LOC101961559 (E3 ubiquitin-protein ligase RNF126) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: LOC101961559 (E3 ubiquitin-protein ligase RNF126) Ictidomys tridecemlineatus
Analyze
Symbol: LOC101961559 (Ensembl: PRSS57)
Name: E3 ubiquitin-protein ligase RNF126 (Ensembl:serine protease 57)
RGD ID: 12603250
Description: ENCODES a protein that exhibits epidermal growth factor receptor binding (inferred); metal ion binding (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN cytoplasm protein quality control by the ubiquitin-proteasome system (inferred); negative regulation of epidermal growth factor receptor signaling pathway (inferred); positive regulation of double-strand break repair via homologous recombination (inferred); ASSOCIATED WITH cerebral creatine deficiency syndrome (ortholog); cyclic hematopoiesis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protease, serine 57; Prss57; ring finger protein 126; Rnf126; serine protease 57
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,572,863 - 217,603,060 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588229,508 - 237,969 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936588255,639 - 260,291 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588231,723 - 237,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LOC101961559
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,572,863 - 217,603,060 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588229,508 - 237,969 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936588255,639 - 260,291 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588231,723 - 237,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF126
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819647,526 - 663,214 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19647,526 - 663,233 (-)EnsemblGRCh38hg38GRCh38
GRCh3719647,526 - 663,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619598,526 - 614,227 (-)NCBINCBI36Build 36hg18NCBI36
Celera19154,322 - 170,071 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19417,361 - 433,064 (-)NCBIHuRef
CHM1_119647,187 - 662,920 (-)NCBICHM1_1
T2T-CHM13v2.019601,753 - 617,249 (-)NCBIT2T-CHM13v2.0
Rnf126
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,594,349 - 79,607,282 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,594,349 - 79,602,786 (-)EnsemblGRCm39 Ensembl
GRCm381079,758,515 - 79,771,448 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,758,515 - 79,766,952 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,221,260 - 79,229,686 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,161,668 - 79,170,053 (-)NCBIMGSCv36mm8
Celera1080,773,108 - 80,791,932 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Rnf126
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,590,013 - 10,597,585 (+)NCBIGRCr8
mRatBN7.279,939,359 - 9,946,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,938,229 - 9,946,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,820,464 - 12,827,752 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,698,545 - 14,705,833 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,557,874 - 12,565,162 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,820,796 - 12,828,325 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,820,840 - 12,828,334 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,991,016 - 12,998,529 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,454,326 - 11,461,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,454,379 - 11,461,302 (+)NCBI
Celera78,112,972 - 8,120,260 (+)NCBICelera
Cytogenetic Map7q11NCBI
Rnf126
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,095,336 - 7,102,757 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,083,952 - 7,098,442 (+)NCBIChiLan1.0ChiLan1.0
RNF126
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,969,822 - 4,988,575 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,211,553 - 4,226,693 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019491,699 - 494,175 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1 Ensembl19614,236 - 618,659 (-)Ensemblpanpan1.1panPan2
RNF126
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,890,333 - 57,899,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,891,413 - 57,898,863 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,694,175 - 57,701,870 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,634,727 - 58,642,433 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12057,688,864 - 57,696,560 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,168,322 - 58,176,002 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,371,682 - 58,379,389 (+)NCBIUU_Cfam_GSD_1.0
RNF126
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,673,353 - 77,683,311 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,673,302 - 77,683,312 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RNF126
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16392,717 - 409,139 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660818,561,985 - 8,593,924 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnf126
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,856,470 - 7,869,926 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,856,822 - 7,865,644 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000008752   ⟹   ENSSTOP00000007845
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936588255,639 - 260,291 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000027570   ⟹   ENSSTOP00000022452
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936588229,508 - 237,969 (-)Ensembl
RefSeq Acc Id: XM_040290805   ⟹   XP_040146739
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118217,572,863 - 217,603,060 (+)NCBI
RefSeq Acc Id: XM_040290806   ⟹   XP_040146740
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118217,573,825 - 217,579,981 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040146739 (Get FASTA)   NCBI Sequence Viewer  
  XP_040146740 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000007845.3
  ENSSTOP00000022452.2
GenBank Protein KAG3280882 (Get FASTA)   NCBI Sequence Viewer  
  KAG3280884 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_040146739   ⟸   XM_040290805
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040146740   ⟸   XM_040290806
- Peptide Label: isoform X2
RefSeq Acc Id: ENSSTOP00000007845   ⟸   ENSSTOT00000008752
RefSeq Acc Id: ENSSTOP00000022452   ⟸   ENSSTOT00000027570
Protein Domains
Peptidase S1   RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008773 Ensembl, UniProtKB/TrEMBL
  ENSSTOG00000025681 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008752.3 UniProtKB/TrEMBL
  ENSSTOT00000027570.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  RNF126_RING-H2 UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene Rnf126 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE PRAJA UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
  PTHR15710:SF21 UniProtKB/TrEMBL
  SERINE PROTEASE 57 UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
  zf-RING_2 UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF50494 UniProtKB/TrEMBL
UniProt I3MC82_ICTTR UniProtKB/TrEMBL
  I3NDK5_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 LOC101961559  E3 ubiquitin-protein ligase RNF126  Rnf126  ring finger protein 126  Symbol and/or name change 5135510 APPROVED
2021-03-25 Rnf126  ring finger protein 126  Prss57  serine protease 57  Data merged from RGD:12558081 737654 PROVISIONAL
2018-01-23 Prss57  serine protease 57    protease, serine 57  Symbol and/or name change 5135510 APPROVED