - 135,744,448 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	136,211,360 - 136,220,042 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	136,020,117 - 136,028,799 (-)	NCBI		MGSCv36	mm8
Celera	5	132,742,669 - 132,751,351 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	75.38	NCBI

Tmem120a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	26,578,859 - 26,587,524 (+)	NCBI		GRCr8
mRatBN7.2	12	20,942,243 - 20,950,908 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	20,942,439 - 20,990,316 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	22,083,966 - 22,092,640 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	22,696,400 - 22,705,078 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	21,762,859 - 21,771,533 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	23,989,596 - 23,998,257 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	23,989,596 - 23,998,254 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	25,986,848 - 25,995,509 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	22,069,814 - 22,078,475 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	22,057,077 - 22,065,739 (+)	NCBI
Celera	12	22,704,874 - 22,713,535 (+)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

Tmem120a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	14,747,621 - 14,754,270 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	14,748,666 - 14,754,270 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM120A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	93,960,294 - 93,968,798 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	142,224,932 - 142,233,436 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	68,026,666 - 68,034,896 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	82,437,650 - 82,444,882 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	82,437,650 - 82,444,882 (-)	Ensembl	panpan1.1		panPan2

TMEM120A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	7,316,257 - 7,321,992 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	7,316,477 - 7,389,842 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	9,013,030 - 9,019,258 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	7,137,088 - 7,143,313 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	7,137,263 - 7,210,023 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	7,106,460 - 7,112,688 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	7,069,926 - 7,076,153 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	7,233,166 - 7,239,394 (-)	NCBI		UU_Cfam_GSD_1.0

TMEM120A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	10,206,630 - 10,212,610 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	10,206,581 - 10,212,612 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TMEM120A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	10,230,961 - 10,238,325 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	10,231,152 - 10,238,226 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	6,183,818 - 6,191,437 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem120a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	14,790,876 - 14,796,635 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	14,790,876 - 14,796,673 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005328510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000022781 ⟹ ENSSTOP00000021540

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936543	2,270,609 - 2,275,679 (+)	Ensembl

RefSeq Acc Id:

XM_005328510 ⟹ XP_005328567

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	131,760,568 - 131,766,176 (-)	NCBI
SpeTri2.0	NW_004936543	2,270,444 - 2,275,999 (+)	NCBI

Sequence:

show sequence

CGGGGCCAGCGCGAGGCCCGCGCCAGGTCTTTCTCCATTGGTGGCGGTGGCGGCGCGAGCCCGG
AAGCGGACGGGGGCGGAGGCGGAGGCGGAGGCGCCTTGGGCCGGCCGGGGTTGCGGCGCAGTCC
TCAACTCGCTGCTCCTGCGGCCCGCGGAGCGGCAGCCATGCAGCCCCTGCCCTCGGACCCGCTG
GGCGACTGCCTGCGGGACTGGGAAGATCTGCAGCAGGACTTCCAGAGCATTCAGGAGACTCACC
GGCTGTACCGCCTGAAGCTGGAGGAGCTGACCAAGCTGCAGAACAACTGCACCAGCTCCATCGC
CCGGCAGAAGAAGCGGCTACAGGAACTGGCCCTCGTCCTGAAGAGATGCAAACCCACCCTTCCG
TCAGAGGCCGCGGGGGCCGCACAGGAGCTGGAGAACCAGATGAAGGAGCGCCAGGGCCTCTTCT
TCGACATGGAGGCCTATTTGCCCAAGAAGAACGGGTTGTACCTGAGCCTGGTTCTGGGGAATGT
CAACGTGACACTCTTGAGCAAGCAGGCCAAGTTTGCCTACAAAGACGAGTACGAGAAGTTCAAG
CTCTACCTCACCATCATCCTCATCCTCATCTCCTTCACCTGCCGTTTCCTGCTCAACTCCAGGG
TGACAGATGCGGCCTTCAACTTCCTGCTGGTCTGGTACTACTGCACGCTGACCATCCGTGAGAG
CATCCTCATCAACAACGGCTCCCGGATCAAAGGCTGGTGGGTGATTCATCACTACGTGTCCACG
TTTCTGTCGGGCGTCATGCTGACGTGGCCCGATGGTCTCATGTACCAGAAGTTCCGGAACCAGT
TCCTGTCTTTCTCCATGTACCAGAGCTTCGTGCAGTTCCTGCAGTATTACTACCAGAGTGGCTG
CCTGTACCGCCTGCGGGCCCTGGGCGAGCGGCACACCATGGACCTCACCGTGGAGGGCTTCCAG
TCCTGGATGTGGCGGGGCCTCACCTTCCTGCTGCCTTTTCTTTTCTTCGGTCATTTTTGGCAGC
TTTTCAATGCGCTCACCTTGTTTAACCTGGCTCGAGACCCACAATGCAAGGAGTGGCAGGTGCT
CATGTGCGGCCTCCCCTTCCTCCTCCTCTTCCTGGGCAATTTCTTCACCACCCTTCGGGTTGTG
CACCAGAAGTTCCACAGCCAGCAGCGCAGGAGCAAGAAGGAGTGAGCAGGGCCTCCACCTGCTG
GCCCCAGAGGGGCCTCTGACCCGTGTGTGGCAGAAGGGTGGGAGGCACCCCTGTGCGTGTGTGG
TGCCTTCTGCTCTCCTGGGCTTCGTGGGCTCTGTGGGCCCTGAGGACGACCTGGGCCCCAGCTG
CGGGAGCTGGGCACCAGGGCCTCAATAAAGGGAGCGAAGCAGAGGCGACCTGACGGATATATTC
TCCCATAGGGAGGCTGGGCTCCTGCTGTATCTGGGGTCTCTGTGTAGGCCCAGGGGACACCCCA
GGGCTGCTCAAGCAATATCAGGCAAATACAGAAAACAGAACTTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005328567	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000021540.2
GenBank Protein	KAG3259823	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005328567 ⟸ XM_005328510

- UniProtKB:

I3NAZ3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQPLPSDPLGDCLRDWEDLQQDFQSIQETHRLYRLKLEELTKLQNNCTSSIARQKKRLQELALV
LKRCKPTLPSEAAGAAQELENQMKERQGLFFDMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFA
YKDEYEKFKLYLTIILILISFTCRFLLNSRVTDAAFNFLLVWYYCTLTIRESILINNGSRIKGW
WVIHHYVSTFLSGVMLTWPDGLMYQKFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHT
MDLTVEGFQSWMWRGLTFLLPFLFFGHFWQLFNALTLFNLARDPQCKEWQVLMCGLPFLLLFLG
NFFTTLRVVHQKFHSQQRRSKKE

hide sequence

RefSeq Acc Id:

ENSSTOP00000021540 ⟸ ENSSTOT00000022781

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000027103	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000022781.2	UniProtKB/TrEMBL
InterPro	TACAN/TMEM120B	UniProtKB/TrEMBL
NCBI Gene	Tmem120a	ENTREZGENE
PANTHER	ION CHANNEL TACAN	UniProtKB/TrEMBL
	PTHR21433	UniProtKB/TrEMBL
Pfam	TMPIT	UniProtKB/TrEMBL
UniProt	I3NAZ3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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