Cxcr5 (C-X-C motif chemokine receptor 5)

Gene: Cxcr5 (C-X-C motif chemokine receptor 5) Ictidomys tridecemlineatus

Analyze

Symbol:

Cxcr5

Name:

C-X-C motif chemokine receptor 5

RGD ID:

12528880

Description:

ENCODES a protein that exhibits C-C chemokine binding (inferred); C-C chemokine receptor activity (inferred); C-X-C chemokine receptor activity (inferred); INVOLVED IN leukocyte chemotaxis (ortholog); lymph node development (ortholog); ASSOCIATED WITH CD3epsilon deficiency (ortholog); Chromosome 11, Partial Trisomy 11q (ortholog); Dwarfism (ortholog); FOUND IN external side of plasma membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C-X-C chemokine receptor type 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	100,939,127 - 100,952,204 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936542	3,860,536 - 3,872,116 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936542	3,860,536 - 3,872,528 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

CD3epsilon deficiency (ISO)

Chromosome 11, Partial Trisomy 11q (ISO)

Dwarfism (ISO)

glycogen storage disease Ib (ISO)

immunodeficiency 17 (ISO)

immunodeficiency 18 (ISO)

immunodeficiency 19 (ISO)

inflammatory bowel disease 28 (ISO)

isolated microphthalmia 5 (ISO)

long QT syndrome 10 (ISO)

primary biliary cholangitis (ISO)

RASopathy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell activation (IEA)

calcium-mediated signaling (IEA)

cell chemotaxis (IEA)

chemokine-mediated signaling pathway (IEA)

chemotaxis (IEA)

G protein-coupled receptor signaling pathway (IEA)

immune response (IEA)

leukocyte chemotaxis (IEA,ISO)

lymph node development (IEA,ISO)

positive regulation of cytokinesis (IEA)

positive regulation of cytosolic calcium ion concentration (IEA)

Cellular Component

external side of plasma membrane (IEA)

membrane (IEA)

Molecular Function

C-C chemokine binding (IEA)

C-C chemokine receptor activity (IEA)

C-X-C chemokine receptor activity (IEA)

G protein-coupled receptor activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cxcr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	100,939,127 - 100,952,204 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936542	3,860,536 - 3,872,116 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936542	3,860,536 - 3,872,528 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CXCR5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	118,883,892 - 118,897,787 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	118,883,892 - 118,897,787 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	118,754,601 - 118,768,496 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	118,259,777 - 118,272,181 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	118,269,310 - 118,272,180	NCBI
Celera	11	115,914,233 - 115,926,662 (+)	NCBI		Celera
Cytogenetic Map	11	q23.3	NCBI
HuRef	11	114,694,357 - 114,706,861 (+)	NCBI		HuRef
CHM1_1	11	118,640,782 - 118,653,288 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	118,902,950 - 118,918,023 (+)	NCBI		T2T-CHM13v2.0

Cxcr5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	44,423,084 - 44,437,741 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	44,423,084 - 44,473,174 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	44,511,787 - 44,526,444 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	44,511,787 - 44,561,877 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	44,319,870 - 44,334,504 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	44,262,782 - 44,277,416 (-)	NCBI		MGSCv36	mm8
Celera	9	41,765,140 - 41,779,807 (-)	NCBI		Celera
Cytogenetic Map	9	A5.2	NCBI
cM Map	9	24.84	NCBI

Cxcr5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	53,738,878 - 53,756,813 (-)	NCBI		GRCr8
mRatBN7.2	8	44,842,098 - 44,858,425 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	44,843,413 - 44,857,893 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	50,338,308 - 50,351,688 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	48,617,025 - 48,630,405 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	46,487,367 - 46,500,722 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	48,835,688 - 48,852,032 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	48,836,957 - 48,850,671 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	47,454,074 - 47,470,348 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	47,485,125 - 47,498,509 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	47,493,890 - 47,494,999 (-)	NCBI
Celera	8	44,428,390 - 44,441,750 (-)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

Cxcr5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	20,016,587 - 20,031,629 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	20,016,768 - 20,031,635 (+)	NCBI	ChiLan1.0	ChiLan1.0

CXCR5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	119,588,864 - 119,602,528 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	120,691,762 - 120,706,394 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	113,722,084 - 113,735,987 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	117,652,368 - 117,664,852 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	117,652,368 - 117,664,852 (+)	Ensembl	panpan1.1		panPan2

CXCR5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	14,921,447 - 14,932,937 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	14,923,089 - 14,932,762 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	14,974,356 - 14,985,789 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	14,864,685 - 14,876,132 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	14,864,690 - 14,876,155 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	15,003,411 - 15,014,858 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	14,907,174 - 14,918,621 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	14,946,968 - 14,958,415 (-)	NCBI		UU_Cfam_GSD_1.0

CXCR5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	46,143,117 - 46,146,636 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	46,134,243 - 46,146,638 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	51,169,120 - 51,183,302 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CXCR5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	110,253,792 - 110,267,251 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	110,254,723 - 110,265,597 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	15,769,647 - 15,781,162 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cxcr5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	14,286,355 - 14,297,383 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	14,285,998 - 14,298,679 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013359949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000029547 ⟹ ENSSTOP00000019480

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936542	3,870,466 - 3,872,116 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000037563 ⟹ ENSSTOP00000030454

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936542	3,860,536 - 3,872,116 (+)	Ensembl

RefSeq Acc Id:

XM_013359949 ⟹ XP_013215403

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	100,939,127 - 100,952,204 (+)	NCBI
SpeTri2.0	NW_004936542	3,860,536 - 3,872,528 (+)	NCBI

Sequence:

show sequence

ATGAACTACCCCCTGGCCCTCGACATGGACTTCACAAACTACAACCTGGGAGACCTGGTAAGCT
TCCTCTGGAAAAATGGAGTCTCAGTTTCTCACCCTTCTATCTCCTTGTCCTTGCAGTACAAGGA
GTTTGCCAACTACAATGACAGCACAGAGACCCCCCTACAGGAAAGTCACTTCTGCTCCACAGTT
GAGGGGCCCCTACTGACTTCCTTCAAGGCTGTGTTCATGCCTGTAGCCTACAGCCTCATCTTCC
TCCTGGGCCTGATGGGCAACATCCTGGTGCTGGTGATCCTCGAGCGGCACCGGCAGACGCGCAG
CTCTACGGAGACCTTCCTGTTCCACCTGGCGGTGGCTGACCTCCTACTAGTCTTCATCCTGCCC
TTTGCTATCGCTGAAGGCTCTGTGGGCTGGGTCCTGGGAAGCTCCCTCTGCAAAATTGTGATTG
CTCTGCACAAGATCAATTTCTACTGCAGCAGCCTGCTCCTAGCCTGCATCGCTGTGGACCGCTA
CCTGGCCATCGTTCATGCCGTCCACGCCTACCGTCACCGCCGCCTCCTCTCCATCCACATCACC
TGCGCAACCATCTGGCTGGCAGGCTTCCTCTTCGCTTTGCCGGAGATCCTCTTCGCCAAGGTCA
GCCAACCCCACAGCAATGACTCCCTGCCACGTTGCACCTTCCCTCAGGAGAACCAAGCTGAAAC
CAATGCCTGGTTTACCTCCCGCTTCCTCTACCATGTTGGGGGCTTTCTGCTGCCAATGCTGGTA
ATGGGCTGGTGCTACGTGGGGGTGGTACACAGACTGTGCCAGGCCCAGCGGCGCCCTCAGCGAC
AGAAAGCAGTCAGAGTGGCTATCCTGGTGACAAGCATCTTCTTTCTCTGCTGGTCACCTTACCA
CATTGTCATCTTCCTGGACACCCTGGCCAGACTGAAGGCAGTGGATAACAGCTGTGAGCTGAAT
GGCTCTCTCCCGGTGGCCATCACCATATGCGAGTTCCTGGGCCTGGCCCACTGCTGCCTCAACC
CCATGCTCTACACTTTCGCTGGAGTGAAGTTTCGAAGTGACCTGTCTCGACTTCTGACCAAGCT
AGGTTGCACCGGCCCTGCTTCCCTGTGCCAGCTCTTCCCTGGCTGGCGCAAGAGCAGTCTGTCT
GAGTCAGAGAATGCCACCTCCCTCACCACCTTCTAAGTCCCAGCACCCCTCTTTGTTTCTGCTT
TCTTCGGGGCAGGCAGTGGCGGTGGAGTCTCTTCCAACAGGAGCTGGGGTCCTGAGTGTTATGT
TGGCTACCTCCCAGCAGGGAGGCAGCTTCTGTCTAGGACATCCCTGTCACTCTTCCACCAGCCC
TGAGGCTAGGCTGGAGTCCAGGGAGGGGAAAGCAGATCAAAAGCAAAGCAAAAGGTCTCTGTAC
CCATCTGCATCACCCTGGGCTGAGAGGACTCCACACACCTCTCACCCTAGCTGGCCAAAGCCCT
GGCCACAGGGAAAGTCAATCCCCTCCCAGAATAAACTCATCCTCTTAAGGGCTGCTGACTGCCA
CAGATACCCACCTCTCCTCCCATGCCCCATGCCAAATGGAGCCAGGAGAAGCTGGAACTGGGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013215403	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000019480.2
	ENSSTOP00000030454.1
GenBank Protein	KAG3286668	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013215403 ⟸ XM_013359949

- UniProtKB:

A0A287DA91 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNYPLALDMDFTNYNLGDLVSFLWKNGVSVSHPSISLSLQYKEFANYNDSTETPLQESHFCSTV
EGPLLTSFKAVFMPVAYSLIFLLGLMGNILVLVILERHRQTRSSTETFLFHLAVADLLLVFILP
FAIAEGSVGWVLGSSLCKIVIALHKINFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHIT
CATIWLAGFLFALPEILFAKVSQPHSNDSLPRCTFPQENQAETNAWFTSRFLYHVGGFLLPMLV
MGWCYVGVVHRLCQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNSCELN
GSLPVAITICEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPGWRKSSLS
ESENATSLTTF

hide sequence

RefSeq Acc Id:

ENSSTOP00000019480 ⟸ ENSSTOT00000029547

RefSeq Acc Id:

ENSSTOP00000030454 ⟸ ENSSTOT00000037563

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000025389	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000029547.2	UniProtKB/TrEMBL
	ENSSTOT00000037563.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Chemokine_CXCR5	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
NCBI Gene	Cxcr5	ENTREZGENE
PANTHER	C-X-C CHEMOKINE RECEPTOR TYPE 5	UniProtKB/TrEMBL
	CELL ADHESION MOLECULE	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	CXCCHMKINER5	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A287DA91	ENTREZGENE, UniProtKB/TrEMBL
	I3N534_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD