Pitrm1 (pitrilysin metallopeptidase 1) - Rat Genome Database

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Gene: Pitrm1 (pitrilysin metallopeptidase 1) Ictidomys tridecemlineatus
Analyze
Symbol: Pitrm1
Name: pitrilysin metallopeptidase 1
RGD ID: 12452097
Description: ENCODES a protein that exhibits metallopeptidase activity (ortholog); INVOLVED IN protein processing (inferred); proteolysis (inferred); ASSOCIATED WITH autosomal recessive spinocerebellar ataxia 30 (ortholog); genetic disease (ortholog); mitochondrial DNA depletion syndrome 7 (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: presequence protease, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934434,906,141 - 34,939,681 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648411,071,372 - 11,104,828 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648411,071,407 - 11,104,828 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pitrm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934434,906,141 - 34,939,681 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648411,071,372 - 11,104,828 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648411,071,407 - 11,104,828 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PITRM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38103,137,727 - 3,172,841 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl103,137,728 - 3,172,841 (-)EnsemblGRCh38hg38GRCh38
GRCh37103,179,919 - 3,215,033 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36103,169,920 - 3,205,003 (-)NCBINCBI36Build 36hg18NCBI36
Build 34103,169,919 - 3,205,003NCBI
Celera103,125,736 - 3,160,789 (-)NCBICelera
Cytogenetic Map10p15.2NCBI
HuRef103,114,941 - 3,150,025 (-)NCBIHuRef
CHM1_1103,179,880 - 3,214,996 (-)NCBICHM1_1
T2T-CHM13v2.0103,138,971 - 3,174,045 (-)NCBIT2T-CHM13v2.0
Pitrm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,598,158 - 6,630,194 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl136,598,185 - 6,630,551 (+)EnsemblGRCm39 Ensembl
GRCm38136,548,122 - 6,580,158 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,548,149 - 6,580,515 (+)EnsemblGRCm38mm10GRCm38
MGSCv37136,547,403 - 6,579,404 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36136,547,403 - 6,579,404 (+)NCBIMGSCv36mm8
Celera136,497,283 - 6,529,453 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map133.25NCBI
Pitrm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81768,705,699 - 68,737,350 (-)NCBIGRCr8
mRatBN7.21763,795,670 - 63,827,317 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1763,795,671 - 63,839,907 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1767,297,936 - 67,329,918 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01771,126,723 - 71,158,705 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01765,148,964 - 65,180,608 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01768,477,423 - 68,509,113 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1768,477,446 - 68,509,120 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01770,194,206 - 70,225,894 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41774,824,700 - 74,856,784 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11774,835,838 - 74,867,610 (-)NCBI
Celera1763,393,689 - 63,425,141 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Pitrm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542128,008,733 - 28,042,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542128,010,756 - 28,041,336 (+)NCBIChiLan1.0ChiLan1.0
PITRM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2815,630,803 - 15,666,523 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11015,636,125 - 15,671,845 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0103,135,895 - 3,171,235 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1103,148,958 - 3,184,120 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl103,148,758 - 3,184,120 (-)Ensemblpanpan1.1panPan2
PITRM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1232,182,934 - 32,220,119 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl232,182,853 - 32,220,072 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha229,211,779 - 29,248,682 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0232,565,906 - 32,602,813 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl232,565,919 - 32,602,810 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1229,652,684 - 29,689,513 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0230,490,239 - 30,527,040 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0231,218,020 - 31,254,840 (+)NCBIUU_Cfam_GSD_1.0
PITRM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1066,996,954 - 67,047,235 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11066,996,919 - 67,021,692 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21073,691,697 - 73,711,221 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PITRM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.193,192,692 - 3,239,667 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660518,339,887 - 8,378,274 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pitrm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247757,292,908 - 7,323,618 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247757,292,855 - 7,324,147 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000006387   ⟹   ENSSTOP00000005709
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648411,071,372 - 11,104,828 (+)Ensembl
RefSeq Acc Id: XM_005320331   ⟹   XP_005320388
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934434,906,141 - 34,939,681 (+)NCBI
SpeTri2.0NW_00493648411,071,407 - 11,104,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040277240   ⟹   XP_040133174
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934434,906,180 - 34,939,681 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005320388 (Get FASTA)   NCBI Sequence Viewer  
  XP_040133174 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000005709.3
GenBank Protein KAG3257777 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005320388   ⟸   XM_005320331
- Peptide Label: isoform X1
- UniProtKB: I3M7U1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040133174   ⟸   XM_040277240
- Peptide Label: isoform X2
RefSeq Acc Id: ENSSTOP00000005709   ⟸   ENSSTOT00000006387
Protein Domains
Peptidase M16C associated


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000006348 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006387.3 UniProtKB/TrEMBL
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/TrEMBL
InterPro Metalloenz_LuxS/M16 UniProtKB/TrEMBL
  Pept_M16_N UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/TrEMBL
  Peptidase_M16C_assoc UniProtKB/TrEMBL
NCBI Gene Pitrm1 ENTREZGENE
PANTHER PRESEQUENCE PROTEASE UniProtKB/TrEMBL
  PRESEQUENCE PROTEASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam M16C_assoc UniProtKB/TrEMBL
  Peptidase_M16 UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/TrEMBL
SMART M16C_associated UniProtKB/TrEMBL
Superfamily-SCOP SSF63411 UniProtKB/TrEMBL
UniProt I3M7U1 ENTREZGENE, UniProtKB/TrEMBL