Tshb (thyroid stimulating hormone subunit beta) - Rat Genome Database

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Gene: Tshb (thyroid stimulating hormone subunit beta) Ictidomys tridecemlineatus
Analyze
Symbol: Tshb
Name: thyroid stimulating hormone subunit beta
RGD ID: 12568720
Description: ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN response to calcium ion (ortholog); response to estrogen (ortholog); response to vitamin A (ortholog); ASSOCIATED WITH bipolar disorder (ortholog); Coma (ortholog); congenital hypothyroidism (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thyroid stimulating hormone beta; thyrotropin subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505814,087,322 - 14,090,893 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936627396,215 - 401,650 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936627399,191 - 404,371 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tshb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505814,087,322 - 14,090,893 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936627396,215 - 401,650 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936627399,191 - 404,371 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381115,029,826 - 115,034,309 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1115,029,826 - 115,034,302 (+)EnsemblGRCh38hg38GRCh38
GRCh371115,572,447 - 115,576,930 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,373,938 - 115,378,464 (+)NCBINCBI36Build 36hg18NCBI36
Build 341115,284,456 - 115,288,983NCBI
Celera1113,801,633 - 113,806,160 (+)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1113,430,739 - 113,435,225 (+)NCBIHuRef
CHM1_11115,687,686 - 115,692,176 (+)NCBICHM1_1
T2T-CHM13v2.01115,041,260 - 115,045,748 (+)NCBIT2T-CHM13v2.0
Tshb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,684,621 - 102,718,175 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3102,682,781 - 102,690,034 (-)EnsemblGRCm39 Ensembl
GRCm383102,777,398 - 102,789,082 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3102,775,465 - 102,782,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv373102,581,321 - 102,586,637 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363102,906,459 - 102,911,775 (-)NCBIMGSCv36mm8
Celera3104,982,812 - 104,987,788 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Tshb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82192,913,171 - 192,918,054 (-)NCBIGRCr8
mRatBN7.22190,224,676 - 190,229,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2190,224,676 - 190,229,559 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2197,842,312 - 197,847,195 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02195,706,354 - 195,711,234 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02190,532,005 - 190,536,888 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02205,207,799 - 205,215,199 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2205,207,799 - 205,212,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,638,392 - 224,643,274 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,908,308 - 197,913,186 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12197,871,064 - 197,875,940 (-)NCBI
Celera2182,644,695 - 182,649,578 (-)NCBICelera
RH 3.4 Map21301.7RGD
Cytogenetic Map2q34NCBI
Tshb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,316,585 - 18,339,935 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,316,585 - 18,339,935 (+)NCBIChiLan1.0ChiLan1.0
TSHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21107,685,126 - 107,689,672 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11107,284,277 - 107,288,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0187,527,267 - 87,531,813 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11122,575,546 - 122,580,028 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1122,575,546 - 122,580,028 (-)Ensemblpanpan1.1panPan2
TSHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11752,659,137 - 52,685,388 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1752,681,357 - 52,685,390 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1752,306,371 - 52,332,583 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01753,525,777 - 53,563,370 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1753,559,339 - 53,563,372 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11752,571,137 - 52,597,347 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01752,616,291 - 52,641,625 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01753,186,781 - 53,212,984 (+)NCBIUU_Cfam_GSD_1.0
TSHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,553,076 - 105,554,015 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14105,553,070 - 105,558,769 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24115,691,689 - 115,697,380 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12018,660,683 - 18,665,226 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2018,657,535 - 18,665,185 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603821,406,905 - 21,411,461 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tshb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477210,737,464 - 10,742,555 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477210,732,527 - 10,742,575 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021732975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000019408   ⟹   ENSSTOP00000023458
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936627396,215 - 401,650 (+)Ensembl
RefSeq Acc Id: XM_021732975   ⟹   XP_021588650
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505814,087,322 - 14,090,893 (-)NCBI
SpeTri2.0NW_004936627399,191 - 404,371 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021588650 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000023458.1
GenBank Protein KAG3281215 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021588650   ⟸   XM_021732975
- UniProtKB: I3NGG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000023458   ⟸   ENSSTOT00000019408
Protein Domains
Glycoprotein hormone subunit beta


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000022113 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000019408.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/TrEMBL
  Gonadotropin_bsu UniProtKB/TrEMBL
  Gonadotropin_bsu_CS UniProtKB/TrEMBL
NCBI Gene Tshb ENTREZGENE
PANTHER PTHR11515 UniProtKB/TrEMBL
  THYROTROPIN SUBUNIT BETA UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/TrEMBL
PROSITE GLYCO_HORMONE_BETA_1 UniProtKB/TrEMBL
  GLYCO_HORMONE_BETA_2 UniProtKB/TrEMBL
SMART GHB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt I3NGG1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-14 Tshb  thyroid stimulating hormone subunit beta  Tshb  thyroid stimulating hormone beta  Symbol and/or name change 5135510 APPROVED