Tars2 (threonyl-tRNA synthetase 2, mitochondrial) - Rat Genome Database

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Gene: Tars2 (threonyl-tRNA synthetase 2, mitochondrial) Ictidomys tridecemlineatus
Analyze
Symbol: Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial
RGD ID: 12593784
Description: ENCODES a protein that exhibits aminoacyl-tRNA editing activity (inferred); aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); INVOLVED IN aminoacyl-tRNA metabolism involved in translational fidelity (inferred); threonyl-tRNA aminoacylation (inferred); translation (inferred); ASSOCIATED WITH combined oxidative phosphorylation deficiency 21 (ortholog); Failure to Thrive (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: threonine--tRNA ligase, mitochondrial; threonyl-tRNA synthetase 2, mitochondrial (putative)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,701,369 - 21,719,739 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580731,938 - 749,815 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936580731,884 - 750,121 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,701,369 - 21,719,739 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580731,938 - 749,815 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936580731,884 - 750,121 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,487,419 - 150,507,602 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1150,487,414 - 150,507,602 (+)EnsemblGRCh38hg38GRCh38
GRCh371150,459,895 - 150,480,078 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,726,544 - 148,746,380 (+)NCBINCBI36Build 36hg18NCBI36
Build 341147,272,992 - 147,292,820NCBI
Celera1123,575,684 - 123,595,519 (+)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,837,982 - 121,858,252 (+)NCBIHuRef
CHM1_11151,855,629 - 151,875,895 (+)NCBICHM1_1
T2T-CHM13v2.01149,612,277 - 149,632,442 (+)NCBIT2T-CHM13v2.0
Tars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,647,286 - 95,663,677 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,647,288 - 95,667,518 (-)EnsemblGRCm39 Ensembl
GRCm38395,739,974 - 95,756,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,739,976 - 95,760,206 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,543,897 - 95,558,900 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,825,381 - 95,840,267 (-)NCBIMGSCv36mm8
Celera397,172,933 - 97,186,093 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.93NCBI
Tars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,982,042 - 185,999,155 (-)NCBIGRCr8
mRatBN7.22183,293,095 - 183,310,210 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,293,097 - 183,310,184 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,957,950 - 190,974,999 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,754,084 - 188,771,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,590,482 - 183,607,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02197,861,071 - 197,881,347 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2197,861,115 - 197,878,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,350,871 - 217,369,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,530,782 - 190,547,829 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,493,537 - 190,510,583 (-)NCBI
Celera2175,823,129 - 175,840,177 (-)NCBICelera
Cytogenetic Map2q34NCBI
Tars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955413300,142 - 314,703 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955413300,142 - 314,703 (-)NCBIChiLan1.0ChiLan1.0
TARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,330,118 - 99,351,014 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,084,610 - 99,104,911 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01125,832,693 - 125,852,918 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11129,480,818 - 129,501,639 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,480,824 - 129,501,639 (+)Ensemblpanpan1.1panPan2
TARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,681,889 - 59,695,747 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,681,936 - 59,695,746 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,128,051 - 59,141,906 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,697,411 - 60,711,268 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,697,454 - 60,717,336 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,527,850 - 59,541,707 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,611,624 - 59,625,484 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,339,288 - 60,353,149 (+)NCBIUU_Cfam_GSD_1.0
TARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,622,494 - 98,635,271 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,622,235 - 98,635,318 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,910,016 - 107,923,245 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TARS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,783,871 - 12,804,424 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tars2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,221,459 - 18,240,601 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,221,704 - 18,234,080 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000008321   ⟹   ENSSTOP00000007459
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936580731,938 - 749,815 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000038712   ⟹   ENSSTOP00000029025
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936580731,938 - 742,400 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000039649   ⟹   ENSSTOP00000025522
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936580731,938 - 749,815 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000040837   ⟹   ENSSTOP00000026562
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936580731,938 - 749,815 (+)Ensembl
RefSeq Acc Id: XM_040287527   ⟹   XP_040143461
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505821,701,369 - 21,719,739 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040143461 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000007459.3
  ENSSTOP00000025522.1
  ENSSTOP00000026562.1
  ENSSTOP00000029025.1
Reference Protein Sequences
RefSeq Acc Id: XP_040143461   ⟸   XM_040287527
- UniProtKB: I3MBF1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000026562   ⟸   ENSSTOT00000040837
RefSeq Acc Id: ENSSTOP00000025522   ⟸   ENSSTOT00000039649
RefSeq Acc Id: ENSSTOP00000029025   ⟸   ENSSTOT00000038712
RefSeq Acc Id: ENSSTOP00000007459   ⟸   ENSSTOT00000008321
Protein Domains
Aminoacyl-transfer RNA synthetases class-II family   TGS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008311 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008321.3 UniProtKB/TrEMBL
  ENSSTOT00000038712.1 UniProtKB/TrEMBL
  ENSSTOT00000039649.1 UniProtKB/TrEMBL
  ENSSTOT00000040837.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.30 UniProtKB/TrEMBL
  3.40.50.800 UniProtKB/TrEMBL
InterPro aa-tRNA-synt_IIb UniProtKB/TrEMBL
  aa-tRNA-synth_II UniProtKB/TrEMBL
  aa-tRNA-synth_II/BPL/LPL UniProtKB/TrEMBL
  Anticodon-bd UniProtKB/TrEMBL
  Anticodon-bd_dom_sf UniProtKB/TrEMBL
  Beta-grasp_dom_sf UniProtKB/TrEMBL
  TGS UniProtKB/TrEMBL
  TGS-like UniProtKB/TrEMBL
  Thr-tRNA-ligase_IIa UniProtKB/TrEMBL
  Thr/Ala-tRNA-synth_IIc_edit UniProtKB/TrEMBL
  ThrRS_anticodon UniProtKB/TrEMBL
  ThrRS_core UniProtKB/TrEMBL
  tRNA_SAD UniProtKB/TrEMBL
NCBI Gene Tars2 ENTREZGENE
PANTHER PTHR11451 UniProtKB/TrEMBL
  THREONINE--TRNA LIGASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam HGTP_anticodon UniProtKB/TrEMBL
  TGS UniProtKB/TrEMBL
  tRNA-synt_2b UniProtKB/TrEMBL
  tRNA_SAD UniProtKB/TrEMBL
PRINTS TRNASYNTHTHR UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_II UniProtKB/TrEMBL
  TGS UniProtKB/TrEMBL
SMART tRNA_SAD UniProtKB/TrEMBL
Superfamily-SCOP Class II aaRS ABD-related UniProtKB/TrEMBL
  SSF55186 UniProtKB/TrEMBL
  SSF55681 UniProtKB/TrEMBL
  SSF81271 UniProtKB/TrEMBL
UniProt A0A287CW42_ICTTR UniProtKB/TrEMBL
  A0A287CZ25_ICTTR UniProtKB/TrEMBL
  A0A287D674_ICTTR UniProtKB/TrEMBL
  I3MBF1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-19 Tars2  threonyl-tRNA synthetase 2, mitochondrial    threonyl-tRNA synthetase 2, mitochondrial (putative)  Symbol and/or name change 5135510 APPROVED