Sgsh (N-sulfoglucosamine sulfohydrolase)

Gene: Sgsh (N-sulfoglucosamine sulfohydrolase) Ictidomys tridecemlineatus

Analyze

Symbol:

Sgsh

Name:

N-sulfoglucosamine sulfohydrolase

RGD ID:

12460807

Description:

ENCODES a protein that exhibits glycosaminoglycan binding (inferred); hydrolase activity (inferred); N-acetylglucosamine-6-sulfatase activity (inferred); INVOLVED IN determination of adult lifespan (ortholog); motor behavior (ortholog); ASSOCIATED WITH carbohydrate metabolic disorder (ortholog); Chediak-Higashi syndrome (ortholog); Developmental Disabilities (ortholog); FOUND IN lysosomal lumen (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

N-sulphoglucosamine sulphohydrolase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	2,208,133 - 2,216,751 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	4,193,983 - 4,204,008 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	4,195,217 - 4,203,802 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

carbohydrate metabolic disorder (ISO)

Chediak-Higashi syndrome (ISO)

Developmental Disabilities (ISO)

diarrhea (ISO)

Familial Pityriasis Rubra Pilaris (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

intellectual disability (ISO)

mucopolysaccharidosis (ISO)

mucopolysaccharidosis III (ISO)

mucopolysaccharidosis type IIIA (ISO)

neurodegenerative disease (ISO)

pathologic nystagmus (ISO)

pityriasis rubra pilaris (ISO)

psoriasis 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

determination of adult lifespan (IEA,ISO)

glycosaminoglycan catabolic process (IEA)

heparan sulfate proteoglycan catabolic process (IEA)

motor behavior (IEA,ISO)

Cellular Component

lysosomal lumen (IEA,ISO)

lysosome (IEA)

Molecular Function

glycosaminoglycan binding (IEA)

hydrolase activity (IEA)

N-acetylglucosamine-6-sulfatase activity (IEA)

N-sulfoglucosamine sulfohydrolase activity (IEA)

protein binding (ISO)

sulfuric ester hydrolase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Sgsh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	2,208,133 - 2,216,751 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	4,193,983 - 4,204,008 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	4,195,217 - 4,203,802 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SGSH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	80,200,673 - 80,220,333 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	80,206,716 - 80,220,923 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	78,183,075 - 78,194,132 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	75,797,685 - 75,808,719 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	75,797,684 - 75,808,719	NCBI
Celera	17	74,812,270 - 74,823,389 (-)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	73,623,348 - 73,634,467 (-)	NCBI		HuRef
CHM1_1	17	78,269,258 - 78,280,378 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	81,101,075 - 81,120,754 (-)	NCBI		T2T-CHM13v2.0

Sgsh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	119,234,315 - 119,246,336 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	119,234,251 - 119,246,362 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	119,343,489 - 119,355,510 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	119,343,425 - 119,355,536 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	119,204,803 - 119,216,824 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	119,159,582 - 119,171,592 (-)	NCBI		MGSCv36	mm8
Celera	11	131,091,260 - 131,103,792 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	83.36	NCBI

Sgsh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	105,095,336 - 105,112,037 (-)	NCBI		GRCr8
mRatBN7.2	10	104,596,810 - 104,613,510 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	104,598,112 - 104,613,486 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	108,469,312 - 108,479,094 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	108,075,298 - 108,085,523 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	10	103,150,568 - 103,160,450 (-)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

Sgsh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	2,701,905 - 2,711,073 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955506	2,701,901 - 2,713,431 (+)	NCBI	ChiLan1.0	ChiLan1.0

SGSH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	96,788,953 - 96,800,097 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	101,688,706 - 101,699,811 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	74,636,854 - 74,647,958 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	80,370,641 - 80,381,698 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	80,371,790 - 80,381,703 (-)	Ensembl	panpan1.1		panPan2

SGSH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	1,540,933 - 1,547,029 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	1,540,932 - 1,547,029 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	2,180,762 - 2,186,880 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	2,173,239 - 2,179,357 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	2,173,260 - 2,179,905 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	2,196,651 - 2,202,770 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	2,322,098 - 2,328,214 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	2,403,348 - 2,409,505 (+)	NCBI		UU_Cfam_GSD_1.0

SGSH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	2,241,840 - 2,248,376 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	2,241,824 - 2,248,388 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	2,193,028 - 2,199,570 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SGSH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	72,192,559 - 72,203,230 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	72,190,310 - 72,203,130 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	43,494,846 - 43,506,201 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sgsh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	9,285,806 - 9,297,151 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	9,287,776 - 9,297,164 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000005460 ⟹ ENSSTOP00000004885

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936594	4,193,983 - 4,204,008 (-)	Ensembl

RefSeq Acc Id:

XM_005332634 ⟹ XP_005332691

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	2,208,133 - 2,216,751 (+)	NCBI
SpeTri2.0	NW_004936594	4,195,217 - 4,203,802 (-)	NCBI

Sequence:

show sequence

GGACCGCGGTCGCCATGCACAGCCTCGGGCCCGCCTGCTGCTCGCTGCTGCTGGTCTTGGGACT
CTGCCGGGCGCGCCCCCGGAACGTGCTGCTGATCCTAGCGGACGATGGAGGTTTTGAGAGTGGA
GTGTACAACAACAGTGCCATCGCCACCCCTCACCTGGACGCCCTGGCCCGCCGCAGCCTCGTCT
TCCGCAACGCCTTCACCTCCGTCAGCAGCTGCTCGCCTAGCCGTGCCAGCCTCCTCACAGGCCT
GCCCCAGCACCAGAATGGCATGTACGGGCTGCACCAGGACGTGCACCACTTCAACTCCTTCGAC
AAGGTGCGGAGCCTGCCGCTGCTGCTCAGCCAGGCCGGCGTGCGCACAGGCATCATCGGGAAGA
AGCACGTGGGGCCGGAGACCGTGTACCCGTTTGACTTTGCGCACACAGAGGAGAACGACTCCGT
GCTCCAGGTGGGGCGGAACATCACCAGGATTAAGCTGCTGGTCCGGAAGTTCCTGCAGACTCAG
GATGACAGGCCTTTCTTCCTGTACGTTGCCTTCCACGACCCCCACCGCTGTGGGCACTCGCAGC
CCCAGTACGGAGCCTTCTGTGAGAAGTTTGGCAACGGGGACAGCGGCATGGGGCGCATCCCAGA
CTGGACACCCCAGGTCTACGACCCTCAGGATGTGCTGGTGCCTTACTTTGTCCCCGACACCCCA
GCAGCCCGAGCTGACCTGGCTGCTCAGTACACCACCATCGGCCGCATGGACCAAGGGATCGGGC
TTGTGCTTGAGGAGCTGCGTGGAGCCGGGGTCCTGAACAACACCCTGGTCATCTTCACATCCGA
CAATGGGATCCCCTTCCCCAGCGGCAGGACCAACCTGTACTGGCCGGGTACCGCCGAGCCCTTG
CTGGTGTCCTCTCCGGAGCACCGGCAGCGCTGGGGCCAGGTCAGCGAGGCCTTCGTGAGCCTCC
TAGATCTCACGCCCACCATCTTGGACTGGTTCTCCCTCTCCTACCCCAGCTACACCATCTTTGG
CTCCAAAACCATCCAGCTCACGGGCCGGTCCCTCCTGCCAGCACTGGAGGCAGAGCCCCTTTGG
GCCACCGTCTTTGGCAGCCAGAGCCACCACGAGGTCACCATGTCCTACCCGATGCGCTCCGTGT
ACCACCAGAACTTCCGCCTGGTGCACAACCTGGGCTTCAAGATGCCCTTCCCCGTGGACCAGGA
CCTCTACGTCTCGCCCACCTTTCAGGACCTCCTGAACCGCACTGTGGCCGGCCAGCCCACGGGC
TGGTACAAGGACCTGCACCACTACTACTACCGCGACCGCTGGGAGCTCTACGATGAGCACAGCG
ACCCCCGCGAGACCCAGAACCTGGCTGCCGACCCCCGCTTCGCCCAGGTCCTGGAGGCGCTGAA
GACCCGCCTGGCCAAGTGGCAGTGGGAGACCCATGACCCCTGGGTGTGTGCCCCCGAGGGCGTC
CTGGAGGAGAAGCTGTCTCCACAGTGCCGGCCCCTCCACAACGAGCTGTGACGTGGGGTGTCAC
ACGGCCTCTCCTCTCCTGAAGGGGAGACCCCATATGCCCTACCTCCTCCCTTGGGGGGGATGCC
TCCATAGCAGGGGACACTGTTGTCCTCGAGTCTGAGCCGTGCCCTGGCACAAGAACTGTGGGGG
GTAGCCTGGGACAGGGTGGGATCCCCAGCCCAGGCTTTCAGGGTGCGTTTGGGGATCCCAAGAC
AAAAGGGCAGGGACCTTGATCAGTGTGAGGCACCAGGGACATTTCTGACCCCTCCACTGGAGGC
AGCCGGACATGGCCTCTGGCGTTACCAGCCCTGCTTGGCTCCACTGCCTTCCTTTGCCCACAGC
CCCGCATCCGCCCCAGGGGGTTCTCACTGGTTCTTGGTGGTGACAGGTTTAGTCCTGGGACCTT
GCTGGGCAGAGCTGGTCCTTCTTTCTGAGCTGCTGGGGACGAGGTGTGAAAGGGCACCCTGTGG
CTTGGGTTGTTTCTTGTGTGACACCAGGGTCTGGCTCCATCCCTGCCTGCCTCTGCGTGCCCAG
AAACTCAGCCTTGAAAAACTAGACAGAGGGTCCTCTCCCTCTAGCGGGGTCCCCTGCACTCCAC
TCCATATGGGCCTGGGGTGGGAGGAAACCACAGCCAGAGCCCTGTAAAAGCCGTTTATTCCATA
AAACACACGGAATCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005332691	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004885.2
GenBank Protein	KAG3268329	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005332691 ⟸ XM_005332634

- UniProtKB:

I3M641 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHSLGPACCSLLLVLGLCRARPRNVLLILADDGGFESGVYNNSAIATPHLDALARRSLVFRNAF
TSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGP
ETVYPFDFAHTEENDSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGA
FCEKFGNGDSGMGRIPDWTPQVYDPQDVLVPYFVPDTPAARADLAAQYTTIGRMDQGIGLVLEE
LRGAGVLNNTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHRQRWGQVSEAFVSLLDLTP
TILDWFSLSYPSYTIFGSKTIQLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVYHQNF
RLVHNLGFKMPFPVDQDLYVSPTFQDLLNRTVAGQPTGWYKDLHHYYYRDRWELYDEHSDPRET
QNLAADPRFAQVLEALKTRLAKWQWETHDPWVCAPEGVLEEKLSPQCRPLHNEL

hide sequence

RefSeq Acc Id:

ENSSTOP00000004885 ⟸ ENSSTOT00000005460

Protein Domains

N-sulphoglucosamine sulphohydrolase C-terminal Sulfatase N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000005466	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000005460.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.720.10	UniProtKB/TrEMBL
InterPro	Alkaline_phosphatase_core_sf	UniProtKB/TrEMBL
	DUF4976	UniProtKB/TrEMBL
	Sulfatase_CS	UniProtKB/TrEMBL
	Sulfatase_N	UniProtKB/TrEMBL
NCBI Gene	Sgsh	ENTREZGENE
PANTHER	N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER	UniProtKB/TrEMBL
	N-SULPHOGLUCOSAMINE SULPHOHYDROLASE	UniProtKB/TrEMBL
Pfam	DUF4976	UniProtKB/TrEMBL
	Sulfatase	UniProtKB/TrEMBL
PROSITE	SULFATASE_1	UniProtKB/TrEMBL
	SULFATASE_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53649	UniProtKB/TrEMBL
UniProt	I3M641	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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