Lipt2 (lipoyl(octanoyl) transferase 2)

Gene: Lipt2 (lipoyl(octanoyl) transferase 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Lipt2

Name:

lipoyl(octanoyl) transferase 2

RGD ID:

12676239

Description:

ENCODES a protein that exhibits acyltransferase activity (inferred); lipoyl(octanoyl) transferase activity (inferred); INVOLVED IN positive regulation of oxygen metabolic process (inferred); ASSOCIATED WITH 3-methylglutaconic aciduria type 7b (ortholog); Brugada syndrome 6 (ortholog); cardiomyopathy (ortholog); FOUND IN mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

lipoyl(octanoyl) transferase 2 (putative); putative lipoyl(octanoyl) transferase 2 (putative); putative lipoyltransferase 2, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	61,897,441 - 61,899,473 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	3,497,053 - 3,499,169 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	3,497,424 - 3,499,131 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria type 7b (ISO)

Brugada syndrome 6 (ISO)

cardiomyopathy (ISO)

ENCEPHALOPATHY, PROGRESSIVE, EARLY-ONSET, WITH BRAIN ATROPHY AND SPASTICITY (ISO)

intellectual disability (ISO)

Neonatal Severe Encephalopathy with Lactic Acidosis and Brain Abnormalities (ISO)

Syncope (ISO)

Ventricular Fibrillation (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of oxygen metabolic process (IEA)

Cellular Component

mitochondrion (IEA)

Molecular Function

acyltransferase activity (IEA)

lipoyl(octanoyl) transferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Lipt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	61,897,441 - 61,899,473 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	3,497,053 - 3,499,169 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	3,497,424 - 3,499,131 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LIPT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	74,490,519 - 74,493,724 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	74,490,519 - 74,493,724 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	74,201,564 - 74,204,769 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	73,879,846 - 73,885,491 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	71,509,689 - 71,511,520 (-)	NCBI		Celera
Cytogenetic Map	11	q13.4	NCBI
HuRef	11	70,498,934 - 70,500,765 (-)	NCBI		HuRef
CHM1_1	11	74,086,444 - 74,088,275 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	74,419,953 - 74,423,157 (-)	NCBI		T2T-CHM13v2.0

Lipt2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	99,808,484 - 99,810,138 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	99,808,484 - 99,810,572 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	100,159,277 - 100,160,931 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	100,159,277 - 100,161,365 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	107,307,787 - 107,309,441 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	100,033,360 - 100,035,448 (+)	NCBI		MGSCv36	mm8
Celera	7	100,493,861 - 100,495,452 (+)	NCBI		Celera
Cytogenetic Map	7	E2	NCBI
cM Map	7	54.33	NCBI

Lipt2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	163,916,695 - 163,919,022 (+)	NCBI		GRCr8
mRatBN7.2	1	154,504,563 - 154,506,890 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	154,504,563 - 154,506,890 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	162,498,895 - 162,501,222 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	169,678,993 - 169,681,320 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	162,552,575 - 162,554,902 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	165,170,645 - 165,172,972 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	165,170,645 - 165,172,972 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	171,371,500 - 171,373,827 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	157,538,704 - 157,541,031 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	157,616,972 - 157,618,123 (+)	NCBI
Celera	1	152,588,580 - 152,590,907 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

LIPT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	75,432,112 - 75,435,568 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	76,476,506 - 76,479,945 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	69,564,555 - 69,566,759 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	72,869,834 - 72,872,050 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	72,869,834 - 72,872,050 (-)	Ensembl	panpan1.1		panPan2

LIPT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	23,845,253 - 23,846,977 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	23,845,268 - 23,846,537 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	23,610,345 - 23,612,296 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	24,047,717 - 24,049,673 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	24,047,719 - 24,050,486 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	23,845,125 - 23,847,080 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	24,042,411 - 24,044,367 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	23,959,988 - 23,961,944 (+)	NCBI		UU_Cfam_GSD_1.0

LIPT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	8,838,102 - 8,840,765 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	8,838,375 - 8,840,607 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	10,001,252 - 10,003,211 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LIPT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	65,731,258 - 65,733,803 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	65,731,969 - 65,733,563 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	60,127,138 - 60,129,477 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lipt2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	2,573,479 - 2,575,259 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624817	2,573,459 - 2,575,259 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005323193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000024724 ⟹ ENSSTOP00000021700

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936498	3,497,053 - 3,499,169 (-)	Ensembl

RefSeq Acc Id:

XM_005323193 ⟹ XP_005323250

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	61,897,441 - 61,899,473 (-)	NCBI
SpeTri2.0	NW_004936498	3,497,424 - 3,499,131 (-)	NCBI

Sequence:

show sequence

TCCCCGCCCTCCGGCCCAGGCAGGGGGCCGGGTCCAGGACGCCACCGCCAGTAAGATGTCGCAA
CCCGGGGTTCGGCTAGTGTGGCTGGGTCGCGTGCAGTATGCCGAGCTACTGGCGCAACAAGAGC
GCTGGCTGCGGCGACTGCAGGCCGAGCCTGCAACTAAGGCCTCGTCGGGGACTGAGGCGGGCGC
GCTCCTGCTGTGCGAGCCCGCGGGGCCCGTGTACACAGCCGGGCTGCGGGGTGGCCTGACATCG
GAGGAAACGGCGCGGCTGCGGGCCTTGGGCGCCGAGGTGCGTGCCACAGGCCGCGGCGGCCTGG
CCACCTTCCACGGCCCGGGGCAGCTGCTTTGCCACCCGTTGCTGGACTTGCGGCGCCTAGGCCT
GCGCTTGCGCACTCACGTGGCGGCGCTGGAGGCGTGCGCCGTGCGCCTGTGCGAACTCCAGGGC
CTCAAGGGCGCCCGCGCGCGGCCCCCGCCCTACACCGGCGTCTGGCTGGGCGAGCGCAAGGTTT
GCGCGATCGGAGTTCGTTGTGGAAGGCACATCACATCCCACGGCCTGGCTCTGAACTGCTCTAC
GGACCTCACATGGTTTGAGCATATTGTACCTTGCGGACTGGTTGGGACAGGCGTCACTTCCCTA
AGTGAGGAGCTCCAGAGGCACATCACCGTGGATGAAGTAATGCCATCTTTCCTTGTGGCCTTTA
AGGAGACGTACAAGTGCACACTGGTCTCGGATGACAGCCCCAGCTGAAGAGTATTCATGTTATC
CCAGCCAGGATGACCCTGTCTTAGAAACCACCAAATCTGACTTGAGTCACTGGAACCCCAGTTC
TAGACCTGGCTTATTATTCACTGACTGTGAGACCAAGGGCAAATCATGAGCTCTGAACCATTGT
CTGCTTATGTGTTGCAGTTTAATTATATTATCTTTGCCTACCTCAGGTTCTAGATTGAAAACAT
GAAAAGAAACATGCTGTATAACATTAGTATGGCCAGTTTCTCAGCCTAGAGAAACTCAGATGTC
ATAGACTGACATTCTCAATTGTTTGTTACTTTCCTAATACTGAATCTAATTGAATATTTCTGGT
GGAGTTCCATTGATTTTTGTAGGAATCAAATCCCTGGATGGCCCACATTAAAGTGATGTGATGT
GGCACTTTTTGCATTCTCAAGAGACCTGGGTGTCTTCTGCAATAAAGGGAAGAGCATTATCAAA
GAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005323250	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000021700.1
GenBank Protein	KAG3286142	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005323250 ⟸ XM_005323193

- UniProtKB:

I3NBF3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSQPGVRLVWLGRVQYAELLAQQERWLRRLQAEPATKASSGTEAGALLLCEPAGPVYTAGLRGG
LTSEETARLRALGAEVRATGRGGLATFHGPGQLLCHPLLDLRRLGLRLRTHVAALEACAVRLCE
LQGLKGARARPPPYTGVWLGERKVCAIGVRCGRHITSHGLALNCSTDLTWFEHIVPCGLVGTGV
TSLSEELQRHITVDEVMPSFLVAFKETYKCTLVSDDSPS

hide sequence

RefSeq Acc Id:

ENSSTOP00000021700 ⟸ ENSSTOT00000024724

Protein Domains

BPL/LPL catalytic

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000026720	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000024724.2	UniProtKB/TrEMBL
InterPro	aa-tRNA-synth_II/BPL/LPL	UniProtKB/TrEMBL
	BPL_LPL_catalytic	UniProtKB/TrEMBL
	Octanoyltransferase	UniProtKB/TrEMBL
NCBI Gene	Lipt2	ENTREZGENE
PANTHER	LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED	UniProtKB/TrEMBL
	OCTANOYLTRANSFERASE	UniProtKB/TrEMBL
PIRSF	LPLase	UniProtKB/TrEMBL
PROSITE	BPL_LPL_CATALYTIC	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55681	UniProtKB/TrEMBL
UniProt	I3NBF3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-15	Lipt2	lipoyl(octanoyl) transferase 2		lipoyl(octanoyl) transferase 2 (putative)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM