MMD (monocyte to macrophage differentiation associated) - Rat Genome Database

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Gene: MMD (monocyte to macrophage differentiation associated) Canis lupus familiaris
Analyze
Symbol: MMD
Name: monocyte to macrophage differentiation associated
RGD ID: 12434290
Description: ENCODES a protein that exhibits metal ion binding (inferred); pore-forming activity (inferred); protein kinase activity (inferred); INVOLVED IN positive regulation of neuron differentiation (inferred); regulation of protein localization (inferred); ASSOCIATED WITH systemic lupus erythematosus (ortholog); FOUND IN Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: monocyte to macrophage differentiation factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1930,426,843 - 30,453,403 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl930,428,490 - 30,453,574 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha929,768,974 - 29,795,468 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0931,226,046 - 31,252,644 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl931,226,043 - 31,252,662 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1929,995,011 - 30,021,504 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0930,251,565 - 30,278,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0930,384,720 - 30,411,254 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Golgi apparatus  (IEA,ISO)
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MMD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1930,426,843 - 30,453,403 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl930,428,490 - 30,453,574 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha929,768,974 - 29,795,468 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0931,226,046 - 31,252,644 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl931,226,043 - 31,252,662 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1929,995,011 - 30,021,504 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0930,251,565 - 30,278,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0930,384,720 - 30,411,254 (-)NCBIUU_Cfam_GSD_1.0
MMD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381755,392,622 - 55,421,835 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1755,392,622 - 55,421,924 (-)EnsemblGRCh38hg38GRCh38
GRCh371753,469,983 - 53,499,196 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361750,824,973 - 50,854,340 (-)NCBINCBI36Build 36hg18NCBI36
Build 341750,824,972 - 50,854,340NCBI
Celera1749,932,255 - 49,961,614 (-)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1748,830,304 - 48,859,555 (-)NCBIHuRef
CHM1_11753,535,395 - 53,564,747 (-)NCBICHM1_1
T2T-CHM13v2.01756,267,612 - 56,296,809 (-)NCBIT2T-CHM13v2.0
Mmd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391190,078,513 - 90,169,399 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1190,140,282 - 90,169,415 (+)EnsemblGRCm39 Ensembl
GRCm381190,249,276 - 90,278,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1190,249,456 - 90,278,589 (+)EnsemblGRCm38mm10GRCm38
MGSCv371190,110,790 - 90,139,887 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361190,065,566 - 90,094,663 (+)NCBIMGSCv36mm8
Celera1199,860,227 - 99,888,323 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1154.89NCBI
Mmd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81075,570,366 - 75,598,610 (+)NCBIGRCr8
mRatBN7.21075,073,278 - 75,101,528 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1075,073,365 - 75,101,528 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1079,691,289 - 79,719,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01079,196,250 - 79,224,404 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01074,670,605 - 74,698,606 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01077,687,964 - 77,783,737 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1077,755,216 - 77,783,779 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01077,616,444 - 77,645,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41078,664,115 - 78,692,402 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1073,969,719 - 73,990,355 (+)NCBICelera
Cytogenetic Map10q26NCBI
Mmd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554517,221,349 - 7,250,479 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554517,221,156 - 7,307,702 (+)NCBIChiLan1.0ChiLan1.0
MMD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21971,577,369 - 71,606,683 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11776,387,465 - 76,416,778 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01749,481,161 - 49,510,478 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11754,345,487 - 54,373,726 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1754,345,487 - 54,373,726 (-)Ensemblpanpan1.1panPan2
Mmd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560229,858,048 - 29,947,396 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364907,188,494 - 7,217,153 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049364907,127,594 - 7,217,153 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364907,127,685 - 7,217,095 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1231,695,851 - 31,723,712 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11231,695,843 - 31,723,723 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21232,362,124 - 32,389,071 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11637,951,329 - 37,980,527 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1637,951,372 - 37,980,714 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660778,789,514 - 8,818,750 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479510,656,561 - 10,685,607 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479510,656,648 - 10,685,615 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MMD
253 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 15 6 6 12 8 10 6
Low 1 5 7 6 6 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022423162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022423163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038486009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038486010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038486011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_537684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000048143   ⟹   ENSCAFP00000038931
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl930,428,490 - 30,453,360 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000059529   ⟹   ENSCAFP00000057892
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl930,428,490 - 30,453,574 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845029498   ⟹   ENSCAFP00845023172
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl931,226,043 - 31,252,662 (-)Ensembl
RefSeq Acc Id: XM_022423162   ⟹   XP_022278870
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1930,426,843 - 30,453,403 (-)NCBI
Dog10K_Boxer_Tasha929,768,974 - 29,795,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022423163   ⟹   XP_022278871
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1930,428,605 - 30,453,403 (-)NCBI
Dog10K_Boxer_Tasha929,770,763 - 29,795,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038486009   ⟹   XP_038341937
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1929,995,011 - 30,021,504 (-)NCBI
RefSeq Acc Id: XM_038486010   ⟹   XP_038341938
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1929,995,011 - 30,021,504 (-)NCBI
RefSeq Acc Id: XM_038486011   ⟹   XP_038341939
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1929,996,799 - 30,021,504 (-)NCBI
RefSeq Acc Id: XM_038547796   ⟹   XP_038403724
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0930,384,720 - 30,411,254 (-)NCBI
RefSeq Acc Id: XM_038547797   ⟹   XP_038403725
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0930,384,720 - 30,411,254 (-)NCBI
RefSeq Acc Id: XM_038547798   ⟹   XP_038403726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0930,386,509 - 30,411,254 (-)NCBI
RefSeq Acc Id: XM_038611769   ⟹   XP_038467697
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0930,251,565 - 30,278,108 (-)NCBI
RefSeq Acc Id: XM_038611770   ⟹   XP_038467698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0930,251,565 - 30,278,108 (-)NCBI
RefSeq Acc Id: XM_038611771   ⟹   XP_038467699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0930,253,352 - 30,278,108 (-)NCBI
RefSeq Acc Id: XM_038676996   ⟹   XP_038532924
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0931,226,046 - 31,252,644 (-)NCBI
RefSeq Acc Id: XM_038676997   ⟹   XP_038532925
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0931,226,046 - 31,252,644 (-)NCBI
RefSeq Acc Id: XM_038676998   ⟹   XP_038532926
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0931,227,834 - 31,252,644 (-)NCBI
RefSeq Acc Id: XM_537684   ⟹   XP_537684
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1930,426,843 - 30,453,403 (-)NCBI
Dog10K_Boxer_Tasha929,768,974 - 29,795,468 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_537684   ⟸   XM_537684
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N6I5 (UniProtKB/TrEMBL),   A0A8I3P8K7 (UniProtKB/TrEMBL),   A0A8C0LMW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022278870   ⟸   XM_022423162
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LMW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022278871   ⟸   XM_022423163
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCAFP00000057892   ⟸   ENSCAFT00000059529
RefSeq Acc Id: ENSCAFP00000038931   ⟸   ENSCAFT00000048143
RefSeq Acc Id: XP_038341938   ⟸   XM_038486010
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038341937   ⟸   XM_038486009
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038341939   ⟸   XM_038486011
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038467698   ⟸   XM_038611770
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038467697   ⟸   XM_038611769
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038467699   ⟸   XM_038611771
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038532925   ⟸   XM_038676997
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LMW9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038532924   ⟸   XM_038676996
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N6I5 (UniProtKB/TrEMBL),   A0A8I3P8K7 (UniProtKB/TrEMBL),   A0A8C0LMW9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038532926   ⟸   XM_038676998
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038403725   ⟸   XM_038547797
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LMW9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403724   ⟸   XM_038547796
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LMW9 (UniProtKB/TrEMBL),   A0A8C0N6I5 (UniProtKB/TrEMBL),   A0A8I3P8K7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403726   ⟸   XM_038547798
- Peptide Label: isoform X3
RefSeq Acc Id: ENSCAFP00845023172   ⟸   ENSCAFT00845029498

Promoters
RGD ID:13684607
Promoter ID:EPDNEW_C2674
Type:single initiation site
Name:MMD_1
Description:monocyte to macrophage differentiation associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1930,453,478 - 30,453,538EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029757 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012337 UniProtKB/TrEMBL
  ENSCAFG00040026008 UniProtKB/TrEMBL
  ENSCAFG00845016643 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000048143.3 UniProtKB/TrEMBL
  ENSCAFT00030022821.1 UniProtKB/TrEMBL
  ENSCAFT00030022883.1 UniProtKB/TrEMBL
  ENSCAFT00040048670.1 UniProtKB/TrEMBL
  ENSCAFT00845029498 ENTREZGENE
  ENSCAFT00845029498.1 UniProtKB/TrEMBL
InterPro AdipoR/HlyIII-related UniProtKB/TrEMBL
  Hy-lIII UniProtKB/TrEMBL
NCBI Gene MMD ENTREZGENE
PANTHER MONOCYTE TO MACROPHAGE DIFFERENTIATION FACTOR UniProtKB/TrEMBL
  PTHR20855 UniProtKB/TrEMBL
Pfam HlyIII UniProtKB/TrEMBL
UniProt A0A8C0LMW9 ENTREZGENE
  A0A8C0N6I5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RIL9_CANLF UniProtKB/TrEMBL
  A0A8I3P8K7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43270 ENTREZGENE