Larp6 (La ribonucleoprotein 6, translational regulator)

Gene: Larp6 (La ribonucleoprotein 6, translational regulator) Ictidomys tridecemlineatus

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Symbol:

Larp6

Name:

La ribonucleoprotein 6, translational regulator

RGD ID:

12572800

Description:

ENCODES a protein that exhibits mRNA 5'-UTR binding (inferred); mRNA binding (inferred); myosin binding (inferred); INVOLVED IN positive regulation of collagen biosynthetic process (inferred); RNA processing (inferred); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); ribonucleoprotein complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

La ribonucleoprotein domain family member 6; la-related protein 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	112,521,849 - 112,539,209 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	30,370,440 - 30,385,518 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	30,369,912 - 30,387,272 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of collagen biosynthetic process (IEA)

RNA processing (IEA)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

ribonucleoprotein complex (IEA)

Molecular Function

mRNA 5'-UTR binding (IEA)

mRNA binding (IEA)

myosin binding (IEA)

protein binding (ISO)

RNA binding (IEA)

RNA stem-loop binding (IEA)

sequence-specific mRNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Larp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	112,521,849 - 112,539,209 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	30,370,440 - 30,385,518 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	30,369,912 - 30,387,272 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LARP6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	70,829,130 - 70,854,157 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	70,829,130 - 70,854,157 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	71,121,469 - 71,146,496 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	68,910,943 - 68,933,552 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	48,014,786 - 48,037,397 (-)	NCBI		Celera
Cytogenetic Map	15	q23	NCBI
HuRef	15	47,959,434 - 47,982,049 (-)	NCBI		HuRef
CHM1_1	15	71,242,143 - 71,264,762 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	68,652,085 - 68,677,121 (-)	NCBI		T2T-CHM13v2.0

Larp6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	60,620,404 - 60,646,084 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	60,620,272 - 60,646,084 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	60,713,121 - 60,738,801 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	60,712,989 - 60,738,801 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	60,560,928 - 60,586,608 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	60,511,127 - 60,536,807 (+)	NCBI		MGSCv36	mm8
Celera	9	57,938,375 - 57,963,474 (+)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	32.87	NCBI

Larp6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	70,079,753 - 70,101,175 (+)	NCBI		GRCr8
mRatBN7.2	8	61,183,744 - 61,205,548 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	61,184,116 - 61,205,535 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	66,692,453 - 66,713,653 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	64,965,027 - 64,986,227 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	62,834,883 - 62,856,084 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	65,611,570 - 65,632,706 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	65,611,570 - 65,632,706 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	65,362,299 - 65,382,759 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	64,655,008 - 64,676,258 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	64,674,131 - 64,694,704 (+)	NCBI
Celera	8	60,610,882 - 60,632,170 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Larp6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	6,050,057 - 6,073,379 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	6,050,260 - 6,073,388 (+)	NCBI	ChiLan1.0	ChiLan1.0

LARP6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	60,095,231 - 60,117,915 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	64,259,145 - 64,281,825 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	49,781,184 - 49,803,856 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	68,547,930 - 68,552,899 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	68,547,937 - 68,552,899 (-)	Ensembl	panpan1.1		panPan2

LARP6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	34,521,695 - 34,535,629 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	34,521,699 - 34,528,027 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	34,455,443 - 34,476,857 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	34,723,013 - 34,744,437 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	34,723,035 - 34,744,422 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	34,668,132 - 34,689,525 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	34,707,475 - 34,728,899 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	34,959,391 - 34,980,801 (-)	NCBI		UU_Cfam_GSD_1.0

LARP6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	168,507,976 - 168,530,239 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	168,508,472 - 168,530,439 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	186,790,170 - 186,814,740 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LARP6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	12,605,050 - 12,626,661 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	12,605,147 - 12,628,761 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	128,862,421 - 128,884,186 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Larp6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	3,014,747 - 3,042,498 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	3,014,655 - 3,050,922 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005316948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000025521 ⟹ ENSSTOP00000019162

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936471	30,370,440 - 30,385,518 (-)	Ensembl

RefSeq Acc Id:

XM_005316948 ⟹ XP_005317005

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	112,521,849 - 112,539,209 (-)	NCBI
SpeTri2.0	NW_004936471	30,369,912 - 30,387,272 (-)	NCBI

Sequence:

show sequence

ATGGATATTGCTTGGTGCAACTCAGGAACTGAAGTTATCAGACCAGAAGGCATGGAGCCTGCTC
AAATCTCTTCAGAGCCTCATCACAGAGTCAAGTTCGAACTACAAAGTCAGATGCGCTGCGCCCC
TCCCGACGCAGGCAGCGAAGACGAGGAGGAGGGGGCGGAGACGCGGAGCGCAGGGGACCTGGCC
CGCTACCTCAGCCCCGGCTGGGGCAGTGCTAGCGAGGAGGAGCCGAGCCGCGGGCACAGCAGCA
CCACTACGAGTGGGGGCGAGAACGAGCACGAGGACCTGGAGCAGGAGTGGAAGCCCCCAGATGA
GGAGCTCATCAAGAAACTGGTGGATCAGATCGAATTCTACTTTTCTGATGAAAACCTGGAGAAG
GATGCCTTCCTGCTGAAGCACGTGAGGAGGAACAAGTTGGGCTACGTGAGCGTCAAGCTGCTCA
CCTCCTTTAAGAAGGTGAAGCATCTCACACGGGACTGGAGAACCACAGCACACGCCTTGAAGTA
TTCAGTGACCCTTGAGTTGAATGAGGACCATCGGAAGGTGAGGAGGACCACCCCCGTCCCACTG
TTTCCAAACGAGAACCTTCCTAGCAAGATGCTCCTGGTCTATGATCTACACTTATCCTCCAAGC
TGTGGGCTCTGGCCACCCCCCAGAAGAATGGAAGAGTGCAGGAGAAGGTGATGGAAAATCTTCT
CAAGCTCTTTGGGACTTTTGGAGTCATCTCATCAGTGAGGATCCTCAAACCTGGAAGAGAGCTG
CCCCCTGATATCCGGAGGATCAGCAGCCGTTACAGCCAGGTGGGGACCCAAGAGTGCGCTATTG
TGGAGTTTGAGGAGGTAGAAGCAGCTATCAAAGCCCACGAATTTATGATCACGGAATCTCAGGG
GAAAGAAAACATGAAAGCTGTCCTGATCGGTATGAAACCACCCAAAAAGAAACCTTCCAAAGAT
AAGAACCATGATGAGGAGCCCTCTGCCAGCATCCACCTGAACAGGTCCCTGAACAAGAGGGTGG
AGGAGCTTCAATACATGGGGGACGAGTCTTCTGCCAACAGCTCCTCTGACCCTGAGAGCAATCC
CGCATCTCCTATGGCTGGCCGACGGCATGTGGTCACCAACAAGCTCAGCCCCTCTGGCCACCAG
AATCTCTTTCTGAGCCCAAATGCCTCCCCGTGCTCAAGTCCTTGGAGCAGCCCCCTGGCCCAAC
GCAAAGGTGTTTCCAGAAAGTCCCCACTGGCTGAGGAAGGTAGGCTGCACGCGAGCACCAGCCC
CGAGATCTTCCGCAAGTGCATGGATTACTCCTCTGACAGTAGCGTCACACCCTCTGGCAGCCCC
TGGGTTCGGAGGCGCCGCCAAGCTGAGATGGGGACACAGGAAAAAAGTCCTGGGGCAAGTCCCC
TGTTGTCTCGGAAGATGCAGACTGCAGATGGGTTACCTGTGGGGGTGCTGAGGCTGCCCAGGGG
CCCTGACGACACCAGAGGATTTCATGGTGGACATGAGAGGAGCAGGGCCTGTGTATAAATGCCT
TCTATTTTTAATACCAGCTCCATGGAAAACCGCCTGGGTTTTCAAGGTTCTGACAAATACCTGG
CATGACATAGAATGGAATTCAGTCCTCTTTGCAAGATTTTTGTATACATGTAGACCTCTTAATT
TATATATTTGTAAGGCATATAAATTGTCTGGTTCCCTATGGTTTTGAGATCATCTTCTAGTTCA
TATCCACCCATTTGTCCCAGCATGGCCATTATTTGGATAGTGCCTGGTGTGTGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTAGTGGCTCTGAAAGGCTGTGGGACAGAGGGTGCCTGGAGAATGT
CTAACAGGTCCCATTTTGGAGACTGTTTCCCCACCACCACCCTGCAGTGATGGAGCTGTCCTTG
GTAGGCCATACTAGGGCTTCCTAAGAGCCAAGGTGAGTCTTGTTGTTTAATGGCAAATAGATAA
ACTTATAGCATGGTGTCTTGTAGGACCAAATGTATGTTCCCTGTCAAGTGAATAAATAATTAAA
CACCCACTGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005317005	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000019162.1
GenBank Protein	KAG3262175	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005317005 ⟸ XM_005316948

- UniProtKB:

I3N466 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDIAWCNSGTEVIRPEGMEPAQISSEPHHRVKFELQSQMRCAPPDAGSEDEEEGAETRSAGDLA
RYLSPGWGSASEEEPSRGHSSTTTSGGENEHEDLEQEWKPPDEELIKKLVDQIEFYFSDENLEK
DAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVTLELNEDHRKVRRTTPVPL
FPNENLPSKMLLVYDLHLSSKLWALATPQKNGRVQEKVMENLLKLFGTFGVISSVRILKPGREL
PPDIRRISSRYSQVGTQECAIVEFEEVEAAIKAHEFMITESQGKENMKAVLIGMKPPKKKPSKD
KNHDEEPSASIHLNRSLNKRVEELQYMGDESSANSSSDPESNPASPMAGRRHVVTNKLSPSGHQ
NLFLSPNASPCSSPWSSPLAQRKGVSRKSPLAEEGRLHASTSPEIFRKCMDYSSDSSVTPSGSP
WVRRRRQAEMGTQEKSPGASPLLSRKMQTADGLPVGVLRLPRGPDDTRGFHGGHERSRACV

hide sequence

RefSeq Acc Id:

ENSSTOP00000019162 ⟸ ENSSTOT00000025521

Protein Domains

HTH La-type RNA-binding SUZ-C

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000024279	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000025521.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	3.30.70.330	UniProtKB/TrEMBL
InterPro	La_dom_prot	UniProtKB/TrEMBL
	La_HTH	UniProtKB/TrEMBL
	LARP6_RRM	UniProtKB/TrEMBL
	Lupus_La	UniProtKB/TrEMBL
	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	SUZ-C	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	Larp6	ENTREZGENE
PANTHER	PTHR22792	UniProtKB/TrEMBL
	PTHR22792:SF71	UniProtKB/TrEMBL
Pfam	PF05383	UniProtKB/TrEMBL
PRINTS	LUPUSLA	UniProtKB/TrEMBL
PROSITE	HTH_LA	UniProtKB/TrEMBL
	SUZ_C	UniProtKB/TrEMBL
SMART	SM00715	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
	SSF54928	UniProtKB/TrEMBL
UniProt	I3N466	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-09-03	Larp6	La ribonucleoprotein 6, translational regulator	Larp6	La ribonucleoprotein domain family member 6	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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