Actn3 (actinin alpha 3) - Rat Genome Database

Name: Actn3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Actn3 (actinin alpha 3) Ictidomys tridecemlineatus

Analyze

Symbol:

Actn3

Name:

actinin alpha 3

RGD ID:

12473994

Description:

ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); calcium ion binding (inferred); INVOLVED IN osteoblast differentiation (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); intellectual disability (ortholog); Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (ortholog); FOUND IN brush border (inferred); cell junction (inferred); cell projection (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

alpha-actinin-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACTN3 (actinin alpha 3)	NCBI	Ortholog
Mus musculus (house mouse):	Actn3 (actinin alpha 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Actn3 (actinin alpha 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Actn3 (actinin alpha 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACTN3 (actinin alpha 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACTN3 (actinin alpha 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACTN3 (actinin alpha 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACTN3 (actinin alpha 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Actn3 (actinin alpha 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	6,591,510 - 6,604,021 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	3,029,202 - 3,046,385 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	3,033,854 - 3,046,364 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 3 (ISO)

intellectual disability (ISO)

Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA)

bone morphogenesis (IEA)

focal adhesion assembly (IEA)

muscle cell development (IEA)

negative regulation of calcineurin-NFAT signaling cascade (IEA)

negative regulation of cold-induced thermogenesis (IEA)

negative regulation of glycolytic process (IEA)

negative regulation of oxidative phosphorylation (IEA)

negative regulation of relaxation of muscle (IEA)

osteoblast differentiation (ISO)

positive regulation of bone mineralization involved in bone maturation (IEA)

positive regulation of fast-twitch skeletal muscle fiber contraction (IEA)

positive regulation of glucose catabolic process to lactate via pyruvate (IEA)

positive regulation of skeletal muscle fiber development (IEA)

positive regulation of skeletal muscle tissue growth (IEA)

regulation of aerobic respiration (IEA)

regulation of muscle system process (IEA)

regulation of the force of skeletal muscle contraction (IEA)

response to denervation involved in regulation of muscle adaptation (IEA)

skeletal muscle atrophy (IEA)

transition between fast and slow fiber (IEA)

Cellular Component

brush border (IEA)

cell junction (IEA)

cell projection (IEA)

cortical actin cytoskeleton (IEA)

cytoplasm (IEA)

focal adhesion (IEA)

plasma membrane (IEA)

sarcomere (IEA)

Z disc (IEA)

Molecular Function

actin binding (IEA)

actin filament binding (IEA)

calcium ion binding (IEA)

identical protein binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

transmembrane transporter binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Actn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	6,591,510 - 6,604,021 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	3,029,202 - 3,046,385 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	3,033,854 - 3,046,364 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACTN3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	66,546,395 - 66,563,334 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	66,546,395 - 66,563,334 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	66,313,866 - 66,330,805 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	66,070,967 - 66,087,373 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	66,070,966 - 66,087,373	NCBI
Celera	11	63,634,667 - 63,651,076 (+)	NCBI		Celera
Cytogenetic Map	11	q13.2	NCBI
HuRef	11	62,641,774 - 62,658,713 (+)	NCBI		HuRef
CHM1_1	11	66,197,591 - 66,214,532 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	66,542,637 - 66,559,581 (+)	NCBI		T2T-CHM13v2.0

Actn3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	4,911,244 - 4,927,937 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	4,911,244 - 4,927,937 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	4,861,216 - 4,877,909 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	4,861,216 - 4,877,909 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	4,861,223 - 4,877,884 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	4,861,223 - 4,877,884 (-)	NCBI		MGSCv36	mm8
Celera	19	4,732,270 - 4,748,828 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	4.12	NCBI

Actn3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	211,588,473 - 211,604,401 (-)	NCBI		GRCr8
mRatBN7.2	1	202,159,081 - 202,175,012 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	202,159,082 - 202,175,012 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	210,512,172 - 210,528,076 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	217,604,503 - 217,620,434 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	210,295,523 - 210,311,455 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	220,120,532 - 220,136,460 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	220,120,533 - 220,136,470 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	227,051,530 - 227,067,458 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	207,475,569 - 207,492,267 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	207,629,022 - 207,645,720 (-)	NCBI
Celera	1	199,698,703 - 199,714,632 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

Actn3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	18,799,372 - 18,812,711 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	18,799,372 - 18,812,458 (-)	NCBI	ChiLan1.0	ChiLan1.0

ACTN3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	67,773,114 - 67,790,673 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	68,815,936 - 68,833,484 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	61,905,722 - 61,922,227 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	65,229,043 - 65,245,429 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	65,228,713 - 65,245,429 (+)	Ensembl	panpan1.1		panPan2

ACTN3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	50,787,353 - 50,801,036 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	50,787,353 - 50,801,197 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	49,396,057 - 49,409,780 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	51,819,196 - 51,832,924 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	51,819,196 - 51,832,713 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	50,920,215 - 50,933,937 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	50,500,258 - 50,513,996 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	51,290,188 - 51,303,909 (-)	NCBI		UU_Cfam_GSD_1.0

ACTN3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	5,860,391 - 5,874,124 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	5,860,386 - 5,873,779 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	4,936,279 - 4,949,682 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACTN3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	7,708,595 - 7,724,634 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	7,705,725 - 7,724,589 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	104,992,438 - 105,008,258 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Actn3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	19,844,884 - 19,858,950 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	19,844,996 - 19,859,274 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000009764 ⟹ ENSSTOP00000008757

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936599	3,029,202 - 3,046,385 (-)	Ensembl

RefSeq Acc Id:

XM_005333375 ⟹ XP_005333432

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	6,591,510 - 6,604,021 (-)	NCBI
SpeTri2.0	NW_004936599	3,033,854 - 3,046,364 (-)	NCBI

Sequence:

show sequence

AATCCGATCCGGGGCTGGGCCGGGACCTACTTAACGGGGCCCGGTTGTCCGGGAACGCGCGGAG
CGGAGCCAGGAGCCCAAGCAAGATGATGATGGTTATGCAGCCCGAGGGTCTGGGGGCCGGGGAG
GGGCCCTTCGCGGGCGGCGGGGGCGGCGAGTACATGGAACAGGAGGAGGACTGGGACCGCGACC
TGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGGAAAACCTTCACTGCCTGGTGCAACTCACA
TCTGCGCAAAGCGGGCACCCAGATCGAGAACATCGAGGAGGACTTCCGAAATGGCCTCAAGCTC
ATGCTGCTCCTGGAGGTCATTTCAGGAGAGAGGCTCCCCAGGCCAGACAAAGGCAAGATGCGCT
TCCACAAAATCGCCAATGTCAACAAGGCCCTGGACTTCATTGCCAGCAAGGGAGTTAAGCTGGT
GTCTATCGGTGCTGAGGAGATCGTCGACGGGAACCTGAAGATGACCCTGGGCATGATCTGGACC
ATCATCCTCCGCTTCGCCATCCAGGACATCTCAGTGGAAGAAACCTCGGCCAAGGAAGGCTTGC
TCCTGTGGTGCCAGCGGAAGACAGCCCCGTACCGCAATGTCAACGTGCAGAACTTCCACACCAG
CTGGAAGGATGGCCTGGCCCTCTGTGCTCTCATCCACCGACACCGGCCTGACCTCATTGACTAT
GCCAAACTGCGCAAGGATGACCCTATTGGCAACCTGAACACTGCCTTTGAAGTGGCGGAGAAAT
ACCTGGACATCCCAAAGATGCTGGATGCGGAAGACATCGTGAACACTCCAAAGCCAGACGAGAA
GGCCATCATGACCTATGTTTCCTGCTTCTACCATGCCTTTGCAGGGGCTGAGCAGGCAGAGACA
GCTGCCAACAGGATCTGCAAGGTGCTGGCCGTGAACCAGGAAAATGAGAAGCTGATGGAAGAGT
ATGAGAAGCTGGCCAGCGAGCTGTTGGAGTGGATCCGCCGCACTGTCCCATGGCTGGAGAACCG
TGTGGGCGAGCCCAGCATGAGTGCCATGCAGCGTAAGTTGGAGGACTTTCGGGACTACCGGCGC
CTGCACAAACCGCCCCGAGTTCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGA
CCAAGTTGCGGCTGAGCCACCGACCCGCCTTCATGCCCTCCGAGGGCAAGCTGGTCTCGGACAT
TGCCAATGCGTGGCGAGGGCTGGAGCAAGTGGAAAAGGGCTATGAGGACTGGCTGCTGTCTGAG
ATCCGGCGCCTACAGCGCCTTCAGCATCTGGCGGAGAAGTTCCAGCAGAAGGCTTCTCTGCATG
AAGCCTGGACCCGGGGGAAGGAGGACATGTTGAACCAGCGCGACTACGAGTCGGCTTCGCTGCA
GGAGGTGCGCGCGTTGCTTCGGCGCCACGAGGCCTTTGAGAGCGACCTGGCAGCGCACCAGGAC
CGCGTGGAGCACATCGCTGCGCTGGCCCAGGAACTCAATGAGCTGGACTACCATGACGCGGCCT
CAGTGAACAGCCGCTGCCAGGCCATCTGCGACCAGTGGGACAACTTGGGCACGCTGACCCAGAA
GAGGAGGGATGCGCTAGAGCGGATGGAGAAGCTCCTGGAAACCATCGACCAGCTGCAGCTGGAG
TTTGCAAGGAGGGCAGCTCCCTTCAACAACTGGCTGGATGGGGCAGTGGAGGACCTGCAGGATG
TGTGGCTGGTGCACTCTGTGGAGGAAACCCAGAGCCTGCTGACAGCTCACGAGCAATTCAAGGC
AACACTGCCTGAGGCTGACCGAGAGCGAGGTGCCATCCTGGGCATCCAGGGCGAGATCCAGAAG
ATCTGCCAAACGTACGGGCTTCGGCCCAAGTCTACCAACCCTTATATCACCCTCAGCCCCCAGG
ACATCAACAACAAGTGGGACATGGTTCGAAAGTTGGTGCCCAGCCGTGACCAGACACTGCAGGA
GGAGCTGGCCCGGCAGCAGGTGAATGAGAGGCTCCGGCGACAGTTTGCTGCCCAGGCCAATGCC
GTAGGACCTTGGATCCAGGCAAAGGTGGAGGAGGTGGGTCGGCTGGCAGCAGGGCTGGCTGGCT
CTCTGGAGGAACAGATGGCAGGACTGCGGCAGCAGGAGCAAAACATCATCAACTACAAGAGCAA
CATCGACCGTCTGGAGGGTGACCACCAGCTGCTGCAAGAGAGCCTGGTCTTTGACAATAAGCAC
ACTGTCTACAGCATGGAGCACATCCGTGTGGGCTGGGAGCAGCTGCTCACCTCCATCGCCCGCA
CCATCAATGAGGTAGAGAACCAGGTACTGACCCGAGACGCCAAGGGCCTGAGCCAGGAGCAGCT
TAATGAGTTCCGGGCATCCTTCAACCACTTTGACCGGAAGCGGAATGGGATGATGGAGCCTGAT
GACTTTCGAGCCTGCCTCATCTCCATGGGGTATGACCTGGGTGAAGTGGAGTTTGCGCGCATCA
TGACCATGGTGGACCCCAACGCAGCTGGGGTTGTGACCTTCCAGGCTTTCATTGACTTCATGAC
CCGAGAGACGGCTGAAACAGACACAGCTGAGCAAGTTGTAGCCTCCTTCAAGATCCTGGCAGGA
GACAAGAACTACATCACCCCCGAGGAGCTGAGGCGGGAGCTCCCAGCTGAGCAGGCTGAGTACT
GCATCCGCCGGATGGTGCCCTACAAGGGAACTGGTGCTCCAGCCGGAGCCCTGGACTACGTGGC
CTTTTCTAGTGCGCTGTATGGGGAAAGCGACCTCTGACCTTAGCCCTGCAGTTCTTGAGAAAAG
AAAAGAAAGAGGGTGTTCCCTGTGGCTCATCCCATCCATCCGCCAGTCAGGCCCTCAGAGATCA
GCCAGCCAAGTACTTCTGAATAAAGATCCCGTGGGCTTCTCTCCATCTCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005333432	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008757.3
GenBank Protein	KAG3284621	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005333432 ⟸ XM_005333375

- UniProtKB:

I3ME63 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMMVMQPEGLGAGEGPFAGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQ
IENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEI
VDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLAL
CALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVS
CFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMS
AMQRKLEDFRDYRRLHKPPRVQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGL
EQVEKGYEDWLLSEIRRLQRLQHLAEKFQQKASLHEAWTRGKEDMLNQRDYESASLQEVRALLR
RHEAFESDLAAHQDRVEHIAALAQELNELDYHDAASVNSRCQAICDQWDNLGTLTQKRRDALER
MEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHEQFKATLPEADR
ERGAILGIQGEIQKICQTYGLRPKSTNPYITLSPQDINNKWDMVRKLVPSRDQTLQEELARQQV
NERLRRQFAAQANAVGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKSNIDRLEGD
HQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASF
NHFDRKRNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETD
TAEQVVASFKILAGDKNYITPEELRRELPAEQAEYCIRRMVPYKGTGAPAGALDYVAFSSALYG
ESDL

hide sequence

RefSeq Acc Id:

ENSSTOP00000008757 ⟸ ENSSTOT00000009764

Protein Domains

Calponin-homology (CH) EF-hand

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009751	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009764.3	UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.10	UniProtKB/TrEMBL
	1.20.58.60	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
InterPro	Actinin_actin-bd_CS	UniProtKB/TrEMBL
	CH-domain	UniProtKB/TrEMBL
	CH_dom_sf	UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF-hand_Ca_insen	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	Spectrin/alpha-actinin	UniProtKB/TrEMBL
	Spectrin_repeat	UniProtKB/TrEMBL
NCBI Gene	Actn3	ENTREZGENE
PANTHER	ALPHA-ACTININ-3	UniProtKB/TrEMBL
	SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN	UniProtKB/TrEMBL
Pfam	EFhand_Ca_insen	UniProtKB/TrEMBL
	PF00307	UniProtKB/TrEMBL
	Spectrin	UniProtKB/TrEMBL
PROSITE	ACTININ_1	UniProtKB/TrEMBL
	ACTININ_2	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	PS50021	UniProtKB/TrEMBL
SMART	EFh	UniProtKB/TrEMBL
	efhand_Ca_insen	UniProtKB/TrEMBL
	SM00033	UniProtKB/TrEMBL
	SPEC	UniProtKB/TrEMBL
Superfamily-SCOP	Spectrin repeat	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
	SSF47576	UniProtKB/TrEMBL
UniProt	I3ME63	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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