Clic2 (chloride intracellular channel 2) - Rat Genome Database

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Gene: Clic2 (chloride intracellular channel 2) Ictidomys tridecemlineatus
Analyze
Symbol: Clic2
Name: chloride intracellular channel 2
RGD ID: 12681345
Description: ENCODES a protein that exhibits glutathione transferase activity (ortholog); INVOLVED IN cellular oxidant detoxification (inferred); chloride transmembrane transport (inferred); chloride transport (inferred); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); autistic disorder (ortholog); Barth syndrome (ortholog); FOUND IN chloride channel complex (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: chloride intracellular channel protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X120,156,502 - 120,186,481 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936927514,899 - 543,693 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936927514,989 - 543,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
Clic2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X120,156,502 - 120,186,481 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936927514,899 - 543,693 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936927514,989 - 543,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLIC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X155,276,211 - 155,334,614 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX155,276,211 - 155,334,657 (-)EnsemblGRCh38hg38GRCh38
GRCh37X154,505,500 - 154,563,923 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X154,158,694 - 154,217,180 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X154,070,159 - 154,127,661NCBI
CeleraX154,664,011 - 154,722,432 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX143,049,088 - 143,107,752 (-)NCBIHuRef
CHM1_1X154,416,162 - 154,475,622 (-)NCBICHM1_1
T2T-CHM13v2.0X153,513,523 - 153,571,950 (-)NCBIT2T-CHM13v2.0
Clic2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr820154,630 - 169,655 (+)NCBIGRCr8
mRatBN7.220149,337 - 164,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl20148,907 - 164,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx20163,856 - 179,662 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.020167,322 - 183,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.020157,735 - 172,759 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.020295,338 - 310,363 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl20295,250 - 310,380 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.020289,420 - 304,445 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42066,518 - 81,543 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12066,517 - 81,536 (+)NCBI
Celera201,021,508 - 1,036,650 (+)NCBICelera
Cytogenetic Map20p12NCBI
Clic2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594374,208 - 393,389 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955594374,332 - 393,802 (+)NCBIChiLan1.0ChiLan1.0
CLIC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X155,241,784 - 155,350,478 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X155,245,392 - 155,354,086 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X144,742,839 - 144,851,524 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X154,581,649 - 154,641,515 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX154,581,649 - 154,641,515 (-)Ensemblpanpan1.1panPan2
CLIC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X123,268,867 - 123,291,467 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX123,268,867 - 123,291,467 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX108,256,144 - 108,278,751 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X126,397,663 - 126,420,289 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX126,397,666 - 126,420,733 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X122,138,186 - 122,160,792 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X124,660,596 - 124,683,207 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X124,381,022 - 124,403,633 (-)NCBIUU_Cfam_GSD_1.0
CLIC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,546,467 - 125,570,523 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,546,451 - 125,560,059 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,872,444 - 142,885,806 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLIC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X129,564,187 - 129,606,324 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX129,560,658 - 129,606,438 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606567,544,925 - 67,587,038 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clic2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462496321,115 - 47,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005342019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000028817   ⟹   ENSSTOP00000018536
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936927514,899 - 543,693 (-)Ensembl
RefSeq Acc Id: XM_005342019   ⟹   XP_005342076
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X120,156,502 - 120,186,481 (-)NCBI
SpeTri2.0NW_004936927514,989 - 543,691 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005342076 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000018536.1
GenBank Protein KAG3273292 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005342076   ⟸   XM_005342019
- UniProtKB: I3N2E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000018536   ⟸   ENSSTOT00000028817
Protein Domains
GST C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000025815 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000028817.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro CLIC UniProtKB/TrEMBL
  Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene Clic2 ENTREZGENE
PANTHER CHLORIDE INTRACELLULAR CHANNEL PROTEIN UniProtKB/TrEMBL
  CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED UniProtKB/TrEMBL
Pfam GST_C_2 UniProtKB/TrEMBL
  GST_N_2 UniProtKB/TrEMBL
PRINTS INTCLCHANNEL UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/TrEMBL
  SSF52833 UniProtKB/TrEMBL
UniProt I3N2E0 ENTREZGENE, UniProtKB/TrEMBL