Lemd2 (LEM domain nuclear envelope protein 2) - Rat Genome Database

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Gene: Lemd2 (LEM domain nuclear envelope protein 2) Ictidomys tridecemlineatus
Analyze
Symbol: Lemd2
Name: LEM domain nuclear envelope protein 2 (Ensembl:LEM domain containing 2)
RGD ID: 12578786
Description: ENCODES a protein that exhibits chromatin DNA binding (inferred); INVOLVED IN negative regulation of MAPK cascade (ortholog); skeletal muscle cell differentiation (ortholog); ASSOCIATED WITH cardiomyopathy (ortholog); cataract (ortholog); cataract 46 juvenile-onset (ortholog); FOUND IN chromatin (inferred); endomembrane system (inferred); endoplasmic reticulum (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LEM domain containing 2; LEM domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,771,969 - 38,789,333 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,170,973 - 25,186,965 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,170,954 - 25,188,298 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Lemd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,771,969 - 38,789,333 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,170,973 - 25,186,965 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,170,954 - 25,188,298 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEMD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,771,213 - 33,789,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,771,202 - 33,789,130 (-)EnsemblGRCh38hg38GRCh38
GRCh37633,738,990 - 33,756,907 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,846,968 - 33,864,874 (-)NCBINCBI36Build 36hg18NCBI36
Celera635,293,376 - 35,311,312 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,480,936 - 33,498,853 (-)NCBIHuRef
CHM1_1633,741,239 - 33,759,156 (-)NCBICHM1_1
T2T-CHM13v2.0633,592,393 - 33,610,310 (-)NCBIT2T-CHM13v2.0
Lemd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,408,574 - 27,426,228 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,408,574 - 27,423,443 (-)EnsemblGRCm39 Ensembl
GRCm381727,189,600 - 27,205,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,189,600 - 27,204,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,326,545 - 27,341,383 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,917,346 - 26,931,337 (-)NCBIMGSCv36mm8
Celera1727,725,463 - 27,740,360 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.82NCBI
Lemd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,284,275 - 5,298,281 (-)NCBIGRCr8
mRatBN7.2205,282,397 - 5,296,621 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,282,397 - 5,296,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,993,689 - 6,007,584 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,355,436 - 5,369,329 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,836,295 - 5,850,161 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,779,742 - 5,786,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,545,083 - 6,556,350 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,789,656 - 8,800,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,425,689 - 5,436,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,426,758 - 5,496,911 (-)NCBI
Celera206,846,384 - 6,857,575 (-)NCBICelera
Cytogenetic Map20p12NCBI
Lemd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,163,878 - 2,176,665 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,163,977 - 2,178,783 (-)NCBIChiLan1.0ChiLan1.0
LEMD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,250,279 - 48,274,131 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1644,117,224 - 44,136,002 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,344,372 - 33,363,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,452,332 - 34,469,795 (-)NCBIpanpan1.1PanPan1.1panPan2
LEMD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,114,175 - 3,131,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,115,460 - 3,131,919 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha123,130,070 - 3,147,660 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,446,589 - 3,464,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,447,058 - 3,464,190 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,112,813 - 3,130,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,194,850 - 3,212,427 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,292,189 - 3,309,758 (-)NCBIUU_Cfam_GSD_1.0
LEMD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,980,401 - 29,997,115 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,980,394 - 29,997,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,640,183 - 34,656,850 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LEMD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,291,100 - 38,309,134 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,291,217 - 38,307,745 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,664,152 - 33,682,118 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lemd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,158,985 - 23,173,885 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,159,234 - 23,173,452 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005318801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000000859   ⟹   ENSSTOP00000000770
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647625,170,973 - 25,186,965 (+)Ensembl
RefSeq Acc Id: XM_005318801   ⟹   XP_005318858
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494638,771,969 - 38,789,333 (-)NCBI
SpeTri2.0NW_00493647625,170,954 - 25,188,298 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005318858 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000000770.2
GenBank Protein KAG3289245 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005318858   ⟸   XM_005318801
- UniProtKB: I3LXG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000000770   ⟸   ENSSTOT00000000859
Protein Domains
LEM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000860 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000859.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1180 UniProtKB/TrEMBL
  1.10.720.40 UniProtKB/TrEMBL
InterPro LEM/LEM-like_dom_sf UniProtKB/TrEMBL
  LEM_dom UniProtKB/TrEMBL
  MAN1_winged_helix_dom UniProtKB/TrEMBL
  MSC UniProtKB/TrEMBL
NCBI Gene Lemd2 ENTREZGENE
PANTHER INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR13428:SF8 UniProtKB/TrEMBL
Pfam LEM UniProtKB/TrEMBL
  MSC UniProtKB/TrEMBL
PROSITE LEM UniProtKB/TrEMBL
SMART LEM UniProtKB/TrEMBL
Superfamily-SCOP SSF63451 UniProtKB/TrEMBL
UniProt I3LXG9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-08 Lemd2  LEM domain nuclear envelope protein 2  Lemd2  LEM domain containing 2  Symbol and/or name change 5135510 APPROVED