Lipe (lipase E, hormone sensitive type) - Rat Genome Database

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Gene: Lipe (lipase E, hormone sensitive type) Ictidomys tridecemlineatus
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Symbol: Lipe
Name: lipase E, hormone sensitive type
RGD ID: 12481620
Description: ENCODES a protein that exhibits 1,2-diacylglycerol acylhydrolase activity (ortholog); 1,3-diacylglycerol acylhydrolase activity (ortholog); acylglycerol lipase activity (ortholog); INVOLVED IN cellular response to cold (ortholog); diacylglycerol catabolic process (ortholog); ether lipid metabolic process (ortholog); ASSOCIATED WITH arteriosclerosis (ortholog); Carpenter Syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); FOUND IN caveola (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hormone-sensitive lipase; HSL; lipase E, hormone sensitive type, transcript variant X1; lipase E, hormone sensitive type, transcript variant X2; lipase E, hormone sensitive type, transcript variant X3; lipase E, hormone sensitive type, transcript variant X4; lipase E, hormone sensitive type, transcript variant X5; lipase E, hormone sensitive type, transcript variant X6; monoacylglycerol lipase LIPE; REH; retinyl ester hydrolase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,772,658 - 15,792,162 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706128,133 - 141,276 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706122,939 - 139,506 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
caveola  (IEA,ISS)
cytoplasm  (IEA,ISS)
cytosol  (IEA,ISS)
extracellular space  (ISO)
lipid droplet  (IEA,ISS)
membrane  (ISS)
mitochondrion  (ISS)
nucleus  (ISS)
plasma membrane  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Lipe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,772,658 - 15,792,162 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706128,133 - 141,276 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706122,939 - 139,506 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,401,514 - 42,427,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1942,401,514 - 42,427,388 (-)EnsemblGRCh38hg38GRCh38
GRCh371942,905,666 - 42,931,540 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,597,506 - 47,623,418 (-)NCBINCBI36Build 36hg18NCBI36
Build 341947,597,505 - 47,623,418NCBI
Celera1939,706,455 - 39,732,367 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1939,335,797 - 39,361,703 (-)NCBIHuRef
CHM1_11942,907,316 - 42,933,231 (-)NCBICHM1_1
T2T-CHM13v2.01945,220,900 - 45,246,776 (-)NCBIT2T-CHM13v2.0
Lipe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,078,952 - 25,097,911 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,078,952 - 25,098,135 (-)EnsemblGRCm39 Ensembl
GRCm38725,379,527 - 25,398,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,379,527 - 25,398,710 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,164,546 - 26,181,006 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,088,287 - 25,104,747 (-)NCBIMGSCv36mm8
Celera719,994,853 - 20,011,313 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.78NCBI
Lipe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,093,433 - 90,112,117 (-)NCBIGRCr8
mRatBN7.2180,965,612 - 80,984,313 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,965,627 - 80,984,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,357,834 - 86,376,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,909,045 - 94,927,749 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,113,613 - 88,132,294 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,248,031 - 82,266,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,248,046 - 82,266,727 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,511,504 - 83,530,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,663,791 - 80,682,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,741,901 - 80,760,591 (-)NCBI
Celera175,407,246 - 75,425,931 (-)NCBICelera
Cytogenetic Map1q21NCBI
Lipe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555514,410 - 530,759 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555511,085 - 531,165 (+)NCBIChiLan1.0ChiLan1.0
LIPE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,506,457 - 48,534,733 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11950,375,028 - 50,400,941 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01939,289,162 - 39,315,067 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,881,292 - 47,907,066 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,881,292 - 47,907,066 (-)Ensemblpanpan1.1panPan2
LIPE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,987,862 - 112,006,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,988,029 - 112,006,461 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,412,499 - 111,431,532 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,598,798 - 112,617,839 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,607,340 - 112,617,499 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,153,322 - 112,171,913 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,788,548 - 111,807,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,715,381 - 112,734,429 (+)NCBIUU_Cfam_GSD_1.0
LIPE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,540,708 - 49,560,125 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,543,671 - 49,560,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,443,742 - 45,454,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q12NCBI
LIPE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,604,822 - 36,630,648 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,605,126 - 36,630,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607314,849,833 - 14,875,994 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lipe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907363,572 - 379,194 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907360,462 - 379,266 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000011578   ⟹   ENSSTOP00000010392
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936706128,133 - 141,276 (+)Ensembl
RefSeq Acc Id: NM_001282250   ⟹   NP_001269179
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,781,235 - 15,792,162 (+)NCBI
SpeTri2.0NW_004936706128,578 - 139,505 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013364162   ⟹   XP_013219616
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,775,536 - 15,791,887 (+)NCBI
SpeTri2.0NW_004936706122,939 - 139,506 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013364164   ⟹   XP_013219618
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,781,155 - 15,791,887 (+)NCBI
SpeTri2.0NW_004936706128,471 - 139,506 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013364165   ⟹   XP_013219619
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,781,319 - 15,791,887 (+)NCBI
SpeTri2.0NW_004936706128,606 - 139,506 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013364166   ⟹   XP_013219620
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,781,266 - 15,791,887 (+)NCBI
SpeTri2.0NW_004936706128,569 - 139,506 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040278772   ⟹   XP_040134706
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,772,663 - 15,791,887 (+)NCBI
RefSeq Acc Id: XM_040278773   ⟹   XP_040134707
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,772,658 - 15,792,146 (+)NCBI
RefSeq Acc Id: XM_040278774   ⟹   XP_040134708
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,774,275 - 15,791,887 (+)NCBI
RefSeq Acc Id: XM_040278775   ⟹   XP_040134709
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,780,709 - 15,791,887 (+)NCBI
RefSeq Acc Id: XM_040278776   ⟹   XP_040134710
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,775,950 - 15,791,887 (+)NCBI
RefSeq Acc Id: XM_040278777   ⟹   XP_040134711
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,775,790 - 15,791,887 (+)NCBI
RefSeq Acc Id: XP_013219616   ⟸   XM_013364162
- Peptide Label: isoform X3
- UniProtKB: I3MHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013219618   ⟸   XM_013364164
- Peptide Label: isoform X4
- UniProtKB: I3MHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013219620   ⟸   XM_013364166
- Peptide Label: isoform X4
- UniProtKB: I3MHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269179   ⟸   NM_001282250
- UniProtKB: Q9R101 (UniProtKB/Swiss-Prot),   I3MHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013219619   ⟸   XM_013364165
- Peptide Label: isoform X4
- UniProtKB: I3MHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040134707   ⟸   XM_040278773
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040134706   ⟸   XM_040278772
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040134708   ⟸   XM_040278774
- Peptide Label: isoform X4
- UniProtKB: I3MHL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040134711   ⟸   XM_040278777
- Peptide Label: isoform X4
- UniProtKB: I3MHL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040134710   ⟸   XM_040278776
- Peptide Label: isoform X4
- UniProtKB: I3MHL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040134709   ⟸   XM_040278775
- Peptide Label: isoform X4
- UniProtKB: I3MHL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000010392   ⟸   ENSSTOT00000011578

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000011564 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000011578.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSL_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_GDXG_HIS_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_GDXG_put_SER_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Lipe ENTREZGENE
PANTHER HORMONE-SENSITIVE LIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIACYLGLYCEROL LIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Abhydrolase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSL_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPASE_GDXG_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPASE_GDXG_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt I3MHL5 ENTREZGENE, UniProtKB/TrEMBL
  LIPS_ICTTR UniProtKB/Swiss-Prot, ENTREZGENE