Tmprss4 (transmembrane serine protease 4)

Gene: Tmprss4 (transmembrane serine protease 4) Ictidomys tridecemlineatus

Analyze

Symbol:

Tmprss4

Name:

transmembrane serine protease 4

RGD ID:

12496629

Description:

ENCODES a protein that exhibits serine-type endopeptidase activity (inferred); serine-type peptidase activity (inferred); INVOLVED IN negative regulation of growth rate (ortholog); regulation of gene expression (ortholog); response to wounding (ortholog); ASSOCIATED WITH CD3epsilon deficiency (ortholog); Chromosome 11, Partial Trisomy 11q (ortholog); COVID-19 (ortholog); FOUND IN extracellular space (inferred); membrane (inferred); secretory granule (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transmembrane protease serine 4; transmembrane protease, serine 4

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	100,258,799 - 100,294,556 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936542	3,204,303 - 3,215,167 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936542	3,180,260 - 3,216,208 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

CD3epsilon deficiency (ISO)

Chromosome 11, Partial Trisomy 11q (ISO)

COVID-19 (ISO)

Dwarfism (ISO)

genetic disease (ISO)

glycogen storage disease Ib (ISO)

Human Influenza (ISO)

immunodeficiency 17 (ISO)

immunodeficiency 18 (ISO)

immunodeficiency 19 (ISO)

inflammatory bowel disease 28 (ISO)

intellectual disability (ISO)

isolated microphthalmia 5 (ISO)

RASopathy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acrosome reaction (IEA)

negative regulation of growth rate (IEA,ISO)

positive regulation of viral entry into host cell (IEA)

protein processing (IEA)

proteolysis (IEA)

regulation of gene expression (IEA,ISO)

response to wounding (IEA,ISO)

Cellular Component

extracellular space (IEA)

membrane (IEA)

secretory granule (IEA)

Molecular Function

protein binding (ISO)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Tmprss4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	100,258,799 - 100,294,556 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936542	3,204,303 - 3,215,167 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936542	3,180,260 - 3,216,208 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMPRSS4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	118,077,078 - 118,125,505 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	118,077,012 - 118,121,890 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	117,947,793 - 117,992,605 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	117,452,937 - 117,495,768 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	117,452,975 - 117,494,380	NCBI
Celera	11	115,105,578 - 115,148,408 (+)	NCBI		Celera
Cytogenetic Map	11	q23.3	NCBI
HuRef	11	113,881,375 - 113,924,217 (+)	NCBI		HuRef
CHM1_1	11	117,833,208 - 117,876,364 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	118,093,464 - 118,141,906 (+)	NCBI		T2T-CHM13v2.0

Tmprss4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	45,084,024 - 45,115,417 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	45,084,024 - 45,115,390 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	45,172,726 - 45,204,119 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	45,172,726 - 45,204,092 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	44,980,809 - 45,012,158 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	44,923,721 - 44,955,070 (-)	NCBI		MGSCv36	mm8
Celera	9	42,448,298 - 42,479,621 (-)	NCBI		Celera
Cytogenetic Map	9	A5.2	NCBI
cM Map	9	24.84	NCBI

Tmprss4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	54,372,805 - 54,405,157 (-)	NCBI		GRCr8
mRatBN7.2	8	45,475,819 - 45,508,409 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	45,476,053 - 45,508,409 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	50,971,333 - 51,003,650 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	49,250,081 - 49,282,399 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	47,120,666 - 47,152,977 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	49,469,804 - 49,503,304 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	49,469,503 - 49,502,647 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	48,096,253 - 48,129,105 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	48,120,501 - 48,154,809 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	48,129,873 - 48,192,563 (-)	NCBI
Celera	8	45,060,426 - 45,092,778 (-)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

Tmprss4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	19,258,949 - 19,292,829 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	19,258,955 - 19,292,766 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMPRSS4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	118,801,549 - 118,823,482 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	119,906,512 - 119,928,432 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	112,910,223 - 112,953,677 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	116,843,287 - 116,884,767 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	116,843,287 - 116,884,767 (+)	Ensembl	panpan1.1		panPan2

TMPRSS4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	15,575,068 - 15,609,819 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	15,575,338 - 15,610,190 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	15,625,320 - 15,660,603 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	15,516,982 - 15,552,268 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	15,518,662 - 15,552,333 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	15,654,797 - 15,690,088 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	15,558,508 - 15,593,779 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	15,600,003 - 15,635,286 (-)	NCBI		UU_Cfam_GSD_1.0

TMPRSS4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	45,400,600 - 45,435,916 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	45,400,263 - 45,436,936 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	50,441,507 - 50,476,053 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103248572
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	109,449,920 - 109,497,169 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	109,470,496 - 109,495,224 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	16,558,383 - 16,604,301 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmprss4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	13,495,297 - 13,539,275 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	13,495,196 - 13,531,670 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021728532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000003484 ⟹ ENSSTOP00000003119

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936542	3,204,303 - 3,215,167 (+)	Ensembl

RefSeq Acc Id:

XM_021728532 ⟹ XP_021584207

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	100,258,799 - 100,294,556 (+)	NCBI
SpeTri2.0	NW_004936542	3,180,260 - 3,216,208 (+)	NCBI

Sequence:

show sequence

TAGGAGGTGGCCGGCCAACGCGCTCAGGGGAGAGGATGCTGGCAATAAGGGGCCAAGGCCAGCC
CTGCACCGAGGCCTCTGCCAGCCAGTGCTGATCAGGGGCTTCTGACCTGCTGACCAGCCAGGAC
CGGTCGGAAAGGCTGTTCTCCTGCCCATCGCAGCTCCACAGACCACAGGAAAAACAGGAGGATC
ACAGAGCCATCATGGATCCTGGCAGTAACCAACCCCTGAACAGCCCCGACGCCACCACCCTGCG
CAAACCCCGCACTCCCCTGGAGACTTTCAGAAAGGTGGGGATCCCCATCATCGCGGTACTGCTG
AGCCTGGCGACCATCATCATTGTGGTTATCCTCATCAAGGTGATTCTGGATAAATACTACTTCA
TCTGCGGCCACCCCCTGCACTTCCTCCCGAGGACACAGATGTGTGATGGACATCCGGACTGTGC
CTCAGGAGAAGATGAGGAGCCCTGTGTCAAGGACTTCCCAGAGAGGCCTGCGGTGGGAGTCCGA
CTCTCCAAGGACCGATCCACCCTGCAGGTGCTGGACCCGGCCACAGGGAACTGGGCCTCTGCCT
GTTTCGACAACTTCACAGAAACTCTGGCCAAGACAGCCTGTGGGCAAATGGGCTACAGCAGCCA
ACCCACTTTCAAAGCTGTGGAGATTGGCCCAGACCAGGATCTGGATGTTGTTAAAGTGACAGAA
GACAGCCAGGAGCTTCAGGTGCGGAACTCAAGTGGACCTTGTCTCTCAGGCTCCCTGGTTGCCC
TGCACTGCCTTGCCTGTGGGAGGAGCCTGAAGGCTCCTCGGGTGGTGGGCGGGGAGGAGGCCTC
TGTGGATTCTTGGCCTTGGCAGGTCAGCCTCCAGTACAACAAGCAACACGTCTGCGGAGGAAGC
ATCCTGGATCCCCAGTGGATCCTCACGGCAGCCCACTGCTTCAGGAACTATCGTGATGTGTCCA
ACTGGAAGGTGAGGGTGGGCTCAGAAAAATTGAGCAGCTTCCCATCCCTACCTGTGGCCAAGAT
CTTCACCACTGAGCACAACACCTTGTACCCCAAAGAGAAGGACATTGCCCTTATGAAACTAGAG
AACCCACTGACATTCTCAGGTACCATCAGGCCCATCTGCCTGCCCTTCTTTGATGAGGAGCTTG
CTCCAGCCACCCAACTCTGGGTCGTCGGCTGGGGCTTTACGGAGGAGAATGGTGGGAAGATGTC
TGACACACTGCTGCAGGCGTCAGTCCAGGTCATTGACCACACCCGGTGCAATGCAGATGATGCC
TACCAGGGAGAAGTCACTGAGAAGATGCTGTGTGCAGGCGTCCCAGGAGGTGGCGTGGACACCT
GCCAGGGTGACAGTGGTGGACCCCTGATGTACAAGTCTGACCACTGGAAGGTGGTGGGCATCGT
GAGCTGGGGACATGGCTGTGGGGGCCCAAGTACCCCAGGAGTGTATACCAAGGTCACAGCCTAT
CTCGACTGGATCTACAGTGTGTGGAAGTCTGAGATGTAAGGCTGCTGTTCCTCTGCAGCGTTCA
GAGCTGCTTCTCTCCAGTCCTCCCCACTGGGGATGCCCCAGAAGTCCCACACTGGGGCTTGTCT
CTCCACCCACGGCCTTGGCATTTGCTAGAGCAGCAAACGGTCTCCGTTCCTGCAAGACCCTCAC
ACCCCAGAGGCACCCAGAAGGAAGGCAGCCGCCCTAGCTCAGTCATCCCCAGTGCTTCCAGAAT
CCCAGGGAGAGATGCAGCCCGCTGAACGGAGCCAGCTATGGACCCAGGTCTCAGAGGCACTGCT
AACTCAGGTGGAACTTTCCCCCTCTACTGAATAGAAGAGGGCTCTCCCCAGATAACCCGGCTGG
AGAGAAGAAGAGGGTCTGGCCAGCCCTCTCCCTTCTCCACCCATTCCCAAGCCCACCAGAACAA
GAAACCAGATGTAGTGTAAATGCACCATCCTACCTTTGGCATGCTACTGTTACCTACAGGTGTT
ATTATTGTTACTTCTAAGTGTTGTTGTCATTAAATGATGGTATCTTTGGTACATGTTTGCTGGG
CTGCTTGATAAGAATGGAGCTAGGACCATCAGGCATTAATTCTTTGGCCTGGGGAGACAATTAC
TTCTCAAAGTAGAGGCACAAGAAACAGAGACAAGGAGACCAGATCTGCTAAGTGGGGGCAACAG
CGAGCTGCACCTGGGGAGGCCAGGGCATCTCCTTCCCACACAGGCTTCTCCCGCAGCCCCGCTT
CCCTTTCTGTCTGCCTGATGTCAGCTGTGGGCTAAGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_021584207	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000003119.3
GenBank Protein	KAG3286635	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021584207 ⟸ XM_021728532

- UniProtKB:

I3M2C9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDPGSNQPLNSPDATTLRKPRTPLETFRKVGIPIIAVLLSLATIIIVVILIKVILDKYYFICGH
PLHFLPRTQMCDGHPDCASGEDEEPCVKDFPERPAVGVRLSKDRSTLQVLDPATGNWASACFDN
FTETLAKTACGQMGYSSQPTFKAVEIGPDQDLDVVKVTEDSQELQVRNSSGPCLSGSLVALHCL
ACGRSLKAPRVVGGEEASVDSWPWQVSLQYNKQHVCGGSILDPQWILTAAHCFRNYRDVSNWKV
RVGSEKLSSFPSLPVAKIFTTEHNTLYPKEKDIALMKLENPLTFSGTIRPICLPFFDEELAPAT
QLWVVGWGFTEENGGKMSDTLLQASVQVIDHTRCNADDAYQGEVTEKMLCAGVPGGGVDTCQGD
SGGPLMYKSDHWKVVGIVSWGHGCGGPSTPGVYTKVTAYLDWIYSVWKSEM

hide sequence

RefSeq Acc Id:

ENSSTOP00000003119 ⟸ ENSSTOT00000003484

Protein Domains

Peptidase S1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000003485	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000003484.3	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	3.10.250.10	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
InterPro	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	SRCR-like_dom	UniProtKB/TrEMBL
	SRCR-like_dom_sf	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
NCBI Gene	Tmprss4	ENTREZGENE
PANTHER	ACROSIN	UniProtKB/TrEMBL
	ACROSIN-RELATED	UniProtKB/TrEMBL
Pfam	SRCR_2	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	SM00202	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
	SSF56487	UniProtKB/TrEMBL
	SSF57424	UniProtKB/TrEMBL
UniProt	I3M2C9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-23	Tmprss4	transmembrane serine protease 4		transmembrane protease, serine 4	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD