Fuca2 (alpha-L-fucosidase 2) - Rat Genome Database

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Gene: Fuca2 (alpha-L-fucosidase 2) Ictidomys tridecemlineatus
Analyze
Symbol: Fuca2
Name: alpha-L-fucosidase 2
RGD ID: 12615351
Description: ENCODES a protein that exhibits alpha-L-fucosidase activity (inferred); fucosidase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); INVOLVED IN fucose metabolic process (inferred); glycoside catabolic process (inferred); regulation of entry of bacterium into host cell (inferred); ASSOCIATED WITH COVID-19 (ortholog); familial hemophagocytic lymphohistiocytosis 4 (ortholog); High Myopia (ortholog); FOUND IN extracellular space (inferred); lysosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fucosidase, alpha-L- 2, plasma; plasma alpha-L-fucosidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946129,982,231 - 129,999,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366252,636,014 - 2,653,432 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366252,636,136 - 2,653,328 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fuca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946129,982,231 - 129,999,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366252,636,014 - 2,653,432 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366252,636,136 - 2,653,328 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FUCA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386143,494,812 - 143,511,720 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6143,494,812 - 143,511,720 (-)EnsemblGRCh38hg38GRCh38
GRCh376143,815,949 - 143,832,857 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366143,857,935 - 143,874,556 (-)NCBINCBI36Build 36hg18NCBI36
Build 346143,857,938 - 143,874,556NCBI
Celera6144,556,372 - 144,573,429 (-)NCBICelera
Cytogenetic Map6q24.2NCBI
HuRef6141,380,071 - 141,397,142 (-)NCBIHuRef
CHM1_16144,078,857 - 144,095,928 (-)NCBICHM1_1
T2T-CHM13v2.06144,687,220 - 144,704,128 (-)NCBIT2T-CHM13v2.0
Fuca2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391013,376,314 - 13,394,779 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1013,375,284 - 13,394,779 (+)EnsemblGRCm39 Ensembl
GRCm381013,500,570 - 13,519,035 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1013,499,540 - 13,519,035 (+)EnsemblGRCm38mm10GRCm38
MGSCv371013,220,834 - 13,237,081 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361013,191,226 - 13,207,473 (+)NCBIMGSCv36mm8
Celera1013,400,306 - 13,417,445 (+)NCBICelera
Cytogenetic Map10A2NCBI
cM Map104.86NCBI
Fuca2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819,706,121 - 9,720,910 (+)NCBIGRCr8
mRatBN7.217,885,986 - 7,900,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl17,885,918 - 7,900,776 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx17,582,261 - 7,597,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0113,581,386 - 13,596,163 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017,864,121 - 7,879,072 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.017,658,919 - 7,673,663 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17,658,890 - 7,673,683 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019,287,057 - 9,301,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418,289,580 - 8,304,369 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.118,289,579 - 8,304,368 (+)NCBI
Celera16,371,147 - 6,385,936 (+)NCBICelera
Cytogenetic Map1p13NCBI
Fuca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543616,896,629 - 16,915,083 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543616,896,629 - 16,912,406 (+)NCBIChiLan1.0ChiLan1.0
FUCA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25163,478,159 - 163,494,927 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16161,372,952 - 161,389,747 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06141,271,678 - 141,288,241 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16145,992,631 - 146,009,163 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6145,992,631 - 146,009,163 (-)Ensemblpanpan1.1panPan2
FUCA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1135,028,152 - 35,091,376 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,999,482 - 35,043,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha135,926,225 - 35,944,404 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0135,209,831 - 35,228,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl135,210,148 - 35,228,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1135,071,490 - 35,089,671 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0134,954,421 - 34,972,573 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0135,266,692 - 35,284,867 (-)NCBIUU_Cfam_GSD_1.0
FUCA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,742,495 - 21,762,900 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,742,192 - 21,762,901 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,129,407 - 24,150,031 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FUCA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11329,729,056 - 29,747,400 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1329,729,604 - 29,749,435 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660401,865,617 - 1,883,713 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fuca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475310,767,162 - 10,783,669 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475310,767,093 - 10,782,963 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005334850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000012843   ⟹   ENSSTOP00000011508
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366252,636,014 - 2,653,432 (+)Ensembl
RefSeq Acc Id: XM_005334850   ⟹   XP_005334907
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946129,982,231 - 129,999,419 (-)NCBI
SpeTri2.0NW_0049366252,636,136 - 2,653,328 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005334907 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000011508.2
GenBank Protein KAG3290378 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005334907   ⟸   XM_005334850
- UniProtKB: I3MJW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000011508   ⟸   ENSSTOT00000012843
Protein Domains
Alpha-L-fucosidase C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012845 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012843.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1180 UniProtKB/TrEMBL
  Glycosidases UniProtKB/TrEMBL
InterPro FUC_metazoa-typ UniProtKB/TrEMBL
  Fucosidase_C UniProtKB/TrEMBL
  Glyco_hydro_29 UniProtKB/TrEMBL
  Glyco_hydro_29_CS UniProtKB/TrEMBL
  Glyco_hydro_b UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
NCBI Gene Fuca2 ENTREZGENE
PANTHER PLASMA ALPHA-L-FUCOSIDASE UniProtKB/TrEMBL
  PTHR10030 UniProtKB/TrEMBL
Pfam Alpha_L_fucos UniProtKB/TrEMBL
  Fucosidase_C UniProtKB/TrEMBL
PIRSF Alpha-L-fucosidase UniProtKB/TrEMBL
PRINTS GLHYDRLASE29 UniProtKB/TrEMBL
PROSITE ALPHA_L_FUCOSIDASE UniProtKB/TrEMBL
SMART Alpha_L_fucos UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/TrEMBL
UniProt I3MJW5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-13 Fuca2  alpha-L-fucosidase 2    fucosidase, alpha-L- 2, plasma  Symbol and/or name change 5135510 APPROVED