Ffar4 (free fatty acid receptor 4)

Gene: Ffar4 (free fatty acid receptor 4) Ictidomys tridecemlineatus

Analyze

Symbol:

Ffar4

Name:

free fatty acid receptor 4

RGD ID:

12685783

Description:

ENCODES a protein that exhibits arrestin family protein binding (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); hormone secretion (ortholog); negative regulation of cytokine production (ortholog); ASSOCIATED WITH familial temporal lobe epilepsy 1 (ortholog); Retinal Dystrophy, Iris Coloboma, and Comedogenic Acne Syndrome (ortholog); FOUND IN endosome membrane (ortholog); lysosomal membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	39,780,633 - 39,800,934 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936601	1,413,208 - 1,433,455 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936601	1,413,236 - 1,434,036 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial temporal lobe epilepsy 1 (ISO)

Retinal Dystrophy, Iris Coloboma, and Comedogenic Acne Syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA)

brown fat cell differentiation (IEA)

cellular response to hormone stimulus (IEA)

detection of chemical stimulus involved in sensory perception of taste (IEA)

fat cell differentiation (IEA)

G protein-coupled receptor signaling pathway (IEA,ISO)

ghrelin secretion (IEA)

hormone secretion (IEA,ISO)

negative regulation of apoptotic process (IEA)

negative regulation of cytokine production (IEA,ISO)

negative regulation of inflammatory response (IEA)

negative regulation of interleukin-1 beta production (IEA)

negative regulation of somatostatin secretion (IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA)

positive regulation of brown fat cell differentiation (IEA)

positive regulation of cold-induced thermogenesis (IEA)

positive regulation of cytosolic calcium ion concentration (IEA)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of glucagon secretion (IEA)

positive regulation of osteoblast differentiation (IEA)

regulation of glucose transmembrane transport (IEA)

white fat cell differentiation (IEA)

Cellular Component

cilium (IEA)

endocytic vesicle (IEA)

endosome membrane (ISO)

lysosomal membrane (ISO)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

arrestin family protein binding (ISO)

fatty acid binding (IEA)

G protein-coupled receptor activity (IEA)

peptide binding (IEA)

protein binding (ISO)

taste receptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ffar4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	39,780,633 - 39,800,934 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936601	1,413,208 - 1,433,455 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936601	1,413,236 - 1,434,036 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FFAR4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	93,566,665 - 93,590,072 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	93,566,665 - 93,604,480 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	95,326,422 - 95,349,829 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	95,316,412 - 95,337,356 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	95,316,411 - 95,337,356	NCBI
Celera	10	89,067,548 - 89,088,491 (+)	NCBI		Celera
Cytogenetic Map	10	q23.33	NCBI
HuRef	10	88,954,184 - 88,977,589 (+)	NCBI		HuRef
CHM1_1	10	95,608,976 - 95,632,383 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	94,446,619 - 94,470,024 (+)	NCBI		T2T-CHM13v2.0

Ffar4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	38,085,527 - 38,102,711 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	38,085,519 - 38,102,711 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	38,097,079 - 38,114,263 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	38,097,071 - 38,114,263 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	38,171,569 - 38,188,753 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	38,162,223 - 38,179,407 (+)	NCBI		MGSCv36	mm8
Celera	19	38,886,831 - 38,905,954 (+)	NCBI		Celera
Cytogenetic Map	19	C2	NCBI
cM Map	19	32.73	NCBI

Ffar4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	245,286,009 - 245,304,029 (+)	NCBI		GRCr8
mRatBN7.2	1	235,873,576 - 235,891,597 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	235,873,576 - 235,891,597 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	244,294,985 - 244,312,990 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	251,190,752 - 251,208,777 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	244,028,985 - 244,047,011 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	256,786,124 - 256,804,156 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	256,786,124 - 256,804,156 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	264,266,658 - 264,284,678 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	242,423,455 - 242,441,475 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	242,609,660 - 242,634,872 (+)	NCBI
Celera	1	232,966,950 - 232,984,949 (+)	NCBI		Celera
Cytogenetic Map	1	q53	NCBI

Ffar4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955507	81,284 - 110,047 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955507	81,910 - 110,047 (+)	NCBI	ChiLan1.0	ChiLan1.0

FFAR4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	105,604,486 - 105,626,075 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	105,609,798 - 105,631,390 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	90,312,647 - 90,336,115 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	93,823,004 - 93,846,402 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	93,823,004 - 93,860,262 (+)	Ensembl	panpan1.1		panPan2

FFAR4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	7,801,713 - 7,820,048 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	7,801,713 - 7,820,048 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	7,978,174 - 7,996,481 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	8,062,006 - 8,080,325 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	8,062,006 - 8,080,325 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	7,781,742 - 7,800,053 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	7,810,948 - 7,829,267 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	7,980,874 - 7,999,192 (+)	NCBI		UU_Cfam_GSD_1.0

FFAR4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	105,011,942 - 105,037,498 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1

FFAR4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	86,805,262 - 86,829,271 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	86,805,848 - 86,829,446 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	47,580,266 - 47,604,364 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ffar4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	4,770,564 - 4,792,585 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	4,770,328 - 4,795,150 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333724	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000016095 ⟹ ENSSTOP00000014407

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936601	1,413,208 - 1,433,455 (-)	Ensembl

RefSeq Acc Id:

XM_005333724 ⟹ XP_005333781

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	39,780,633 - 39,800,934 (-)	NCBI
SpeTri2.0	NW_004936601	1,413,236 - 1,434,036 (-)	NCBI

Sequence:

show sequence

ACATTTAATCAGTGATTACTGTGCATGAGTTTTGTGCTAAACTCTTTATGACAGCCTTACAATA
ACTTAATGGTAGTATTATCATTCCCATTTTACACGTGCAAAACGGGAGTACAGAGAGATTAATC
CATCTGAAGTCACACATTATTAAGTGATGATAAAACAACTCCCCTACCAATAAATTTGGGGTCA
TTACAAGTGGTTTTTGGATATACCTCCAACAGCGGGGCTTCTTAAGTGAAGTCTGAAAGACTCA
GTCCAAAACAATATCCAAAGTTCAGCTCTGACATTCTTAAATCAATTTTAGCTAAATGGGAGGA
TAGTTGGCTTCACACCCGGTATCGCTGTAGGTTAAAGGAAGCTGTGGTTTTTCCGCGAGGGCTG
GGGAATTTCTGGCCTTTTGGGAGCTTTCAAACAGCCTCAGAGCTGGAGGCCTCCGCCTCCGCAG
CCGCTTCCCAGCCCAGCTGGTGTTGCCCGGCACTTCCTCGTTCCCGTGCGTCCGGGACGCAGTT
CCCTACGCCCAACGCTCGCTCTCCTCTGGCGGGAGGGGTCCAGAGGACGGTGTCGCAACCACCT
CCCTCTCTCTTTCCCCGCCTTGGCACTCAGTCACCTCCCAGATGAGCGCGCTCGCCTGCAGACC
GCTGCTGGAGGTCGGGTGCCCGGCGGCATGTCCCCTGAGTTCGCGCAGACGACAGTCACCGGTC
CTCTGTGCAGCCTAGAGCAAGCCAACCGCACCCGCTTCCCTTTCTTCTCTGATGTCAAGAGAGA
CCACCGGCTGGTGCTGAGCACCGTGGAGACAATCGTGCTGGCGCTCATCTTTGCGGTGTCTCTG
CTGGGCAACGTGTACGCTCTGGTGCTGGTTGCGCGCCGACGGCGCCGAGGGGCCACCACCAGCC
TGGTGCTGAACCTCTTCTGCGCGGACCTGCTCTTCACCAGCTCCATCCCCCTAGTGCTAGTCGT
ACGCTGGACAGAGGCTTGGGTGCTGGGCCCCGTCGCTTGCCATCTGCTCTTCTACATGATGACC
CTGAGCGGCAGTGTCACCATTCTCACGCTGGCCGCAGTCAGCCTGGAGCGCATGGTGTGTATCG
TGCGCCTGCAGCGCGGAATGCGCGGCCCGGGGCGGCGGGCACAGGCTGCGATGCTGGCGTTCAT
CTGGGGCTACTCCGCTCTTGCCGCGCTGCCGCTCTTCATCTTCTTCCAGGTGGTCCCGCAGCGG
CTCCCGGGTGCCGACCAGATCACAAAGGCATCGCGGAAGAGGCTCACCATGAGCCTGGCGTACT
CGGAGAGCCACCAGATCCGAGTGTCGCAGCAGGACTTCCGGCTCTTCCGCACCCTCTTCCTGCT
CATGGTGTCCTTCTTCATCATGTGGAGCCCCATCATCATCACCATCCTCCTCATCTTGATCCAG
AACTTCCAGCAAGACCTGGTCATCTGGCCGTCCCTCTTCTTCTGGGTGGTGGCCTTCACATTTG
CCAATTCTGCCCTGAACCCCATTCTCTACAACATGTCACTGTTTAGGAATGAGTGGCGGAAATT
TTTTTGCTGCTTCTCCCTCCCAGAAAAAGGAGCCATTTTTACAGACACATCTGTCAGAAGAAAT
GATTTGTCTGTTATTTCCAGCTAATTCGTTTTTTCTCGACACATGAAGTCTCTCCCTGTGGTGA
GCCACGGTGTGCTTTGATCATCCACCAGTGCACCCTGCTTTACGGAAACAACCTATGCAAACAT
ACATCTGCAGCAGCAGCAAATTAGGGGACGATCATTCCATGTAAACATACTTTTCCTTTATAAG
AGGACTCACGATGGGTTCCTTTGAAATAATGAACTTTTTCAGTGTGTTTGTAATATGATGGAAA
TTAATAAATTTTTATTTATACCTGT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005333781	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000014407.3
GenBank Protein	KAG3264479	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005333781 ⟸ XM_005333724

- UniProtKB:

I3MQX0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSPEFAQTTVTGPLCSLEQANRTRFPFFSDVKRDHRLVLSTVETIVLALIFAVSLLGNVYALVL
VARRRRRGATTSLVLNLFCADLLFTSSIPLVLVVRWTEAWVLGPVACHLLFYMMTLSGSVTILT
LAAVSLERMVCIVRLQRGMRGPGRRAQAAMLAFIWGYSALAALPLFIFFQVVPQRLPGADQITK
ASRKRLTMSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFQQDLVIW
PSLFFWVVAFTFANSALNPILYNMSLFRNEWRKFFCCFSLPEKGAIFTDTSVRRNDLSVISS

hide sequence

RefSeq Acc Id:

ENSSTOP00000014407 ⟸ ENSSTOT00000016095

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000016093	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000016095.3	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
NCBI Gene	Ffar4	ENTREZGENE
PANTHER	FREE FATTY ACID RECEPTOR 4	UniProtKB/TrEMBL
	NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	I3MQX0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar