Ensa (endosulfine alpha) - Rat Genome Database

Name: Ensa
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Ensa (endosulfine alpha) Ictidomys tridecemlineatus

Analyze

Symbol:

Ensa

Name:

endosulfine alpha

RGD ID:

12540471

Description:

ENCODES a protein that exhibits potassium channel inhibitor activity (inferred); protein phosphatase inhibitor activity (inferred); signaling receptor binding (inferred); INVOLVED IN regulation of insulin secretion (ortholog); response to glucose (ortholog); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); immunodeficiency 42 (ortholog); MHC class II deficiency (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

alpha-endosulfine; endosulfine alpha, transcript variant X1; endosulfine alpha, transcript variant X2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ENSA (endosulfine alpha)	NCBI	Ortholog
Mus musculus (house mouse):	Ensa (endosulfine alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ensa (endosulfine alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ensa (endosulfine alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ENSA (endosulfine alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ENSA (endosulfine alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ENSA (endosulfine alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ENSA (endosulfine alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ensa (endosulfine alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	21,821,126 - 21,828,827 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	851,907 - 859,213 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	803,452 - 859,215 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

immunodeficiency 42 (ISO)

MHC class II deficiency (ISO)

Myocardial Ischemia (ISO)

parathyroid carcinoma (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Spinal Cord Injuries (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

negative regulation of protein dephosphorylation (IEA)

regulation of insulin secretion (IEA,ISO)

response to glucose (ISO)

Cellular Component

cytoplasm (IEA)

Molecular Function

potassium channel inhibitor activity (IEA)

protein binding (ISO)

protein phosphatase inhibitor activity (IEA)

signaling receptor binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Ensa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	21,821,126 - 21,828,827 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	851,907 - 859,213 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	803,452 - 859,215 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ENSA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	150,621,246 - 150,629,612 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	150,600,851 - 150,629,612 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	150,593,722 - 150,602,088 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	148,861,223 - 148,868,722 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	147,412,596 - 147,415,171	NCBI
Celera	1	123,710,348 - 123,717,847 (-)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	121,972,436 - 121,979,935 (-)	NCBI		HuRef
CHM1_1	1	151,990,344 - 151,997,841 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	149,745,280 - 149,753,646 (-)	NCBI		T2T-CHM13v2.0

Ensa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	95,532,291 - 95,539,428 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	95,532,304 - 95,539,413 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	95,624,980 - 95,632,117 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	95,624,993 - 95,632,102 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	95,428,902 - 95,436,039 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	95,710,384 - 95,717,521 (+)	NCBI		MGSCv36	mm8
Celera	3	97,056,582 - 97,063,720 (+)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	40.74	NCBI

Ensa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	185,874,500 - 185,881,838 (+)	NCBI		GRCr8
mRatBN7.2	2	183,185,552 - 183,192,888 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	183,185,552 - 183,194,847 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	190,850,420 - 190,857,742 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	188,645,895 - 188,653,229 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	183,482,946 - 183,490,268 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	197,752,544 - 197,759,882 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	197,752,544 - 197,759,882 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	217,239,490 - 217,246,148 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	2	175,716,326 - 175,723,664 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Ensa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	197,242 - 204,867 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	197,239 - 204,867 (+)	NCBI	ChiLan1.0	ChiLan1.0

ENSA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	99,202,747 - 99,210,250 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	98,956,708 - 98,977,817 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	125,973,344 - 125,980,839 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	129,622,289 - 129,629,779 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	129,599,495 - 129,629,779 (-)	Ensembl	panpan1.1		panPan2

ENSA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	59,800,822 - 59,807,884 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	59,801,306 - 59,807,869 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	59,246,980 - 59,254,042 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	60,816,450 - 60,823,514 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	60,813,255 - 60,823,500 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	59,646,480 - 59,653,541 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	59,730,413 - 59,737,476 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	60,458,340 - 60,465,403 (-)	NCBI		UU_Cfam_GSD_1.0

ENSA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	98,527,907 - 98,542,959 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	98,527,902 - 98,535,647 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	107,777,849 - 107,783,673 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ENSA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666038	12,652,568 - 12,660,079 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ensa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	18,327,865 - 18,335,870 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	18,327,206 - 18,335,422 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005331172	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021730418	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000002735 ⟹ ENSSTOP00000002446

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936580	851,907 - 859,213 (-)	Ensembl

RefSeq Acc Id:

XM_005331172 ⟹ XP_005331229

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	21,821,126 - 21,828,827 (-)	NCBI
SpeTri2.0	NW_004936580	851,508 - 859,214 (-)	NCBI

Sequence:

show sequence

CACGGGCCAGAGCCGCCATTTTGACTGAGCAACCATAGTGACAGGAGCCGAAGCAGCAGCGCAG
GTTGTCCCCGTTTCCCCTCCCCCTTCCCTTCTCCGGTTAACTACCCGGGTCCCCTACACTCCAC
AGTCCCGGTCCCGTCATGTCCCAGAATCTAGAAGAAGAGAACCCTGCGGAGGAGACCGGCGAGG
AGAAGCAGGACACGCAAGAGAAAGAAGGTCTTCTCCCTGAGAGAGCTGAGGAGGCAAAGCTAAA
GGCCAAATATCCAAGTCTAGGACAAAAACCTGGAGGCTCTGACTTCCTCATGAAGAGACTTCAA
AAAGGGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAGC
AGCTGCCAAGTGCAGGACCAGACAAGAACCTGGTGACTGGTGACCACATCCCCACCCCACAGGA
TCTGCCCCAGAGAAAGTCCTCACTCGTCACCAGCAAGCTTGCGGGTGGCCAAGTTGAATGATGC
TGCCTGGGGCTCCGCCAGATCCTGAGACGCTGCCCTCCTGGGTCCTGTGCTGGCTCCTGCCCCT
CCCTGCTTTTGCAGCCAGGGGTCAGGAGGTGGCTTGGGCGTGGGCTGGAGAGGCAGAAGCCCCT
GCCCATTGGTGTCCCAGCACATGGAGCCCCTTGGGCTGAGCACCAAGACCTTGAACCTTTTTTG
TTTTACCTTTTTTTCCAAATAACTGTTGAGAAATCTCAATGAAATCTCATGGGTGGGGTTGAGA
GGGTGGGTGGGAGATTTGGGATTTACAGTTGATAAAAACATTCCTGACAATCCTCCCTCTTAAC
CCAGTGGCTAATGTGGGGGAGATGTGAGGGGGAGGAAGTGGAGTAGACTAATGATAAGGGGTTC
TAATTCAGCTCTGTAGACAGATGCCTAGTGTGGATAAACAGGCTGTTGATGTACACAGAGCAGA
TAGGCCCTCTGGTTCTGCAGAGCAAGACTCAATGTTAATTGTTCATTTAAAAAAAAAAAAAGTG
CTTTCCTTGAAATAGATTTGCTATGGAGAGAAGGGTAGTGAATGTTGGGGAAAGGAGCCATGAG
TGTGGGGAGCCCCACTGAGCCCAAGGGACTTTTTCAGTGTTTGAAATAAAAAACAACAAAAAAA
GACCCATGAAAAAACCTAACCCAGAAATACTCTGAAGCAGTTGGTGTGTTTATTGGGGTTTGGG
AAGGGGAAGAAAACCAGTGTGAAAACACTGTTCAGGGGAAAAGCTGGTGGGTGTCCCTGAATTT
CTAAGGAACACAGAGACCTTTAATATGGGATATGGCTGGGCTGCCTGTTTCCATCATGTAGGAA
AAGGGAGCATTCCTTTGGCATACAGACTTTTCTTAACCCCTATACATTTCTTAAGATGCATCAA
ACAAATGTAAGGTATTTGATCCAAATGGCTTGTTGACATAAAGCTTAGTCTAGACTCAGCAAAA
AAGGAAGCCTATTCTTCCTTTTCCCTTTCAACTATCTTTTCCTTTGCAAGTTCCCATGCCTGTG
AAGAAGAAATGTGTACTATTAGTAATAAACCAAAAGAATTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005331229	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000002446.3
GenBank Protein	KAG3281472	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005331229 ⟸ XM_005331172
- UniProtKB:	I3M104 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSQNLEEENPAEETGEEKQDTQEKEGLLPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKY FDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE hide sequence

RefSeq Acc Id:

ENSSTOP00000002446 ⟸ ENSSTOT00000002735

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000002742	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000002735.3	UniProtKB/TrEMBL
InterPro	Endosulphine	UniProtKB/TrEMBL
NCBI Gene	Ensa	ENTREZGENE
PANTHER	ALPHA-ENDOSULFINE	UniProtKB/TrEMBL
	PTHR10358	UniProtKB/TrEMBL
Pfam	Endosulfine	UniProtKB/TrEMBL
UniProt	I3M104	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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