Adhfe1 (alcohol dehydrogenase iron containing 1) - Rat Genome Database

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Gene: Adhfe1 (alcohol dehydrogenase iron containing 1) Ictidomys tridecemlineatus
Analyze
Symbol: Adhfe1
Name: alcohol dehydrogenase iron containing 1
RGD ID: 12609622
Description: ENCODES a protein that exhibits alcohol dehydrogenase (NAD+) activity (inferred); hydroxyacid-oxoacid transhydrogenase activity (inferred); metal ion binding (inferred); INVOLVED IN glutamate catabolic process via 2-oxoglutarate (inferred); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alcohol dehydrogenase, iron containing 1; hydroxyacid-oxoacid transhydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,228,274 - 67,256,260 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364967,530,415 - 7,562,847 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364967,529,217 - 7,562,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adhfe1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,228,274 - 67,256,260 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364967,530,415 - 7,562,847 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364967,529,217 - 7,562,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADHFE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38866,432,504 - 66,468,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl866,432,492 - 66,468,907 (+)EnsemblGRCh38hg38GRCh38
GRCh37867,344,739 - 67,381,142 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,507,272 - 67,543,598 (+)NCBINCBI36Build 36hg18NCBI36
Build 34867,507,287 - 67,543,596NCBI
Celera863,336,419 - 63,372,728 (+)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef862,834,707 - 62,871,046 (+)NCBIHuRef
CHM1_1867,399,402 - 67,435,714 (+)NCBICHM1_1
T2T-CHM13v2.0866,858,074 - 66,894,463 (+)NCBIT2T-CHM13v2.0
Adhfe1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3919,618,173 - 9,648,195 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl19,618,173 - 9,650,898 (+)EnsemblGRCm39 Ensembl
GRCm3819,547,948 - 9,577,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl19,547,948 - 9,580,673 (+)EnsemblGRCm38mm10GRCm38
MGSCv3719,538,127 - 9,568,049 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3619,533,294 - 9,563,182 (+)NCBIMGSCv36mm8
Celera19,522,208 - 9,552,158 (+)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.08NCBI
Adhfe1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8514,488,784 - 14,515,405 (-)NCBIGRCr8
mRatBN7.259,705,966 - 9,732,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl59,705,970 - 9,732,517 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,859,881 - 11,886,366 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0513,491,307 - 13,517,863 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0513,194,558 - 13,221,043 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.059,403,194 - 9,429,783 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl59,403,196 - 9,429,859 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0514,202,072 - 14,228,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.459,276,929 - 9,303,483 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.159,276,932 - 9,303,483 (-)NCBI
Celera59,215,174 - 9,241,478 (-)NCBICelera
Cytogenetic Map5q11NCBI
Adhfe1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544412,706,912 - 12,745,056 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544412,706,404 - 12,745,106 (-)NCBIChiLan1.0ChiLan1.0
ADHFE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2782,170,179 - 82,206,474 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1857,809,545 - 57,847,393 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0862,975,711 - 63,012,102 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1864,642,062 - 64,678,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,642,062 - 64,678,306 (+)Ensemblpanpan1.1panPan2
ADHFE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12916,019,183 - 16,054,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2916,019,246 - 16,050,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2916,333,976 - 16,376,910 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02916,097,874 - 16,141,174 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2916,097,773 - 16,182,387 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12916,130,334 - 16,173,264 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,229,683 - 16,272,642 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02916,485,707 - 16,528,705 (+)NCBIUU_Cfam_GSD_1.0
ADHFE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl468,250,646 - 68,285,405 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1468,251,970 - 68,285,436 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2474,419,430 - 74,452,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADHFE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1862,300,884 - 62,337,886 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl862,300,979 - 62,338,096 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603979,168,492 - 79,205,076 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adhfe1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474424,880,010 - 24,913,873 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474424,883,104 - 24,913,885 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000008784   ⟹   ENSSTOP00000007873
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364967,530,415 - 7,562,847 (-)Ensembl
RefSeq Acc Id: XM_005322947   ⟹   XP_005323004
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530367,228,274 - 67,256,260 (+)NCBI
SpeTri2.0NW_0049364967,529,217 - 7,562,881 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040293999   ⟹   XP_040149933
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530367,228,274 - 67,247,720 (+)NCBI
RefSeq Acc Id: XR_005737860
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530367,228,274 - 67,256,260 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005323004 (Get FASTA)   NCBI Sequence Viewer  
  XP_040149933 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000007873.3
GenBank Protein KAG3274096 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005323004   ⟸   XM_005322947
- Peptide Label: isoform X1
- UniProtKB: I3MCA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040149933   ⟸   XM_040293999
- Peptide Label: isoform X2
RefSeq Acc Id: ENSSTOP00000007873   ⟸   ENSSTOT00000008784
Protein Domains
Alcohol dehydrogenase iron-type/glycerol


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008788 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008784.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1970 UniProtKB/TrEMBL
  Dehydroquinate synthase-like - alpha domain UniProtKB/TrEMBL
InterPro ADH_Fe/GldA UniProtKB/TrEMBL
  Alcohol_dehydrogenase_Fe UniProtKB/TrEMBL
  HOT UniProtKB/TrEMBL
NCBI Gene Adhfe1 ENTREZGENE
PANTHER HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR11496 UniProtKB/TrEMBL
Pfam Fe-ADH UniProtKB/TrEMBL
Superfamily-SCOP Dehydroquinate synthase-like UniProtKB/TrEMBL
UniProt I3MCA2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Adhfe1  alcohol dehydrogenase iron containing 1    alcohol dehydrogenase, iron containing 1  Symbol and/or name change 5135510 APPROVED