Cbr4 (carbonyl reductase 4) - Rat Genome Database

Name: Cbr4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cbr4 (carbonyl reductase 4) Ictidomys tridecemlineatus

Analyze

Symbol:

Cbr4

Name:

carbonyl reductase 4

RGD ID:

12588409

Description:

ENCODES a protein that exhibits 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity (inferred); NAD(P)H dehydrogenase (quinone) activity (inferred); NADPH binding (inferred); INVOLVED IN daunorubicin metabolic process (inferred); doxorubicin metabolic process (inferred); fatty acid biosynthetic process (inferred); ASSOCIATED WITH genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); pancreatic adenocarcinoma (ortholog); FOUND IN mitochondrial matrix (inferred); oxidoreductase complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

carbonyl reductase family member 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CBR4 (carbonyl reductase 4)	NCBI	Ortholog
Mus musculus (house mouse):	Cbr4 (carbonyl reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cbr4 (carbonyl reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cbr4 (carbonyl reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CBR4 (carbonyl reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CBR4 (carbonyl reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CBR4 (carbonyl reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CBR4 (carbonyl reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cbr4 (carbonyl reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	20,768,596 - 20,791,385 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936516	1,181,524 - 1,205,760 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936516	1,184,859 - 1,205,668 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

pancreatic adenocarcinoma (ISO)

pancreatic cancer (ISO)

pancreatic carcinoma (ISO)

short-rib thoracic dysplasia 6 with or without polydactyly (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

daunorubicin metabolic process (IEA)

doxorubicin metabolic process (IEA)

fatty acid biosynthetic process (IEA)

fatty acid metabolic process (IEA)

protein heterotetramerization (IEA)

protein homotetramerization (IEA)

Cellular Component

mitochondrial matrix (IEA)

oxidoreductase complex (IEA)

Molecular Function

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity (IEA)

NAD(P)H dehydrogenase (quinone) activity (IEA)

NADPH binding (IEA)

NADPH dehydrogenase (quinone) activity (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA)

protein binding (ISO)

quinone binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Cbr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	20,768,596 - 20,791,385 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936516	1,181,524 - 1,205,760 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936516	1,184,859 - 1,205,668 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CBR4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	168,894,486 - 169,010,255 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	168,863,770 - 169,010,275 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	169,908,741 - 169,931,406 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	170,145,316 - 170,167,997 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	167,240,084 - 167,262,804 (-)	NCBI		Celera
Cytogenetic Map	4	q32.3	NCBI
HuRef	4	165,662,191 - 165,684,917 (-)	NCBI		HuRef
CHM1_1	4	169,885,180 - 169,907,907 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	172,254,054 - 172,369,681 (-)	NCBI		T2T-CHM13v2.0

Cbr4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	61,940,768 - 61,956,534 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	61,940,768 - 61,959,728 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	61,487,734 - 61,503,500 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	61,487,734 - 61,506,694 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	63,966,531 - 63,982,297 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	64,379,926 - 64,395,624 (+)	NCBI		MGSCv36	mm8
MGSCv36	8	60,656,117 - 60,671,212 (+)	NCBI		MGSCv36	mm8
Celera	8	64,050,917 - 64,066,676 (+)	NCBI		Celera
Cytogenetic Map	8	B3.1	NCBI
cM Map	8	31.18	NCBI

Cbr4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	33,625,734 - 33,695,067 (-)	NCBI		GRCr8
mRatBN7.2	16	28,629,928 - 28,684,230 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	28,617,224 - 28,645,712 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	32,224,831 - 32,240,582 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	35,658,872 - 35,674,623 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	31,860,531 - 31,876,269 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	31,944,328 - 31,972,553 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	31,956,753 - 31,972,507 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	31,794,520 - 31,810,263 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	31,943,125 - 31,957,556 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	31,943,200 - 31,957,630 (-)	NCBI
Celera	16	28,625,441 - 28,641,135 (-)	NCBI		Celera
Cytogenetic Map	16	p12	NCBI

Cbr4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	37,206,634 - 37,226,407 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	37,201,474 - 37,226,414 (+)	NCBI	ChiLan1.0	ChiLan1.0

CBR4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	166,663,224 - 166,794,172 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	167,015,483 - 167,149,427 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	161,103,477 - 161,235,840 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	173,182,755 - 173,309,905 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	173,282,162 - 173,309,905 (-)	Ensembl	panpan1.1		panPan2

CBR4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	19,475,562 - 19,618,144 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	19,597,518 - 19,618,180 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	19,566,496 - 19,649,192 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	19,673,638 - 19,756,294 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	19,734,924 - 19,756,246 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	19,541,290 - 19,623,984 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	19,541,898 - 19,624,490 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	19,604,132 - 19,686,873 (-)	NCBI		UU_Cfam_GSD_1.0

CBR4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	20,621,981 - 20,682,240 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	20,621,960 - 20,642,351 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	21,908,782 - 21,929,179 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CBR4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	115,223,813 - 115,246,925 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	115,223,386 - 115,246,818 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	95,082,408 - 95,160,389 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cbr4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624769	581,800 - 604,075 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624769	564,148 - 603,402 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005325495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000021927 ⟹ ENSSTOP00000022019

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936516	1,185,009 - 1,205,467 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000038723 ⟹ ENSSTOP00000031333

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936516	1,181,524 - 1,205,760 (-)	Ensembl

RefSeq Acc Id:

XM_005325495 ⟹ XP_005325552

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	20,768,596 - 20,791,385 (-)	NCBI
SpeTri2.0	NW_004936516	1,184,859 - 1,205,668 (-)	NCBI

Sequence:

show sequence

GTCAGCGCGTTTACATCTTACTCTTCGCGGCTTCTTAAATTGCCAGAGTCTGTGGGCTGGAGCT
AGCGCCCGCTGGGGTGTTGTGCTCCGGCTTGGCTTTATCTATCTATCCATTTATTTATTTATTT
ATTTTTTAAAAGCCCGAGGTTCTCTGGAGAAGGGCGGCAGCTCTCAGCCAAGTTTTCGACTCAC
GGGTTCAAGATGAACAAAGTGTGCGCTATTTTTGGAGGTTCCCGGGGTATTGGCAGGGCAGTAG
CCCAGTTAATGGCCCAGAAAGGCTACCGACTGGCGATCATCGCCAGAAATCTGGAAGTGGCCAA
AGCCGCCGCAGGTGACCTCGGCGGAAATCATTTAGCATTTAGCTGTGATGTTGCTAAAGAACAT
GATGTTCAAAATACATTTGAAGAGATGGAGAAACATTTAGGTCAAGTAAATTTTTTGGTAAATG
CAGCTGGTATTAACAGGGATAGTCTTTTAGTAAGAACAAAAACCGAAGATATGATATCTCAACT
TAATACTAATCTCTTGGGTTCTATGCTGACTTGTAAAGCTGCCATGAGGACTATGATTCAACAA
CAGGGAGGGTCTATTGTTAATGTAGGAAGTATTATCGGTTTAAAAGGCAATTCTGGCCAGTCTG
TGTATAGTGCCAGTAAAGGAGGATTGGTTGGATTTTCACGTGCACTTGCTAAAGAGGTAGCACG
AAAGAAAATTAGAGTGAATGTAGTTGCACCAGGATTTGTTCACACAGATATGACGAAAGACCTG
AAAGAAGAACAGTTAAAGAAAAGCATTCCTCTTGGAAGGTTTGGAGAAACCATTGAGGTGGCAC
ACGCAATTGTGTTTCTTTTAGAATCACCATATATTACAGGACATGTTCTAGTAGTGGATGGAGG
GTTACAACTTGTGGTATAATTTAGAGATTGTTCAGTTATAATGGTGATTAGAATCAAGTCACAC
TTTAGCTATTGATTAGACAATCATACTACCTGGTGACACTTGCTAATCAAACCTACTGATGCTA
CCAATGTTGATTTCCTTCTTTATATAAATGTTTGAAAAGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005325552	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022019.1
	ENSSTOP00000031333.1
GenBank Protein	KAG3294485	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005325552 ⟸ XM_005325495

- UniProtKB:

I3NCC2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNKVCAIFGGSRGIGRAVAQLMAQKGYRLAIIARNLEVAKAAAGDLGGNHLAFSCDVAKEHDVQ
NTFEEMEKHLGQVNFLVNAAGINRDSLLVRTKTEDMISQLNTNLLGSMLTCKAAMRTMIQQQGG
SIVNVGSIIGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTDMTKDLKEE
QLKKSIPLGRFGETIEVAHAIVFLLESPYITGHVLVVDGGLQLVV

hide sequence

RefSeq Acc Id:

ENSSTOP00000022019 ⟸ ENSSTOT00000021927

RefSeq Acc Id:

ENSSTOP00000031333 ⟸ ENSSTOT00000038723

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000026243	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000021927.2	UniProtKB/TrEMBL
	ENSSTOT00000038723.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
NCBI Gene	Cbr4	ENTREZGENE
PANTHER	3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE	UniProtKB/TrEMBL
	SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER	UniProtKB/TrEMBL
Pfam	adh_short_C2	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/TrEMBL
SMART	PKS_KR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	I3NCC2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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