Dtnbp1 (dystrobrevin binding protein 1)

Gene: Dtnbp1 (dystrobrevin binding protein 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Dtnbp1

Name:

dystrobrevin binding protein 1

RGD ID:

12644502

Description:

INVOLVED IN actin cytoskeleton organization (ortholog); anterograde axonal transport (ortholog); anterograde synaptic vesicle transport (ortholog); ASSOCIATED WITH disease of mental health (ortholog); genetic disease (ortholog); Hermansky-Pudlak syndrome (ortholog); FOUND IN asymmetric synapse (ortholog); axon (ortholog); BLOC-1 complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

dysbindin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	9,804,409 - 9,943,254 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936552	1,787,687 - 1,926,516 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

disease of mental health (ISO)

genetic disease (ISO)

Hermansky-Pudlak syndrome (ISO)

Hermansky-Pudlak syndrome 7 (ISO)

interstitial lung disease 2 (ISO)

platelet storage pool deficiency (ISO)

schizophrenia (ISO)

temporal lobe epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (ISO)

anterograde axonal transport (ISO)

anterograde synaptic vesicle transport (ISO)

blood coagulation (ISO)

cilium assembly (ISO)

dendrite morphogenesis (ISO)

kidney development (ISO)

memory (ISO)

negative regulation of dendritic spine morphogenesis (ISO)

neuron projection development (ISO)

neuron projection morphogenesis (ISO)

platelet dense granule organization (ISO)

positive regulation of gene expression (ISO)

positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization (ISO)

positive regulation of neurotransmitter secretion (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of receptor internalization (ISO)

protein transmembrane transport (ISO)

regulation of dopamine receptor signaling pathway (ISO)

regulation of dopamine secretion (ISO)

regulation of synaptic vesicle exocytosis (ISO)

retina development in camera-type eye (ISO)

Cellular Component

asymmetric synapse (ISO)

axon (ISO)

BLOC-1 complex (ISO)

cytoplasm (ISO)

dendritic spine (ISO)

endoplasmic reticulum membrane (ISO)

glutamatergic synapse (ISO)

growth cone (ISO)

hippocampal mossy fiber to CA3 synapse (ISO)

microtubule cytoskeleton (ISO)

midbody (ISO)

neuron projection (ISO)

neuronal cell body (ISO)

nucleus (ISO)

plasma membrane (ISO)

postsynaptic density (ISO)

sarcolemma (ISO)

sarcoplasm (ISO)

Schaffer collateral - CA1 synapse (ISO)

synaptic vesicle membrane (ISO)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Dtnbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	9,804,409 - 9,943,254 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936552	1,787,687 - 1,926,516 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DTNBP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	15,522,807 - 15,663,058 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	15,522,807 - 15,663,058 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	15,523,038 - 15,663,289 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	15,631,017 - 15,771,250 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	15,631,019 - 15,771,250	NCBI
Celera	6	16,760,985 - 16,901,244 (-)	NCBI		Celera
Cytogenetic Map	6	p22.3	NCBI
HuRef	6	15,470,266 - 15,609,971 (-)	NCBI		HuRef
CHM1_1	6	15,525,522 - 15,665,696 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	15,395,977 - 15,536,251 (-)	NCBI		T2T-CHM13v2.0

Dtnbp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	45,075,552 - 45,155,614 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	45,075,551 - 45,155,623 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	44,922,079 - 45,002,096 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	44,922,075 - 45,002,147 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	45,017,448 - 45,097,465 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	44,933,051 - 45,013,068 (-)	NCBI		MGSCv36	mm8
Celera	13	45,997,733 - 46,077,631 (-)	NCBI		Celera
Cytogenetic Map	13	A5	NCBI
cM Map	13	21.73	NCBI

Dtnbp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	19,891,313 - 19,982,770 (+)	NCBI		GRCr8
mRatBN7.2	17	19,685,218 - 19,776,668 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	19,685,215 - 19,776,661 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	19,569,853 - 19,660,683 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	21,173,678 - 21,264,514 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	19,496,978 - 19,587,817 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	20,090,136 - 20,182,332 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	20,090,246 - 20,182,206 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	22,105,208 - 22,193,087 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	17	19,386,624 - 19,477,026 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

Dtnbp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955590	281,704 - 386,189 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955590	276,143 - 382,812 (+)	NCBI	ChiLan1.0	ChiLan1.0

DTNBP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	30,187,857 - 30,334,277 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	26,176,679 - 26,319,812 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	15,377,263 - 15,523,317 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	15,741,698 - 15,887,039 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	15,741,698 - 15,887,256 (-)	Ensembl	panpan1.1		panPan2

DTNBP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	14,738,025 - 14,862,609 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	14,738,029 - 14,864,169 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	14,686,008 - 14,811,763 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	14,835,041 - 14,960,915 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	14,833,870 - 14,961,018 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	14,660,216 - 14,785,689 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	14,712,028 - 14,837,283 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	16,038,025 - 16,163,457 (-)	NCBI		UU_Cfam_GSD_1.0

DTNBP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	11,600,795 - 11,720,318 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	11,602,470 - 11,720,156 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	12,191,535 - 12,309,282 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DTNBP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	56,500,523 - 56,650,925 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	56,500,574 - 56,651,491 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	15,563,141 - 15,713,959 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dtnbp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	10,810,413 - 10,942,034 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	10,810,368 - 10,932,801 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005329134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040282121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005329134 ⟹ XP_005329191

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	9,804,413 - 9,943,254 (+)	NCBI
SpeTri2.0	NW_004936552	1,787,687 - 1,926,516 (-)	NCBI

Sequence:

show sequence

AAGTCTTTGAGTGACAAGTCAAAAGAAGCTAAAGTAAAAAGCAAACCCAGGACTGTTCCATATT
TGCCAAGGTACTCTGCTGGACTGGAATTACTTAACAGATATGAAGATACCTGGGCTGCACTTCA
CAGAAGAGCCAAAGAATGTGCAAATGCTGGAGAGTTGGTGGACAGTGAGGTGGTCATGCTTTCA
GCACACTGGGAGAAAAAGAAGACCAGCCTGATAGAGCTGCAAGAACAGCTCCAGCAGCTTCCAG
GTTTAATAGCAGACCTAGAATCCATGACAGCAAATCTGGCTCACTTAGAAGCTAGCTTTGAGGA
AGTAGAAAACCACCTGCTGCATCTGGAGGATTTGTGTGGGCAGTGTGAGTTAGAAAGGTACAAA
CATACGCAGTCCCAGCACCTGGAGAATTACAAGAAAAGTAAGAGGAAGGAGCTTGAAACCTTCA
AAGCTGAACTGGATGCTGAGCACACGCAGAAGGTCCTGGAAATGGAGCACACCCAGCAAATGAA
GCTGAAGGAGCGGCAGAAGTTTTTTGAGGAAGCCTTCCAGCAGGACATGGAGCAGTACCTTTCC
ACGGGGTACCTGCAGATTGCAGAGAGGCGCGAGCCCATGGGCAGCATGTCATCCATGGAGGTGA
ACGTGGACATGCTAGAGCAGATGGATTTGATGGACATCTCTGACCAGGAGGCCCTGGATGTCTT
CTTGAATTCGGGTGGAGAGGAGAACCCTGTGCTGTCCCCGGGGTTAGGGCCGGAAACTGACACC
TGTCAGGATGAAATTACTCTTCAGGTTCCAAATGCCTCAGAGTCCCTGCCCAAGCTACCTTCCT
CACCCTGTGTGTGCACAGAATCGGCCACCCTGGACCCCAGTGAAGGTGGGGAATGCCCCCTTGT
CCAGTCTGATGAGGAGGAAGTTCAGGTGGACACTGCCCTGGCCACTTCCCATGCTGACAGCCAG
GCCACTCCAGATGCTAGTGATGACAGTGACTCAAATCAGGAGTGACTGAAGTGTCAGTCGTGCA
CAGAACGCTCCTGTAAAGCCAGATTTTTAATGATTTTACACAATTGCCAATGATGTGTGAGAAA
CTGACAGAAGAGCTGACAATAAAGTTTGAGGACTTTGAACATTGA

hide sequence

RefSeq Acc Id:

XM_040282121 ⟹ XP_040138055

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	9,804,409 - 9,943,254 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005329191	(Get FASTA)	NCBI Sequence Viewer
	XP_040138055	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	KAG3288654	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005329191 ⟸ XM_005329134

- Peptide Label:

isoform X2

- Sequence:

show sequence

MLSAHWEKKKTSLIELQEQLQQLPGLIADLESMTANLAHLEASFEEVENHLLHLEDLCGQCELE
RYKHTQSQHLENYKKSKRKELETFKAELDAEHTQKVLEMEHTQQMKLKERQKFFEEAFQQDMEQ
YLSTGYLQIAERREPMGSMSSMEVNVDMLEQMDLMDISDQEALDVFLNSGGEENPVLSPGLGPE
TDTCQDEITLQVPNASESLPKLPSSPCVCTESATLDPSEGGECPLVQSDEEEVQVDTALATSHA
DSQATPDASDDSDSNQE

hide sequence

RefSeq Acc Id:	XP_040138055 ⟸ XM_040282121
- Peptide Label:	isoform X1

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Dtnbp1	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM